89 results match your criteria subtype adhd-i


Efficacy and safety of guanfacine extended-release in Japanese adults with attention-deficit/hyperactivity disorder: Exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study.

Neuropsychopharmacol Rep 2021 03 10;41(1):26-39. Epub 2020 Dec 10.

Department of Psychiatry, Showa University, School of Medicine, Tokyo, Japan.

Aim: Previously, we reported on the efficacy and safety of guanfacine extended-release (GXR) in Japanese adults with attention-deficit/hyperactivity disorder (ADHD) from a phase 3, double-blind, placebo-controlled, randomized trial. In this exploratory post hoc analysis, we assessed the efficacy and/or safety of GXR in the following subgroups: ADHD-combined (ADHD-C) and ADHD-predominantly inattentive (ADHD-I) subtypes, age (≥31, <31 years), sex (male, female), and body weight (≥50, <50 kg).

Methods: The primary efficacy endpoint was change from baseline in the Japanese version of the investigator-rated ADHD-Rating Scale-IV (ADHD-RS-IV) with adult prompts (total scores) at week 10. Read More

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ADHD subtype-specific cognitive correlates and association with self-esteem: a quantitative difference.

BMC Psychiatry 2020 10 12;20(1):502. Epub 2020 Oct 12.

Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.

Background: Attention-deficit hyperactivity disorder (ADHD) is a major neurodevelopmental disorder with heterogeneous symptoms, subtypes, and cognitive deficits. Cognitive deficits are central to ADHD pathophysiology and one potential source of heterogeneity in ADHD. Subtype-specific cognitive correlates are not, however, well-studied. Read More

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October 2020

Symptom Level Associations Between Attention-Deficit Hyperactivity Disorder and School Performance.

Clin Pediatr (Phila) 2020 09 22;59(9-10):874-884. Epub 2020 May 22.

Vermont Department of Health, Burlington, VT, USA.

Attention-deficit hyperactivity disorder (ADHD) is associated with reduced school performance. To determine which ADHD symptoms and subtypes have the strongest association, we used type and frequency of symptoms on the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome (NS-DATA) to create symptom scores for inattention and hyperactivity-impulsivity and define subtypes (ADHD-Inattentive [ADHD-I], ADHD-Hyperactive-Impulsive, ADHD-Combined [ADHD-C]). Regression methods were used to examine associations between symptoms and subtype and a composite measure of school performance. Read More

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September 2020

Epidemiology of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents in Africa: a systematic review and meta-analysis.

Ann Gen Psychiatry 2020 13;19:21. Epub 2020 Mar 13.

Department of Psychiatry, Paulo's Millennium Medical College, Addis Ababa, Ethiopia.

Background: Attention-deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental disorders in childhood and adolescence, affecting 2.2 to 17.8% of all school-aged children and adolescents. Read More

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Attention deficit hyperactivity disorder (ADHD) in children with epilepsy.

Ir J Med Sci 2020 Feb 11;189(1):305-313. Epub 2019 Jun 11.

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Wuhan, 430030, China.

Background: Attention deficit hyperactivity disorder (ADHD) is a common comorbidity of childhood epilepsy. ADHD symptoms in children with epilepsy have been studied since 1970s in western countries. However, relative studies are still rather limited in China. Read More

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February 2020

Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder.

Neuroimage Clin 2019 19;21:101600. Epub 2018 Nov 19.

Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore; Clinical Imaging Research Centre, The Agency for Science, Technology and Research-National University of Singapore, Singapore, Singapore. Electronic address:

Accumulating evidence suggests brain network dysfunction in attention-deficit/hyperactivity disorder (ADHD). Whether large-scale brain network connectivity patterns reflect clinical heterogeneity in ADHD remains to be fully understood. This study aimed to characterize the differential within- and between-network functional connectivity (FC) changes in children with ADHD combined (ADHD-C) or inattentive (ADHD-I) subtypes and their associations with ADHD symptoms. Read More

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December 2019

Behavior problems in children with epilepsy and attention-deficit hyperactivity disorder in Central China.

Epilepsy Behav 2018 12 31;89:79-83. Epub 2018 Oct 31.

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

In this study, we aimed to evaluate the prevalence of attention-deficit hyperactivity disorder (ADHD) in children with epilepsy in Central China and compare the behavioral problems in children with epilepsy combined with and without ADHD. Children with epilepsy aged between 6 and 16 years were recruited for this study. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria were administered for the diagnosis of ADHD and ADHD subtype in children with epilepsy. Read More

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December 2018

Latent class analysis of attention and white matter correlation in children with attention-deficit/hyperactivity disorder.

Braz J Med Biol Res 2018 Oct 4;51(11):e7653. Epub 2018 Oct 4.

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

This study aimed to explore attentional patterns among children with inattentive attention-deficit/hyperactivity disorder (ADHD-I) and children with typical development (TD), using a latent class analysis (LCA). Patterns of brain connectivity were also explored. The sample comprised 29 ADHD-I and 29 TD matched children. Read More

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October 2018

Attention profiles in autism spectrum disorder and subtypes of attention-deficit/hyperactivity disorder.

Eur Child Adolesc Psychiatry 2018 Nov 6;27(11):1433-1447. Epub 2018 Mar 6.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe-Universität, Frankfurt am Main, Germany.

Attention problems are observed in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Most neuropsychological studies that compared both disorders focused on complex executive functions (EF), but missed to contrast basic attention functions, as well as ASD- and ADHD subtypes. The present study compared EF as well as basic attention functioning of children with the combined subtype (ADHD-C), the predominantly inattentive subtype (ADHD-I), and autism spectrum disorder without ADHD (ASD-) with typically developing controls (TD). Read More

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November 2018

Sluggish Cognitive Tempo as a Possible Predictor of Methylphenidate Response in Children With ADHD: A Randomized Controlled Trial.

J Clin Psychiatry 2018 Mar/Apr;79(2)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objective: To examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects.

Methods: Stimulant-naive children with ADHD predominantly inattentive type (ADHD-I; n = 126) or ADHD combined type (ADHD-C; n = 45) aged 7-11 years were recruited from the community from September 2006 to June 2013 to participate in a prospective, randomized, double-blind, 4-week crossover trial of long-acting methylphenidate. ADHD diagnosis and subtype were established according to DSM-IV criteria using a structured interview and teacher ADHD symptom ratings. Read More

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Comparative Analysis of the WISC between Two ADHD Subgroups.

Psychiatry Investig 2018 Feb 21;15(2):172-177. Epub 2017 Nov 21.

Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan.

Objective: The prevalence of attention deficit/hyperactivity disorder (ADHD) in school-age children is 7.2%, and ADHD is divided into clinical subtypes.

Methods: The current study explored whether specific cognitive profiles as assessed using the Wechsler Intelligence Scale for Children (WISC)-IV could be obtained for each clinical ADHD subtype (ADHD-Inattentive type and ADHD-Combined type) and investigated the correlation between WISC scores and parental age at their children's birth or birthweight. Read More

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February 2018

Attention-deficit/hyperactivity disorder associated with KChIP1 rs1541665 in Kv channels accessory proteins.

PLoS One 2017 27;12(11):e0188678. Epub 2017 Nov 27.

Department of Epidemiology and Biostatistics and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Attention-deficit/hyperactivity disorder (ADHD) is an early onset childhood neurodevelopmental disorder with high heritability. A number of genetic risk factors and environment factors have been implicated in the pathogenesis of ADHD. Genes encoding for subtypes of voltage-dependent K channels (Kv) and accessory proteins to these channels have been identified in genome-wide association studies (GWAS) of ADHD. Read More

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December 2017

Childhood ADHD and Negative Self-Statements: Important Differences Associated With Subtype and Anxiety Symptoms.

Behav Ther 2017 11 16;48(6):793-807. Epub 2017 May 16.

Louisiana State University.

The current study examined the role negative self-statements have on the comorbidity between anxious symptomatology and ADHD-combined presentation (ADHD-C) and ADHD-predominantly inattentive (ADHD-I). A total of 114 children and adolescents with ADHD (M age = 10.15; SD = 2. Read More

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November 2017

Regional brain network organization distinguishes the combined and inattentive subtypes of Attention Deficit Hyperactivity Disorder.

Neuroimage Clin 2017 22;15:383-390. Epub 2017 May 22.

Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Australia; The Discipline of Psychiatry, University of Sydney Medical School: Western, Westmead Hospital, Australia. Electronic address:

Attention Deficit Hyperactivity Disorder (ADHD) is characterized clinically by hyperactive/impulsive and/or inattentive symptoms which determine diagnostic subtypes as Predominantly Hyperactive-Impulsive (ADHD-HI), Predominantly Inattentive (ADHD-I), and Combined (ADHD-C). Neuroanatomically though we do not yet know if these clinical subtypes reflect distinct aberrations in underlying brain organization. We imaged 34 ADHD participants defined using DSM-IV criteria as ADHD-I ( = 16) or as ADHD-C ( = 18) and 28 matched typically developing controls, aged 8-17 years, using high-resolution T1 MRI. Read More

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The Impact of Pharmacotherapy on Substance Use in Adolescents With Attention-Deficit/Hyperactivity Disorder: Variations Across Subtypes.

Subst Use Misuse 2017 08 21;52(10):1266-1274. Epub 2017 Mar 21.

a Department of Pharmaceutical Health Outcomes & Policy , University of Houston , Houston , Texas , USA.

Objective: The primary purpose of this study was to investigate the impact of attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy on the risk of substance use within each ADHD subtype.

Methods: The study used data from the National Comorbidity Survey-Adolescent supplement, a nationally representative sample of US adolescents (ages 13-18) collected from 6,483 adolescent-parent interviews conducted between 2001 and 2004. ADHD was categorized into three subtypes: ADHD-predominantly hyperactive-impulsive type (ADHD-H); ADHD-predominantly inattentive type (ADHD-I); and ADHD-combined type (ADHD-C) using Diagnostic and Statistical Manual of Mental Disorders-IV criteria. Read More

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Sluggish Cognitive Tempo in a Child and Adolescent Clinical Outpatient Setting.

J Psychiatr Pract 2016 09;22(5):355-62

CAMPRODON-ROSANAS: Institut de Neuropsiquiatria i Addiccions, CSMIJ Sant Martí i La Mina, Parc de Salut Mar, and Departament de Psiquiatria i de Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain BATLLE, ESTRADA-PRAT, ACEÑA-DÍAZ, PETRIZAN-ALEMAN, PUJALS, and MARTIN-LÓPEZ: Institut de Neuropsiquiatria i Addiccions, CSMIJ Sant Martí i La Mina, Parc de Salut Mar, Barcelona PÉREZ-SOLÁ: Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), IMIM (Institut Hospital del Mar d'Investigacions Mèdiques); Departament de Psiquiatria i de Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain RIBAS-FITÓ: CSMIJ Gavà. Fundació Orienta.

Sluggish cognitive tempo (SCT) symptoms have largely emerged from investigations of attention-deficit/hyperactivity disorder (ADHD). Recent research has demonstrated the relevance of SCT symptoms in the field of clinical child and adolescent psychiatry. The goal of this research was to study the symptoms of SCT in a clinical child and adolescent sample and to define its features and comorbid conditions. Read More

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September 2016

Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type.

Psychiatry Res Neuroimaging 2016 Aug 20;254:119-26. Epub 2016 Jun 20.

Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville Australia; Developmental Imaging, Murdoch Childrens Research Institute, Parkville, Australia. Electronic address:

Attention-deficit/hyperactivity disorder (ADHD) has reliably been associated with global grey matter reductions but local alterations are largely inconsistent with perhaps the exception of the caudate nucleus. The aim of this study was to examine local and global brain volume differences between typically developing children (TD) and children with a diagnosis of ADHD. We also addressed whether these parameters would differ between children with the ADHD-combined type (ADHD-C) and those with the ADHD-inattentive type (ADHD-I). Read More

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Treatment dropout and missed appointments among adults with attention-deficit/hyperactivity disorder: associations with patient- and disorder-related factors.

J Clin Psychiatry 2016 Feb;77(2):232-9

Psychiatric Research Unit West, Regional Psychiatric Services West, 7400 Herning, Gl. Landevej 49, Denmark

Objective: Knowledge of factors associated with treatment dropout and missed appointments in adults with attention-deficit/hyperactivity disorder (ADHD) is very limited. On the basis of proposed hypotheses that past behavior patterns are more predictive of current behaviors of treatment dropout and missed appointments than are sociodemographic and clinical characteristics, we examined the associations of sociodemographic variables, clinical variables, risk-taking behavior, educational and occupational instability, and behaviors during mandatory schooling with the primary outcome measures of treatment dropout and missed appointments.

Method: In a naturalistic cohort study of 151 adult outpatients with ADHD initiating assessment in a Danish ADHD unit from September 1, 2010, to September 1, 2011, the Adult ADHD Self-Report Scale v1. Read More

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February 2016

Clinical Effects of ADHD Subtypes in Patients With Social Anxiety Disorder.

J Atten Disord 2019 Oct 4;23(12):1464-1469. Epub 2015 Dec 4.

3 Istanbul University, Turkey.

Our aim in this study is to evaluate the impacts of inattentive and combined types of childhood ADHD (ADHD-I, ADHD-C) in patients with social anxiety disorder (SAD). A total of 142 adult outpatients with a primary diagnosis of SAD were included. All patients were assessed by using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), ADHD module and a clinical and sociodemographic data form and scales were filled out. Read More

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October 2019

Executive Functioning in Subtypes of Attention Deficit Hyperactivity Disorder.

Noro Psikiyatr Ars 2015 Dec 1;52(4):386-392. Epub 2015 Dec 1.

Department of Child and Adolescent Psychiatry, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.

Introduction: This study aims to evaluate executive functions (EF), such as inhibition, planning, working memory, and set shifting, in children with attention deficit hyperactivity disorder (ADHD) by comparing three ADHD subtype groups (ADHD-Inattentive, ADHD-Combined, and ADHD-Comorbid) and a normal control group.

Methods: Participants included 147 children. In total, 111 children were assigned to the ADHD groups of the study. Read More

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December 2015

Poor Memory Confidence Mediates the Association between Inattention Symptoms and Hoarding Severity and Impairment.

J Obsessive Compuls Relat Disord 2015 Oct 14;7:43-48. Epub 2015 Oct 14.

Anxiety Disorders Center/Center for CBT, Institute of Living/Hartford Hospital, 200 Retreat Avenue, Hartford, CT 06106.

Hoarding disorder (HD) is characterized by excessive saving and difficulty discarding possessions, which results in severe clutter and functional impairment. HD shows patterns of elevated comorbidity with the inattentive subtype of attention deficit-hyperactivity disorder (ADHD-I). ADHD-I symptoms are associated with more severe HD pathology (Tolin & Villavicencio, 2011), but the mechanisms underlying this association are unclear. Read More

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October 2015

Maternal Functioning Differences Based on ADHD Subtype.

J Atten Disord 2018 11 14;22(13):1218-1223. Epub 2015 Jan 14.

1 Marquette University, Milwaukee, WI, USA.

Objective: Maternal functioning differences in parenting stress, parental efficacy, and parenting behaviors were examined for mothers of children with ADHD.

Method: Participants included 29 mothers of children with ADHD, Predominantly Inattentive Type (ADHD-I) and 38 mothers of children with ADHD, Predominantly Hyperactive-Impulsive or Combined Type (ADHD-HI/C).

Results: Findings suggest that mothers of children with ADHD-HI/C reported significantly greater parenting stress and engaged in more negative parenting behaviors than mothers of children with ADHD-I. Read More

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November 2018

Screening for the ADHD Phenotype Using the Strengths and Difficulties Questionnaire in a Clinical Sample of Newly Referred Children and Adolescents.

J Atten Disord 2018 09 16;22(11):1032-1039. Epub 2014 Dec 16.

1 Universidad Autónoma de Madrid, Spain.

Objective: To examine the screening ability of the Strengths and Difficulties Questionnaire (SDQ) for ADHD subtypes in a clinical sample.

Method: Parents of 523 children (3 to 17 years old) referred to Child and Adolescent Mental Health Services completed the Spanish version of the SDQ and the ADHD Rating Scale-IV. Receiver operating curve (ROC) curve analyses and likelihood ratios (LRs) were conducted. Read More

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September 2018

Interactions between MAOA and SYP polymorphisms were associated with symptoms of attention-deficit/hyperactivity disorder in Chinese Han subjects.

Am J Med Genet B Neuropsychiatr Genet 2015 Jan 8;168B(1):45-53. Epub 2014 Dec 8.

Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.

As candidate genes of attention--deficit/hyperactivity disorder (ADHD), monoamine oxidase A (MAOA), and synaptophysin (SYP) are both on the X chromosome, and have been suggested to be associated with the predominantly inattentive subtype (ADHD-I). The present study is to investigate the potential gene-gene interaction (G × G) between rs5905859 of MAOA and rs5906754 of SYP for ADHD in Chinese Han subjects. For family-based association study, 177 female trios were included. Read More

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January 2015

Microstructural abnormalities in the combined and inattentive subtypes of attention deficit hyperactivity disorder: a diffusion tensor imaging study.

Sci Rep 2014 Nov 3;4:6875. Epub 2014 Nov 3.

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Previous research has demonstrated that there are specific white matter abnormalities in patients with attention deficit/hyperactivity disorder (ADHD). However, the results of these studies are not consistent, and one of the most important factors that affects the inconsistency of previous studies maybe the ADHD subtype. Different ADHD subtypes may have some overlapping microstructural damage, but they may also have unique microstructural abnormalities. Read More

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November 2014

Prevalence and diagnostic validity of motivational impairments and deficits in visuospatial short-term memory and working memory in ADHD subtypes.

Eur Child Adolesc Psychiatry 2015 May 6;24(5):575-90. Epub 2014 Sep 6.

Developmental Psychology, University of Amsterdam, Weesperplein 4, 1018 XA, Amsterdam, The Netherlands,

Deficits in working memory (WM) and reinforcement sensitivity are thought to give rise to symptoms in the combined (ADHD-C) and inattentive subtype (ADHD-I) of ADHD. Children with ADHD are especially impaired on visuospatial WM, which is composed of short-term memory (STM) and a central executive. Although deficits in visuospatial WM and reinforcement sensitivity appear characteristic of children with ADHD on a group-level, the prevalence and diagnostic validity of these impairments is still largely unknown. Read More

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EEG spectral analysis of attention in ADHD: implications for neurofeedback training?

Front Hum Neurosci 2014 21;8:611. Epub 2014 Aug 21.

Department of Child and Adolescent Mental Health, University Hospital of Erlangen Erlangen, Germany.

Objective: In children with attention-deficit/hyperactivity disorder (ADHD), an increased theta/beta ratio in the resting EEG typically serves as a rationale to conduct theta/beta neurofeedback (NF) training. However, this finding is increasingly challenged. As NF may rather target an active than a passive state, we studied the EEG in a condition that requires attention. Read More

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September 2014

Differential perinatal risk factors in children with attention-deficit/hyperactivity disorder by subtype.

Psychiatry Res 2014 Nov 28;219(3):609-16. Epub 2014 May 28.

Division of Child & Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

We compared the attention-deficit/hyperactivity disorder(ADHD) combined subtype (ADHD-C) to the ADHD inattentive subtype (ADHD-I) in terms of genetic, perinatal, and developmental risk factors as well as clinical and neuropsychological characteristics. A total of 147 children diagnosed with ADHD between the ages of 6 and 15 years participated in this study. The parents of the children completed the structured diagnostic interview, the ADHD Rating Scale-IV, the Children's Behavior Checklist, and structured questionnaires on perinatal risk factors, and the children underwent a neuropsychological test and were genotyped. Read More

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November 2014

Brain activity in predominantly-inattentive subtype attention-deficit/hyperactivity disorder during an auditory oddball attention task.

Psychiatry Res 2014 Aug 4;223(2):121-8. Epub 2014 Jun 4.

Olin Neuropsychiatry Research Center, The Institute of Living/Hartford Hospital, Whitehall Building, Hartford, CT 06106, USA; Yale University School of Medicine, New Haven, CT, USA. Electronic address:

Previous functional neuroimaging studies have found brain activity abnormalities in attention-deficit/hyperactivity disorder (ADHD) on numerous cognitive tasks. However, little is known about brain dysfunction unique to the predominantly-inattentive subtype of ADHD (ADHD-I), despite debate as to whether DSM-IV-defined ADHD subtypes differ in etiology. This study compared brain activity of 18 ADHD-I adolescents (ages 12-18) and 20 non-psychiatric age-matched control participants on a functional magnetic resonance image (fMRI) auditory oddball attention task. Read More

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Sex differences and the interaction of age and sleep issues in neuropsychological testing performance across the lifespan in an ADD/ADHD sample from the years 1989 to 2009.

Psychol Rep 2014 Apr;114(2):404-38

Chart review of population (9 to 80 years) neuropsychological test battery for ADHD diagnosis, questionnaires with multiple responders were evaluated in outpatient setting from 1989-2009. The focus was gender differences across age, diagnostic group (ADHD-Inattentive/ADHD plus), neuropsychological test performance, and reported sleep symptoms over the lifespan. Individuals were assigned to ADHD-I group or ADHD plus group (based upon secondary diagnosis of sleep, behavioral, emotional disturbance); ADHD not primary was excluded (brain insult, psychosis). Read More

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