116,107 results match your criteria substituted s-n-alpha-methylbenzylaziridines


Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.

Bioorg Chem 2021 Sep 11;116:105353. Epub 2021 Sep 11.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012 Jinan, Shandong, PR China. Electronic address:

Herein, alkenylpiperidine and alkynylpiperidine moieties were introduced into the left wing of DAPYs (diarylpyrimidines) to explore the new site of the NNIBP (non-nucleoside inhibitor binding pocket) protein-solvent interface region via the structure-based drug design strategy. All the synthesized compounds displayed nanomolar to submicromolar activity against WT (wild-type) HIV-1. Among all, compound FT1 (EC = 19 nM) was found to be the most active molecule, which is better than NVP (EC = 0. Read More

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September 2021

Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents.

Bioorg Chem 2021 Sep 11;116:105346. Epub 2021 Sep 11.

School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023 China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China; Pharm-X Center, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address:

Starting from the antimalarial drugs chloroquine and hydroxychloroquine, we conducted a structural optimization on the side chain of chloroquine by introducing amino substituted longer chains thus leading to a series of novel aminochloroquine derivatives. Anti-infectious effects against SARS-Cov2 spike glycoprotein as well as immunosuppressive and anti-inflammatory activities of the new compounds were evaluated. Distinguished immunosuppressive activities on the responses of T cell, B cell and macrophages upon mitogen and pathogenic signaling were manifested. Read More

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September 2021

4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.

Bioorg Chem 2021 Sep 11;116:105349. Epub 2021 Sep 11.

College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address:

A series of fluorinated and hydroxylated 2,4-diphenyl indenopyridinols were designed and synthesized using l-proline-catalyzed and microwave-assisted synthetic methods for the development of new anticancer agents. Adriamycin and etoposide were used as reference compounds for the evaluation of topo IIα inhibitory and anti-proliferative activity of the synthesized compounds. Exploring the structure-activity relationships of 36 prepared compounds and biological results, most of the compounds with ortho- and para-fluorophenyl at 4-position of indenopyridinol ring displayed strong topo IIα inhibition. Read More

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September 2021

A DFT study of the double (3 + 2) cycloaddition of nitrile oxides and allenoates for the formation of spirobiisoxazolines.

J Mol Graph Model 2021 Sep 12;109:108033. Epub 2021 Sep 12.

Theoretical and Computational Chemistry Laboratory, Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address:

The molecular mechanism of the double (3 + 2) cycloaddition (32CA) reaction between nitrile oxides and allenoates has been studied using density functional theory at the M06-2X/6-311G (d,p) level of theory. In the first 32CA, the nitrile oxide adds chemo- and regio-selectively to the C-C double bond of the allenoate closest to the carboxylate group followed by a subsequent regioselective addition to the olefinic bond of the isoxazoline intermediate. The rate constant for the preferred pathway (formation of 4-methylene-2-isoxazoline intermediate) in the reaction of ethyl substituted allenoate and mesitonitrile oxide is 5. Read More

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September 2021

Inhibition of huntingtin aggregation by its N-terminal 17-residue peptide and its analogs.

Arch Biochem Biophys 2021 Sep 14:109033. Epub 2021 Sep 14.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781 039, India. Electronic address:

The N-terminal 17-residue stretch of huntingtin (htt) folds into an amphipathic α-helix. The htt-harboring polyQ peptides form oligomers that are mediated via the assembly of the htt α-helices. The oligomerization results in higher local concentration of the polyglutamine (polyQ) region, thereby facilitating amyloid formation. Read More

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September 2021

Skeleton Reorganization of Substituted Benzocyclobutenols through Rh-Catalyzed C-C Bond Cleavage Manipulated by Hydrogen Transfer.

Org Lett 2021 Sep 17. Epub 2021 Sep 17.

Department of Chemistry, Fudan University, Shanghai 200433, P. R. China.

Although transition-metal-catalyzed C-C bond activation has been investigated extensively, C-C bond cleavage manipulated by hydrogen transfer has been unexplored. In this work, we disclose a skeleton reorganization of alkene-tethered benzocyclobutenols through Rh-catalyzed C-C bond cleavage coupled with intra- and intermolecular hydrogen transfer. The reaction pathway was well-tuned by the catalytic systems. Read More

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September 2021

Axially Chiral Stable Radicals: Resolution and Characterization of Blatter Radical Atropisomers.

Org Lett 2021 Sep 17. Epub 2021 Sep 17.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Łódź, Poland.

Atropisomers of three Blatter radicals were obtained by the addition of 8-substituted 1-naphthyllithiums to 3-phenyl and 3--butylbenzo[][1,2,4]triazine and separated by chiral high-performance liquid chromatography. Their absolute configurations were assigned by a comparison of experimental and time-dependent density functional theory calculated electronic circular dichroism spectra. The free energy of activation, Δ, and the half life of racemization, , at 298 K were determined at ∼25 kcal mol and <130 h, respectively. Read More

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September 2021

gem-Heteroatom-substituted fluoroalkenes as mimics of amide derivatives or phosphates: a comprehensive review.

Chemistry 2021 Sep 17. Epub 2021 Sep 17.

INSA Rouen Normandie, UMR 6014 COBRA, 1 rue tesnière, 76821, Mont-Saint-Aignan, FRANCE.

gem -Heteroatom-substituted fluoroalkenes have received little attention despite their great potential in medicinal chemistry or in fine chemistry. Indeed, due to the electronic and steric similarity between fluoroalkene moiety and amide bond as well as the high strength of carbon-fluorine bond, these gem -heteroatom-substituted fluoroalkenes could be envisioned as stable mimics of various important organic functions such as phosphates, carbamates, S-thiocarbamates and ureas. We present herein an overview describing the syntheses over the last decade of heteroatom-substituted fluoroalkenes in geminal position. Read More

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September 2021

Stereodivergent Construction of Vicinal Acyclic Quaternary-Tertiary Carbon Stereocenters by Michael-Type Alkylation of α,α-Disubstituted --Butanesulfinyl Ketimines.

Org Lett 2021 Sep 17. Epub 2021 Sep 17.

School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.

Vicinal quaternary-tertiary carbon stereocenters were constructed with excellent stereoselectivity via aza-enolization of enantioenriched acyclic --butanesulfinyl ketimines bearing two sterically similar α-linear alkyl substituents followed by conjugate addition to nitroalkenes. Further changes of the absolute configuration of the sulfinyl group and/or the α-stereocenter in the ketimine allowed the facile stereodivergent synthesis of all four diastereomers of the Michael-type alkylation adducts. This reaction is a successful example of acyclic stereocontrol based on stereoselective α-deprotonation for the formation of fully substituted aza-enolates from ketone derivatives. Read More

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September 2021

A Three-Dimensional sp Carbon-Conjugated Covalent Organic Framework.

J Am Chem Soc 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China.

A first example of an sp carbon-conjugated three-dimensional (3D) covalent organic framework (COF) (BUCT-COF-4) is synthesized via the Knoevenagel condensation of the saddle-shaped aldehyde-substituted cyclooctatetrathiophene and 1,4-phenylenediacetonitrile. Ascribed to the extended π-conjugation and long-range ordered structures, BUCT-COF-4 displays high Hall electron mobility of 1.97 cm V s at room temperature. Read More

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September 2021

A {TiW}-Cluster-Substituted Polyoxotungstate: Synthesis, Structure, and Catalytic Oxidation Properties.

Inorg Chem 2021 Sep 17. Epub 2021 Sep 17.

MOE Key Laboratory of Cluster Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China.

A novel Ti-W-O-cluster-substituted tungstoantimonate (TA), [HN(CH)]NaH[{TiWO(OH)(HO)}(B-α-SbWO)]·20HO (), has been made by hydrothermal reactions of trivacant [B-α-SbWO] units, Ti cations, and WO anions in the presence of [HN(CH)]·Cl and structurally characterized. Intriguingly, the polyoxoanion of is constructed from three [B-α-SbWO] units and a previously unobserved decanuclear heterometallic Ti-W-O cluster [TiWO(OH)(HO)] ({TiW}) that is comprised of an octahedral [TiWO(HO)] cluster and an edge-sharing [WO(OH)] fragment via six W-O-Ti/W linkers. Furthermore, studies on the catalytic oxidation properties reveal that possesses good catalytic activity toward the oxidation reactions of various sulfides and cyclooctene based on the environmentally friendly oxidant HO. Read More

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September 2021

Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE.

Immun Inflamm Dis 2021 Sep 17. Epub 2021 Sep 17.

Animal Allergy Clinical Laboratories Inc., Sagamihara, Kanagawa, Japan.

Background: The efficacy assessment of human anti-IgE monoclonal antibodies (mAbs) in animal models before clinical trials is hampered due to the lack of cross-reactivity of anti-IgE mAbs between species.

Objective: We developed CRE-DR (an anti-dog IgE monoclonal antibody), an anti-IgE mouse mAb that recognizes canine and human IgE, and then examined its IgE specificity and cross-reactivity between three animal and human species.

Methods: After mouse immunization with a synthetic peptide derived from canine IgE ( NTNDWIEGETYYC ), we generated a hybridoma producing CRE-DR. Read More

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September 2021

Synthesis of -CF hydrazines through radical trifluoromethylation of azodicarboxylates.

Chem Commun (Camb) 2021 Sep 17. Epub 2021 Sep 17.

UMR 8076, BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290 Châtenay-Malabry, France.

We report here the synthesis of a novel family of -CF hydrazines from a direct way involving the available and cheap Langlois reagent (CFSONa). These derivatives have shown very high stability whatever the conditions used and are excellent precursors for building previously inaccessible -CF functionalized compounds, such as substituted hydrazides, hydrazine-amino-acids, hydrazones, -aziridines and pyrazoles. Read More

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September 2021

Transition metal-catalyzed synthesis of new 3-substituted coumarin derivatives as antibacterial and cytostatic agents.

Future Med Chem 2021 Sep 17. Epub 2021 Sep 17.

Faculty of Chemical Engineering & Technology, Department of Organic Chemistry, University of Zagreb, Marulićev trg 20, HR-10000, Zagreb, Croatia.

The aim of this study was to synthesize new coumarin-based compounds and evaluate their antibacterial and antitumor potential. Using transition metal-catalyzed reactions, a series of 7-hydroxycoumarin derivatives were synthesized with aliphatic and aryl moiety attached directly at C-3 of the coumarin ring and through the ethynyl or 1,2,3-triazole linker. The 3-substituted coumarin derivative bearing bistrifluoromethylphenyl at the C-4 position of 1,2,3-triazole () showed strong and selective antiproliferative activity against cervical carcinoma cells. Read More

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September 2021

New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line.

Drug Dev Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

Novel 2-[2-(chroman-4-ylidene)hydrazinyl]-4/5-substituted thiazole derivatives (2a-i) were synthesized and investigated for their anticancer activity. Cytotoxic activity on A549 and NIH/3T3 cell lines was determined, most of the compounds exhibited high cytotoxic profile with selectivity. Selected compounds 2b, 2c, 2e, 2g, 2h, and 2i were tested to determine induction of apoptosis, mitochondrial membrane depolarization, and cell cycle arrest. Read More

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September 2021

Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745.

ACS Med Chem Lett 2021 Sep 30;12(9):1498-1502. Epub 2021 Aug 30.

Medicine Design, Early Development Leaders, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

GSK2798745, an antagonist of the transient receptor potential vanilloid 4 (TRPV4) ion channel, was recently investigated in clinical trials for the treatment of cardiac and respiratory diseases. Human plasma and urine samples collected from healthy volunteers following oral administration were analyzed to identify circulating and excreted metabolites of the parent drug. One major circulating metabolite () was found in pooled human plasma samples, accounting for approximately half of the observed drug-related material. Read More

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September 2021

Discovery and Characterization of a Rapidly Fungicidal and Minimally Toxic Peptoid against .

ACS Med Chem Lett 2021 Sep 23;12(9):1470-1477. Epub 2021 Aug 23.

Department of Chemistry, Middle Tennessee State University, 1301 E. Main St., Murfreesboro, Tennessee 37132, United States.

A limited number of antifungals are available to treat infections caused by fungal pathogens such as and . Current clinical antifungals are generally toxic, and increasing resistance to these therapies is being observed, necessitating new, effective, and safe antifungals. Peptoids, or N-substituted glycines, have shown promise as antimicrobial agents against bacteria, fungi, and parasites. Read More

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September 2021

Novel Substituted 1,6-Naphthyridines as CDK 5 Inhibitors for Treating Kidney Diseases.

Authors:
Ram W Sabnis

ACS Med Chem Lett 2021 Sep 17;12(9):1363-1364. Epub 2021 Aug 17.

Smith, Gambrell & Russell LLP, 1230 Peachtree Street NE, Suite 3100, Atlanta, Georgia 30309, United States.

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September 2021

Novel Substituted Heterocyclic Carboxamides as Adrenoreceptor ADRAC2 Inhibitors for Treating Diseases.

Authors:
Ram W Sabnis

ACS Med Chem Lett 2021 Sep 17;12(9):1361-1362. Epub 2021 Aug 17.

Smith, Gambrell & Russell LLP, 1230 Peachtree Street NE, Suite 3100, Atlanta, Georgia 30309, United States.

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September 2021

The influence of heteroatom doping on local properties of phosphorene monolayer.

Sci Rep 2021 Sep 16;11(1):18494. Epub 2021 Sep 16.

Institute of Thermal Machinery, Czestochowa University of Technology, Ave. Armii Krajowej 21, 42-200, Czestochowa, Poland.

New energy storage technologies that can serve as a reliable alternative to lithium-ion batteries are in the spotlight. Particular attention has been recently devoted to magnesium-ion systems due to the considerable abundance of this element and also due to its promising electro-chemical performance. Our results show that monolayer black phosphorene doped by B, Sc, Co, and Cu atoms possesses good structural stability with the minimal cohesive energy of [Formula: see text] eV/atom, the adsorption energy per Mg atom ranging from [Formula: see text] to [Formula: see text] eV, and the charge transfer from double-side adsorbed single Mg-ions to the B-substituted phosphorene increased by [Formula: see text]0. Read More

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September 2021

Insights into the Enhanced Structural and Thermal Stabilities of Nb-Substituted Lithium-Rich Layered Oxide Cathodes.

ACS Appl Mater Interfaces 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan 410083, P. R. China.

Lithium-rich manganese-based layered oxides (LLOs) are considered to be the most promising cathode materials for next-generation lithium-ion batteries (LIBs) for their higher reversible capacity, higher operating voltage, and lower cost compared with those of other commercially available cathode materials. However, irreversible lattice oxygen release and associated severe structural degradation that exacerbate under high temperature and deep delithiation hinder the large-scale application of LLOs. Herein, we propose a strategy to stabilize the layered lattice framework and improve the thermal stability of cobalt-free LiMnNiO by doping with 4d transition metal niobium (Nb). Read More

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September 2021

Corrigendum: Bioactive Sr/Feco-substituted hydroxyapatite in cryogenically 3D printed porous scaffolds for bone tissue engineering. Liang Yang 2021  035007.

Biofabrication 2021 Sep 16. Epub 2021 Sep 16.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei, 430000, CHINA.

Developing multi-doped bioceramics that possess biological multifunctionality is becoming increasingly attractive and promising for bone tissue engineering. In this view innovative Sr/Feco-substituted nano-hydroxyapatite with gradient doping concentrations fixed at 10 mol% has been deliberately designed previously. Herein, to evaluate their therapeutic potentials for bone healing, novel gradient SrFeHA/PCL scaffolds are fabricated by extrusion cryogenic 3D printing technology with subsequent lyophilization. Read More

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September 2021

Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA.

Bioorg Chem 2021 Sep 13;116:105339. Epub 2021 Sep 13.

Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt. Electronic address:

Microbial resistance is a big concern worldwide, making the development of new antimicrobial drugs difficult. The thiazole and pyrazole rings are important heterocyclic compounds utilized to produce a variety of antimicrobial medications. As a result, a series of new bis-thiazolyl-pyrazole derivatives 3, 4a-c, 5a, b, and 6a-c was synthesized by reacting bis hydrazonoyl bromide with several active methylene reagents in a one-pot reaction. Read More

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September 2021

A Mononuclear Non-heme Iron(III)-Peroxo Complex with an Unprecedented High O-O Stretch and Electrophilic Reactivity.

J Am Chem Soc 2021 Sep 16. Epub 2021 Sep 16.

Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea.

A mononuclear non-heme iron(III)-peroxo complex, [Fe(III)(O)(13-TMC)] (), was synthesized and characterized spectroscopically; the characterization with electron paramagnetic resonance, Mössbauer, X-ray absorption, and resonance Raman spectroscopies and mass spectrometry supported a high-spin = / Fe(III) species binding an O unit. A notable observation was an unusually high ν at ∼1000 cm for the peroxo ligand. With regard to reactivity, showed electrophilic reactivity in H atom abstraction (HAA) and O atom transfer (OAT) reactions. Read More

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September 2021

Speciation of Transition-Metal-Substituted Keggin-Type Silicotungstates Affected by the Co-crystallization Conditions with Proteinase K.

Inorg Chem 2021 Sep 16. Epub 2021 Sep 16.

Universität Wien, Fakultät für Chemie, Institut für Biophysikalische Chemie, Althanstraße 14, 1090 Wien, Austria.

We report on the synthesis of the tetrasubstituted sandwich-type Keggin silicotungstates as the pure Na salts Na[(A-α-SiWO){Co(OH)(HO)}]·37HO () and Na[(A-α-SiWO){Ni(OH)(HO)}]·77.5HO (), which were prepared by applying a new synthesis protocol and characterized thoroughly in the solid state by single-crystal and powder X-ray diffraction, IR spectroscopy, thermogravimetric analysis, and elemental analysis. Proteinase K was applied as a model protein and the polyoxotungstate (POT)-protein interactions of and were studied side by side with the literature-known KNa[A-α-SiWO(OH){Co(OAc)}]·28. Read More

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September 2021

Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders.

ACS Chem Neurosci 2021 Sep 16. Epub 2021 Sep 16.

School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, Camerino 62032, Italy.

In the search for novel bitopic compounds targeting the dopamine D receptor (DR), the -(2,3-dichlorophenyl)piperazine nucleus (primary pharmacophore) has been linked to the 6,6- or 5,5-diphenyl-1,4-dioxane-2-carboxamide or the 1,4-benzodioxane-2-carboxamide scaffold (secondary pharmacophore) by an unsubstituted or 3-F-/3-OH-substituted butyl chain. This scaffold hybridization strategy led to the discovery of potent DR-selective or multitarget ligands potentially useful for central nervous system disorders. In particular, the 6,6-diphenyl-1,4-dioxane derivative showed a DR-preferential profile, while an interesting multitarget behavior has been highlighted for the 5,5-diphenyl-1,4-dioxane and 1,4-benzodioxane derivatives and , respectively, which displayed potent DR antagonism, 5-HTR and DR agonism, as well as potent DR partial agonism. Read More

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September 2021

Insights into High-Efficiency Ag-Alloyed CZTSSe Solar Cells Fabricated through Aqueous Spray Deposition.

ACS Appl Mater Interfaces 2021 Sep 16. Epub 2021 Sep 16.

Department of Physics, Incheon National University, Incheon 22012, Republic of Korea.

Kesterite CuZnSnSe (CZTSe), CuZnSn(S,Se) (CZTSSe), and CuZnSnS (CZTS) solar cells show considerably lower open-circuit voltages than their theoretical values. The large open-circuit voltage deficiency () hinders the improvement of the power conversion efficiency (PCE) and the development of the pathway to mass production of kesterite solar cells. The main reason behind the is considered to be the low formation energy of Cu/Zn disorders and their highly distributed defect complexes. Read More

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September 2021

A series of Iron(II)-NHC Sensitizers with remarkable power conversion efficiency in photoelectrochemical cells.

Chemistry 2021 Sep 16. Epub 2021 Sep 16.

UNIVERSITE DE LORRAINE, HECRIN-SRSMC, CNRS, Bd des Aiguillettes, 54506, Vandoeuvre-Les-Nancy, FRANCE.

A series of six new Fe(II)NHC-carboxylic sensitizers with their ancillary ligand decorated with functions of varied electronic properties have been designed with the aim to increase the metal-to- surface charge separation and light harvesting in iron-based Dye-sensitized solar cells (DSCCs). ARM130 scored the highest efficiency ever reported for an iron-sensitized solar cell (1.83%) using Mg 2+ and NBu 4 I-based electrolyte and a thick 20μm TiO 2 anode. Read More

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September 2021

A Rh-substituted polyoxometalate with an acetate-modified building block {AsWO(CHCOO)}.

Chem Commun (Camb) 2021 Sep 16. Epub 2021 Sep 16.

Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, P. R. China.

The first example of Rh-substituted organic-inorganic hybrid arsenotungstate [HN(CH)]{[Na(HO)]NaAsW(CHCOO)O Rh(N(CH))}·HO (1) synthesised in an aqueous solution by the conventional method is reported. Two [Rh(N(CH))] fragments are imbedded into the vacancy of the [NaAsW(CHCOO)O] unit by Rh-As bonds [2.439(1) Å], which are observed in POM chemistry for the first time. Read More

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September 2021

A one-pot synthesis of piperidinium spirooxindoline-pyridineolates and indole-substituted pyridones in aqueous or ethanol medium.

Mol Divers 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran.

Piperidinium spirooxindoline-pyridineolate has been prepared via one-pot multicomponent reaction of isatin, malononitrile, cyanoacetohydrazide, and piperidine in water or ethanol medium at room temperature. In addition, the synthesis of two indole-substituted 2-pyridones from indole-3-carbaldehyde, malononitrile, and cyanoacetohydrazide in the presence of piperidine is described. Read More

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September 2021