Mitochondrion 2021 03 17;57:37-46. Epub 2020 Dec 17.
Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Greater Noida, Gautam Buddha Nagar, Uttar Pradesh 201314, India; Academy of Scientific and Innovative Research, CSIR-HRDG, Ghaziabad, Uttar Pradesh 201002, India. Electronic address:
Background: Biogenesis and function of mitochondria is profoundly dependent on cytosolic translation of mitochondrial pre-proteins and its subsequent translocation and folding inside the organelle. Continuous exposure of non-native precursor proteins, exposure to damaging by-products of oxidative phosphorylation, load of mis-targeted or misfolded proteins from neighbouring compartments and unremitting demand of communication between mitochondrial and nuclear genomes, continuously pose proteotoxic threats to the organelle. Our knowledge of cellular mechanisms to cope up with such impending threat of proteotoxicity to mitochondria, is currently evolving. Read More