160,146 results match your criteria subcutaneous

Luspatercept as a therapy for myelodysplastic syndromes with ring sideroblasts.

Expert Rev Hematol 2021 Jun 23. Epub 2021 Jun 23.

Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Düsseldorf, Germany.

Introduction: Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell diseases characterized by cell dysplasia, ineffective hematopoiesis and risk of transformation to acute myeloid leukemia (AML). The median age of 75 years at diagnosis is associated with the presence of comorbidities, which preclude intensive therapies like allogeneic hematopoietic stem cell transplantation in most MDS patients. Risk stratification using the (Revised) International Prognostic Scoring System (IPSS/IPSS-R) is necessary to plan individualized treatment. Read More

View Article and Full-Text PDF

Risk Factors for Surgical Site Infection After Lower Limb Revascularization Surgery in Adults with Peripheral Artery Disease: Protocol for a Systematic Review and Meta-Analysis.

JMIR Res Protoc 2021 Jun 23. Epub 2021 Jun 23.

University of Ottawa, The Ottawa Hospital, Civic Campus, Room A-280, 1053 Carling Avenue, Ottawa, CA.

Background: Surgical site infections are common, costly, and associated with increased morbidity and potentially mortality after lower limb revascularization surgery (i.e., arterial bypass, endarterectomy, and patch angioplasty). Read More

View Article and Full-Text PDF

A Finite Element Analysis and Circuit Modelling Methodology for Studying Electrical Impedance Myography of Human Limbs.

IEEE Trans Biomed Eng 2021 Jun 23;PP. Epub 2021 Jun 23.

Objective: Electrical impedance myography (EIM) measures bioimpedance over muscles. This paper proposes a circuit-based modelling methodology originated from finite element analysis (FEA), to emulate tissues and effects from anthropometric variations, and electrode placements, on EIM measurements. The proposed methodology is demonstrated on the upper arms and lower legs. Read More

View Article and Full-Text PDF

Clinical Benefit of Insulin Glargine 300 U/mL Among Patients with Type 2 Diabetes Mellitus Previously Uncontrolled on Basal or Premixed Insulin in Serbia: A Prospective, Observational, Single-Arm, Multicenter, Real-World Study.

Diabetes Ther 2021 Jun 23. Epub 2021 Jun 23.

Medical Faculty, University of Novi Sad, Novi Sad, Serbia.

Introduction: Insulin glargine 300 U/mL (Gla-300) is a novel glargine formulation which shows slower and more prolonged absorption following subcutaneous administration in comparison to insulin glargine 100 U/mL. In this prospective, observational, single-arm, multicenter, real-world study conducted in Serbia, we evaluated the effectiveness and safety of Gla-300 in patients with type 2 diabetes mellitus (T2DM) previously inadequately controlled with different basal or premix insulin therapy regimes.

Methods: A total of 350 patients with T2DM were enrolled by 27 physicians, from date of the first patient in (12 December 2017) to the date of last patient completed/last patient out (30 October 2018), from both medical centers and general hospitals. Read More

View Article and Full-Text PDF

A lysosome-targeted near-infrared photosensitizer for photodynamic therapy and two-photon fluorescence imaging.

Org Biomol Chem 2021 Jun 23. Epub 2021 Jun 23.

College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, 443002, China.

Organelle-targeted two-photon near-infrared photosensitizers are highly desirable for photodynamic therapy (PDT) of cancer. Herein, in this contribution, we have developed a 2-dicyanomethylenethiazole-based D-π-A structured near-infrared photosensitizer (TTR). TTR exhibits near-infrared emission (704 nm), a large Stokes shift (200 nm), and smaller ΔES1-T1 (the energy gap between S1 and T1) (0. Read More

View Article and Full-Text PDF

Bilateral breast myxedema caused by Graves' disease and responsive to multipoint subcutaneous injection of long-acting glucocorticoid: Case report.

Medicine (Baltimore) 2021 Jun;100(25):e26469

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Branch of National Clinical Research Center for Metabolic Disease, Hubei.

Rationale: With the absence of ophthalmopathy, thyroid dermopathy especially lesions at atypical locations is a very rare presentation. We herein report an original case of bilateral breast myxedema caused by Grave's disease.

Patient Concerns: A 21-year-old unmarried woman presented with a 4-month history of Grave's disease and a 1-month history of progressive bilateral breast enlargement. Read More

View Article and Full-Text PDF

A clinical observational study on the efficacy of subcutaneous etonogestrel implants for adenomyosis in 20 patients.

Gynecol Endocrinol 2021 Jun 23:1-5. Epub 2021 Jun 23.

Department of Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.

To evaluate the efficacy of subcutaneous etonogestrel implants for adenomyosis. We conducted a clinical observational study of 20 patients suffering from adenomyosis treated with subcutaneous etonogestrel implants from August 2015 to July 2017 and followed up for 36 months. We evaluated the efficacy of subcutaneous etonogestrel implants primarily based on the following indicators: the pictorial blood loss assessment chart (PBAC) for menstrual blood volume, changes in bleeding patterns, the visual analog scale (VAS) pain score for dysmenorrhea, uterine volume, serum cancer antigen 125 (CA125) levels, hemoglobin levels and side effects. Read More

View Article and Full-Text PDF

Intravital Imaging of Candida albicans Identifies Differential and Filamentation Phenotypes for Transcription Factor Deletion Mutants.

mSphere 2021 Jun 23:e0043621. Epub 2021 Jun 23.

Department of Pediatrics, Carver College of Medicine, University of Iowagrid.412584.egrid.214572.7, Iowa City, Iowa, USA.

Candida albicans is an important cause of human fungal infections. A widely studied virulence trait of C. albicans is its ability to undergo filamentation to hyphae and pseudohyphae. Read More

View Article and Full-Text PDF

Biological sealing and integration of a fibrinogen-modified titanium alloy with soft and hard tissues in a rat model.

Biomater Sci 2021 Jun 23. Epub 2021 Jun 23.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.

Percutaneous or transcutaneous devices are important and unique, and the corresponding biological sealing at the skin-implant interface is the key to their long-term success. Herein, we investigated the surface modification to enhance biological sealing, using a metal sheet and screw bonded by biomacromolecule fibrinogen mediated via pre-deposited synthetic macromolecule polydopamine (PDA) as a demonstration. We examined the effects of a Ti-6Al-4V titanium alloy modified with fibrinogen (Ti-Fg), PDA (Ti-PDA) or their combination (Ti-PDA-Fg) on the biological sealing and integration with skin and bone tissues. Read More

View Article and Full-Text PDF

Postoperative analgesic effect of ultrasound-guided rectus sheath block and local anesthetic infiltration after laparoscopic cholecystectomy: Results of a prospective randomized controlled trial.

Asian J Endosc Surg 2021 Jun 22. Epub 2021 Jun 22.

Department of Surgery, Shiga University of Medical Science, Otsu, Japan.

Introduction: Even if laparoscopic cholecystectomy (LC) has lower invasiveness through small incisions compared with laparotomy, postoperative pain control is important.

Methods: This prospective, randomized, single-blinded, interventional, single-center study was conducted from December 2016 to March 2018 at the Shiga University of Medical Science Hospital in Japan. Enrolled patients were assigned to either a rectus sheath block (RSB) group or an infiltrative local anesthesia (LA) group. Read More

View Article and Full-Text PDF

Effect of 2-year caloric restriction on organ and tissue size in nonobese 21- to 50-year-old adults in a randomized clinical trial: the CALERIE study.

Am J Clin Nutr 2021 Jun 22. Epub 2021 Jun 22.

Pennington Biomedical Research Center, Baton Rouge, LA, USA.

Background: Sustained calorie restriction (CR) promises to extend the lifespan. The effect of CR on changes in body mass across tissues and organs is unclear.

Objectives: We used whole-body MRI to evaluate the effect of 2 y of CR on changes in body composition. Read More

View Article and Full-Text PDF

Subcutaneous REGEN-COV Antibody Combination for Covid-19 Prevention.

medRxiv 2021 Jun 17. Epub 2021 Jun 17.

Background: Casirivimab and imdevimab (REGEN-COV™) markedly reduces risk of hospitalization or death in high-risk individuals with Covid-19. Here we explore the possibility that subcutaneous REGEN-COV prevents SARS-CoV-2 infection and subsequent Covid-19 in individuals at high risk of contracting SARS-CoV-2 by close exposure in a household with a documented SARS-CoV-2-infected individual.

Methods: Individuals ≥12 years were enrolled within 96 hours of a household contact being diagnosed with SARS-CoV-2 and randomized 1:1 to receive 1200 mg REGEN-COV or placebo via subcutaneous injection. Read More

View Article and Full-Text PDF

Subcutaneous REGEN-COV Antibody Combination in Early SARS-CoV-2 Infection.

medRxiv 2021 Jun 14. Epub 2021 Jun 14.

Background: Casirivimab and imdevimab administered together (REGEN-COV ) markedly reduces the risk of hospitalization or death in high-risk, symptomatic individuals with COVID-19. Here, we report phase 3 results of early treatment of asymptomatic, SARS-CoV-2-positive adults and adolescents with subcutaneous REGEN-COV.

Methods: Individuals ≥12 years of age were eligible if identified within 96 hours of a household contact being diagnosed as SARS-CoV-2-positive; 314 were randomized 1:1 to receive subcutaneous REGEN-COV 1200mg or placebo. Read More

View Article and Full-Text PDF

Reconstruction of nasal vestibular obstruction after total nasal reconstruction using superior subcutaneous pedicle nasolabial flaps.

JPRAS Open 2021 Sep 17;29:60-64. Epub 2021 May 17.

Department of Plastic and Reconstructive Surgery, Matsunami General Hospital, 185-1, Dendai, Kasamatsu, Hashima-gun Gifu, Japan 501-6062.

Objective And Methods: Nasal obstruction after total nasal reconstruction is a serious complication that contributes to breathing difficulty, snoring, and obstructive sleep apnea, which can negatively influence daily activities. However, few treatments have been reported in detail for this condition. Here, a case of nasal vestibular obstruction after total nasal reconstruction that was treated with bilateral superior subcutaneous pedicle nasolabial flaps is reported. Read More

View Article and Full-Text PDF
September 2021

A newly developed subcutaneous nodule 15 years after liver transplantation.

Hepatobiliary Surg Nutr 2021 Jun;10(3):430-432

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

View Article and Full-Text PDF

Egg white-induced inflammation models: A study of edema profile and histological change of rat's paw.

J Adv Pharm Technol Res 2021 Apr-Jun;12(2):109-112. Epub 2021 Apr 27.

Department of Pharmacy, Poltekkes Kemenkes Manado, North Sulawesi, Indonesia.

The egg white was used to induce rat paw inflammation, with inadequate references to explain its mechanism. It's contained protein was identified as an allergen was suspected to trigger an inflammatory reaction. This research was aimed to evaluate the use of egg white as an inflammatory inductor in inflammation animal models through edema profile and histological change. Read More

View Article and Full-Text PDF

RV lead placement - A forgotten cause of right heart failure.

Ann Med Surg (Lond) 2021 Jul 7;67:102461. Epub 2021 Jun 7.

Thomas Jefferson University, PA, USA.

Introduction: Cardiac implantable electronic devices (CIEDs) have opened new doors, improving the quality, and increasing the duration of life by providing support of heart rate, atrioventricular and interventricular synchrony, thereby preventing sudden cardiac death. Nevertheless, these devices can pose some risks to the patients, including pacemaker-mediated cardiomyopathy and endocarditis.

Case Presentation: We elucidate the case of a patient who had severe Tricuspid Regurgitation as a result of single chamber Implantable Cardioverter Defibrillator (ICD) placement which led to right heart failure (RHF). Read More

View Article and Full-Text PDF

Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice.

Sci Rep 2021 Jun 22;11(1):13021. Epub 2021 Jun 22.

Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa, 920-8641, Japan.

A syngeneic mouse model bearing a transplanted tumor is indispensable for the evaluation of the efficacy of immune checkpoint inhibitors (ICIs). However, few syngeneic mouse models of liver cancer are available. We established liver tumor cell lines (MHCF1 and MHCF5) from hepatitis C virus transgenic mice fed an atherogenic high-fat diet. Read More

View Article and Full-Text PDF

Intratracheal inoculation of AHc vaccine induces protection against aerosolized botulinum neurotoxin A challenge in mice.

NPJ Vaccines 2021 Jun 22;6(1):87. Epub 2021 Jun 22.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

Botulinum neurotoxin (BoNT), produced by Clostridium botulinum, is generally known to be the most poisonous of all biological toxins. In this study, we evaluate the protection conferred by intratracheal (i.t. Read More

View Article and Full-Text PDF

Bleeding Risk and Mortality Associated With Uninterrupted Antithrombotic Therapy During Percutaneous Endoscopic Gastrostomy Tube Placement.

Am J Gastroenterol 2021 Jun 23. Epub 2021 Jun 23.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.

Introduction: Antithrombotic therapy is often interrupted before the placement of a percutaneous endoscopic gastrostomy (PEG) tube because of potentially increased risk of hemorrhagic events. The aim of our study was to evaluate the risk of bleeding events and overall complication rates after PEG in patients on uninterrupted antiplatelet and anticoagulation therapy in a high-volume center.

Methods: Data regarding demographics, diagnoses, comorbidities, and clinical outcomes pertinent to PEG were collected from 2010 to 2016. Read More

View Article and Full-Text PDF

Association of measures of body fat with serum alpha-tocopherol and its metabolites in middle-aged individuals.

Nutr Metab Cardiovasc Dis 2021 May 18. Epub 2021 May 18.

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Background And Aims: The accumulation of fat increases the formation of lipid peroxides, which are partly scavenged by alpha-tocopherol (α-TOH). Here, we aimed to investigate the associations between different measures of (abdominal) fat and levels of urinary α-TOH metabolites in middle-aged individuals.

Methods And Results: In this cross-sectional analysis in the Netherlands Epidemiology of Obesity study (N = 511, 53% women; mean [SD] age of 55 [6. Read More

View Article and Full-Text PDF

Extravasation Injuries of the Limbs in Neonates and Children-Development of a Treatment Algorithm.

Dtsch Arztebl Int 2021 Aug 23(Forthcoming). Epub 2021 Aug 23.

Background: Hospitalized children and neonates very often receive intravenous treatment. There has not yet been any systematic study of the incidence of extravasation injuries in this age group. In a few studies of neonates in intensive care receiving intravenous treatment, incidence figures in the range of 18-46% have been reported; 2. Read More

View Article and Full-Text PDF

CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.

World J Surg Oncol 2021 Jun 22;19(1):184. Epub 2021 Jun 22.

Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136, Jingzhou Street, Xiangyang, 441021, Hubei, China.

Background: Circular RNA low-density lipoprotein receptor-related protein 6 (circLRP6) is considered as an oncogene in many types of cancers. However, the function and mechanisms of circLRP6 in prostate cancer (PCa) tumorigenesis remain largely undefined.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were conducted to assess the expression of circLRP6, microRNA (miR)-330-5p, and nuclear receptor binding protein 1 (NRBP1). Read More

View Article and Full-Text PDF

CT-P13 subcutaneous infliximab in gastroenterology and rheumatology.

Immunotherapy 2021 Jun 23. Epub 2021 Jun 23.

Department of Rheumatology, Royal Alexandra Hospital, Paisley, UK.

The drug infliximab has been a key milestone in the treatment of inflammatory conditions such as Crohn's disease, ulcerative colitis, rheumatoid arthritis and the seronegative spondyloarthritides. Biosimilar drugs followed the originator, further improving access and diversity of therapy choice. Subcutaneous infliximab (CT-P13) holds potential for greater patient flexibility by self administration, reducing travel and hospital attendance for infusion, particularly relevant at a time of pandemic. Read More

View Article and Full-Text PDF

An epigallocatechin-3-gallate formulation developed for endodontic use: a physicochemical and biological evaluation.

J Endod 2021 Jun 19. Epub 2021 Jun 19.

Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

Introduction: Although epigallocatechin-3-gallate (EGCG) from green tea has been sucessfully used in the prevention and treatment of several infectious and immunoinflammatory diseases due to its proven anti-inflammatory, anti-oxidant, antimicrobial and anti-resorptive role, its use as an intracanal dressing has not been proposed. The aim of this study was to develop a formulation based on Epigallocatechin-3-gallate (EGCG) for endodontic use by assessing its physicochemical and biological properties.

Methods: Initially, physicochemical characterization of EGCG was performed by ultraviolet-visible (UV/Vis) and fluorescence spectroscopy to evaluate if the properties were maintained in acidic pH and time (1-6, 24 and 27 hours). Read More

View Article and Full-Text PDF

Clinic-on-a-Needle Array toward Future Minimally Invasive Wearable Artificial Pancreas Applications.

ACS Nano 2021 Jun 22. Epub 2021 Jun 22.

Department of Materials Science and Engineering, the Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel.

In order to reduce medical facility overload due to the rise of the elderly population, modern lifestyle diseases, or pandemics, the medical industry is currently developing point-of-care and home medical device systems. Diabetes is an incurable and lifetime disease, accountable for a significant mortality and socio-economic public health burden. Thus, tight glucose control in diabetic patients, which can prevent the onset of its late complications, is of enormous importance. Read More

View Article and Full-Text PDF

Co-immunization with L-Myc enhances CD8 or CD103 DCs mediated tumor-specific multi-functional CD8 T cell responses.

Cancer Sci 2021 Jun 22. Epub 2021 Jun 22.

Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Renal carcinoma shows a high risk of invasion and metastasis without effective treatment. Herein, we developed a chitosan (CS) nanoparticle-mediated DNA vaccine containing an activated factor L-Myc and a tumor-specific antigen CAIX for renal carcinoma treatment. The subcutaneous tumor models were intramuscularly immunized with CS-pL-Myc/pCAIX or control vaccine, respectively. Read More

View Article and Full-Text PDF

Immunomodulatory effects of lenvatinib plus anti-PD1 in mice and rationale for patient enrichment in hepatocellular carcinoma.

Hepatology 2021 Jun 22. Epub 2021 Jun 22.

Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

Background & Aims: Lenvatinib is an effective drug in advanced hepatocellular carcinoma (HCC). Its combination with the anti-PD1 immune checkpoint inhibitor pembrolizumab has generated encouraging results in phase Ib and is currently being tested in phase III trials. Here, we aimed to explore the molecular and immunomodulatory effects of lenvatinib alone or in combination with anti-PD1. Read More

View Article and Full-Text PDF

Photoactivated Indium Phosphide Quantum Dots Treat Multidrug-Resistant Bacterial Abscesses .

ACS Appl Mater Interfaces 2021 Jun 22. Epub 2021 Jun 22.

Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.

The increasing prevalence of drug-resistant bacterial strains is causing illness and death in an unprecedented number of people around the globe. Currently implemented small-molecule antibiotics are both increasingly less efficacious and perpetuating the evolution of resistance. Here, we propose a new treatment for drug-resistant bacterial infection in the form of indium phosphide quantum dots (InP QDs), semiconductor nanoparticles that are activated by light to produce superoxide. Read More

View Article and Full-Text PDF

Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):3967-3980

Department of General Surgery, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China.

Objective: Ribosomal protein S15A (RPS15A) has been implicated in tumorigenesis, but its role in colorectal cancer (CRC) is not fully studied. The objective of this study was to investigate the role of RPS15A in CRC carcinogenesis.

Patients And Methods: RBSP15A expression was detected in 120 colorectal adenocarcinoma biopsies by immunohistological staining, and we examined the association of RSP15A expression with clinicopathological outcomes. Read More

View Article and Full-Text PDF