33,405 results match your criteria subarachnoid hemorrhage

Dural Venous Sinus Variations in Idiopathic Subarachnoid Hemorrhage: a New Indicator of the Venous Origin with Diagnostic Utility?

World Neurosurg 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurological Surgery, Germans Trias i Pujol University Hospital, Badalona, Spain. Electronic address:

Objective: Venous hypertension associated with a primitive basal vein of Rosenthal (BVR) has been noted as the most likely cause of idiopathic subarachnoid hemorrhage (iSAH). Other types of venous drainage variations have been scarcely studied but may further explain the cases not associated with a BVR anomaly. Our aim was to investigate if dural venous sinus (DVS) anomalies are related with iSAH. Read More

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September 2021

Identifying critical genes associated with aneurysmal subarachnoid hemorrhage by weighted gene co-expression network analysis.

Aging (Albany NY) 2021 Sep 20;13(undefined). Epub 2021 Sep 20.

The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.

Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening medical condition with a high mortality and disability rate. aSAH has an unclear pathogenesis, and limited treatment options are available. Here, we aimed to identify critical genes involved in aSAH pathogenesis using peripheral blood gene expression data of 43 patients with aSAH due to ruptured intracranial aneurysms and 18 controls with headache, downloaded from Gene Expression Omnibus. Read More

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September 2021

Isolated aneurysms of the spinal circulation: a systematic review of the literature.

Neurosurg Rev 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 5-109, Baltimore, MD, 21287, USA.

Aneurysms arising in the spinal circulation are rare and underreported. The objective of this study was to systematically review the English literature on different aspects of isolated spinal aneurysms using the PubMed, Ovid MEDLINE, and Google Scholar databases. Eighty-two papers reporting 107 individual patient cases were included. Read More

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September 2021

The Role of the Glycocalyx in the Pathophysiology of Subarachnoid Hemorrhage-Induced Delayed Cerebral Ischemia.

Front Cell Dev Biol 2021 3;9:731641. Epub 2021 Sep 3.

Department of Neurosurgery, Maastricht University Medical Center, Maastricht, Netherlands.

The glycocalyx is an important constituent of blood vessels located between the bloodstream and the endothelium. It plays a pivotal role in intercellular interactions in neuroinflammation, reduction of vascular oxidative stress, and provides a barrier regulating vascular permeability. In the brain, the glycocalyx is closely related to functions of the blood-brain barrier and neurovascular unit, both responsible for adequate neurovascular responses to potential threats to cerebral homeostasis. Read More

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September 2021

Efficacy of Melatonin in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Stratified Meta-Analysis.

Front Neurol 2021 3;12:685731. Epub 2021 Sep 3.

Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, China.

Subarachnoid hemorrhage (SAH) is a severe disease characterized by sudden headache, loss of consciousness, or focal neurological deficits. Melatonin has been reported as a potential neuroprotective agent of SAH. It provides protective effects through the anti-inflammatory effects or the autophagy pathway. Read More

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September 2021

Plasma cellular prion protein concentrations correlate with severity and prognosis of aneurysmal subarachnoid hemorrhage.

Clin Chim Acta 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurosurgery Zhuji Affiliated Hospital of Wenzhou Medical University, 9 Jianmin Road, Zhuji 311800, China.

Background: Cellular prion protein (PrPc) is greatly expressed in injured brain tissues. We investigates correlation of plasma PrPc concentrations with severity, delayed cerebral ischemia (DCI) plus prognosis following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: Plasma PrPc concentrations were measured in 110 aSAH patients and 110 healthy controls. Read More

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September 2021

Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved.

Neurochem Int 2021 Sep 16;150:105188. Epub 2021 Sep 16.

Laboratorio de Dolor en Cáncer, Instituto de Investigaciones en Medicina Traslacional CONICET - Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina; Facultad de Ciencias Biomédicas, Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina. Electronic address:

After different types of acute central nervous system insults, including stroke, subarachnoid haemorrhage and traumatic brain and spinal cord injuries, secondary damage plays a central role in the induction of cell death, neurodegeneration and functional deficits. Interestingly, secondary cell death presents an attractive target for clinical intervention because the temporal lag between injury and cell loss provides a potential window for effective treatment. While primary injuries are the direct result of the precipitating insult, secondary damage involves the activation of pathological cascades through which endogenous factors can exacerbate initial tissue damage. Read More

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September 2021

Experience with outreach services of a multidisciplinary team for child abuse identification.

J Formos Med Assoc 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Background/purpose: Identifying child abuse is sometimes challenging due to its various presentations. To facilitate timely identification of critical or complex cases of physical abuse outside our child protection center, we established an outreach multidisciplinary team (OMDT) to support Kaohsiung City Government in 2014. The objective of this study was to describe our experience of OMDT services during a 6-year period and examine its role in assisting law enforcement. Read More

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September 2021

The influence of aneurysm morphology on the volume of hemorrhage after rupture.

J Neurosurg 2021 Sep 17:1-9. Epub 2021 Sep 17.

1Department of Neurosurgery, Hospital Universitario 12 de Octubre.

Objective: Factors determining the risk of rupture of intracranial aneurysms have been extensively studied; however, little attention is paid to variables influencing the volume of bleeding after rupture. In this study the authors aimed to evaluate the impact of aneurysm morphological variables on the amount of hemorrhage.

Methods: This was a retrospective cohort analysis of a prospectively collected data set of 116 patients presenting at a single center with subarachnoid hemorrhage due to aneurysmal rupture. Read More

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September 2021

Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture.

J Neuropathol Exp Neurol 2021 Sep 17. Epub 2021 Sep 17.

Neurosurgery Research Group, Biomedicum, Helsinki, Finland.

Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Read More

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September 2021

Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.

J Neuroinflammation 2021 Sep 16;18(1):210. Epub 2021 Sep 16.

Department of Neurological Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Jiefang Road 88th, Hangzhou, 310009, Zhejiang Province, China.

Background: Neuroinflammation and oxidative stress plays an important role in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). This study is the first to show that activation of autophagy protein nuclear receptor binding factor 2 (NRBF2) could reduce endoplasmic reticulum stress (ERS)-associated inflammation and oxidative stress after SAH.

Methods: Male C57BL/6J mice were subjected to endovascular perforation to establish a model of SAH. Read More

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September 2021

Injectable hydrogels for vascular embolization and cell delivery: The potential for advances in cerebral aneurysm treatment.

Biomaterials 2021 Aug 31;277:121109. Epub 2021 Aug 31.

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Cerebral aneurysms are vascular lesions caused by the biomechanical failure of the vessel wall due to hemodynamic stress and inflammation. Aneurysmal rupture results in subarachnoid hemorrhage often leading to death or disability. Current treatment options include open surgery and minimally invasive endovascular options aimed at secluding the aneurysm from the circulation. Read More

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Not All Subarachnoid Hemorrhages in Pregnancy Are Intracranial in Origin: A Case Report.

A A Pract 2021 Sep 15;15(9):e01521. Epub 2021 Sep 15.

From the Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland.

Subarachnoid hemorrhage is uncommon in pregnancy and may be caused by intracranial aneurysms, arteriovenous malformations, venous thrombosis, or preeclampsia. We present an unusual case of subarachnoid hemorrhage in a term parturient where the bleeding originated from an extracranial source, namely a cervicothoracic arteriovenous malformation. This case highlights the challenge of diagnosing this condition when the initial presentation may be nonspecific, lacking in neurologic deficits, and confounded by the simultaneous presence of preeclampsia. Read More

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September 2021

Severe intracranial atherosclerotic disease presenting as symptomatic isolated convexity subarachnoid haemorrhage.

J R Coll Physicians Edinb 2021 Sep;51(3):269-271

Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medicine-Qatar, Doha, Qatar.

Isolated convexity cortical subarachnoid haemorrhage (cSAH) is a rare form of non-traumatic subarachnoid haemorrhage localised to one or few cortical sulci of the brain without involving the adjacent brain parenchyma or spreading to sylvian fissure, interhemispheric fissure, basal cisterns and ventricles. cSAH has multiple aetiologies described in medical literature. Intracranial high-grade stenosis is rarely presented as cSAH, especially in young adult patients. Read More

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September 2021

The Relationship Between Elevated Serum Uric Acid and Risk of Stroke in Adult: An Updated and Dose-Response Meta-Analysis.

Front Neurol 2021 10;12:674398. Epub 2021 Aug 10.

No.3 Neurology Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.

Uric acid (UA) is proposed as a potential risk factor for stroke in adult, yet the results from published studies are not generally accordant. We included prospective studies that explored the relationship between serum UA (SUA) and strokes. In this study, strokes include ischemic stroke and hemorrhagic stroke, which consists of intracerebral hemorrhage and subarachnoid hemorrhage. Read More

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A case of suspected low-pressure hydrocephalus caused by spinal drainage following subarachnoid hemorrhage.

J Nippon Med Sch 2021 Sep 14. Epub 2021 Sep 14.

Nippon Medical School, Department of Neurological Surgery.

Background: Hydrocephalus induced by low cerebrospinal fluid (CSF) pressure is extremely rare and sporadically reported. Subarachnoid hemorrhage, head trauma, and spinal drainage were reported to be the causative factors for surgical treatments.

Case Description: A 33-year-old male with subarachnoid hemorrhage caused by right vertebral artery aneurysm rupture developed a headache. Read More

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September 2021

Artificial Intelligence Trained by Deep Learning Can Improve Computed Tomography Diagnosis of Nontraumatic Subarachnoid Hemorrhage by Nonspecialists.

Neurol Med Chir (Tokyo) 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurosurgery, Saiseikai Kumamoto Hospital, Stroke Center.

Subarachnoid hemorrhage (SAH) is a serious cerebrovascular disease with a high mortality rate and is known as a disease that is hard to diagnose because it may be overlooked by noncontrast computed tomography (NCCT) examinations that are most frequently used for diagnosis. To create a system preventing this oversight of SAH, we trained artificial intelligence (AI) with NCCT images obtained from 419 patients with nontraumatic SAH and 338 healthy subjects and created an AI system capable of diagnosing the presence and location of SAH. Then, we conducted experiments in which five neurosurgery specialists, five nonspecialists, and the AI system interpreted NCCT images obtained from 135 patients with SAH and 196 normal subjects. Read More

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September 2021

Central sympathetic nerve activation in subarachnoid hemorrhage.

J Neurochem 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Kurume University School of Medicine 67, Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Subarachnoid hemorrhage (SAH) is a life-threatening condition, and although its two main complications-cerebral vasospasm (CVS)/delayed cerebral ischemia (DCI) and early brain injury (EBI)-have been widely studied, prognosis has not improved over time. The sympathetic nerve (SN) system is important for regulating cardiovascular function and is closely associated with cerebral vessels and the regulation of cerebral blood flow and cerebrovascular function; thus, excessive SN activation leads to a rapid breakdown of homeostasis in the brain. In the hyperacute phase, patients with SAH can experience possibly lethal conditions that are thought to be associated with SN activation (catecholamine surge)-related arrhythmia, neurogenic pulmonary edema, and irreversible injury to the hypothalamus and brainstem. Read More

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September 2021


World Neurosurg 2021 Sep 11. Epub 2021 Sep 11.

Dipartimento di Scienze Medico-Chirurgiche, Diagnostiche e Pediatriche, Università di Pavia; UOC Anestesia e Rianimazione 1, Dipartimento di Medicina Intensiva.

Objectives: The main objective of this study was to analyze intracranial (ICP) and cerebral perfusion pressure (CPP) changes during coiling. We also evaluated the prevalence of rebleeding and outcome in patients monitored earlier (before coiling) and in patients monitored later, after coiling.

Methods: Ninety-nine consecutive poor-grade patients with aneurysmal subarachnoid hemorrhage (aSAH) (grades IV-V of the WFNS) were enrolled in this prospective observational study. Read More

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September 2021

Dynamic causal modeling of the working memory system of aneurysmal subarachnoid hemorrhage patients: Searching for targets for cortical intervention.

Brain Behav 2021 Sep 14:e2307. Epub 2021 Sep 14.

Department of Neurosurgery, The first Hospital of Kunming, Kunming, China.

Introduction: Aneurysmal subarachnoid hemorrhage (aSAH), caused by rupture of an intracranial aneurysm and bleeding into the subarachnoid space, is a life-threatening cerebrovascular disease. Because of improvements in clinical interventions, the mortality rate of aSAH is gradually decreasing. Thus, many survivors recover from aSAH but still have sequelae. Read More

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September 2021

Relationship Between Nutrition Intake and Outcome After Subarachnoid Hemorrhage: Results From the International Nutritional Survey.

J Intensive Care Med 2021 Oct;36(10):1141-1148

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, USA.

Background: A previous study suggested an association between low caloric intake(CI), negative nitrogen balance, and poor outcome after subarachnoid hemorrhage(SAH). Objective of this multinational, multicenter study was to investigate whether clinical outcomes vary by protein intake(PI) or CI in SAH patients adjusting for the nutritional risk as judged by the modified NUTrition Risk in the Critically Ill (mNUTRIC) score.

Methods: The International Nutrition Survey(INS) 2007-2014 was utilized to describe the characteristics, outcomes and nutrition use. Read More

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October 2021

Acute Kidney Injury at the Neurocritical Care Unit.

Neurocrit Care 2021 Sep 13. Epub 2021 Sep 13.

Department of Medicine, Università di Padova, Padua, Italy.

Neurocritical care has advanced substantially in recent decades, allowing doctors to treat patients with more complicated conditions who require a multidisciplinary approach to achieve better clinical outcomes. In neurocritical patients, nonneurological complications such as acute kidney injury (AKI) are independent predictors of worse clinical outcomes. Different research groups have reported an AKI incidence of 11. Read More

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September 2021

Effects of Smoking on Short-Term and Long-Term Mortality after Aneurysmal Subarachnoid Hemorrhage.

Cerebrovasc Dis 2021 Sep 9:1-11. Epub 2021 Sep 9.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Objective: The relationship between smoking and clinical outcomes after aneurysmal subarachnoid hemorrhage (aSAH) is poorly clarified, and current pieces of evidence are inconsistent. The purpose of this multicenter cohort study is therefore to explore the relationship between smoking and mortality as well as several complications after aSAH.

Methods: Databases of patient records were from 4 tertiary hospitals. Read More

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September 2021

Diagnosing Subarachnoid Hemorrhage.

Jonathan Edlow

J Emerg Med 2021 Sep 10. Epub 2021 Sep 10.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, Harvard Medical School, Boston, Massachusetts.

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September 2021

Trends in interventional stroke device utilization during the COVID-19 pandemic.

Clin Neurol Neurosurg 2021 Sep 2;209:106931. Epub 2021 Sep 2.

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Objectives: The collateral effect of the COVID-19 pandemic on interventional stroke care is not well described. We studied this effect by utilizing stroke device sales data as markers of interventional stroke case volume in the United States.

Methods: Using a real-time healthcare device sales registry, this observational study examined trends in the sales of thrombectomy devices and cerebral aneurysm coiling from the same 945 reporting hospitals in the U. Read More

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September 2021

Thrombectomy for distal medium vessel occlusion with a new generation of Stentretriever (Tigertriever 13).

Interv Neuroradiol 2021 Sep 13:15910199211039926. Epub 2021 Sep 13.

Department of Interventional Neuroradiology, 70496Erasme University Hospital, Brussels, Belgium.

Purpose: To evaluate the safety and efficacy of the Tigertriever 13 (Rapid Medical, Yoqneam, Israel) stent retriever in acute ischemic stroke (AIS) patients with primary or secondary distal, medium vessel occlusions (DMVO).

Methods: We performed a retrospective analysis of all consecutive AIS patients who underwent thrombectomy with the Tigertriever13 for DMVO. Patients' characteristics were reviewed, procedural complications, angiographic (modified thrombolysis in cerebral infarction score [mTICI]) and clinical (modified Rankin Scale [mRS]) outcomes were documented. Read More

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September 2021

Safety and efficacy of intravenous tirofiban for stent-assisted coiling in acutely ruptured intracranial aneurysms: A single center experience.

Interv Neuroradiol 2021 Sep 13:15910199211042463. Epub 2021 Sep 13.

Department of Neurosurgery, 89674Zhongnan Hospital of Wuhan University, China.

Background: There have been few reports on the use of tirofiban in ruptured intracranial aneurysms and the results were conflicting. However, the safety and efficacy of optimal dosage and the reasonable treatment course of tirofiban have not been determined.

Objective: To determine the safety and efficacy of a new protocol for its prophylactic tirofiban application during the endovascular treatment of ruptured intracranial aneurysms with no oral antiplatelet medications. Read More

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September 2021

Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome.

J Cereb Blood Flow Metab 2021 Sep 13:271678X211045222. Epub 2021 Sep 13.

Department of Neurology, Faculty of Medicine of University of Porto, Centro Hospitalar Universitário de São João, Porto, Portugal.

Acute stroke is associated with high morbidity and mortality. In the last decades, new therapies have been investigated with the aim of improving clinical outcomes in the acute phase post stroke onset. However, despite such advances, a large number of patients do not demonstrate improvement, furthermore, some unfortunately deteriorate. Read More

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September 2021

Seasonal Variation in Incidence of Stroke in a General Population of 1.4 Million Japanese: The Shiga Stroke Registry.

Cerebrovasc Dis 2021 Aug 27:1-7. Epub 2021 Aug 27.

Department of Neurosurgery, Shiga University of Medical Science, Otsu, Japan.

Introduction: The purpose of this study was to investigate seasonal variation in stroke incidence using data from a large-scale stroke registry of general population in current Japan.

Methods: Shiga Stroke Registry (SSR) is an ongoing population-based registry of stroke that occurred in the Shiga Prefecture in central Honshu, Japan. A total 6,688 cases of first-ever stroke, with onset dates ranging from 1 January 2011 to 31 December in 2013 were included in this study. Read More

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A History of Cerebrovascular Disease Is Independently Associated with Increased Morbidity and Mortality in Patients with COVID-19: A Cohort Study of 369,563 COVID-19 Cases in the USA.

Cerebrovasc Dis 2021 Aug 6:1-9. Epub 2021 Aug 6.

Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.

Objectives: We set out to evaluate the risk for severe coronavirus disease 2019 (COVID-19) infection and subsequent cerebrovascular disease (CVD) in the population with a prior diagnosis of CVD within the past 10 years.

Methods: We utilized the TriNetX Analytics Network to query 369,563 CO-VID-19 cases up to December 30, 2020. We created 8 cohorts of patients with COVID-19 diagnosis based on a previous diagnosis of CVD. Read More

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