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Surgical outcomes of unilateral lateral rectus recession versus recess-resect in children with convergence insufficiency type intermittent exotropia.

Sci Rep 2022 May 21;12(1):8591. Epub 2022 May 21.

Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 665 Shiheongdae-ro, Seoul, 07442, South Korea.

To determine the efficacy of unilateral lateral rectus recession (ULR) for convergence insufficiency-type intermittent exotropia (CI-type IXT), we compared surgical outcomes following ULR and recess‒resect (RR) procedures for CI-type IXT. In this retrospective study, medical records of 57 children who underwent ULR (n = 30) or RR (n = 27) for CI-type IXT of less than 25 PD at distance with a postoperative follow-up of 6 months or more were reviewed. Surgical success was defined as an alignment between 10 PD exodeviation and 5 PD esodeviation at distance and near fixation. Read More

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Is Reddit a reliable source for information on erectile dysfunction treatment?

Int J Impot Res 2022 May 21. Epub 2022 May 21.

Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Patients may turn to social media websites, such as Reddit, for information on erectile dysfunction prior to seeking care from a physician. We sought to identify, characterize, and assess the quality of the erectile dysfunction treatments discussed on the highly influential Reddit website. We assessed 2634 comments from two subreddits, r/AskMen and r/ErectileDysfunction, for positive and negative statements regarding treatments for erectile dysfunction. Read More

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Short-Coupled Idiopathic Ventricular Fibrillation: A Literature Review With Extended Follow-Up.

JACC Clin Electrophysiol 2022 Apr 28. Epub 2022 Apr 28.

Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel; Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.

Idiopathic ventricular fibrillation is responsible for approximately 10% of cases of aborted cardiac arrest. Recent studies have shown that short-coupled ventricular premature complexes are present at the onset of idiopathic ventricular fibrillation in 6.6%-17% of patients. Read More

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Digital single-operator cholangioscopy in diagnostic and therapeutic bilio-pancreatic diseases: A prospective, multicenter study.

Dig Liver Dis 2022 May 18. Epub 2022 May 18.

Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, Vita-Salute San Raffaele University, Milan, Italy, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background And Aim: Digital single-operator cholangioscopy (D-SOC) is an endoscopic procedure that is increasingly used for the management of bilio-pancreatic diseases. We aimed to investigate the efficacy and safety of D-SOC for diagnostic and therapeutic indications.

Methods: This is a multicenter, prospective study(January 2016-June 2019) across eighteen tertiary centers. Read More

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Comparison of left ventricular with right ventricular rapid pacing on tamponade during TAVI.

Int J Cardiol 2022 May 18. Epub 2022 May 18.

Department of Cardiology, Queen Elizabeth University Hospital, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK; Institute for Cardiovascular Sciences, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.. Electronic address:

Background: Small studies have suggested left ventricular (LV) rapid pacing has similar safety and efficacy to conventional right ventricular (RV) rapid pacing in transcatheter aortic valve implantation (TAVI). However, there are limited data on the comparative rates of tamponade. The study compared the rate of cardiac tamponade between LV and RV-pacing during TAVI. Read More

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Supercritical fluid chromatography for separation of chiral planar metallocenes.

J Chromatogr A 2022 May 13;1674:463115. Epub 2022 May 13.

Univ. Lille, Inserm, Institut Pasteur de Lille, U1167 - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France. Electronic address:

Unsymmetrically disubstituted metallocene derivatives, characterized as the first sandwich structure, have found interest in asymmetrical synthesis and in medicinal chemistry as well. Besides, they present a particular case of chirality. Twenty original and six commercially available molecules presenting either i) a planar chirality or ii) an asymmetrical carbon containing group or iii) being symmetrically substituted were analyzed in supercritical fluid chromatography on eleven polysaccharide-based chiral stationary phases with carbon dioxide containing 30% of methanol or 2-propanol as a co-solvent mobile phase. Read More

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Free-breathing dynamic T1WI using compressed sensing-golden angle radial sparse parallel imaging for liver MRI in patients with limited breath-holding capability.

Eur J Radiol 2022 May 6;152:110342. Epub 2022 May 6.

Department of Radiology, Seoul National University Hospital, Republic of Korea; Department of Radiology, Seoul National University, College of Medicine, Republic of Korea. Electronic address:

Purpose: Evaluating the performance of free-breathing dynamic T1-weighted imaging (T1WI) using compressed sensing golden-angle radial sparse parallel imaging (CS-GRASP) in non-cooperative patients compared with a general group.

Method: This retrospective study included patients who underwent gadoxetic acid-enhanced liver MRI using CS-GRASP at 3 T between March 2018 and October 2019. Patients were divided chronologically, into one of two groups: Group 1, who underwent MRI during the sequence implementation period regardless of breath-hold capability; and Group 2, who underwent MRI from June 2018 due to limited breath-hold capability. Read More

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Retrospective comparison of motor and somatosensory MEG mapping-Considerations for better clinical applications.

Neuroimage Clin 2022 May 12;35:103045. Epub 2022 May 12.

Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, USA; College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA.

While magnetoencephalography (MEG) has proven to be a valuable and reliable tool for presurgical functional mapping of eloquent cortices for at least two decades, widespread use of this technique by clinicians has remained elusive. This modest application may be attributable, at least in part, to misunderstandings regarding the success rate of such mapping procedures, as well as the primary sources contributing to mapping failures. To address this, we conducted a retrospective comparison of sensorimotor functional mapping success rates in 141 patients with epilepsy and 75 tumor patients from the Center for MEG in Omaha, NE. Read More

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Clinical and radiographic comparison of Biodentine and Formocresol: an updated meta-analysis with trial sequential analysis.

Eur Arch Paediatr Dent 2022 May 20. Epub 2022 May 20.

Department of Pediatric Dentistry, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: This meta-analysis aimed to compare the clinical and radiographic success rate of Biodentine as an alternative to Formocresol to provide a critical appraisal of the available literature and evidence-based conclusion as well as update the previous systematic review.

Methods: MEDLINE, CENTRAL, Web of Science, Scopus, and Google Scholar databases were searched up to 20 October 2021 to identify RCTs evaluating pulpotomy with Biodentine/Formocresol in carious primary molars among children ≤ 10 years old. The risk of bias was assessed using the Cochrane RoB-2 tool. Read More

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Local nitroglycerin to facilitate peripheral arterial cannulation in children: systematic review and meta-analysis.

Arch Dis Child 2022 May 20. Epub 2022 May 20.

Neonatology, Perth Children's Hospital Neonatal Clinical Care Unit, Nedlands, Western Australia, Australia.

Background: Neonates and children admitted to intensive care units require peripheral arterial cannulation to monitor their blood pressures and for blood sampling, but many times it is unsuccessful.

Objective: To conduct a systematic review and meta-analysis to evaluate the efficacy and safety of local nitroglycerin (NTG) to facilitate peripheral artery cannulation in neonates and children.

Review Methods: PubMed, EMBASE, CINAHL, Emcare and Cochrane library were searched till August 2021. Read More

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Vaginal birth after cesarean section: Experience from a regional hospital.

Taiwan J Obstet Gynecol 2022 May;61(3):422-426

Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Obstetrics and Gynecology, Hsin-Chu Br, National Taiwan University Hospital, National Taiwan University College of Medicine, Hsin-Chu, Taiwan. Electronic address:

Objective: Trial of labor after cesarean section (TOLAC) is an option for women with previous cesarean section. However, few women choose this option because of safety concerns. We evaluate the safety and risks associated with TOLAC and the success rate of vaginal birth after cesarean delivery (VBAC). Read More

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Patient-derived organoids as a model for tumor research.

Prog Mol Biol Transl Sci 2022 22;189(1):259-326. Epub 2022 Apr 22.

The First Affiliated Hospital of Shantou University, Shantou University Medical College, Shantou, China; Department of Urology, Shenzhen Institute of Translational Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, China; International Cancer Center of Shenzhen University, Shenzhen, China; Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address:

Cancer represents a leading cause of death, despite the rapid progress of cancer research, leading to urgent need for accurate preclinical model to further study of tumor mechanism and accelerate translational applications. Cancer cell lines cannot fully recapitulate tumors of different patients due to the lack of tumor complexity and specification, while the high technical difficulty, long time, and substantial cost of patient-derived xenograft model makes it unable to be used extensively for all types of tumors and large-scale drug screening. Patient-derived organoids can be established rapidly with a high success rate from many tumors, and precisely replicate the key histopathological, genetic, and phenotypic features, as well as therapeutic response of patient tumor. Read More

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The Influence of the Motivational Climate on Rehabilitation Behaviors and Patient Satisfaction.

J Sport Rehabil 2022 May 20:1-7. Epub 2022 May 20.

Department of Kinesiology, University of Northern Iowa, Cedar Falls, IA,USA.

Context: Athletic trainers influence the motivational climate in rehabilitation, but little is known about the role of the motivational climate on patient outcomes. The purpose of this study was to investigate the influence of the motivational climate in rehabilitation on athletes' behaviors in rehabilitation (eg, effort and energy) and overall satisfaction with rehabilitation.

Design: Cross-sectional, descriptive research. Read More

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A Power-Efficient Brain-Machine Interface System with a Sub-mW Feature Extraction and Decoding ASIC Demonstrated in Nonhuman Primates.

IEEE Trans Biomed Circuits Syst 2022 May 20;PP. Epub 2022 May 20.

Intracortical brain-machine interfaces have shown promise for restoring function to people with paralysis, but their translation to portable and implantable devices is hindered by their high power consumption. Recent devices have drastically reduced power consumption compared to standard experimental brain-machine interfaces, but still require wired or wireless connections to computing hardware for feature extraction and inference. Here, we introduce a Neural Recording And Decoding (NeuRAD) application specific integrated circuit (ASIC) in 180 nm CMOS that can extract neural spiking features and predict two-dimensional behaviors in real-time. Read More

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Enhancing Radioiodine Incorporation Into Radio Iodine Refractory Thyroid Cancer With MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study.

Clin Cancer Res 2022 May 20. Epub 2022 May 20.

University Hospital Essen, West German Cancer Center, Essen, Germany.

Purpose: Restoration of iodine incorporation (redifferentiation) by mitogen-activated protein kinase (MAPK) inhibition was achieved in previously radioiodine-refractory, unresectable thyroid carcinoma (RR-TC). However, results were unsatisfactory in BRAFV600E-mutant RR-TC. Here we assess safety and efficacy of redifferentiation therapy through genotype-guided MAPK-modulation in patients with BRAFV600E-mutant (BRAF-MUT) or wildtype (BRAF-WT) RR-TC. Read More

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Competence development of trainees performing short-type single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy.

J Hepatobiliary Pancreat Sci 2022 May 20. Epub 2022 May 20.

Department of Gastroenterology, Saitama Medical University International Medical Center.

Objectives: This study aimed to evaluate the trainees' practice and learning curve in short-type single-balloon enteroscopy (short SBE)-assisted endoscopic retrograde cholangiopancreatography (ERCP) for patients with surgically altered anatomy (SAA) and determine how to train these trainees.

Methods: The data of short SBE-assisted ERCP procedures between September 2011 and June 2021 were analyzed.

Results: Three trainees and 180 cases were included in the analysis. Read More

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Analysis of serological treatment response to doxycycline versus benzathine penicillin in syphilis infections, a retrospective single-centre study.

Dermatol Ther 2022 May 20:e15586. Epub 2022 May 20.

Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 9, Bologna, Italy.

Introduction: Doxycilicine is the second-line treatment of choice for infectious syphilis when treatment with penicillin G is not feasible. To date, difficulties in the penicillin supply chain make it necessary to evaluate and resort to antibiotic therapies which are currently considered a second-line choice. Moreover, systematic studies comparing the two treatments in affected patients are still few, and many do not consider late and indeterminate latent infections. Read More

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Ultrasound-guided microwave and radiofrequency ablation for primary hyperparathyroidism: a prospective, multicenter study.

Eur Radiol 2022 May 20. Epub 2022 May 20.

Department of Interventional Ultrasound, The Fifth Medical Center, Chinese PLA General Hospital, NO.28 Fuxing Road, Beijing, 100853, China.

Objectives: To prospectively investigate the efficacy and safety of ultrasound (US)-guided microwave ablation (MWA) and radiofrequency ablation (RFA) for primary hyperparathyroidism (PHPT).

Methods: We performed a prospective multicenter study of MWA and RFA for PHPT between August 2017 and October 2020 at five centers. Laboratory testing was performed pre- and post-ablation and followed for at least 6 months. Read More

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Mid-term outcomes of the Wagner Cone Prosthesis™ stem for developmental dysplasia of the hip: minimum two year follow-up.

Int Orthop 2022 May 20. Epub 2022 May 20.

Department of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.

Purpose: Treatment of symptomatic developmental dysplasia of the hip (DDH) requires a technically demanding total hip arthroplasty (THA) reconstruction. In patients with DDH, prostheses can be difficult to implant and often face the risk of fracture, mismatch, and loosening. The Wagner Cone Prosthesis™ is a tapered, conical stem which can improve treatment success in this population. Read More

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Rapid Superficial Vein Assessment (RaSuVA): A pre-procedural systematic evaluation of superficial veins to optimize venous catheterization in neonates.

J Vasc Access 2022 May 20:11297298221098481. Epub 2022 May 20.

Department of Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Placement of peripheral intra-venous cannulas and epicutaneo-caval catheters is routinely performed in in Neonatal Intensive Care Unit (NICU), and both devices require visible superficial veins easy to cannulate. NICU patients are intrinsically characterized by poor and fragile vein asset, so that puncture and cannulation of superficial veins is often a challenge even for trained clinicians and cannulation frequently results in a stressful, painful, difficult procedure.

Methods And Results: Rapid Superficial Vein Assessment is meant to offer a systematic pre-procedural evaluation of all superficial veins of the newborn, so to allow a rational choice of the best insertion site, tailored on the single patient, and optimized for the specific type of venous access device. Read More

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Real-world experience with the new Watchman FLX device: Data from two high-volume Sicilian centers. The FLX-iEST registry.

Catheter Cardiovasc Interv 2022 May 20. Epub 2022 May 20.

Cardiology Unit, "Umberto I" Hospital, ASP Siracusa, Siracusa, Italy.

Introduction: The Watchman-FLX left atrial appendage closure (LAAC) device presents innovative features: higher conformability, reduced length, closed distal "flex-ball" during deployment, and flattened surface. We report our real-world experience with the Watchman-FLX device in two centers with consolidated LAAC expertise.

Methods: We enrolled 200 consecutive Watchman-FLX patients (2019-2021) in a nonrandomized double-center registry; procedural data and follow-up for midterm clinical outcomes were collected. Read More

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A Biomechanical Study on Failed Snatch Based on the Human and Bar Combination Barycenter.

Appl Bionics Biomech 2022 10;2022:9279638. Epub 2022 May 10.

Research Academy of Grand Health, Ningbo University, China.

Objective: The purpose of this research was to use a new method the human and bar combination barycenter to exposit the differences between successful and failed characteristics of snatch attempts in competition. Try to establish an effective biomechanical method that can uncover the main factors for the failed snatch. The obtained results will provide valuable information for weightlifters to improve the success rate in snatch by altering their technical issues accordingly. Read More

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Preliminary Surgical Outcomes of a Trimmed-Plate Aurolab Aqueous Drainage Implant (AADI) in Eyes at High Risk of Hypotony.

Clin Ophthalmol 2022 13;16:1487-1496. Epub 2022 May 13.

Glaucoma Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: We describe the technique of trimming the 350 mm AADI glaucoma shunt plate and report preliminary results that test the hypothesis that the IOP-lowering efficacy of the trimmed AADI glaucoma shunt is comparable to the Baerveldt 250 mm glaucoma drainage implant with a comparable safety profile to the standard AADI implant.

Methods: Consecutive patients who had received the modified trimmed-plate AADI, standard AADI and Baerveldt 250 mm were included in the study. This included patients with refractory or primary or secondary glaucoma of all ages and eyes with and without previous glaucoma surgery. Read More

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Acute or Subacute, the Optimal Timing for Uncomplicated Type B Aortic Dissection: A Systematic Review and Meta-Analysis.

Front Surg 2022 3;9:852628. Epub 2022 May 3.

Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Objective: To evaluate the optimal timing (acute or subacute) of thoracic endovascular aortic repair (TEVAR) for uncomplicated B aortic dissection (uTBAD) through a systematic review and meta-analysis.

Method: A comprehensive literature search was undertaken across three major databases (EMBASE/Medline, PubMed, and Cochrane Library) and was assessed until November 2021 to identify studies reporting the outcomes of TEVAR utilized to treat patients with uTBAD. The continuous variables were compared between the two groups using -test and the categorical variables were compared using the χ-test. Read More

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Recent scoring systems predicting stone-free status after retrograde intrarenal surgery; a systematic review and meta-analysis.

Cent European J Urol 2022 24;75(1):72-80. Epub 2022 Mar 24.

Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of Urology, Istanbul, Turkey.

Introduction: Several scoring systems and nomograms have been developed to predict the success of retrograde intrarenal surgery. But no meta-analysis for the performance of scoring systems has yet been performed. The aim of this study was to compare predictive ability of recent scoring systems for stone-free rate of retrograde intrarenal surgery. Read More

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Results from Genetic Studies in Patients Affected with Craniosynostosis: Clinical and Molecular Aspects.

Front Mol Biosci 2022 28;9:865494. Epub 2022 Apr 28.

Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, Poland.

Craniosynostosis (CS) represents a highly heterogeneous genetic condition whose genetic background has not been yet revealed. The abnormality occurs either in isolated form or syndromic, as an element of hundreds of different inborn syndromes. Consequently, CS may often represent a challenging diagnostic issue. Read More

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Use of Temporary Membrane-Covered Self-Expandable Metallic Stent - UVENTA for Treatment of Recurrent Bulbar Urethral Stricture.

Res Rep Urol 2022 12;14:219-223. Epub 2022 May 12.

Department of Surgery, Weill Cornell Medicine, Doha, Qatar.

Introduction: Recurrent urethral stricture is a real challenge. Interestingly use of temporary double layered self-expanding nitinol urethral stent with polytetrafluoroethylene (PTFE) membrane coating (Uventa, Taewoong Medical, South Korea) has been recently reported with promising short-term results in recurrent urethral stricture. However most of the reported studies are published as abstracts of either case reports or case series of miniscule numbers. Read More

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Does Root Development Status Affect the Outcome of Tooth Autotransplantation? A Systematic Review and Meta-Analysis.

Materials (Basel) 2022 May 8;15(9). Epub 2022 May 8.

Department of Oral and Maxillofacial Surgery, Universitat Internacional de Catalunya, C/Josep Trueta s/n St Cugat del Vallés, 08195 Barcelona, Spain.

Tooth autotransplantation is defined as the surgical repositioning of an autogenous tooth in another surgical site within the same individual. The aim of this research was to analyze the outcome of tooth transplantation using immature donor teeth compared with closed apex teeth and to compare differences between donor tooth positions on the arch. Electronic and manual literature searches were performed in different databases, including the National Library of Medicine (MEDLINE), EMBASE (OVID), Cochrane Central (CENTRAL), and the digital library of the Universitat Internacional de Catalunya (UIC University) from 1978 to March 2021. Read More

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Prognostic Factors in Endodontic Surgery Using an Endoscope: A 1 Year Retrospective Cohort Study.

Materials (Basel) 2022 May 7;15(9). Epub 2022 May 7.

Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, 1-2-1 Asahi-machi, Takamatsu 760-8557, Japan.

This retrospective study clarified the success rate of endoscopic endodontic surgeries and identified predictors accounting for successful surgeries. In this retrospective study, 242 patients (90 males, 152 females) who underwent endoscopic endodontic surgery at a single general hospital and were diagnosed through follow-up one year later were included. Risk factors were categorized into attributes, general health, anatomy, and surgery. Read More

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Research on Fast Recognition and Localization of an Electric Vehicle Charging Port Based on a Cluster Template Matching Algorithm.

Sensors (Basel) 2022 May 9;22(9). Epub 2022 May 9.

School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, China.

With the gradual maturity of driverless and automatic parking technologies, electric vehicle charging has been gradually developing in the direction of automation. However, the pose calculation of the charging port (CP) is an important part of realizing automatic charging, and it represents a problem that needs to be solved urgently. To address this problem, this paper proposes a set of efficient and accurate methods for determining the pose of an electric vehicle CP, which mainly includes the search and aiming phases. Read More

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