138 results match your criteria subconjunctival triamcinolone


Development of Triamcinolone Acetonide-Loaded Microemulsion as a Prospective Ophthalmic Delivery System for Treatment of Uveitis: In Vitro and In Vivo Evaluation.

Pharmaceutics 2021 Mar 25;13(4). Epub 2021 Mar 25.

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Treatment of uveitis (i.e., inflammation of the uvea) is challenging due to lack of convenient ophthalmic dosage forms. Read More

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Anterior Migration of Triamcinolone Acetonide after Posterior Subtenon Injection for Macular Edema Predisposes to Intraocular Pressure Elevation.

Curr Eye Res 2020 Sep 27:1-5. Epub 2020 Sep 27.

Department of Ophthalmology, National Taiwan University Hospital , Taipei, Taiwan.

Purpose: To evaluate the effect of anterior migration of triamcinolone acetonide on intraocular pressure (IOP) elevation after posterior subtenon injection of triamcinolone acetonide (PSTA) for macular edema.

Methods: One hundred and ten eyes from 89 patients who received PSTA for macular edema were prospectively enrolled. The extent of anterior migration of triamcinolone acetonide was recorded immediately after the injection. Read More

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September 2020

Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives.

Drug Deliv Transl Res 2020 Sep 8. Epub 2020 Sep 8.

Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.

Corticosteroids remain the mainstay of the treatment for various ocular conditions affecting the ocular surface, anterior and posterior segments of the eye due to their anti-inflammatory, anti-oedematous, and anti-neovascularization properties. Prednisolone, prednisolone acetate, dexamethasone, triamcinolone acetonide, fluocinolone acetonide, and loteprednol etabonate are amongst the most widely used ophthalmic corticosteroids. Corticosteroids differ in their activity and potency in the eye due to their inherent pharmacological and pharmaceutical differences. Read More

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September 2020

Subconjunctival injections of triamcinolone acetonide to treat uveitic macular edema.

Int J Ophthalmol 2020 18;13(7):1087-1091. Epub 2020 Jul 18.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Aim: To evaluate the efficacy and safety of subconjunctival triamcinolone acetonide (TA) injections for treating uveitic macular edema (UME).

Methods: This retrospective case series study included patients with UME who received subconjunctival TA injections with a minimum follow-up period of 6mo. The main outcome measure was central macular thickness (CMT). Read More

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Intraorbital Steroid Injection for Active Thyroid Ophthalmopathy.

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):69-77. Epub 2020 Feb 2.

Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the effect of orbital steroid injections in patients with active thyroid ophthalmopathy resistant to or dependent on systemic steroids, or with complications related to systemic steroid use.

Methods: This prospective non-comparative case series includes 31 eyes of 17 patients with active thyroid ophthalmopathy and clinical activity score (CAS) of 3 or more, without compressive optic neuropathy or overt exposure keratopathy. All subjects had a history of previous systemic steroid use (with steroid resistance or dependence) or had developed complications related to steroids. Read More

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February 2020

Comparison of two techniques used in routine care for the treatment of inflammatory macular oedema, subconjunctival triamcinolone injection and intravitreal dexamethasone implant: medical and economic importance of this randomized controlled trial.

Trials 2020 Feb 10;21(1):159. Epub 2020 Feb 10.

Department of Ophthalmology, CHU Nantes, Nantes, France.

Background: Whether they are injected peri- or intraocularly, corticosteroids are still essential tools in the therapeutic arsenal for treating inflammatory macular oedema. A few years ago, however, only triamcinolone acetonide was available to ophthalmologists. While this compound was initially developed for rheumatological or dermatological use, it has been increasingly deployed in ophthalmology, despite still being off-label. Read More

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February 2020

Calzone-Like Traumatic Flap Dislocation Four Years after Laser in situ Keratomileusis.

Case Rep Ophthalmol 2019 May-Aug;10(2):281-286. Epub 2019 Aug 13.

Department of Ophthalmology, Augentagesklinik Spreebogen, Berlin, Germany.

A 46-year-old patient presented with a flip-folded partially dislocated flap after trauma caused by a sheet of paper, four years after a reportedly uneventful laser in situ keratomileusis procedure using microkeratome. Flap re-lift, mechanical debridement, and flap stretching were performed in a first interventional approach. Due to epithelial ingrowth two month after the first intervention, a flap re-lift and mechanical removal of epithelial cells from the stroma bed and flap were performed. Read More

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Perioperative subconjunctival triamcinolone acetonide injection for prevention of inflammation and macular oedema after cataract surgery.

Acta Ophthalmol 2020 Feb 18;98(1):36-42. Epub 2019 Jun 18.

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.

Purpose: To compare the efficacy, safety and tolerability of a single perioperative subconjunctival injection of triamcinolone acetonide (TA) with steroid drops for the prevention of macular oedema and ocular inflammation after cataract surgery.

Methods: This prospective non-randomized controlled clinical trial analysed 101 eyes of 101 patients having an elective cataract surgery at Kymenlaakso Central Hospital, Kotka, Finland. Fifty eyes received conventional postoperative care with dexamethasone 1 mg/ml eye drops (DEX), and 51 eyes received a perioperative 20 mg subconjunctival injection of TA. Read More

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February 2020

Safety & efficacy of single subconjunctival triamcinolone 5 mg depot topical loteprednol post cataract surgery: less drop cataract surgery.

Int J Ophthalmol 2019 18;12(5):774-778. Epub 2019 May 18.

Department of Cornea, Sankara Eye Hospital, Coimbatore 641035, Tamil Nadu, India.

Aim: To do a randomized prospective interventional study for comparing the effects of a single subconjunctival triamcinolone acetonide (SCTA) injection to tapering topical loteprednol in patients undergoing phacoemulsification surgery under topical anesthesia.

Methods: A total of 400 patients were randomized into 2 groups; Group A (200 patients) received 5 mg SCTA at the end of surgery and topical ketorolac tromethamine (0.5%) with ofloxacin (0. Read More

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The Role of Steroids and NSAIDs in Prevention and Treatment of Postsurgical Cystoid Macular Edema.

Curr Pharm Des 2018 ;24(41):4896-4902

Private Practice, Gdansk, Poland.

Background: Pseudophakic cystoid macular edema (PCME) remains one of the most common visionthreatening complication of phacoemulsification cataract surgery (PCS). Pharmacological therapy is the current mainstay of both prophylaxis, and treatment of PCME in patients undergoing PCS. We aimed to review pharmacological treatment options for PCME, which primarily include topical steroids, topical nonsteroidal antiinflammatory drugs (NSAIDS), periocular and intravitreal steroids, as well as anti-vascular endothelial growth factor therapy. Read More

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November 2019

Long-term effect of triamcinolone acetonide in the treatment of upper lid retraction with thyroid associated ophthalmopathy.

Int J Ophthalmol 2018 18;11(8):1290-1295. Epub 2018 Aug 18.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Aim: To report the long-term outcomes of a large cohort of upper lid retraction patients treated with subconjunctival triamcinolone acetonide injections.

Methods: This retrospective clinical study was conducted from 2009 to 2016. The documents of 97 patients (126 eyes) were reviewed. Read More

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Healing modulation in glaucoma surgery after application of subconjunctival triamcinolone acetate alone or combined with mitomycin C: an experimetal study.

Rev Col Bras Cir 2018 Jul 30;45(4):e1861. Epub 2018 Jul 30.

Universidade Federal de Minas Gerais, Departamento de Oftalmologia, Belo Horizonte, MG, Brasil.

Objective: to study the efficacy and safety of the use of subconjunctival triamcinolone acetate alone or in combination with mitomycin C as a modulator of trabeculectomy healing in rabbits.

Methods: we submitted thirty male, albino, New Zealand rabbits to bilateral trabeculectomy. We divided the animals into four experimental groups with 15 eyes per group: control, mitomycin C, triamcinolone acetate and triamcinolone acetate + mitomycin C. Read More

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Randomized controlled European multicenter trial on the prevention of cystoid macular edema after cataract surgery in diabetics: ESCRS PREMED Study Report 2.

J Cataract Refract Surg 2018 Jul;44(7):836-847

From University Eye Clinic Maastricht UMC+, Maastricht University Medical Center+ (Wielders, Schouten, van den Biggelaar, Veldhuizen, Nuijts), Maastricht, Maastricht University, Care and Public Health Research Institute, Department of Methodology and Statistics (Winkens), Maastricht, Zuyderland Medical Center, Department of Ophthalmology (Wielders, Schouten, Nuijts), Heerlen; Elisabeth-TweeSteden Hospital, Department of Ophthalmology (Goslings), Tilburg, Haaglanden Medical Center, Department of Ophthalmology (Joosse), The Hague, VU University Medical Center, Department of Ophthalmology (Henry), Amsterdam, and Eye Hospital Zonnestraal (Rulo), Hilversum, the Netherlands; Centro Hospitalar Universitário Coimbra and Association for Innovation and Biomedical Research on Light (Murta), Coimbra, Portugal; Goethe University, Department of Ophthalmology (Kohnen); Frankfurt am Main, Germany Antwerp University Hospital and University of Antwerp, Department of Ophthalmology (Tassignon), Antwerp, Belgium Semmelweis University, Department of Ophthalmology (Nagy), Budapest, Hungary Vienna Institute for Research in Ocular Surgery, Hanusch Hospital (Findl), and Hospital of the Brothers of St. John of God, Department of Ophthalmology (Amon), Vienna, Austria.

Purpose: To compare the efficacy of perioperative treatment strategies, in addition to topical bromfenac 0.09% and dexamethasone 0.1%, to reduce the risk for developing cystoid macular edema (CME) after uneventful cataract surgery in diabetic patients. Read More

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Simultaneous Subconjunctival Triamcinolone and Bevacizumab Injections for Management of Blepharokeratoconjunctivitis in Children.

Case Rep Ophthalmol Med 2018 5;2018:2602487. Epub 2018 Jun 5.

Department of Ophthalmology, Royal North Shore Hospital, Sydney, NSW, Australia.

Purpose: To report the efficacy of subconjunctival triamcinolone (Kenalog A-40, Alcon) and bevacizumab (Avastin, Genentech) injections in fraternal twins with blepharokeratoconjunctivitis (BKC) causing progressive, bilateral corneal neovascularization and scarring.

Methods: In this retrospective observational case series, two three-year-old male twins with BKC had presented with bilateral red eyes, photophobia, and frequent blinking. Examination of each child showed bilateral deep stromal and superficial corneal neovascularization, corneal infiltrates, multiple follicles on the palpebral conjunctiva bilaterally with blepharitis, and thick turbid sebum expressed from the Meibomian glands. Read More

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Steroid-induced protracted severe ocular hypertension in a 14-year-old girl.

BMJ Case Rep 2018 Jun 27;2018. Epub 2018 Jun 27.

Ophthalmology Department, Hospital de Santa Maria, Lisboa, Portugal.

Steroid-induced ocular hypertension (SIOH) is a challenging entity in paediatric age, with many being refractory to medical therapy. Literature is scarce about surgical options in these cases. A 14-year-old girl with bilateral uveitis and macular oedema had received an intravitreal and subconjunctival triamcinolone injection in the right (OD) and left (OS) eye, respectively. Read More

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Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis.

Sci Rep 2018 04 26;8(1):6604. Epub 2018 Apr 26.

Singapore National Eye Centre (SNEC), 11 Third Hospital Avenue, Singapore, 168751, Singapore.

Non-infectious anterior uveitis (AU) is a potentially sight threatening inflammatory condition. The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. Read More

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Topical steroids eye drops in conjunctival reactive lymphoid hyperplasia: Case report.

Medicine (Baltimore) 2017 Nov;96(47):e8656

Department of Ophthalmology, University of São Paulo, São Paulo, Brazil.

Rationale: Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocytic infiltrative disorders. Read More

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November 2017

Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center.

Ophthalmic Surg Lasers Imaging Retina 2018 01;49(1):70-75

In a prospective case series of patients with Blau-Jabs syndrome (BJS) conducted in the Ophthalmology Department/Federal University of Sao Paulo, seven patients with clinical and ophthalmologic manifestations of the disease and a positive genetic test result for the presence of a mutation in the CARD15/NOD2 gene were followed for a minimal period of 1 year. All patients had uveitis, five had nummular corneal subepithelial opacities, and four had multifocal choroiditis. Oral prednisolone was administered to all patients; inflammation was controlled in six patients with at least one immunosuppressive drug. Read More

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January 2018

Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas.

Clin Ophthalmol 2017 8;11:2177-2181. Epub 2017 Dec 8.

Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.

Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma.

Patients And Methods: This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Read More

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December 2017

Cystoid macular oedema associated with Rosai-Dorfman disease: a case report.

BMC Ophthalmol 2017 Aug 14;17(1):141. Epub 2017 Aug 14.

Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.

Background: The aim of this study is to report a case of cystoid macular oedema (CME) associated with Rosai-Dorfman Disease (RDD).

Case Presentation: A 52-year-old male initially presented with a two-month history of a congested left eye. At presentation, visual acuity was 20/20 in the right eye and 20/80 in the left eye. Read More

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Subconjunctival Delivery of p75NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy.

Invest Ophthalmol Vis Sci 2017 06;58(7):2852-2862

Lady Davis Institute - Jewish General Hospital, Center for Translational Research, McGill University, Montreal, Quebec, Canada 2Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada 4McGill Cancer Center, McGill University, Montreal, Quebec, Canada.

Purpose: The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and neurodegenerative phases of the retinal pathology. To simplify clinical translation, we sought a superior drug delivery method that circumvents risks associated with IVT injections. Read More

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Eyelid Fat Atrophy and Depigmentation After an Intralesional Injection of Triamcinolone Acetonide to Treat Chalazion.

J Craniofac Surg 2017 May;28(3):e198-e199

*Nune Eye Hospital, Daegu †Department of Ophthalmology, Dongguk University, Ilsan Hospital, Gyounggi, South Korea.

Two patients with depigmentation and fat atrophy after an intralesional injection of triamcinolone acetonide (TA) to treat chalazion are reported. A 2-year-old girl with chalazion in her right lower eyelid received a subconjunctival injection of TA and developed fat atrophy and depigmentation around the injected area. These changes subsided after 7 months. Read More

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[Treatment of macular edema: Comparison of efficacy and tolerability of subconjunctival triamcinolone injections, sub-tenon's triamcinolone injections and intravitreal dexamethasone implant].

J Fr Ophtalmol 2017 Mar 17;40(3):177-186. Epub 2017 Mar 17.

CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.

The area of uveitis is related to numerous pathological entities. One of the main causes of decreased visual acuity in these patients is macular edema. One aspect of the treatment includes cortosteroids used peri- and intra-ocularly. Read More

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Scleral abscess following posterior subtenon triamcinolone acetonide injection for diabetic macular edema.

Saudi J Ophthalmol 2016 Apr-Jun;30(2):130-2. Epub 2016 Jan 2.

Unit I, Department of Retina and Uvea, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India.

A 65-year-old male with uncontrolled diabetes, received posterior subtenon triamcinolone (PST) injection in the right eye for diabetic macular edema. Two days following PST, he developed scleral abscess at the injection site. The Gram stain showed Gram positive cocci in clusters. Read More

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[The efficacy and safety of subconjunctival triamcinolone acetonide injections in treatment of uveitic macular edema].

Zhonghua Yan Ke Za Zhi 2015 Oct;51(10):734-8

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Email:

Objective: To observe the efficacy and safety of subconjunctival triamcinolone acetonide injections in the treatment of uveitic macular edema (UME).

Methods: A retrospective case series study. The clinical data of uveitis patients with macular edema were collected and analyzed at Peking Union Medical College Hospital from July 2009 to June 2014 with a minimum follow-up period of 6 months. Read More

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October 2015

Comparative Effectiveness of Three Prophylactic Strategies to Prevent Clinical Macular Edema after Phacoemulsification Surgery.

Ophthalmology 2015 Dec 26;122(12):2450-6. Epub 2015 Sep 26.

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Purpose: To study the relationship of chemoprophylaxis and other factors with the occurrence of acute, clinical, postoperative macular edema.

Design: Retrospective cohort study. The drug regimens consisted of postoperative topical prednisolone acetate (PA) alone or with a nonsteroidal anti-inflammatory drug (NSAID) or intraoperative subconjunctival injection of 2 mg triamcinolone acetonide (TA) alone. Read More

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December 2015

Revisiting the Role of the Myofibroblast in Socket Surgery: An Immunohistochemical Study.

Ophthalmic Plast Reconstr Surg 2016 Jul-Aug;32(4):292-5

*Department of Ophthalmology, †Medical Student, and ‡Department of Pathology, Ain-Shams University, Cairo, Egypt.

Purpose: To determine the impact of a single injection of various anti-inflammatory, antimitotic, and antiangiogenic agents on the cell count of myofibroblasts in an eviscerated socket.

Methods: One eye from 15 skeletally mature New Zealand white rabbits was eviscerated, and the rabbits were divided into 5 groups. Each group of 3 rabbits received a 0. Read More

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February 2017

Conjunctival necrosis following a subconjunctival injection of triamcinolone acetonide in a child.

Middle East Afr J Ophthalmol 2015 Jan-Mar;22(1):125-8

Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Conjunctival necrosis is a rare complication following periocular/intraocular triamcinolone acetonide injection and has been reported extensively in adults. We describe a child who developed conjunctival necrosis following subconjunctival injection of triamcinolone acetonide for severe chronic anterior uveitis. Prompt diagnosis and management of this uncommon condition is vital. Read More

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The functional and histopathologic change in the levator palpebrae superioris and Müller muscle after subconjunctival injection of triamcinolone acetonide.

J Craniofac Surg 2015 Jan;26(1):285-9

From the *Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang; and Departments of †Pathology and ‡Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Aims: The aim of this study was to evaluate the functional and histopathologic changes in the levator palpebrae superioris and Müller muscles after subconjunctival injection of triamcinolone acetonide (TA) in rabbits.

Methods: Twenty-four white New Zealand rabbits were divided into 2 groups. In group A, a subconjunctival injection of 0. Read More

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January 2015

A case of herpetic keratitis after subconjunctival triamcinolone acetonide injection.

Case Rep Ophthalmol 2014 Sep 3;5(3):277-80. Epub 2014 Sep 3.

Department of Ophthalmology, Ehime University, Graduate School of Medicine, Toon, Japan.

Purpose: We report a case of herpetic epithelial keratitis that developed after subconjunctival triamcinolone acetonide injection (STI).

Methods: A 65-year-old female with anterior uveitis and hypotony in her right eye was given a STI (2 mg/0.5 ml). Read More

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September 2014