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Sleep quality and daytime sleepiness in epilepsy: Systematic review and meta-analysis of 25 studies including 8,196 individuals.

Sleep Med Rev 2021 Mar 13;57:101466. Epub 2021 Mar 13.

Department of Neurology, Medical University Innsbruck, Austria. Electronic address:

We sought to gain a better understanding of the relationship between epilepsy and sleep quality and daytime sleepiness by performing a literature search of PubMed for case-control studies that compared patients with epilepsy to controls and reported the Pittsburgh sleep quality index (PSQI) and/or the Epworth sleepiness scale (ESS). Study-specific mean differences in the PSQI and ESS between cases and controls were extracted from the publications and pooled using random-effects meta-analysis. Twenty-five studies (2964 cases, 5232 controls) were included. Read More

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Bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: A meta-analysis of individual patients' data from 3 phase III studies.

Cancer Treat Rev 2021 Mar 30;97:102202. Epub 2021 Mar 30.

Asklepios Tumorzentrum Hamburg AK Altona, Hamburg, Germany.

Background: The real impact of bevacizumab maintenance as single agent in metastatic colorectal cancer (mCRC) remains unclear. SAKK-41/06 and PRODIGE-9 failed to demonstrate the non-inferiority and superiority of bevacizumab versus no maintenance, respectively, while AIO-KRK-0207 showed the non-inferiority of maintenance bevacizumab versus bevacizumab and fluoropyrimidines for time to strategy failure.

Methods: Bibliography electronic databases (PubMed, MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials) were searched for English published clinical trials prospectively randomizing mCRC patients to receive bevacizumab maintenance or not after first-line chemotherapy plus bevacizumab. Read More

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Treatment of B-cell depleted COVID-19 patients with convalescent plasma and plasma-based products.

Clin Immunol 2021 Apr 7:108723. Epub 2021 Apr 7.

Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel; Allergy and Clinical Immunology Unit, Hebrew University-Hadassah Medical Center, Jerusalem, Israel. Electronic address:

Severe acute respiratory syndrome coronavirus 2 infected patients, receiving background anti-CD20 therapy, were treated with convalescent plasma or plasma-based products. Eight patients were included in the study, presenting with prolonged disease course and delayed viral clearance. CP/plasma-based products were offered as an add-on therapy to standard medical treatment. Read More

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The association of rocuronium dosing and first-attempt intubation success in adult emergency department patients.

CJEM 2021 Apr 10. Epub 2021 Apr 10.

Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The recommended rocuronium dose for rapid sequence intubation is 1.0 mg/kg; however, the optimal dose for emergency airway management is not clear. We assessed the relationship between rocuronium dose and first-attempt success among emergency department (ED) patients undergoing rapid sequence intubation. Read More

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Association of gender and age at onset with glucocerebrosidase associated Parkinson's disease: a systematic review and meta-analysis.

Neurol Sci 2021 Apr 10. Epub 2021 Apr 10.

Department of Neurosurgery, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China.

Glucocerebrosidase (GBA) gene has been proved to be a risk factor for the development of Parkinson's disease (PD). However, the gender effect in the prevalence of GBA-associated PD (GBA-PD) is still controversial. And there is no conclusion whether the age at onset (AAO) of PD is different between carriers and non-carriers of GBA. Read More

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Circadian rhythm and gestational diabetes: working conditions, sleeping habits and lifestyle influence insulin dependency during pregnancy.

Acta Diabetol 2021 Apr 10. Epub 2021 Apr 10.

Department of Obstetrics, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.

Objective: Management of gestational diabetes (GDM) is currently changing toward a more personalized approach. There  is a growing number of GDM patients requiring only a single dose of basal insulin at night to achieve glucose control. Well-known risk factors like obesity, parity and family history have been associated with GDM treatment requirements. Read More

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Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas.

J Pathol Clin Res 2021 Apr 9. Epub 2021 Apr 9.

Institut de Recerca Sant Joan de Deu, Barcelona, Spain.

The goals of this work were to identify factors favoring patient-derived xenograft (PDX) engraftment and study the association between PDX engraftment and prognosis in pediatric patients with Ewing sarcoma, osteosarcoma, and rhabdomyosarcoma. We used immunodeficient mice to establish 30 subcutaneous PDX from patient tumor biopsies, with a successful engraftment rate of 44%. Age greater than 12 years and relapsed disease were patient factors associated with higher engraftment rate. Read More

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Carotid intima-media thickness in patients with hyperuricemia: a systematic review and meta-analysis.

Aging Clin Exp Res 2021 Apr 9. Epub 2021 Apr 9.

Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, 1 Xianglin Road, Luzhou, 646000, Sichuan, China.

Objective: Despite the high incidence and mortality of cardiovascular events in hyperuricemia patients, the role of serum uric acid in cardiovascular diseases is still controversial. The aim of this meta-analysis was to explore the difference of carotid intima-media thickness in hyperuricemia and control groups.

Methods: We performed this meta-analysis by searching the PubMed, Cochrane Library, Embase and Web of Science databases up to July 2020. Read More

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Body Weight Loss Before Allogeneic Hematopoietic Stem Cell Transplantation Predicts Survival Outcomes in Acute Leukemia Patients.

Transplant Cell Ther 2021 Apr 9;27(4):340.e1-340.e6. Epub 2021 Jan 9.

Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan. Electronic address:

Most acute leukemia patients receive consecutive intensive chemotherapy, which usually takes several months before allogeneic hematopoietic stem cell transplantation (allo-HCT). Intensive chemotherapy often induces gastrointestinal adverse events. These adverse events leave patients in a state of malnutrition, leading to a reduction in body weight. Read More

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Long-Term Outcomes After Autologous Versus Allogeneic Stem Cell Transplantation in Molecularly-Stratified Patients With Intermediate Cytogenetic Risk Acute Myeloid Leukemia: A PETHEMA Study.

Transplant Cell Ther 2021 Apr 8;27(4):311.e1-311.e10. Epub 2021 Jan 8.

Department of Hematology, Hospital Universitario La Fe, Valencia, Spain.

Acute myeloid leukemia (AML) with intermediate risk cytogenetics (IRcyto) comprises a variety of biological entities with distinct mutational landscapes that translate into differential risks of relapse and prognosis. Optimal postremission therapy choice in this heterogeneous patient population is currently unsettled. In the current study, we compared outcomes in IRcyto AML recipients of autologous (autoSCT) (n = 312) or allogeneic stem cell transplantation (alloSCT) (n = 279) in first complete remission (CR1). Read More

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Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns.

Exp Hematol Oncol 2021 Apr 9;10(1):27. Epub 2021 Apr 9.

Department of Hematology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Background: The receptor tyrosine kinase FLT3 with internal tandem duplications within the juxtamembrane domain (FLT3-ITD) is a poor prognostic factor; however, the prognostic significance of missense mutation in the tyrosine kinase domain (FLT3-TKD) is controversial. Furthermore, the accompanying mutations and fusion genes with FLT3 mutations are unclear in acute myeloid leukemia (AML).

Methods: We investigated FLT3 mutations and their correlation with other gene mutations and gene fusions through two RNA-seq based next-generation sequencing (NGS) method and prognostic impact in 207 de novo AML patients. Read More

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Unsupervised phenotyping of sepsis using nonnegative matrix factorization of temporal trends from a multivariate panel of physiological measurements.

BMC Med Inform Decis Mak 2021 Apr 9;21(Suppl 5):95. Epub 2021 Apr 9.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Background: Sepsis is a highly lethal and heterogeneous disease. Utilization of an unsupervised method may identify novel clinical phenotypes that lead to targeted therapies and improved care.

Methods: Our objective was to derive clinically relevant sepsis phenotypes from a multivariate panel of physiological data using subgraph-augmented nonnegative matrix factorization. Read More

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Association of ST6GAL1 and CYP19A1 polymorphisms in the 3'-UTR with astrocytoma risk and prognosis in a Chinese Han population.

BMC Cancer 2021 Apr 9;21(1):391. Epub 2021 Apr 9.

Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, 277 YanTa West Road, Xi'an, 710061, Shaanxi, China.

Background: Astrocytoma is a common type of central nervous system tumor. In this study, we investigated the correlation between ST6GAL1 and CYP19A1 polymorphisms and the risk and prognosis of astrocytoma.

Methods: A total of 365 astrocytoma patients and 379 healthy controls were genotyped using the Agena MassARRAY system. Read More

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Gene expression and immune infiltration in melanoma patients with different mutation burden.

BMC Cancer 2021 Apr 9;21(1):379. Epub 2021 Apr 9.

Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, No.76 Linjiang Road, Yuzhong District, Chongqing, 400010, China.

Background: Immunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, a clear prediction index for efficacy has not been established. Tumor mutation burden (TMB) is one of the essential factors that affect immunotherapeutic efficacies, but it has not been determined whether the mutation is associated with the survival of Skin Cutaneous Melanoma (SKCM) patients. Read More

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Laparoscopic versus open pancreatic resection for ductal adenocarcinoma: separate propensity score matching analyses of distal pancreatectomy and pancreaticoduodenectomy.

BMC Cancer 2021 Apr 9;21(1):382. Epub 2021 Apr 9.

Department of Hepatopancreatobiliary Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Currently, laparoscopic pancreatic resection (LPR) is extensively applied to treat benign and low-grade diseases related to the pancreas. The viability and safety of LPR for PDAC needs to be understood better. Read More

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Effect of intrapartum oxygen on the rate of cesarean delivery: a meta-analysis: Condensation: Intrapartum oxygen administration does not change rate of cesarean delivery or other maternal or fetal outcomes.

Am J Obstet Gynecol MFM 2021 Apr 6:100374. Epub 2021 Apr 6.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA. Electronic address:

Background: Maternal supplemental oxygen is often used intrapartum, with other fetal resuscitative maneuvers, for non-reassuring fetal heart rate monitoring (NRFHRM).

Objective: To determine if maternal intrapartum administration of oxygen altered the rate of cesarean delivery (CD) when compared to room air.

Study Design: This was a systematic review and meta-analysis of randomized controlled trials (RCTs). Read More

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Metformin and cancer-specific survival among breast, colorectal, or endometrial cancer patients: a nationwide data linkage study.

Diabetes Res Clin Pract 2021 Apr 6:108755. Epub 2021 Apr 6.

Centre for Medicine Use and Safety (CMUS), Faculty of Pharmacy and Pharmaceutical Science, Monash University, Melbourne, VIC, Australia; School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Perth, WA, Australia.

Aims: Equivocal results of association between metformin and cancer-specific survival need more investigation. We tested the hypothesis that adherence to the drug had a lower cancer-specific mortality in a homogeneous population (i.e. Read More

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Fire Acupuncture versus conventional acupuncture to treat spasticity after stroke: A systematic review and meta-analysis.

PLoS One 2021 9;16(4):e0249313. Epub 2021 Apr 9.

Department of Rehabilitation, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), HangZhou, China.

Background: Post-stroke spasm is currently a complex clinical problem that remains to be resolved. Due to its excellent efficacy and few side effects, clinicians have used fire acupuncture to treat post-stroke spasticity in China.

Objectives: The purpose of this study was to evaluate the clinical efficacy of fire acupuncture compared with conventional acupuncture to treat post-stroke spasms and provide a detailed summary of the commonly used acupoints. Read More

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Pediatric Acute Pancreatitis: Changes in Management and Disease Outcomes Over 16 Years.

Pancreas 2021 Mar;50(3):341-346

Department of Biostatistics.

Objective: To examine the changes over time of pediatric acute pancreatitis (AP) severity, management, and disease outcomes at our academic tertiary center.

Methods: We reviewed 223 pediatric AP admissions (2002-2018) and used a time-to-event regression model to study changes over time. Disease outcomes were analyzed using a subgroup of 89 patients in whom only the AP event determined length of hospital stay and duration of opioid use. Read More

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Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature.

Pancreas 2021 Mar;50(3):300-305

From the National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, Heidelberg.

Objectives: Acinar cell carcinoma of the pancreas (pACC) forms a rare subgroup of pancreatic tumors. We report on our institutional experience with systemic first- and further-line therapy in patients with metastatic pACC and embed our findings in a review of the literature.

Methods: Patients with stage IV pACC who started systemic treatment between 2008 and 2019 at our institution were identified via our institutional database. Read More

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Utility of gastric and duodenal biopsy sampling in adult eosinophilic esophagitis patients to rule out other gastrointestinal disorders.

Scand J Gastroenterol 2021 Apr 9:1-8. Epub 2021 Apr 9.

Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Rationale: According to consensus guidelines, if eosinophilic esophagitis (EoE) is suspected, not only esophageal but also gastric and duodenal biopsy specimens should be sampled in order to exclude other generalized or eosinophilic gastrointestinal (GI) disorders, such as eosinophilic gastroenteritis or celiac disease. However, the diagnostic yield for this remains unclear.

Aim: To assess the diagnostic yield of biopsy sampling from the stomach and duodenum in adult EoE patients to rule out generalized or eosinophilic GI disorders. Read More

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Prediction of vancomycin dose on high-dimensional data using machine learning techniques.

Expert Rev Clin Pharmacol 2021 Apr 9:1-11. Epub 2021 Apr 9.

Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Objectives: Despite therapeutic vancomycin is regularly monitored, its dose requirements vary considerably between individuals. Various innovative vancomycin dosing strategies have been developed for dose optimization; however, the utilization of individual factors and extensibility is insufficient. We aimed to develop an optimal dosing algorithm for vancomycin based on the high-dimensional data using the proposed variable engineering and machine-learning methods. Read More

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Safety and Efficacy of Atezolizumab in Understudied Populations with Pretreated Urinary Tract Carcinoma: Subgroup Analyses of the SAUL Study in Real-World Practice.

J Urol 2021 Apr 9:101097JU0000000000001768. Epub 2021 Apr 9.

San Camillo and Forlanini Hospitals, Rome, Italy (present address: Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York, USA).

Purpose: Atezolizumab is an established treatment option for pretreated urothelial carcinoma, demonstrating efficacy in phase II/III trials. The SAUL study enrolled a broader patient population to determine safety and efficacy in under-represented subgroups.

Materials And Methods: Patients with metastatic urinary tract carcinoma received atezolizumab 1,200 mg every 3 weeks until disease progression, unacceptable toxicity, loss of clinical benefit or patient/physician decision. Read More

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Evaluation of Reproducibility of Brain Volumetry between Commercial Software, Inbrain and Established Research Purpose Method, FreeSurfer.

J Clin Neurol 2021 Apr;17(2):307-316

Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Background And Purpose: We aimed to determine the intermethod reproducibility between the commercial software Inbrain (MIDAS IT) and the established research-purpose method FreeSurfer, as well as the effect of MRI resolution and the pathological condition of subjects on their intermethod reproducibility.

Methods: This study included 45 healthy volunteers and 85 patients with mild cognitive impairment (MCI). In 43 of the 85 patients with MCI, three-dimensional, T1-weighted MRI data were obtained at an in-plane resolution of 1. Read More

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Association between surgical excision margins and outcomes in patients with dermatofibrosarcoma protuberans: A meta-analysis.

Dermatol Ther 2021 Apr 9:e14954. Epub 2021 Apr 9.

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Dermatofibrosarcoma protuberans (DFSP) is a tumor with low-grade malignancy and high recurrence rates. Wide local excision (WLE) is essential for DFSP, but its surgical excision margin is controversial. This study aimed to examine whether resection margin is associated with the prognosis of patients with DFSP by systematically reviewing related literature. Read More

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Unmet needs of the oldest old primary care patients with common somatic and psychiatric disorders-A psychometric evaluation.

Int J Methods Psychiatr Res 2021 Apr 9. Epub 2021 Apr 9.

Institute of Social Medicine, Occupational Health and Public Health, Medical Faculty, University of Leipzig, Leipzig, Germany.

Objectives: Unmet needs are common in older patients and should be assessed via suitable instruments. The adapted German version of the Camberwell Assessment of Need for the Elderly (CANE) represents an often used tool to determine the needs in older individuals. Evidence on the psychometric properties of the CANE is still pending. Read More

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[A Meta-analysis of the predictive effect of neutrophil-lymphocyte ratio on acute kidney injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):311-317

Department of Kidney Diseaseand Blood Purification, the Second Hospital of Tianjin Medical University, Tianjin 300211, China. Corresponding author: Wang Lihua, Email:

Objective: To systematically evaluate the predictive value of neutrophil-lymphocyte ratio (NLR) in acute kidney injury (AKI).

Methods: All studies about the predictive effect of NLR on AKI were searched in the National Medical Library of the United States PubMed Database, the Embase database in the Netherlands, the Chinese Biology Medicine disc (CBMdisc) and the Chinese Evidence Based Medicine Cochrane Centre Database (CEBM/CCD). The data updated by October 2020, and regardless of language, region or whether blind method was used. Read More

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Clinical efficacy of lenvatinib for the treatment of radioiodine-refractory thyroid carcinoma: a systematic review and meta-analysis of clinical trials.

Clin Endocrinol (Oxf) 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Objective: To evaluate the efficacy of lenvatinib in the treatment of Radioiodine-refractory thyroid carcinoma.

Background: Thyroid carcinoma is one of the top ten carcinoma worldwide. Clinically, thyroid cancers are managed with resections and adjuvant therapy with radioiodine. Read More

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Association between frailty and postoperative delirium: a meta-analysis of cohort study.

Aging Clin Exp Res 2021 Apr 8. Epub 2021 Apr 8.

Intensive Care Unit, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 118 Xingguang Avenue, Liangjiang New Area, Chongqing, 400010, China.

Background: Frailty has been suggested as a possible risk factor for postoperative delirium (POD). However, results of previous studies were not consistent. We performed a meta-analysis of cohort study to evaluate the above association. Read More

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Predictors of 30-Day Unplanned Readmission After Carotid Artery Stenting Using Artificial Intelligence.

Adv Ther 2021 Apr 9. Epub 2021 Apr 9.

Ahmanson-UCLA Cardiomyopathy Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, 90095, USA.

Introduction: This study aimed to describe the rates and causes of unplanned readmissions within 30 days following carotid artery stenting (CAS) and to use artificial intelligence machine learning analysis for creating a prediction model for short-term readmissions. The prediction of unplanned readmissions after index CAS remains challenging. There is a need to leverage deep machine learning algorithms in order to develop robust prediction tools for early readmissions. Read More

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