19,008 results match your criteria substitute treatment

Improvement of mechanical properties of zein porous scaffolds by quenching/electrospun fiber reinforcement.

Biomed Mater 2021 Sep 13. Epub 2021 Sep 13.

Shanghai Jiao Tong University, 800 Dongchuan RD. Minhang District, Shanghai, China, Shanghai, 200240, CHINA.

As a novel bone substitute material, zein-based scaffolds (ZS) should have suitable mechanical properties and porosity. ZS have shown good compressive properties matching cancellous bone, but there is still a demand to improve the mechanical properties, especially tensile and bending properties, without adding plasticizers. The present study explored two simple and environment-friendly factors for this purpose: fiber reinforcement and quenching. Read More

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September 2021

Expanding Role of Technology in Rehabilitation After Lower-Extremity Joint Replacement: A Systematic Review.

JBJS Rev 2021 09 13;9(9). Epub 2021 Sep 13.

Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: The effectiveness of telehealth programs in the administration of rehabilitation and the monitoring of postoperative progress after joint replacement is not well studied. The purpose of the present study was to systematically review the currently available evidence on the use of smart-device technology and telehealth programs to guide and monitor postoperative rehabilitation following total joint arthroplasty and to assess their impact on outcomes following surgery.

Methods: A literature search of the MEDLINE database was performed using keywords "mobile," "app," "telehealth," "virtual," "arthroplasty," "outcomes," "joint replacement," "web based," "telemedicine," "TKA," "THA," "activity tracker," "fitness tracker," "monitor," "rehab," "online," and "stepcounter" in all possible combinations. Read More

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September 2021

The comparison of albumin and 6% hydroxyethyl starches (130/0.4) in cardiac surgery: a meta-analysis of randomized controlled clinical trials.

BMC Surg 2021 Sep 11;21(1):342. Epub 2021 Sep 11.

Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Background: Fluid administration is a key tool in the maintenance of normovolemia in patients with cardiac surgery. The trials that evaluated the safety of 6% hydroxyethyl starch (HES) 130/0.4 in cardiac surgical patients were inconsistent. Read More

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September 2021

Generation of a novel model of bioengineered human oral mucosa with increased vascularization potential.

J Periodontal Res 2021 Sep 12. Epub 2021 Sep 12.

Department of Histology (Tissue Engineering Group), University of Granada, Granada, Spain.

Objective: The aim of this study was to generate novel models of bioartificial human oral mucosa with increased vascularization potential for future use as an advanced therapies medicinal product, by using different vascular and mesenchymal stem cell sources.

Background: Oral mucosa substitutes could contribute to the clinical treatment of complex diseases affecting the oral cavity. Although several models of artificial oral mucosa have been described, biointegration is a major issue that could be favored by the generation of novel substitutes with increased vascularization potential once grafted in vivo. Read More

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September 2021

Residual municipal solid waste as co-substrate at wastewater treatment plants: An assessment of methane yield, dewatering potential and microbial diversity.

Sci Total Environ 2021 Aug 27;804:149936. Epub 2021 Aug 27.

Unit of Environmental Engineering, Department of Infrastructure, University of Innsbruck, Technikerstraße 13, 6020 Innsbruck, Austria.

Separately collected organic fraction of municipal solid waste, also known as biowaste, is typically used to fill the available capacity of digesters at wastewater treatment plants. However, this approach might impair the use of the ensuing digestate for fertilizer production due to the presence of sewage sludge, a contaminated substrate. Worldwide, unsorted municipal solid household waste, i. Read More

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The vitamin a transporter STRA6 adjusts the stoichiometry of chromophore and opsins in visual pigment synthesis and recycling.

Hum Mol Genet 2021 Sep 11. Epub 2021 Sep 11.

Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, 44106, OH, USA.

The retinal pigment epithelium of the vertebrate eyes acquires vitamin A from circulating retinol binding protein for chromophore biosynthesis. The chromophore covalently links with an opsin protein in the adjacent photoreceptors of the retina to form the bipartite visual pigment complexes. We here analyzed visual pigment biosynthesis in mice deficient for the retinol binding protein receptor STRA6. Read More

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September 2021

Urine N-acetyl-Ser-Asp-Lys-Pro measurement as a versatile biomarker to assess adherence to angiotensin-converting enzyme inhibitors.

J Hypertens 2021 Sep 9. Epub 2021 Sep 9.

Assistance Publique des Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Pharmacology Unit and DMU BIOPHYGEN INSERM UMRS970 Université de Paris, INSERM, CIC1418 Assistance Publique des Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Hypertension Department and DMU CARTE, Paris, France.

Background: Poor adherence to treatment is a major health issue in hypertension. The large number of drugs to be detected limits the implementation of chemical adherence testing by liquid chromatography/mass spectrometry (LC-MS/MS). AcSDKP, a peptide accumulating in the presence of angiotensin-converting-enzyme inhibitor (ACEI) treatment, has been validated as a proven marker of adherence by enzyme-linked immunosorbent assay. Read More

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September 2021

Effect of Biochar and Inorganic Fertilizer on the Soil Properties and Growth and Yield of Onion () in Tropical Ethiopia.

ScientificWorldJournal 2021 30;2021:5582697. Epub 2021 Aug 30.

Department of Natural Resource Management, College of Agriculture and Natural Resource, Wolkite University, Wolkite, Ethiopia.

Biochar is a carbon-rich product, which is processed by pyrolyzing biomass to improve soil properties and maintain environmental sustainability. This study aim was to investigate the effect of biochar and inorganic fertilizer on soil properties, growth, and yield. Four treatments and four replications have been used for the experimental plots using Randomized Complete Block Design (RCBD). Read More

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Documenting plans for care: advance care directives and the 7-step pathway in the acute care context.

BMC Palliat Care 2021 Sep 9;20(1):138. Epub 2021 Sep 9.

School of Public Health, University of Adelaide, Adelaide, 5005, Australia.

Background: Advance care planning involves the discussion and documentation of an individual's values and preferences to guide their future healthcare should they lose capacity to make or communicate treatment decisions. Advance care planning can involve the individual's completion of an Advance Care Directive (ACD), a legislated and common-law instrument which may include appointment of a substitute decision-maker and binding refusals of treatment. In South Australia, ACDs intersect in the acute-care context with the Resuscitation Plan 7-Step Pathway (7-SP), an integrated care plan written for and by clinicians, designed to organise and improve patients' end-of-life care through the use of structured documentation. Read More

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September 2021

Peritoneal patch in vascular reconstruction during pancreaticoduodenectomy for pancreatic cancer: a single centre experience.

Acta Chir Belg 2021 Sep 10:1-22. Epub 2021 Sep 10.

Medico-Surgical Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium.

Background: Concomitant venous resection during pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma with mesenterico-portal vein involvement is increasingly performed to achieve oncological resection. This study aims to report a single centre experience in peritoneal patch (PP) as autologous graft for vascular reconstruction (VR) during PD.

Methods: A retrospective analysis of all patients who underwent PD + VR with PP between December 2019 and September 2020 was performed, using a prospective collected database. Read More

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September 2021

The Use of Modal Analysis in Addition Percentage Differentiation, and Mechanical Properties of Ordinary Concretes with the Addition of Fly Ash from Sewage Sludge.

Materials (Basel) 2021 Sep 3;14(17). Epub 2021 Sep 3.

Faculty of Mechanical Engineering, UTP-University of Science and Technology in Bydgoszcz, 85-796 Bydgoszcz, Poland.

Production cost reduction and constraints on natural resources cause the use of waste materials as substitutes of traditional raw materials to become increasingly important. The dynamic development of sewerage systems and sewage treatment plants leads to increases in the produced sewage sludge. According to the Waste Law, municipal sewage sludge can be used if it is properly stabilized. Read More

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September 2021

Assessment of the Impact of Decellularization Methods on Mechanical Properties of Biocomposites Used as Skin Substitute.

Materials (Basel) 2021 Aug 24;14(17). Epub 2021 Aug 24.

Department of Biomechatronics, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 Str., 41-800 Zabrze, Poland.

This work aimed to assess the impact of acellularization and sterilization methods on the mechanical properties of biocomposites used as a skin substitute. On the basis of the statistical analysis, it was ascertained that the values of the Young modulus for the samples before the sterilization process-only in the cases of substances such as: trypsin, 15% glycerol and dispase-changed in a statistically significant way. In the case of dispase, the Young modulus value before the sterilization process amounted to 66. Read More

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Fed or fasted state for oral therapies in breast cancer treatment? A comprehensive review of clinical practice recommendations.

Cancer Treat Rev 2021 Aug 18;100:102281. Epub 2021 Aug 18.

Division of New Drugs and Early Drug Development, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy. Electronic address:

In the last decades several anti-cancer drugs have been developed to treat patients with breast cancer, many of them orally administered, with ongoing efforts to substitute parenteral drugs with oral therapy. The latter is attractive because of its convenience and ease of administration, finally improving quality of life. The drawback of oral administration is that exposure to the drug is affected by different factors and the high variability, combined with the relatively narrow therapeutic index of most of these agents, would predispose some individuals to risk for treatment inefficacy or increase toxicity. Read More

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Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABA receptor subtypes.

Drug Alcohol Depend 2021 Aug 27;228:108985. Epub 2021 Aug 27.

Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA, 01772, USA; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. Electronic address:

Background: To assess GABA receptor subtypes involved in benzodiazepine tolerance and dependence, we evaluated the ability of subtype-selective and non-selective ligands to substitute for (i.e., produce "cross-tolerance") or precipitate withdrawal during chronic alprazolam treatment. Read More

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Validation of pelvic magnetic resonance imaging as the method of choice to determine the distance to the anal margin in rectal cancer.

Cir Esp 2021 Sep 4. Epub 2021 Sep 4.

Centro Europeo de Cirugía Colorrectal, Hospital Vithas Valencia 9 de Octubre, Valencia, España; La filiación de Miguel Ángel Lorenzo Liñán, Juan García Armengol, Gonzalo Pablo Martin Martin y José Vicente Roig Vila en el momento de la realización de este artículo era: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.

Introduction: Distance from anal verge of rectal tumors and their anatomical relationships contribute to determine the multidisciplinary therapeutic strategy based on the combination of radio-chemotherapy and radical surgery. Our aims are to investigate which is the most accurate method for the preoperative measuring of the distance from the anal verge in rectal tumors and if the pelvic MRI can substitute the classical instrumental methods.

Methods: Prospective study of diagnostic precision between flexible colonoscopy (FC), preoperative rigid rectosigmoidoscopy (pRR) and pelvic MRI in patients scheduled to radical surgery. Read More

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September 2021

The diagnostic performance of diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging in evaluating the pathological response of breast cancer to neoadjuvant chemotherapy: A meta-analysis.

Eur J Radiol 2021 Aug 23;143:109931. Epub 2021 Aug 23.

First Hospital of Lanzhou University, Lanzhou 730000, China. Electronic address:

Purpose: To evaluate and compare the diagnostic performance of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting the pathological response of breast cancer to neoadjuvant chemotherapy (NAC).

Methods: We searched PubMed, EMBASE, Cochrane Library, and Web of Science systematically to identify relevant studies from inception to December 2020. The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to assess the methodological quality of the included studies. Read More

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Reattachment After Foldable Capsular Vitreous Body Implantation in Severe Retinal Detachment Eyes.

Transl Vis Sci Technol 2021 Sep;10(11)

Affiliated Shenzhen Eye Hospital of Jinan University, Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Shenzhen University School of Medicine, Shenzhen, Guangdong province, China.

Purpose: To evaluate the clinical effectiveness and safety of foldable capsular vitreous body (FCVB) implantation for severe retinal detachment.

Methods: A retrospective analysis was performed on 26 patients with severe ocular trauma and one with recurrent retinal detachment. Clinical data-including surgery success, complications, retinal reattachment, vision, and intraocular pressure (IOP)-were analyzed for patients who underwent 23G pars plana vitrectomy and FCVB implantation combined with silicone oil tamponade. Read More

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September 2021

Effect of metformin on the behavior of dental pulp stem cells cultured on freeze-dried bone allografts.

Dent Med Probl 2021 Sep 7. Epub 2021 Sep 7.

Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Considering the complications associated with autogenous bone grafting, the use of freezedried bone allograft (FDBA) granules may be considered as an alternative treatment plan.

Objectives: The aim of this study was to evaluate the effect of metformin on both the proliferation and osteogenic capability of dental pulp stem cells (DPSCs) cultured on FDBA granules.

Material And Methods: First, a pilot study was conducted only on DPSCs to confirm cellular viability and the osteoinducing effect of 100 μmol/L metformin. Read More

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September 2021

Ultrasound-guided percutaneous transluminal angioplasty for the treatment of cephalic arch stenosis in hemodialysis arteriovenous fistulas.

Semin Dial 2021 Sep 6. Epub 2021 Sep 6.

Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: Cephalic arch stenosis (CAS) is a common cause that leads to the failure of hemodialysis arteriovenous fistulas (AVFs). Patients with CAS are primarily treated with fluoroscopy-guided angioplasty. Here, seven patients with de novo cephalic arch stenosis who underwent office-based UG-PTA were. Read More

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September 2021

Case Report: Cariprazine in a Patient With Schizophrenia, Substance Abuse, and Cognitive Dysfunction.

Front Psychiatry 2021 18;12:727666. Epub 2021 Aug 18.

Pharmacilitator AB, Vallda, Sweden.

This case report describes a 30-year old male diagnosed with schizophrenia at the age of 23, and with a long history of drug abuse. He had previously received a wide range of antipsychotic drug treatment regimens, all with some degree of effect, but never with complete symptom relief. He was also suffering from persistent cognitive and negative symptoms. Read More

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REDV-modified decellularized microvascular grafts for arterial and venous reconstruction.

J Biomed Mater Res A 2021 Sep 5. Epub 2021 Sep 5.

Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.

Recently, a decellularized microvascular graft (inner diameter: 0.6 mm) modified with the integrin α4β1 ligand, REDV, was developed to provide an alternative to autologous-vein grafting in reconstructive microsurgery, showing good early-stage patency under arterial flow in rats. This consecutive study evaluated its potential utility not only as an arterial substitute, but also as a venous substitute, using a rat-tail replantation model. Read More

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September 2021

Pyoderma Gangrenosum After Bilateral Total Knee Arthroplasty.

Arthroplast Today 2021 Oct 26;11:73-79. Epub 2021 Aug 26.

Palo Alto Medical Foundation, Center for Total Joint Replacement, Palo Alto, CA.

Pyoderma gangrenosum is a neutrophilic dermatosis, which mimics both infection and necrotizing fasciitis, that can present after surgical interventions. We present the case of a 62-year-old male who underwent one-stage bilateral total knee arthroplasty. Nine days after the surgery, he presented with wound breakdown, high fever, and elevated white blood cell count. Read More

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October 2021

Long-term experience with a collagen-elastin scaffold in combination with split-thickness skin grafts for the treatment of full-thickness soft tissue defects: improvements in outcome-a retrospective cohort study and case report.

Langenbecks Arch Surg 2021 Sep 4. Epub 2021 Sep 4.

Department of Trauma, University Hospital Zurich, Raemistr. 100, 8091, Zürich, Switzerland.

Purpose: The management of severe soft tissue injuries to the extremities with full-thickness wounds poses a challenge to the patient and surgeon. Dermal substitutes are used increasingly in these defects. The aim of this study was to investigate the impact of the type of injury on the success rate of Matriderm® (MD)-augmented split-thickness skin grafting, as well as the role of negative pressure wound therapy (NPWT) in preconditioning of the wounds, with a special focus on the reduction of the bioburden. Read More

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September 2021

[Priorities of national surgery. Evgeny Illarionovich Zakharov. Stomach repair with small bowel substitutes].

Khirurgiia (Mosk) 2021 (9):103-106

Sechenov First Moscow State Medical University, Moscow, Russia.

The manuscript is devoted to the outstanding Russian surgeon Zakharov E.I.. Read More

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September 2021

Carcass and meat traits of bubaline finished on sugarcane-based diets supplemented with spineless cactus as a replacement for wheat bran.

Anim Biosci 2021 Aug 24. Epub 2021 Aug 24.

Department of Animal Science, Federal Rural University of Pernambuco - UFRPE, Recife, Brazil.

Objective: An experiment was conducted to evaluate the effects of increasing levels of spineless cactus (0%, 33%, 66% and 100%) used as a substitute for wheat bran in buffalo diets on quantitative and qualitative traits of the meat and carcass.

Methods: Twenty Murrah buffaloes at 18 months of age, with a mean initial weight of 292.9±57. Read More

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Therapeutic plasma exchange for life-threatening pediatric disorders.

J Clin Apher 2021 Sep 1. Epub 2021 Sep 1.

Hôpital Necker Enfants Malades, Paris, France.

Introduction: Therapeutic plasma exchange (TPE) is acknowledged to be an effective treatment in life-threatening pediatric disorders. Apheresis for pediatric diseases has been poorly investigated, and most studies to date featured small numbers of patients and lacked control groups. The objective of the present study was to evaluate the tolerance of TPE in pediatric patients. Read More

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September 2021

Determining a healthy reference range and factors potentially influencing PRO-C3 - A biomarker of liver fibrosis.

JHEP Rep 2021 Aug 10;3(4):100317. Epub 2021 Jul 10.

Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany.

Background & Aims: Progressive fibrosis has been identified as the major predictor of mortality in patients with non-alcoholic fatty liver disease (NAFLD). Several biomarkers are currently being evaluated for their ability to substitute the liver biopsy as the reference standard. Recent clinical studies in NAFLD/NASH patients support the utility of PRO-C3, a marker of type III collagen formation, as a marker for the degree of fibrosis, disease activity, and effect of treatment. Read More

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The current knowledge concerning solid cancer and therapy.

J Biochem Mol Toxicol 2021 Aug 31:e22900. Epub 2021 Aug 31.

Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Solid cancers comprise a large number of new cases and deaths from cancer each year globally. There are a number of strategies for addressing tumors raised from solid organs including surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy, combinational therapy, and stem cell and extracellular vesicle (EV) therapy. Surgery, radiotherapy, and chemotherapy are the dominant cures, but are not always effective, in which even in a localized tumor there is a possibility of tumor relapse after surgical resection. Read More

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Photobiomodulation as an antioxidant substitute in post-thawing trauma of human stem cells from the apical papilla.

Sci Rep 2021 Aug 30;11(1):17329. Epub 2021 Aug 30.

Department of Biosystems Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

Cryopreservation, the most common method of preserving stem cells, requires post-processing because it produces trauma to the cells. Post-thawing trauma typically induces cell death, elevates reactive oxygen species (ROS) concentration, and lowers mitochondrial membrane potential (MMP). Although this trauma has been solved using antioxidants, we attempted to use photobiomodulation (PBM) instead of chemical treatment. Read More

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Assessing tumor heterogeneity: integrating tissue and circulating tumor DNA (ctDNA) analysis in the era of immuno-oncology - blood TMB is not the same as tissue TMB.

J Immunother Cancer 2021 Aug;9(8)

Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Tissue tumor mutational burden (tTMB) is calculated to aid in cancer treatment selection. High tTMB predicts a favorable response to immunotherapy in patients with non-small cell lung cancer. Blood TMB (bTMB) from circulating tumor DNA is reported to have similar predictive power and has been proposed as an alternative to tTMB. Read More

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