1,071,572 results match your criteria subjects [135


Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.

Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. Read More

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Pediatric Ocular Injury Due to Hand Sanitizer Exposure An Emerging Hazard.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer Pediatric Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Objectives: The objective of this study was to describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children presenting to a tertiary medical center during the severe acute respiratory syndrome coronavirus 2 pandemic.

Methods: A retrospective single-center observational study conducted from February 21, 2020, to October 11, 2020. Subjects 10 years or younger who presented with ABHR-induced ocular injury were included. Read More

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Implications of Electronic Consultations for Clinician Communication and Relationships: A Qualitative Study.

Med Care 2021 Jun 11. Epub 2021 Jun 11.

Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford Department of Population and Quantitative Health Sciences, Division of Health Informatics and Implementation Science, University of Massachusetts Medical School, Worcester Section of Endocrinology, Diabetes, and Metabolism, Boston University School of Medicine Medical Service, VA Boston Healthcare System Evans Department of Medicine, Boston University School of Medicine Medical Service and Section of Infectious Diseases, VA Boston Healthcare System, Boston Harvard Medical School, Cambridge Department of Population and Quantitative Health Sciences, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester Section of Pulmonary, Allergy, Sleep, and Critical Care Medicine, Boston University School of Medicine, Boston, MA.

Background: Strong relationships and effective communication between clinicians support care coordination and contribute to care quality. As a new mechanism of clinician communication, electronic consultations (e-consults) may have downstream effects on care provision and coordination.

Objective: The objective of this study was to understand primary care providers' and specialists' perspectives on how e-consults affect communication and relationships between clinicians. Read More

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Single-breath oxygen dilution for the measurement of total lung capacity: technical description and preliminary results in healthy subjects.

Physiol Meas 2021 Jun 11. Epub 2021 Jun 11.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, ITALY.

Total lung capacity (TLC) assessment outside of a research laboratory is challenging. We describe a novel method for measuring TLC that is both simple and based only on portable equipment, and report preliminary data on healthy subjects.We developed an open circuit system to administer a known amount of oxygen to a subject in a single maximal inspiratory maneuver. Read More

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Elevated peritoneal soluble endoglin and GDF-15 in infertile women with severe endometriosis and pelvic adhesion.

J Reprod Immunol 2021 Jun 5;146:103343. Epub 2021 Jun 5.

Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University, 60286, Surabaya, Indonesia. Electronic address:

Objectives: Chronic inflammation and pelvic adhesion play a critical role in endometriosis-related infertility. Research studies suggest that TGF-β superfamily members, such as soluble endoglin (sEng), growth differentiation factor 15 (GDF-15) and tumor growth factor-beta (TGF-β1) contribute to the regulation of inflammation, angiogenesis and cell adhesion. The objective of this study is to investigate the association between the concentrations of these TGF-β-related members and the clinical parameters of infertile women with endometriosis. Read More

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A non-parametric propensity score for estimating the effect of interferon-beta or glatiramer acetate on long-term outcomes of multiple sclerosis.

Mult Scler Relat Disord 2021 May 30;53:103050. Epub 2021 May 30.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada; Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada.

Background: The few observational studies that investigated the long-term effects of interferon-beta and glatiramer acetate were usually focused on progression to irreversible disability and other outcomes such as number of relapses and transition to secondary-progressive multiple sclerosis (SPMS) have been rarely studied. The objective of this paper is to estimate the effect of interferon-beta/glatiramer acetate on progression to irreversible disability, transition from relapsing-remitting multiple sclerosis (RRMS) to SPMS and the rate of relapses over 10 years.

Methods: Analyses included 2498 patients with confirmed diagnosis of RRMS followed in Montréal from 1977 to 2016. Read More

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Influence of tibial tuberosity position and trochlear depth on patellar tracking in patellar instability: Variations with Patella Alta.

Clin Biomech (Bristol, Avon) 2021 Jun 8;87:105406. Epub 2021 Jun 8.

Department of Research, Cleveland Clinic Akron General, 1 Akron General Ave, Akron, OH 44307, United States. Electronic address:

Background: Patella alta reduces articular constraints acting on the patella from the trochlear groove with the knee extended. The current study was performed to address how patella alta alters the influence of tibial tuberosity position and trochlear depth on patellar tracking in patients being treated for patellar instability.

Methods: Fifteen subjects with recurrent patellar instability participated in knee extension within a dynamic CT scanner. Read More

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Evaluating a social marketing campaign on healthy nutrition and lifestyle among primary-school children: A mixed-method research design.

Eval Program Plann 2021 Jun 1;89:101965. Epub 2021 Jun 1.

Department of Marketing and International Business, Toulouse Business School, 1 Place Alphonse Jourdain - CS 66810, 31068, Toulouse Cedex 7, France. Electronic address:

Italy has one of the highest levels of childhood overweight and obesity in Europe. Therefore, preventing children from becoming overweight is a major public health challenge. Here, we used a mixed-method research approach - including a quasi-experimental design and three surveys - to create a formative evaluation of a social marketing campaign on healthy nutrition and lifestyle in Italian primary school children. Read More

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Posttraumatic stress disorder symptoms and neurocognitive functioning in fire fighters: The mediating role of sleep problems and resilience.

Compr Psychiatry 2021 May 19;109:152250. Epub 2021 May 19.

Department of Neuropsychiatry, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Republic of Korea. Electronic address:

Background: Firefighters are often exposed to terrible and dangerous scenes due to their duties, and thus have a high risk of developing posttraumatic stress disorder(PTSD). The purpose of the study is to examine the relationship between PTSD symptoms, sleep problems, resilience and neurocognitive functioning of firefighters, and to identify the sequential mediating effects of sleep problems and resilience on the relationship between PTSD symptoms and neurocognitive functioning (especially psychomotor speed and processing speed).

Methods: Data were collected from 325 firefighters in eight fire departments in four regions of Korea. Read More

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Effect of azithromycin on bronchial wall thickness in severe persistent asthma: A double-blind placebo-controlled randomized clinical trial.

Respir Med 2021 Jun 2;185:106494. Epub 2021 Jun 2.

Department of Radiology, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran. Electronic address:

Background: Azithromycin reduced airway remodeling in animal models of asthma. However, its effect on human subjects has not been studied yet. This study aimed to investigate the effect of long-term treatment with azithromycin on airways wall thickness in patients with severe persistent asthma. Read More

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The importance of working memory capacity for improving speech in noise comprehension in children with hearing aid.

Int J Pediatr Otorhinolaryngol 2021 May 24;147:110774. Epub 2021 May 24.

Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Electronic address:

Background: One of the most common complaints of hearing aid users is difficulty in receiving speech in noise which is very important for all hearing impaired specially children with limited auditory and language experiences. Since working memory plays a significant role in speech perception, especially in challenging auditory situations such as background noise, it is likely that differences in its performance and capacity may impair the ability to understand speech in noise in hearing aid users. Therefore, we aimed to compare memory capacity between two groups of children using hearing aids in both ears, who differed only in the ability to understand speech in noise. Read More

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Left ventricle motion estimation for cine MR images using sparse representation with shape constraint.

Phys Med 2021 Jun 8;87:49-64. Epub 2021 Jun 8.

College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China.

Purpose: To propose a left ventricle (LV) motion estimation method based on sparse representation, in order to handle the spatial-varying intensity distortions caused by tissue deformation.

Methods: For each myocardial landmark, an adaptive dictionary was generated by learning transformations from a training dataset. Then the landmark was tracked using sparse representation. Read More

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Creating Clinically Relevant Aneurysm Sizes in the Rabbit Surgical Elastase Model.

World Neurosurg 2021 Jun 8. Epub 2021 Jun 8.

Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; Department of Radiology, Foothills Medical Centre, Calgary, Alberta; Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, Alberta. Electronic address:

Background: Creating aneurysm sizes in animal models that resemble human aneurysms is essential to study and test neuroendovascular devices. The commonly used rabbit surgical elastase model, however, produces saccular aneurysms that are smaller than those typically treated in humans. The goal of this study was to determine whether an increased vessel stump length and the addition of calcium chloride to the incubation solution has an effect on the resulting aneurysm size. Read More

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The Effects of At-Birth Adoption on Atypical Behavior and Anxiety: A Nonhuman Primate Model.

J Am Acad Child Adolesc Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Objective: Adopted children tend to show an increased risk for a variety of psychopathological outcomes, even when adoption occurs at birth, which some suggest is a result of non-random assignment of adoptees and parents. This study utilizes a nonhuman primate model, in which adoptions were randomly assigned, to investigate the behavioral and physiological outcomes associated with at-birth adoption.

Method: Immediately following birth, rhesus monkey infants were randomly assigned to be reared by either their biological mother (n=113) or by an unrelated, lactating, adoptive mother (n=34). Read More

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Clinical connectome fingerprints of cognitive decline.

Neuroimage 2021 Jun 8:118253. Epub 2021 Jun 8.

Institute of Bioengineering, Center for Neuroprosthetics, EPFL, Geneva, Switzerland; Department of Radiology and Medical Informatics, University of Geneva (UNIGE), Geneva, Switzerland. Electronic address:

Brain connectome fingerprinting is rapidly rising as a novel influential field in brain network analysis. Yet, it is still unclear whether connectivity fingerprints could be effectively used for mapping and predicting disease progression from human brain data. We hypothesize that dysregulation of brain activity in disease would reflect in worse subject identification. Read More

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Feasibility of MR fingerprinting using a high-performance 0.55 T MRI system.

Magn Reson Imaging 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiology, Case Western Reserve University, Cleveland, OH, United States of America. Electronic address:

Background: MR fingerprinting (MRF) is a versatile method for rapid multi-parametric quantification. The application of MRF for lower MRI field could enable multi-contrast imaging and improve exam efficiency on these systems. The purpose of this work is to demonstrate the feasibility of 3D whole-brain T1 and T2 mapping using MR fingerprinting on a contemporary 0. Read More

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Superficial fibromatosis: MRI radiomics and T2 mapping correlate with treatment response.

Magn Reson Imaging 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiology, Sylvester Comprehensive Cancer Center, the University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL 33136, USA. Electronic address:

Background: Superficial fibromatosis exhibits variable MR signal intensity due to collagenous and fibroproliferative components. Quantifying this signal heterogeneity using image texture analysis and T2-mapping could have prognostic and therapeutic implications.

Methods: This IRB-approved retrospective study included 13 patients with superficial fibromatosis, managed by observation, electron beam radiotherapy (EBT), or pentoxifylline/vitamin E. Read More

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Signal transducer and activator of transcription 3 as a potential therapeutic target for Graves' orbitopathy.

Mol Cell Endocrinol 2021 Jun 8:111363. Epub 2021 Jun 8.

Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul 03722, Korea. Electronic address:

The roles of signal transducer and activator of transcription 3 (STAT3) in inflammation, oxidative stress, and adipogenesis during Graves' orbitopathy (GO) are incompletely understood. Here, STAT3 expression in orbital tissues (from individuals with GO and healthy control subjects) was studied, and the role of STAT3 in GO pathogenesis was examined through small-interfering RNA (siRNA)-mediated silencing in primary orbital fibroblasts. STAT3 mRNA expression was significantly higher in GO orbital tissues than in non-GO tissues. Read More

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The Incessant increase Curve during the Oral Glucose Tolerance Test and its association with gut hormone level in Chinese T2DM Adults: A preliminary study.

Peptides 2021 Jun 8:170595. Epub 2021 Jun 8.

Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Purpose: To investigate glucose curve shape during an oral glucose tolerance test (OGTT) and its association with β-cell function or gut hormone.

Materials And Methods: Glucose curves during 180 min OGTTs (n = 89) were classified as incessant increase and monophasic. Data on demographics, β-cell function, and insulin sensitivity were collected. Read More

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Meta-analysis of ocular axial length in newborns and infants up to three years of age.

Surv Ophthalmol 2021 Jun 8. Epub 2021 Jun 8.

Amsterdam UMC, University of Amsterdam, department of Ophthalmology, Meibergdreef 9, Amsterdam, Netherlands.

In pediatric ophthalmology it is often necessary to obtain axial length in young children. For children older than three years, non-contact biometry can be used. For younger children this is usually not an option, and the clinician needs to rely on other imaging modalities. Read More

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Lack of Effects of the Genetic Polymorphisms of Interleukin-10 in Clinical Outcomes of COVID-19.

Viral Immunol 2021 Jun 11. Epub 2021 Jun 11.

Hospital General de Culiacán, "Bernardo J Gastélum," Secretaria de Salud de Sinaloa (Z.C: 80230), Culiacán, México.

Interleukin-10 () gene polymorphisms have been associated with severity and outcomes in patients with respiratory and nonrespiratory viral infections. The aim of this study was to assess whether rs1800871 and rs1800872 polymorphisms of gene are associated with the clinical outcomes of COVID-19 in a Mexican population. Study subjects were 193 COVID-19 patients. Read More

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Causes of in-hospital death in patients with type 2 diabetes with micro- and macrovascular complications in Taiwan.

Int J Clin Pract 2021 Jun 11:e14491. Epub 2021 Jun 11.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Aims: Diabetes mellitus is a major cause of death worldwide, including Taiwan. The mortality data of the subsets of patients who suffered from micro- or macrovascular complications is limited. The aim of this study was to investigate the causes of in-hospital death of patients with type 2 diabetes, especially the patients with microvascular, macrovascular and, both micro-macrovascular complications. Read More

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Should nutritional therapy be modified to account for mitochondrial dysfunction in critical illness?

JPEN J Parenter Enteral Nutr 2021 Jun 11. Epub 2021 Jun 11.

William Harvey Research Institute, Queen Mary University of London, London.

Metabolic dysfunction, and its associated muscle atrophy, remains the most common complication of critical care. At the centre of this is mitochondrial dysfunction, secondary to hypoxia and systemic inflammation. This leads to a bioenergetic crisis, with decreased intramuscular adenosine tri-phosphate content and a reduction in the highly energy dependent process of protein synthesis. Read More

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Physiotherapists' perspectives on barriers to implementation of direct access of physiotherapy services in the United Arab Emirates: A cross-sectional study.

PLoS One 2021 11;16(6):e0253155. Epub 2021 Jun 11.

Department of Physiotherapy, College of Health sciences, University of Sharjah, Sharjah, UAE.

Background: There are two primary ways of accessing physiotherapy for service users around the world. The direct access, as opposed to the indirect access which requires a referral from a general physician, has several merits including better quality, timeliness, cost effectiveness of treatment and better probability of preventing acute conditions from turning into chronic ailments. Despite these benefits, several countries including the UAE, do not allow direct access to physiotherapists. Read More

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A soft voting ensemble classifier for early prediction and diagnosis of occurrences of major adverse cardiovascular events for STEMI and NSTEMI during 2-year follow-up in patients with acute coronary syndrome.

PLoS One 2021 11;16(6):e0249338. Epub 2021 Jun 11.

Department of Computer Science, Chungbuk National University, Cheongju, Chungbuk, South Korea.

Objective: Some researchers have studied about early prediction and diagnosis of major adverse cardiovascular events (MACE), but their accuracies were not high. Therefore, this paper proposes a soft voting ensemble classifier (SVE) using machine learning (ML) algorithms.

Methods: We used the Korea Acute Myocardial Infarction Registry dataset and selected 11,189 subjects among 13,104 with the 2-year follow-up. Read More

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Lumbar Thecal Sac Dimensions and Axial Spinal Cord Areas on Magnetic Resosnace Imaging in 626 Healthy Subjects.

Spine (Phila Pa 1976) 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan Department of Orthopedics Surgery, Chubu Rosai Hospital, Minato-ku, Nagoya, Japan.

Study Design: A cross-sectional study.

Objective: The aim of this study was to investigate the lumbar thecal sac dimensions and spinal cord area on magnetic resonance (MR) imaging in healthy volunteers.

Summary Of Background Data: There are few reports regarding lumbar spine MRI in healthy subjects, and the difference in spinal canal dimensions by age remains unclear. Read More

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COVID-19 Vaccination-Associated Lymphadenopathy on FDG PET/CT: Distinctive Features in Adenovirus-Vectored Vaccine.

Clin Nucl Med 2021 Jun 10. Epub 2021 Jun 10.

From the Department of Nuclear Medicine Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: This study investigated 18F-FDG PET/CT features of adenovirus-vectored vaccination against COVID-19 in healthy subjects.

Patients And Methods: Thirty-one health care workers had been vaccinated Vaxzevria and underwent FDG PET/CT as an optional test for a cancer screening program. Size and FDG uptake of the hypermetabolic lymph nodes were measured. Read More

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Trends in Endotracheal Intubation During In-Hospital Cardiac Arrests: 2001-2018.

Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Center for the Study of Healthcare Innovation, Implementation, and Policy, Health Services Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA. Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Division of Hospital Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA. Division of Pulmonary, Critical Care Medicine, and Sleep Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Objectives: Airway management during in-hospital cardiac arrest represents a fundamental component of resuscitative efforts, yet little is known about temporal trends in intubation during in-hospital cardiac arrest. Our objective was to investigate changes in in-hospital cardiac arrest airway management over time and in response to national guideline updates.

Design: Observational cohort study of a prospectively collected database. Read More

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Impact of Nonpharmaceutical Interventions on ICU Admissions During Lockdown for Coronavirus Disease 2019 in New Zealand-A Retrospective Cohort Study.

Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.

Cardiothoracic and Vascular ICU (CVICU), Auckland City Hospital, Auckland, New Zealand. Medical Research Institute of New Zealand, Wellington, New Zealand. ANZIC-Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia. School of Nursing, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Objectives: Nonpharmaceutical interventions are implemented internationally to mitigate the spread of severe acute respiratory syndrome coronavirus 2 with the aim to reduce coronavirus disease 2019-related deaths and to protect the health system, particularly intensive care facilities from being overwhelmed. The aim of this study is to describe the impact of nonpharmaceutical interventions on ICU admissions of non-coronavirus disease 2019-related patients.

Design: Retrospective cohort study. Read More

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Maturation and degeneration of the human brainstem across the adult lifespan.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Brainstem tissue microstructural properties change across the adult lifespan. However, studies elucidating the biological processes that govern brainstem maturation and degeneration are lacking. In the present work, conducted on a large cohort of 140 cognitively unimpaired subjects spanning a wide age range of 21 to 94 years, we implemented a multi-parameter approach to characterize the sex- and age differences. Read More

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