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Clinical validation of Whole Genome Sequencing for cancer diagnostics.

J Mol Diagn 2021 May 5. Epub 2021 May 5.

Hartwig Medical Foundation, Science Park 408, 1098 XH Amsterdam, the Netherlands; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

Whole genome sequencing (WGS) using fresh frozen tissue and matched blood samples from cancer patients is becoming in reach as the most complete genetic tumor test. With a trend towards the availability of small biopsies and the need to screen an increasing number of (complex) biomarkers, the use of a single all-inclusive test is preferred over multiple consecutive assays. To meet high-quality diagnostics standards, we optimized and clinically validated WGS sample and data processing procedures resulting in a technical success rate of 95. Read More

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MUSIC INTERVENTIONS IN PEDIATRIC ONCOLOGY: systematic review and meta-analysis.

Complement Ther Med 2021 May 5:102725. Epub 2021 May 5.

Pediatrics Department of the University of São Paulo, Av. Dr Enéas Carvalho Aguiar No. 647, Cerqueira Cesar, São Paulo, CEP: 05403-901, Brazil. Electronic address:

Background: Pain is a disagreeable and distressing feeling that affects human beings in multi-dimensional ways. A number of non-pharmacological interventions have had varying degrees of success in treating cancer-related pain, such as breathing and relaxation techniques, and music therapy, which have been identified as beneficial therapies for alleviating pain and anxiety.

Objective: Identify the therapeutic effects of music interventions in psychological and physiological terms and on the quality of life of children undergoing cancer treatment. Read More

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Lack of Conclusive Evidence of the Benefit of Biologic Augmentation in Core Decompression for Nontraumatic Osteonecrosis of the Femoral Head: A Systematic Review.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Orthopaedics, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland.

Purpose: To assess whether biologic augmentation in addition to core decompression (CD), compared to CD alone, improves clinical and radiographic outcomes in the treatment of nontraumatic osteonecrosis of the femoral head (ONFH). Our hypothesis was that biologic augmentation would reduce the progression of osteonecrosis and therefore also the rate of conversion to THA.

Methods: A systematic review was performed in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) statement. Read More

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ENB-guided microwave ablation combined with uniportal VATS for multiple ground glass opacities.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. Electronic address:

Background: An increasing number of patients are being diagnosed with multiple ground glass opacities (GGOs), but a consensus on the treatment of these patients is still lacking. The aim of this study was to investigate the safety and feasibility of a novel technique, electromagnetic navigation bronchoscopy (ENB)-guided microwave ablation combined with uniportal video-assisted thoracoscopic surgery (Uni-VATS), in patients with multiple GGOs.

Methods: The clinical, radiographic, surgical, and pathological data of patients with multiple GGOs who underwent ENB-guided microwave ablation combined with Uni-VATS from October 2018 to December 2019 were reviewed. Read More

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"Accidents waiting to happen" - insights from a simple model on the emergence of infectious agents in new hosts.

Transbound Emerg Dis 2021 May 8. Epub 2021 May 8.

Biological Interactions, Universidade Federal do Paraná, Curitiba, PR, 81531-980, Brazil.

This study evaluates through modeling the possible individual and combined effect of three populational parameters of pathogens (reproduction rate; rate of novelty emergence; and propagule size) on the colonization of new host species - putatively the most fundamental process leading to the emergence of new infectious diseases. The results are analyzed under the theoretical framework of the Stockholm Paradigm using IBM simulations to better understand the evolutionary dynamics of the pathogen population and the possible role of Ecological Fitting. The simulations suggest that all three parameters positively influence the success of colonization of new hosts by a novel parasite population but contrary to the prevailing belief, the rate of novelty emergence (e. Read More

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Evaluation of Dosing Strategies and Trough Concentrations of Vancomycin in Patients Undergoing Continuous Venovenous Hemofiltration.

Pharmacotherapy 2021 May 8. Epub 2021 May 8.

Harper University Hospital, Detroit, Michigan, USA.

Background: Recommendations regarding vancomycin dosing in critically ill patients on continuous venovenous hemofiltration (CVVH) are limited. The purpose of this study was to evaluate current dosing practices of pharmacists for patients treated with CVVH, develop guidelines for optimal dosing and monitoring of vancomycin to improve target trough attainment, and reduce pharmacist workload.

Methods: A retrospective cohort study was performed of critically ill adult patients at an academic medical center in Detroit, Michigan, from January 2015 to December 2018. Read More

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Clinical judgment is a cornerstone for validating and using clinical prediction rules: a head-to-head study on ambulation outcomes for spinal cord injured patients.

Spinal Cord 2021 May 7. Epub 2021 May 7.

Université de Montréal, Faculty of Medicine, Montréal, QC, Canada.

Study Design: Retrospective comparative study.

Objective: Clinical prediction rules (CPRs) are an effervescent topic in the medical literature. Recovering ambulation after a traumatic spinal cord injury (tSCI) is a priority for patients and multiple CPRs have been proposed for predicting ambulation outcomes. Read More

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Predictors of Deceased Organ Donation in the Pediatric Population.

Pediatrics 2021 May 7. Epub 2021 May 7.

Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.

Background: A shortage of donor organs represents the major barrier to the success of solid organ transplantation. This is especially true in the pediatric population for which the number of organ donors has decreased over time. With this study, we aimed to assess the factors associated with deceased organ donor consent in the pediatric population and determine the variability in consent rates across organ procurement organizations (OPOs). Read More

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[Functional results and satisfaction in 44 patients after implantation of a NS3-type sacral neurostimulator for refractory idiopathic overactive bladder followed at 43 months, single-center series].

Prog Urol 2021 May 4. Epub 2021 May 4.

Service d'urologie, Clinique Pasteur, 17200 Royan, France.

Objectives: Sacred neuromodulation (SNM) has been used in France since 1997 for the management of non-neurogenic urinary disorders that do not respond to first-line pharmacological treatment. The aim of this study is to analyze the clinical efficacy and satisfaction of patients with refractory idiopathic overactive bladder (OAB) treated with SNM.

Methods: This single-center retrospective series included 59 patients with refractory OAB of idiopathic origin and eligible for the SNM between January 2010 and December 2017. Read More

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Phase 3 multicenter randomized trial of PSMA PET/CT prior to definitive radiation therapy for unfavorable intermediate-risk or high-risk prostate cancer [PSMA dRT]: study protocol.

BMC Cancer 2021 May 7;21(1):512. Epub 2021 May 7.

Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Hufelandstraße 55, 45131, Essen, Germany.

Background: Definitive radiation therapy (dRT) is an effective initial treatment of intermediate-risk (IR) and high-risk (HR) prostate cancer (PCa). PSMA PET/CT is superior to standard of care imaging (CT, MRI, bone scan) for detecting regional and distant metastatic PCa. PSMA PET/CT thus has the potential to guide patient selection and the planning for dRT and improve patient outcomes. Read More

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The analgesic efficacy of forearm vfversus upper arm intravenous regional anesthesia (Bier's block): A randomized controlled non-inferiority trial.

J Clin Anesth 2021 May 5;73:110329. Epub 2021 May 5.

Department of Anaesthesiology and Pain Medicine, Jessa Hospital, Hasselt, Belgium; UHasselt, Faculty of Medicine and Life Sciences, Diepenbeek, Belgium.

Study Objective: This study aimed to assess if a forearm (FA) intravenous regional anesthesia (IVRA) with a lower, less toxic, local anesthetic dosage is non-inferior to an upper arm (UA) IVRA in providing a surgical block in patients undergoing hand and wrist surgery.

Design: Observer-blinded, randomized non-inferiority study.

Setting: Operating room. Read More

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Rapid population increase of the threatened Australian amphibian Litoria aurea in response to wetlands constructed as a refuge from chytrid-induced disease and introduced fish.

J Environ Manage 2021 May 4;291:112638. Epub 2021 May 4.

Conservation Science Research Group, School of Environmental and Life Sciences, Biology Building, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.

Amphibians have declined due to multiple impacts including invasive fish and the disease chytridiomycosis caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd). Wetland restoration can be used to increase amphibian populations. However the design of created wetlands must account for threats such as Bd and introduced fish. Read More

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Integration of hard and soft supervised machine learning for flood susceptibility mapping.

J Environ Manage 2021 May 4;291:112731. Epub 2021 May 4.

Team Soil, Water and Land Use, Wageningen Environmental Research, Droevendaalsesteeg 3, 6708RC, Wageningen, the Netherlands; Civil, Surveying and Environmental Engineering, The University of Newcastle, Callaghan, 2308, Australia.

Flooding is a destructive natural phenomenon that causes many casualties and property losses in different parts of the world every year. Efficient flood susceptibility mapping (FSM) can reduce the risk of this hazard, and has become the main approach in flood risk management. In this study, we evaluated the prediction ability of artificial neural network (ANN) algorithms for hard and soft supervised machine learning classification in FSM by using three ANN algorithms (multi-layer perceptron (MLP), fuzzy adaptive resonance theory (FART), self-organizing map (SOM)) with different activation functions (sigmoidal (-S), linear (-L), commitment (-C), typicality (-T)). Read More

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Elevated sperm DNA fragmentation does not predict recurrent implantation failure.

Andrologia 2021 May 7:e14094. Epub 2021 May 7.

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

In this study, we sought to determine whether sperm DNA fragmentation (DFI%) and high DNA stainability (HDS%) evaluated by sperm chromatin structure assay (SCSA) predict recurrent implantation failure (RIF) or pregnancy rate. A retrospective study was performed of consecutive cycles of ICSI treatment from 2009 to 2018. A total of 386 couples that underwent 1,216 frozen embryo transfer (FET) cycles were analysed. Read More

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Effects of light spectrum on morpho-physiological traits of grafted tomato seedlings.

PLoS One 2021 7;16(5):e0250210. Epub 2021 May 7.

College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou, China.

It is already known that there are many factors responsible for the successful grafting process in plants, including light intensity. However, the influence of the spectrum of light-emitting diodes (LEDs) on this process has almost never been tested. During the pre-grafting process tomato seedlings grew for 30 days under 100 μmol m-2 s-1 of mixed LEDs (red 70%+ blue 30%). Read More

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A Simple Method for Endoscopic Treatment of Large Gastric Phytobezoars: "Hand-Made Bezoaratome".

Turk J Gastroenterol 2021 Feb;32(2):141-147

Department of Gastroenterology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Background: Large gastric phytobezoars are generally resistant to standard chemical or endoscopic treatments. We presented our experience of an alternative endoscopic method using a hand-made tool called a "hand-made bezoaratome" for the treatment of large gastric phytobezoars.

Methods: Patients who consulted or who were diagnosed with gastric bezoars at an education and research hospital between January 2015 and December 2018 were prospectively included in the study. Read More

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February 2021

[Correction of Valgus Knee Deformity by Hemiepiphyseodesis: a Restrospective Analysis].

Acta Chir Orthop Traumatol Cech 2021 ;88(2):87-94

Ortopedická klinika 1. lékařské fakulty Univerzity Karlovy, IPVZ a Fakultní nemocnice Na Bulovce, Praha.

PURPOSE OF THE STUDY Hemiepiphyseodesis is commonly used to correct a coronal plane knee deformity during childhood. Since 2007 Blount staple method has been replaced by the eight-Plate Guided Growth System. We retrospectively analysed the indications, results and complications of the older Blount staple method so as to compare them with the newer eight-Plate Guided Growth system. Read More

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January 2021

A patient-specific algorithm to achieve commissural alignment with Acurate Neo: The sextant technique.

Catheter Cardiovasc Interv 2021 May 7. Epub 2021 May 7.

Clinical and Interventional Cardiology Department, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Aims: The aim of this proof-of-concept study was to investigate safety and efficacy of a CT-scan based patient-specific algorithm to maximize coronary clearance and secondarily to achieve anatomically correct commissural alignment with the Acurate Neo device.

Method And Results: A total of 45 consecutive patients undergoing TAVR with the Acurate Neo THV were prospectively enrolled in the study. Mean age was 81. Read More

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Transarterial Embolization for Bleeding in Patients with Head and Neck Cancer: Who Benefits?

Laryngoscope 2021 May 7. Epub 2021 May 7.

Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.

Objectives/hypothesis: The present study aimed to investigate the efficacy of transarterial embolization (TAE) for bleeding in patients with head and neck cancer (HNC) and to evaluate the prognostic factors after TAE.

Study Design: Outcome study.

Methods: This retrospective study included 31 consecutive patients (27 men and 4 women; median age, 61 years) who presented uncontrollable hemorrhage associated with HNC and underwent emergency TAE at our institution during a 10-year period (January 2011-December 2020). Read More

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The effect of optical dilatation before retrograde intrarenal surgery on success and complications: results of the RIRSearch group study.

Int J Clin Pract 2021 May 6:e14335. Epub 2021 May 6.

Florence Nightingale Hospital, Department of Urology, Istanbul, Turkey.

Aim: The guidelines propose optical dilatation before retrograde intrarenal surgery (RIRS), but there are currently no evidence-based studies concerning the impact of optical dilatation with semirigid ureteroscopy (sURS). The aim of this study was to evaluate the effect of optical dilatation through sURS prior to the RIRS procedure on the success and complications of RIRS.

Methods: A total of 422 patients were included in the retrospective multicentre study. Read More

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Laparoscopic Heller-Dor Is an Effective Treatment for Esophageal-Gastric Junction Outflow Obstruction.

J Gastrointest Surg 2021 May 6. Epub 2021 May 6.

Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, School of Medicine, Clinica Chirurgica 3, Azienda Ospedale Università di Padova, Padova, Italy.

Background: The treatment of esophagogastric junction outflow obstruction (EGJOO) currently mirrors that of achalasia, but this is based on only a few studies on small case series. The aim of this prospective, controlled study was to assess the outcome of laparoscopic Heller-Dor (LHD) in patients with EGJOO, as compared with patients with esophageal achalasia.

Materials And Methods: Between 2016 and 2019, patients with manometric diagnosis of idiopathic EGJOO and patients with radiological stage I achalasia, both treated with LHD, were compared. Read More

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Safety and effectiveness of hemorrhoidal artery ligation using the HAL-RAR technique for hemorrhoidal disease.

Langenbecks Arch Surg 2021 May 6. Epub 2021 May 6.

Amalia Fleming Surgical Department, Sismanoglio - Amalia Fleming General Hospital, Athens, Greece.

Purpose: A wide variety of methods has been proposed for treating hemorrhoidal disease. The aim of the study is to assess the safety and effectiveness of hemorrhoidal artery ligation with rectoanal repair (HAL-RAR).

Methods: Retrospective study from January 2010 to November 2019 of patients who underwent HAL-RAR for grade II, resistant to conservative treatment, and grades III and IV hemorrhoidal disease. Read More

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Exploring effectiveness of ab-initio protein-protein docking methods on a novel antibacterial protein complex dataset.

Brief Bioinform 2021 May 6. Epub 2021 May 6.

School of Computer Science and Technology, College of Intelligence and Computing, Tianjin University, Tianjin, China.

Diseases caused by bacterial infections become a critical problem in public heath. Antibiotic, the traditional treatment, gradually loses their effectiveness due to the resistance. Meanwhile, antibacterial proteins attract more attention because of broad spectrum and little harm to host cells. Read More

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Objective interictal electrophysiology biomarkers optimize prediction of epilepsy surgery outcome.

Brain Commun 2021 14;3(2):fcab042. Epub 2021 Mar 14.

Department of Paediatrics, Children's Hospital of Michigan, Detroit Medical Centre, Wayne State University, Detroit, MI 48201, USA.

Researchers have looked for rapidly- and objectively-measurable electrophysiology biomarkers that accurately localize the epileptogenic zone. Promising candidates include interictal high-frequency oscillation and phase-amplitude coupling. Investigators have independently created the toolboxes that compute the high-frequency oscillation rate and the severity of phase-amplitude coupling. Read More

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An Overview of Systematic Reviews of Acupuncture for Infertile Women Undergoing Fertilization and Embryo Transfer.

Front Public Health 2021 20;9:651811. Epub 2021 Apr 20.

Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Currently, more and more subfertility couples are opting for combined acupuncture to improve the success rate of fertilization and embryo transfer (IVF-ET). However, the efficacy and safety of acupuncture in IVF-ET is still highly controversial. The purpose of this overview is to summarize evidence of essential outcomes of systematic reviews (SRs) of acupuncture in IVF-ET and evaluate their methodological quality. Read More

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The female effect-how female receptivity influences faecal testosterone metabolite levels, socio-positive behaviour and vocalization in male Southern white rhinoceroses.

Conserv Physiol 2021 28;9(1):coab026. Epub 2021 Apr 28.

Institute of Zoology, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany.

Testosterone is known to be essential for sexual maturation as well as for the display of behavioural traits linked to reproduction. At the same time, external factors such as the presence of receptive females may affect testosterone levels, stressing the hormone's substantial role in reproductive success. It is therefore of major interest to investigate the links between androgens, behaviour and the social environment especially in species that rely on a resilient reproduction rate, such as the white rhinoceros (WR). Read More

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Fatal arterial hemorrhage after pancreaticoduodenectomy: How do we simultaneously accomplish complete hemostasis and hepatic arterial flow?

World J Hepatol 2021 Apr;13(4):483-503

Department of Surgery, Shiga General Hospital, Moriyama 524-8524, Shiga, Japan.

Background: Although arterial hemorrhage after pancreaticoduodenectomy (PD) is not frequent, it is fatal. Arterial hemorrhage is caused by pseudoaneurysm rupture, and the gastroduodenal artery stump and hepatic artery (HA) are frequent culprit vessels. Diagnostic procedures and imaging modalities are associated with certain difficulties. Read More

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Osmotic stress-induced somatic embryo maturation of coffee Coffea arabica L., shoot and root apical meristems development and robustness.

Sci Rep 2021 May 6;11(1):9661. Epub 2021 May 6.

Departamento de Ingeniería Genética, Centro de Investigación y Estudios Avanzados del IPN (CINVESTAV), Unidad Irapuato, Km. 9.6 Libramiento Norte Carretera Irapuato-León, CP 36824, Irapuato, Guanajuato, Mexico.

Somatic embryogenesis (SE) is the most important plant biotechnology process for plant regeneration, propagation, genetic transformation and genome editing of coffee, Coffea arabica L. Somatic embryo (SEs) conversion to plantlets is the principal bottleneck for basic and applied use of this process. In this study we focus on the maturation of SEs of C. Read More

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Headless Compression Screw Fixation of Delayed Union Jones Fractures: A Case Series.

Ortop Traumatol Rehabil 2021 Apr;23(2):121-127

University Hospitals Derby and Burton , Orthopaedic Department, UK.

Background: Different methods have been adopted to treat delayed union and non-union of fractures of the base of the fifth metatarsal using screws, plates and tension band wires. There has been increasing use of intramedullary screw fixation to treat these fractures with variable rates of success. The optimum screw diameter and properties have been a subject of debate. Read More

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Automated intracellular pharmacological electrophysiology for ligand-gated ionotropic receptor and pharmacology screening.

Mol Pharmacol 2021 May 6. Epub 2021 May 6.

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, United States

Communication between neuronal cells, central to brain function, is performed by several classes of ligand-gated ionotropic receptors. The gold standard technique for measuring rapid receptor response to agonist is manual patch-clamp electrophysiology, capable of the highest temporal resolution of any current electrophysiology technique. We report an automated high-precision patch-clamp system which substantially improves the throughput of these time-consuming pharmacological experiments. Read More

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