4,289 results match your criteria subconjunctival

Poor Outcome in Camel-Related Eye Trauma with Ruptured Globe.

Int Med Case Rep J 2021 7;14:219-222. Epub 2021 Apr 7.

Department of Ophthalmology, Tabuk University, Tabuk, Saudi Arabia.

Purpose: To report the poor visual outcome of ruptured globe caused by camel bites.

Observations: A 48-year-old camel caregiver presented to the emergency department after being bitten by a camel in the left side of his face. Ophthalmic examination revealed a superior scleral wound from 9 to 2 o'clock, about 6 mm from the limbus extending to the equator with prolapse of uveal and vitreous tissues, an opaque cornea, total hyphema, diffuse subconjunctival hemorrhage, and a lower lid laceration involving the lid margin and the nasolacrimal duct. Read More

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Candidatus Dirofilaria Hongkongensis Infections in Humans During 2005 to 2020, in Kerala, India.

Am J Trop Med Hyg 2021 Apr 12. Epub 2021 Apr 12.

3Center for Nanoscience and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita University, Cochin, Kerala 682041, India.

We tried to determine the epidemiology and species of human dirofilariasis observed at two tertiary care hospitals in Kerala. We searched the hospital database to identify cases of dirofilariosis from January 2005 to March 2020. Along with human isolates, one dog Dirofilaria isolate was also subjected to PCR and sequencing of pan filarial primers cytochrome oxidase subunits 1 and 12S rDNA. Read More

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Protective roles of the TIR/BB-loop mimetic AS-1 in alkali-induced corneal neovascularization by inhibiting ERK phosphorylation.

Exp Eye Res 2021 Apr 8:108568. Epub 2021 Apr 8.

Center of Clinical Research, The Affiliated Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi, Jiangsu, 214023, People's Republic of China.

Hydrocinnamoyl-L-valylpyrrolidine (AS-1), a synthetic low-molecule mimetic of myeloid differentiation primary response gene 88 (MyD88), inhibits inflammation by disrupting the interaction between the interleukin-1 receptor (IL-1R) and MyD88. Here, we describe the effects of AS-1 on injury-induced increases in inflammation and neovascularization in mouse corneas. Mice were administered a subconjunctival injection of 8 μL AS-1 diluent before or after corneal alkali burn, followed by evaluation of corneal resurfacing and corneal neovascularization (CNV) by slit-lamp biomicroscopy and clinical assessment. Read More

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Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice.

Stem Cell Res Ther 2021 Apr 6;12(1):227. Epub 2021 Apr 6.

College of Medicine, Nursing and Health Sciences, Biomedical Sciences, Regenerative Medicine Institute, National University of Ireland Galway, Galway, Ireland.

Background: Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC administration in the context of corneal transplantation. The purpose of this study was to assess the potential of subconjunctival injection of MSCs to promote corneal allograft survival.

Methods: MSCs were isolated from female C57BL/6 (H-2) or Balb/c (H-2) mice and extensively characterized. Read More

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Subconjunctival injections of dimethyl fumarate inhibit lymphangiogenesis and allograft rejection in the rat cornea.

Int Immunopharmacol 2021 Apr 3;96:107580. Epub 2021 Apr 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Corneal lymphangiogenesis induced by macrophages played a critical role in corneal allograft rejection (CGR). However, there are few Food and Drug Administration (FDA)-approved drugs that target lymphangiogenesis. The aim of our study is to evaluate the effects of dimethyl fumarate (DMF) on corneal allograft survival in rats. Read More

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Corneal Ulcer in Dogs and Cats: Novel Clinical Application of Regenerative Therapy Using Subconjunctival Injection of Autologous Platelet-Rich Plasma.

Front Vet Sci 2021 18;8:641265. Epub 2021 Mar 18.

Department of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Corneal ulcer could be a major source of distress in small animals, with many contributing agents. In recent years, few studies evaluated the efficacy of platelet-rich plasma (PRP) in healing corneal ulcers. This study aimed to assess the ability of subconjunctival injection of autologous PRP in the treatment of corneal ulcers in dogs and cats as well as estimate the expression of matrix metalloproteinase (MMP)-2, MMP-9, and oxidative stress biomarkers in these patients. Read More

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Development of Triamcinolone Acetonide-Loaded Microemulsion as a Prospective Ophthalmic Delivery System for Treatment of Uveitis: In Vitro and In Vivo Evaluation.

Pharmaceutics 2021 Mar 25;13(4). Epub 2021 Mar 25.

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Treatment of uveitis (i.e., inflammation of the uvea) is challenging due to lack of convenient ophthalmic dosage forms. Read More

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Periorbital ecchymosis and subconjunctival hemorrhage due to leech therapy for headache.

Arq Bras Oftalmol 2021 Mar-Apr;84(2):183-185

Department of Dermatomology, Istanbul Medeniyet University School of Medicine, Goztepe, Kadikoy, Istanbul, Turkey.

A 62-year-old woman was admitted to our clinic with the complaints of periorbital ecchymosis and subconjunctival hemorrhage that are visible, especially on the right eye. We noted that her complaints began the day after she underwent leech therapy on the glabella area for headache. On the glabella, 2 leech bites were observed close to the right side. Read More

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Case report of unilateral retrobulbar hematoma associated with von Willebrand disease in a Doberman Pinscher dog.

Clin Case Rep 2021 Mar 19;9(3):1235-1240. Epub 2021 Jan 19.

Lorrainevet Ludres France.

A 5-year-old Doberman Pinscher dog was presented with sudden onset left-sided periocular bleeding following third eyelid gland replacement surgery. Left-sided exophthalmos and 360-degrees subconjunctival hemorrhage were present. The ophthalmic examination revealed blindness with absent direct and consensual pupillary light reflexes. Read More

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Evaluation of Clinical and Histological Outcomes of Adipose-Derived Mesenchymal Stem Cells in a Rabbit Corneal Alkali Burn Model.

Stem Cells Int 2021 7;2021:6610023. Epub 2021 Mar 7.

Laboratory of Experimental Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

To assess effects of adipose-derived mesenchymal stem cells (AMSCs) in corneal alkali injuries in an experimental animal model. Twenty white New Zealand rabbits were included in the study. The animal models were randomly divided into 2 groups. Read More

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Ab-Externo Implantation of XEN Gel Stent for Refractory Steroid-Induced Glaucoma After Lamellar Keratoplasty.

Cureus 2021 Feb 12;13(2):e13320. Epub 2021 Feb 12.

Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

The hazy corneal donor-recipient interface after corneal transplant may cause difficulties when implanting the XEN gel stent via ab-interno approach. We aim to describe XEN gel stent implantation via ab-externo approach in refractory steroid-induced glaucoma after corneal lamellar keratoplasty. Under local anaesthesia, the XEN injector needle was inserted 7 mm behind the limbus with the bevel facing up, directly beneath the conjunctiva and advanced to the marked 2. Read More

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February 2021

Massive spontaneous subconjunctival hemorrhage in a patient on therapeutic warfarin: A case report.

Am J Ophthalmol Case Rep 2021 Jun 26;22:101049. Epub 2021 Feb 26.

Department of Ophthalmology, University of Cincinnati, 3230 Eden Ave, Cincinnati, OH, 45267, USA.

Purpose: To describe a case of massive spontaneous subconjunctival hemorrhage in a patient taking warfarin with a therapeutic international normalized ratio (INR).

Observations: Massive circumferential hemorrhagic chemosis, extensive periorbital and facial ecchymosis, and active arterial extravasation in the subconjunctiva which required cessation and reversal of anticoagulation. Findings gradually resolved over several months after discharge. Read More

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Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients.

Sci Rep 2021 Mar 16;11(1):6018. Epub 2021 Mar 16.

Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Fukui, 910-1193, Japan.

Intraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind, interventional study comparing the efficacy and safety of 0. Read More

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Ocular manifestations in renal allograft recipients: An Indian perspective.

Indian J Ophthalmol 2021 Apr;69(4):900-905

Department of Ophthalmology, Army Hospital (Research and Referral), New Delhi, India.

Purpose: The aim of this study was to report the ocular findings in renal allograft recipients in India.

Methods: A cross-sectional, comprehensive ophthalmic evaluation was performed, at least three months postrenal transplant, in 152 renal allograft recipients for the ocular findings. In addition, ocular findings were assessed for an association with the clinical variables like major etiologies of end-stage renal disease, pre-transplant dialysis duration, post-transplant duration, and dosage of immunosuppressive drugs. Read More

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[Retrobulbar hematoma in endoscopic endonasal dacryocystorhinostomy].

Vestn Otorinolaringol 2021 ;86(1):112-116

Research Institute of Eye Diseases, Moscow, Russia.

Recently, an increase in the number of operations on the lacrimal ducts performed by otorhinolaryngologists has been noted throughout the world. During these operations, intra- and postoperative complications may develop, which require the intervention of an ophthalmologist. A rare complication of endoscopic dacryocystorhinostomy is the development of retrobulbar hemorrhage. Read More

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Ethylparaben induces subconjunctival fibrosis via the Wnt/β-catenin signaling pathway.

Exp Ther Med 2021 Apr 28;21(4):295. Epub 2021 Jan 28.

Department of Ophthalmology, Zoucheng People's Hospital, Zoucheng, Shandong 273500, P.R. China.

The aim of the present study was to explore the etiology of subconjunctival fibrosis (SCF) induced by ethylparaben, the most prevalent preservative in Chinese eye drops. Ethylparaben was administered to the left eyes of male Sprague-Dawley rats in the experimental group twice daily for 1 month, whereas the control group received PBS. Experimental group rats displayed a mild promotion in density of fibroblasts and a tighter deposition of collagen in the bulbar subepithelial connective tissue compared with the control group. Read More

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Bilateral Exudative Retinal Detachment in a Young Patient with Chronic Renal Failure.

Int Med Case Rep J 2021 3;14:139-144. Epub 2021 Mar 3.

Ophthalmology Unit, Department of Surgery, Abia State University Teaching Hospital, Aba, Abia State, Nigeria.

Introduction: Chronic renal failure (CRF) is a multi-systemic disease affecting different organ systems of the body. Ocular manifestations of chronic renal disease include squint, subconjunctival hemorrhage, vitreous hemorrhage, neovascular glaucoma, cataracts and retinal detachment. These result in visual impairment or blindness. Read More

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Toxicity Evaluation of a Novel Rapamycin Liposomal Formulation After Subconjunctival and Intravitreal Injection.

J Ocul Pharmacol Ther 2021 Mar 10. Epub 2021 Mar 10.

Laboratorio Santgar, Benito Juarez, Mexico City, Mexico.

Safety and toxicity evaluation of a novel, liposome-encapsulated rapamycin formulation, intended for autoimmune ocular disorders. The formulation was assessed by micronucleus polychromatic erythrocyte production, irritability by Hen's Egg Test-Chorioallantoic Membrane (HET CAM), sterility, and pyrogenicity testing. Subconjunctival (SCJ) and intravitreal (IVT) administration of the formulation were performed to evaluate subacute and acute toxicity, respectively. Read More

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The Results of Preoperative Use of Topical Brimonidine in Strabismus Surgery.

J Ocul Pharmacol Ther 2021 Mar 8. Epub 2021 Mar 8.

Ophthalmology Department, Konyagoz Eye Hospital, Konya, Turkey.

In this study, we wanted to retrospectively evaluate the effect of the use of topical brimonidine on intraoperative bleeding and surgical hemostasis before strabismus surgery. Brimonidine tartrate 0.15% (Brimogut, Bilim Ilac, Turkey) eye drops were applied 6 and 3 min before surgery to 44 eyes of 22 patients in group 1 for vasoconstriction. Read More

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Subconjunctival enucleation with orbital implant placement in standing horses: 20 cases (2014-2017).

J Am Vet Med Assoc 2021 Mar;258(6):661-667

Objective: To develop a protocol for subconjunctival enucleation and orbital implant placement in standing horses and to document short- and long-term complications, cosmesis, and client satisfaction.

Animals: 20 horses with nonneoplastic ocular disease requiring enucleation.

Procedures: A standardized protocol of surgical suite cleaning, patient preparation, sedation, local nerve blocks, surgical procedure, and postoperative care was performed. Read More

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An Atypical Presentation of Sympathetic Ophthalmia in an Intact Globe Following Mechanical Fall: A Case Report and Literature Review.

Vision (Basel) 2021 Feb 21;5(1). Epub 2021 Feb 21.

Department of Ophthalmology, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, UK.

Purpose: To describe an atypical case of sympathetic ophthalmia presenting after blunt trauma causing disinsertion of the iris in an intact globe.

Methods: Case report.

Results: A 71-year-old lady presented to the Emergency Department following a mechanical fall. Read More

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February 2021

Sterile subconjunctival abscess in an HLA-B51-positive patient with ulcerative colitis.

Am J Ophthalmol Case Rep 2021 Jun 9;22:101033. Epub 2021 Feb 9.

Department of Ophthalmology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Purpose: To report a rare case of aseptic abscess presenting as a subconjunctival abscess in an HLA-B51-positive patient with ulcerative colitis.

Observations: A 25-year-old, male, Japanese patient with ulcerative colitis presented with an unilateral subconjunctival abscess. Infective endocarditis with endophthalmitis was suspected of being the cause, and systemic antimicrobial therapy was begun. Read More

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Keratitis by Fungus After LASIK - A Case Report.

Int Med Case Rep J 2021 17;14:107-110. Epub 2021 Feb 17.

Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Purpose: To describe a rare case of an interface filamentous fungal keratitis and its successful clinical approach and management.

Patients And Methods: Retrospective case report. Analysis of the patient's clinical records. Read More

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February 2021

Prevalence of Ocular Complications in Patients with Zygomatic Bone Fractures in an Iranian Population.

Front Dent 2020 May 15;17(9):1-4. Epub 2020 May 15.

Craniomaxillofcial Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Damages to the middle third of the facial bone generally involve the orbital skeleton and can lead to eye impairment. In this study, it is attempted to determine the incidence of ophthalmic injuries in maxillofacial trauma with zygomatic bone fractures.

Materials And Methods: One hundred and fifteen cases with ophthalmic (ocular) involvement after maxillofacial trauma were referred to the Shariati Hospital, Tehran, Iran, and were visited at the Ophthalmology Department between 2016 and 2018. Read More

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Topical interferon alpha-2b for a giant ocular surface squamous neoplasia: 7 years of follow-up after complete remission.

BMJ Case Rep 2021 Feb 19;14(2). Epub 2021 Feb 19.

Ophthalmology, Universidad Autonoma de Bucaramanga, Bucaramanga, Santander, Colombia.

A man with a history of blind eye due to trauma 22 years earlier consulted at 53 years of age with a large conjunctival neoplastic lesion, compromising almost the entire temporal limbus, and reaching a size of approximately 16 mm on its larger diameter, in the conjunctiva. Management was started with topical and subconjunctival chemotherapy (interferon alpha-2b) in order to perform immunoreduction, but a dramatic response with total disappearance of the lesion was observed. In the follow-up time period of more than 7 years, there were no signs of recurrence. Read More

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February 2021

[Perthes Syndrome after Roll-Over Trauma].

Anasthesiol Intensivmed Notfallmed Schmerzther 2021 Feb 19;56(2):135-140. Epub 2021 Feb 19.

Roll-over trauma and associated traumatic entrapments frequently result in serious polytraumatisation. In rare cases, severe extrathoracic compressions and a protracted entrapment period can lead to Perthes syndrome, also known as traumatic asphyxia. The Perthes syndrome manifests itself by a triad of craniocervical cyanosis, facial petechiae and subconjunctival haemorrhages, enabling a rapid diagnosis based on these typical clinical features. Read More

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February 2021

Liposomal drug delivery system for anti-inflammatory treatment after cataract surgery: a phase I/II clinical trial.

Drug Deliv Transl Res 2021 Feb 10. Epub 2021 Feb 10.

Singapore National Eye Centre (SNEC), 11 Third Hospital Avenue, Singapore City, 168751, Singapore.

Liposomes as a drug delivery system may overcome the problems associated with non-compliance to eyedrops and inadequate control of inflammation after cataract surgery. We evaluated the safety and efficacy of a single subconjunctival injection of liposomal prednisolone phosphate (LPP) for the treatment of post-cataract surgery inflammation. This is a phase I/II, open-label non-comparative interventional trial of patients undergoing cataract surgery. Read More

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February 2021

Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma.

Eur J Pharm Sci 2021 May 7;160:105748. Epub 2021 Feb 7.

Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000 Córdoba, Argentina. Electronic address:

Glaucoma is a degenerative optic neuropathy characterized by increased intraocular pressure that if untreated can result in blindness. Ophthalmological drug therapy is a challenge of great clinical importance due to the diversity of ocular biological barriers which commonly causes limited or no effectiveness for drugs delivered through the eye. In this work, we proposed the development of nanosized cubic liquid crystals (cubosomes) as a new drug carrier system for latanoprost, an anti-glaucoma drug. Read More

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Ahmed glaucoma valve implantation with and without subconjunctival bevacizumab in refractory glaucoma.

Int Ophthalmol 2021 Feb 9. Epub 2021 Feb 9.

Farabi Eye Hospital, Tehran, Iran.

Purpose: To evaluate the effects of subconjunctival bevacizumab injection on intraocular pressure (IOP), hypertensive phase, and failure and success rates of Ahmed Glaucoma Valve (AGV) implantation.

Methods: A total of 63 eyes of 63 patients (30 cases in control and 33 cases in bevacizumab group) were included in this randomized masked prospective clinical trial. Pre- and postoperative BCVA, IOP, number of medications, complications and success rates were compared between AGV + bevacizumab and AGV alone group. Read More

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February 2021

Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision.

BMC Ophthalmol 2021 Feb 8;21(1):75. Epub 2021 Feb 8.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Room E7, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Purpose: Infrared monitor-guided bleb revision (IRGBR), an alternative needling system, visualizes anterior-segment tissues around the bleb not visible during needle revision after trabeculectomy. This study determined the safety and efficiency of 5-fluorouracil (5-FU) as an adjunctive anti-metabolite in IRGBR.

Methods: We retrospectively analyzed 43 consecutive eyes (40 patients; 14 eyes, primary open-angle; 29 eyes, secondary glaucoma) treated with IRGBR for failing filtering blebs. Read More

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February 2021