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The distribution of Fusarium graminearum and F. asiaticum causing Fusarium head blight of wheat in relation to climate and cropping system.

Plant Dis 2021 Apr 21. Epub 2021 Apr 21.

Henan Academy of Agricultural SciencesZhengzhou , China, 450002;

In the main wheat production area of China (The Huang Huai Plain, HHP), both Fusarium graminearum and F. asiaticum, the causal agents of Fusarium head blight (FHB), are present. We investigated whether the relative prevalence of F. Read More

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Management of an acute cerebral embolic infarct with thrombolysis and mechanical thrombectomy in the presence of an aortic arch floating thrombus.

BMJ Case Rep 2021 Apr 20;14(4). Epub 2021 Apr 20.

Department of Stroke Medicine, Luton and Dunstable Hospital NHS Foundation Trust, Luton, UK.

An aortic arch floating thrombus is a rare cause of embolic ischaemic cerebral infarction. Previously, thrombolysis or mechanical thrombectomy has been used to treat acute cerebral infarction in this context; however, combination therapy using both modalities is yet to be published. The optimal management of aortic arch floating thrombi is debated. Read More

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Preventing sepsis; how can artificial intelligence inform the clinical decision-making process? A systematic review.

Int J Med Inform 2021 Apr 10;150:104457. Epub 2021 Apr 10.

School of Pharmacy, Newcastle University, King George VI Building, Newcastle upon Tyne, NE1 7RU, UK. Electronic address:

Background And Objectives: Sepsis is a life-threatening condition that is associated with increased mortality. Artificial intelligence tools can inform clinical decision making by flagging patients at risk of developing infection and subsequent sepsis. This systematic review aims to identify the optimal set of predictors used to train machine learning algorithms to predict the likelihood of an infection and subsequent sepsis. Read More

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Computer-assisted contralateral side comparison of the ankle joint using flat panel technology.

Int J Comput Assist Radiol Surg 2021 Apr 20. Epub 2021 Apr 20.

Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.

Purpose: Reduction and osteosynthesis of ankle fractures is a challenging surgical procedure when it comes to the verification of the reduction result. Evaluation is conducted using intra-operative imaging of the injured ankle and depends on the expertise of the surgeon. Studies suggest that intra-individual variance of the ankle bone shape and pose is considerably lower than the inter-individual variance. Read More

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Ultrafast nonequilibrium dynamic process of separate electrons and holes during exciton formation in few-layer tungsten disulfide.

Phys Chem Chem Phys 2021 Mar 23;23(12):7135-7144. Epub 2021 Mar 23.

School of Physics and Optoelectronic Engineering, Guangdong University of Technology, Guangzhou 510006, Guangdong, China.

Femtosecond transient absorption spectroscopy has been employed to unravel separate initial nonequilibrium dynamic processes of photo-injected electrons and holes during the formation process of the lowest excitons at the K-valley in few-layer tungsten disulfide. Charge carrier thermalization and cooling, as well as concomitant many-body effects on the exciton resonances, are distinguished. The thermalization of holes is observed to be faster than that of electrons. Read More

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Nitrate and ammonium uptake by maize: adaptation during relief from nitrogen suppression.

New Phytol 1992 Nov;122(3):439-446

Department of Soil Science, North Carolina State University, Raleigh, NC 27695-7619, USA.

Initial (0-1 h) net rates of nitrate and ammonium uptake from 200 μM NH NO were progressively increased as 8-d-old maize (Zea mays L.) seedlings, grown on 5 mM nitrate, were exposed to nitrogen-free solutions for up to 48 h. Further nitrogen deprivation to 72 h resulted in a decline in the nitrate uptake rate. Read More

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November 1992

A case report on a protracted course of a hidden insulinoma.

Ann Med Surg (Lond) 2021 Apr 24;64:102240. Epub 2021 Mar 24.

Endocrine Unit, Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA (UiTM), 47000, Jalan Hospital, Sungai Buloh, Selangor, Malaysia.

Introduction: Insulinoma is a functioning pancreatic neuroendocrine tumor primarily leading due to hypoglycemia due to hypersecretion of insulin. This case illustrates the real challenges faced in the detection of an occult insulinoma, which resulted in a protracted course of the disease.

Case Presentation: A 33-year-old female presented with recurrent hypoglycemia. Read More

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Everolimus Related Fulminant Hepatitis in Pancreatic Neuroendocrine Tumor With Liver Metastases: A Case Report and Literature Review.

Front Endocrinol (Lausanne) 2021 1;12:639967. Epub 2021 Apr 1.

Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background: Everolimus, an immunosuppressant, is approved for the treatment of advanced renal cell carcinoma, metastatic hormone receptor-positive breast cancer, and pancreatic neuroendocrine tumors (P-NETs) but has been reported to be related to hepatitis B reactivation. Here, we present the first case of fatal fulminant hepatitis B reactivation in a man with P-NET accompanied by multiple liver metastases who received everolimus and octreotide long-acting repeatable (LAR).

Case Presentation: A 45-year-old male had a history of chronic hepatitis B infection. Read More

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Mitigation of petroleum-hydrocarbon-contaminated hazardous soils using organic amendments: A review.

J Hazard Mater 2021 Mar 22;416:125702. Epub 2021 Mar 22.

Global Centre for Environmental Remediation, The University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address:

The term "Total petroleum hydrocarbons" (TPH) is used to describe a complex mixture of petroleum-based hydrocarbons primarily derived from crude oil. Those compounds are considered as persistent organic pollutants in the terrestrial environment. A wide array of organic amendments is increasingly used for the remediation of TPH-contaminated soils. Read More

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Role of IGFBP-2 in oral cancer metastasis.

Biochim Biophys Acta Mol Basis Dis 2021 Apr 14:166143. Epub 2021 Apr 14.

Department of Medical Science, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:

Cancer metastasis is one of most main causes of failure in cancer treatment. Nonetheless, more than half of oral cancer patients were diagnosed as advanced oral cancer with dramatically decreased 5-year survival rate to lower than 20%, while the stages become more advanced. In order to improve oral cancer treatment, the identification of cancer metastatic biomarkers and mechanisms is critical. Read More

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Colocutaneous fistula following infection managed as an 'autocolostomy': a novel approach to a recognised complication.

BMJ Case Rep 2021 Apr 16;14(4). Epub 2021 Apr 16.

General Surgery, The Dudley Group NHS Foundation Trust, Dudley, UK

Colocutaneous fistula is a rare entity in colorectal disease. We present a case of colocutaneous fistula in a patient whose postoperative course following a laparoscopic anterior resection for sigmoid cancer was complicated by colitis. During the follow-up period, it was found that his bowel contents were preferentially discharging through this fistula which had taken up the role of an 'autocolostomy'. Read More

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Physician Responsiveness to Positive Blood Culture Results at the Minneapolis Veterans Affairs Hospital-Is Anyone Paying Attention?

Fed Pract 2021 Mar;38(3):128-135

is a Medical Student at Case Western Reserve University School of Medicine in Cleveland, Ohio. is a Surgeon and Assistant Service Chief at the Minneapolis Veterans Affairs Health Care System in Minnesota and an Assistant Professor of Surgery at the University of Minnesota.

Background: Patients presenting with suspected infections are typically placed on empiric broad-spectrum antibiotics. With mounting evidence supporting the efficacy of using the narrowest spectrum of antimicrobial therapy to cover the suspected pathogen, current guidelines recommend decreasing the breadth of coverage in response to culture results both in relation to microbe identification and antibiotic sensitivity.

Methods: A retrospective chart review of electronic health records at the Minneapolis Veterans Affairs Medical Center (VAMC) in Minnesota was performed for 208 positive blood cultures with antibiotic spectrum analysis from July 1, 2015 to June 30, 2016. Read More

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Energy drink-induced cardiomyopathy.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Cardiology and Division of Cardiovascular Sciences, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK

We report a case of severe biventricular heart failure potentially related to excessive energy drink consumption in a 21-year-old man. The patient presented with a 4-month history of shortness of breath on exertion, orthopnoea and weight loss. Transthoracic echocardiography demonstrated severely impaired biventricular systolic function and bilateral ventricular thrombi, subsequently confirmed on cardiac magnetic resonance imaging, which found in addition no oedema, inflammation or focal fibrosis. Read More

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Tyrosinemia type 1 in pediatric nephrology: Not always straightforward.

Arch Pediatr 2021 Apr 12. Epub 2021 Apr 12.

Centre de Référence des Maladies Rénales Rares, Filières de santé maladies rares ORKID et ERK-Net, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Faculté de Médecine Lyon Est, Université Claude Bernard Lyon 1, Lyon, France; INSERM, UMR 1033, Faculté de Medecine Lyon Est, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

The main clinical features of tyrosinemia type 1 usually appear in the first months of life, including fever, diarrhea, vomiting, liver involvement, growth failure, and renal proximal tubulopathy with subsequent hypophosphatemic rickets. An early diagnosis is crucial in order to provide specific management and to prevent complications. Here, we report on two cases referred primarily to pediatric nephrologists for the diagnosis of "neonatal tubulopathy" and management of "X-linked hypophosphatemia (XLH)," respectively. Read More

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3D dissimilar-siamese-u-net for hyperdense Middle cerebral artery sign segmentation.

Comput Med Imaging Graph 2021 Mar 14;90:101898. Epub 2021 Mar 14.

Department of Radiology and Imaging, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, Hong Kong.

The hyperdense middle cerebral artery sign (HMCAS) representing a thromboembolus has been declared as a vital CT finding for intravascular thrombus in the diagnosis of acute ischemia stroke. Early recognition of HMCAS can assist in patient triage and subsequent thrombolysis or thrombectomy treatment. A total of 624 annotated head non-contrast-enhanced CT (NCCT) image scans were retrospectively collected from multiple public hospitals in Hong Kong. Read More

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Cerebral venous sinus thrombosis and thrombocytopenia after COVID-19 vaccination - a report of two UK cases.

Brain Behav Immun 2021 Apr 12. Epub 2021 Apr 12.

Department of Neurology, King's College Hospital NHS Foundation Trust, London, UK. Electronic address:

Recent reports have highlighted rare, and sometimes fatal, cases of cerebral venous sinus thrombosis (CVST) and thrombocytopenia following the Vaxzevria vaccine. An underlying immunological mechanism similar to that of spontaneous heparin-induced thrombocytopenia (HIT) is suspected, with the identification of antibodies to platelet factor-4 (PF4), but without previous heparin exposure. This unusual mechanism has significant implications for the management approach used, which differs from usual treatment of CVST. Read More

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Patterns of Media Use, Strength of Belief in COVID-19 Conspiracy Theories, and the Prevention of COVID-19 from March to July 2020 in the US.

J Med Internet Res 2021 Apr 8. Epub 2021 Apr 8.

Annnenberg Public Policy Center, University of Pennsylvania, 202 S. 36th ST, Philadelphia, US.

Background: Holding conspiracy beliefs regarding the coronavirus pandemic in the US has been associated with reductions in both actions to prevent the spread of the infection (e.g., mask wearing) and intentions to accept a vaccine when one becomes available. Read More

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Emergency Department Patients Who Leave Before Treatment Is Complete.

West J Emerg Med 2021 Feb 26;22(2):148-155. Epub 2021 Feb 26.

Emergency Services Institute, Cleveland Clinic Health System, Cleveland, Ohio.

Introduction: Emergency department (ED) patients who leave before treatment is complete (LBTC) represent medicolegal risk and lost revenue. We sought to examine LBTC return visits characteristics and potential revenue effects for a large healthcare system.

Methods: This retrospective, multicenter study examined all encounters from January 1-December 31, 2019 at 18 EDs. Read More

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February 2021

Ultrasound-directed reduction of distal radius fractures in adults: a systematic review.

Emerg Med J 2021 Apr 14. Epub 2021 Apr 14.

Exeter Policy Research Programme, Evidence Review Facility, Exeter, UK.

Objective: To conduct a systematic review of the clinical literature to determine whether ultrasound can be used to improve the reduction of distal radius fractures in adults in the ED.

Methodology: A study protocol was registered on PROSPERO. EMBASE, PubMed/MEDLINE, the Cochrane Central Register of Controlled Trials and ClinicalTrials. Read More

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SA-Net: A scale-attention network for medical image segmentation.

PLoS One 2021 14;16(4):e0247388. Epub 2021 Apr 14.

School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Semantic segmentation of medical images provides an important cornerstone for subsequent tasks of image analysis and understanding. With rapid advancements in deep learning methods, conventional U-Net segmentation networks have been applied in many fields. Based on exploratory experiments, features at multiple scales have been found to be of great importance for the segmentation of medical images. Read More

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Results of Obturator Foramen Bypass in Patients with Groin Infection and Arterial Involvement.

Ann Vasc Surg 2021 Apr 10. Epub 2021 Apr 10.

MedStar Washington Hospital Center.

Objective: Arterial bypass tunneling via the obturator foramen (OFB) can be performed to circumvent groin infections during lower extremity revascularization. The objective of this study is to report safety and efficacy outcomes of OFB in the setting of infected femoral pseudoaneurysms and infected prosthetic femoral bypass grafts.

Methods: A multi-hospital, single-entity healthcare system retrospective review was conducted for all patients who underwent OFB between January 2014 through June 2020. Read More

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Rock glacier inventory, permafrost probability distribution modeling and associated hazards in the Hunza River Basin, Western Karakoram, Pakistan.

Sci Total Environ 2021 Mar 30;782:146833. Epub 2021 Mar 30.

Key Laboratory of Mountain Hazards and Earth Surface Process, Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China; China-Pakistan Joint Research Center on Earth Science, QAU, Islamabad, Pakistan.

The destabilization of rock glaciers and permafrost variations is of great importance to the safety of the population and infrastructure in the Karakoram region because of their effects on land stability and river obstructions. In this study, we compiled the first complete rock glacier inventory for the Hunza Basin, western Karakoram, of 616 rock glaciers with an area of 194 km between 2800 and 5700 m a.s. Read More

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Identification of intra-individual variation in intracranial arterial flow by MRI and the effect on computed hemodynamic descriptors.

MAGMA 2021 Apr 11. Epub 2021 Apr 11.

Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.

Objectives: To determine the intra-individual flow variation in serially acquired studies, and the influence of this variation on subsequent hemodynamic simulations using the inlet flow as a boundary condition. Author: Kindly check and confirm whether the corresponding authors are correctly identified.Confirmed. Read More

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Clinical and CT features of mild-to-moderate COVID-19 cases after two sequential negative nucleic acid testing results: a retrospective analysis.

BMC Infect Dis 2021 Apr 8;21(1):333. Epub 2021 Apr 8.

Department of Respiratory and Critical Care Medicine, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China.

Background: The clinical and imaging features of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections that progressed to coronavirus disease 2019 (COVID-19) have been explored in numerous studies. However, little is known about these features in patients who received negative respiratory nucleic acid test results after the infections resolved. In this study, we aim to describe these features in a group of Chinese patients. Read More

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Residual ozone in microorganisms enhanced organics removal and shaped microbial community.

Chemosphere 2021 Mar 25;278:130322. Epub 2021 Mar 25.

School of Chemical and Environmental Engineering, China University of Mining and Technology, Beijing, 100083, China.

The residual ozone played an important role in enhancing the organics removal by stimulate subsequent biological processes. However, how the residual ozone affects the biological process is not well studied. In this work, a pilot scale integrated O-BAF, ordinary BAF and separated O-BAF were compared in advanced treatment of real bio-treated petrochemical wastewater. Read More

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Treating trauma and aggression with narrative exposure therapy in former child and adult soldiers: A randomized controlled trial in Eastern DR Congo.

J Consult Clin Psychol 2021 Mar;89(3):143-155

Department of Psychology.

Objective: Individuals who return from armed groups present with a history of traumatic events including perpetration. Subsequent severe mental stress and heightened levels of reactive and appetitive aggression may persist and if left untreated, frequently impede peacebuilding and societal stability. In this study, we tested a revised adaptation of Narrative Exposure Therapy (NET; Schauer et al. Read More

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Oxidative Addition of Aryl and Alkyl Halides to a Reduced Iron Pincer Complex.

J Am Chem Soc 2021 Apr 8;143(15):5928-5936. Epub 2021 Apr 8.

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

The two-electron oxidative addition of aryl and alkyl halides to a reduced iron dinitrogen complex with a strong-field tridentate pincer ligand has been demonstrated. Addition of iodobenzene or bromobenzene to (3,5-MeCNC)Fe(N) (3,5-MeCNC = 2,6-(2,4,6-Me-CH-imidazol-2-ylidene)-3,5-Me-pyridine) resulted in rapid oxidative addition and formation of the diamagnetic, octahedral Fe(II) products (3,5-MeCNC)Fe(Ph)(N)(X), where X = I or Br. Competition experiments established the relative rate of oxidative addition of aryl halides as I > Br > Cl. Read More

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Prostatic urethral lift (UroLift): a real-world analysis of outcomes using hospital episodes statistics.

BMC Urol 2021 Apr 7;21(1):55. Epub 2021 Apr 7.

The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Background: To determine real-world outcomes of prostatic urethral lift (UroLift) procedures conducted in hospitals across England.

Methods: A retrospective observational cohort was identified from Hospital Episode Statistics data including men undergoing UroLift in hospitals in England between 2017 and 2020. Procedure uptake, patient demographics, inpatient complications, 30-day accident and emergency re-attendance rate, requirement for further treatment and catheterization were captured. Read More

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Prediction of Distal Aortic Enlargement after Proximal Repair of Aortic Dissection Using Machine Learning.

Ann Vasc Surg 2021 Apr 3. Epub 2021 Apr 3.

Department of Vascular Surgery, Institute of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

Objectives: This study aimed to construct a risk prediction model for distal aortic enlargement in patients with type B aortic dissection (TBAD) treated with proximal thoracic endovascular aortic repair (TEVAR).

Methods: From June 2010 to June 2016, patients with TBAD who underwent proximal TEVAR were retrospectively analyzed. A total of 38 clinical and imaging variables were collected. Read More

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