8,147 results match your criteria subacute chronic


Weighted gene co-expression network analysis reveals that CXCL10, IRF7, MX1, RSAD2, and STAT1 are related to the chronic stage of spinal cord injury.

Ann Transl Med 2021 Aug;9(15):1248

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.

Background: The process of spinal cord injury involves acute, subacute, and chronic stages; however, the specific pathological mechanism remains unclear. In this study, weighted gene co-expression network analysis (WGCNA) was used to clarify specific modules and hub genes that associated with SCI.

Methods: The gene expression profiles GEO Series (GSE)45006 and GEO Series (GSE)2599 were downloaded, and the co-expression network modules were identified by the WGCNA package. Read More

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Case series of two successful pelvic ring reconstructions using a pedicled anterolateral thigh flap.

JPRAS Open 2021 Dec 10;30:84-90. Epub 2021 Aug 10.

Division of Plastic Surgery, MetroHealth, Cleveland, OH, United States.

Open pelvic ring fractures can have devastating functional consequences including prolonged disability, chronic pain, infection, and even death. These injuries are uncommon but often involve soft tissue defects. Without early and appropriate coverage, patients are likely to sustain infection, which can be fatal. Read More

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December 2021

Fulminant subacute sclerosing panencephalitis (SSPE) presented with acute hemiparesis in a 13-year-old girl with perinatally acquired HIV infection.

BMJ Case Rep 2021 Sep 13;14(9). Epub 2021 Sep 13.

General Medicine, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.

A 13-year-old girl with perinatally acquired HIV infection was admitted to us with acute onset, right-sided hemiparesis of 30 days duration and right-sided myoclonic jerks of 2 days duration affecting the face, upper and lower limbs. On examination, she exhibited increased tone and a pyramidal pattern of weakness in her right upper and lower limbs, along with spontaneous multifocal myoclonic jerks in the affected area. IgG levels in the serum and cerebrospinal fluid for measles were significantly elevated. Read More

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September 2021

Vogt-Koyanagi-Harada disease during prolonged intermittent steroid therapy for chronic obstructive pulmonary disease: a case report.

Pan Afr Med J 2021 3;39:101. Epub 2021 Jun 3.

Department of Radiology, BGS Global Institute of Medical Sciences, Bangalore, India.

Vogt-Koyanagi-Harada Disease (VKHD) is a rare systemic granulomatous autoimmune condition that affects melanocyte-rich organs including the eyes, inner ears, meninges, skin, and hair. VKHD causes chronic uveal inflammation and a loss in visual acuity in some patients. Patients generally respond well to steroid therapy. Read More

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Markers of Central Neuropathic Pain in Higuchi Fractal Analysis of EEG Signals From People With Spinal Cord Injury.

Front Neurosci 2021 26;15:705652. Epub 2021 Aug 26.

Biomedical Engineering Division, University of Glasgow, Glasgow, United Kingdom.

Central neuropathic pain (CNP) negatively impacts the quality of life in a large proportion of people with spinal cord injury (SCI). With no cure at present, it is crucial to improve our understanding of how CNP manifests, to develop diagnostic biomarkers for drug development, and to explore prognostic biomarkers for personalised therapy. Previous work has found early evidence of diagnostic and prognostic markers analysing Electroencephalogram (EEG) oscillatory features. Read More

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Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19.

Int J Gen Med 2021 29;14:4977-4985. Epub 2021 Aug 29.

Department of Nuclear Medicine, Gazi University Medical School, Ankara, Turkey.

Background: In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acute COVID-19 by using biomarkers such as NT-proBNP and nitric oxide (NO) and cardiac imaging modalities. Read More

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Tularemia: A rare cause of pediatric lymph nodes adenitis.

Arch Pediatr 2021 Sep 9. Epub 2021 Sep 9.

Pédiatrie générale et spécialisée, CHU Reims, 51100 Reims, France.

Adenopathy in pediatrics can have many different causes: infectious, tumoral, and inflammatory. We report the case of an 8-year-old patient with a febrile popliteal ulceration associated with an inflammatory satellite inguinal lymph node adenitis. Serological tests and polymerase chain reaction analyses confirmed the diagnosis of ulceroglandular tularemia. Read More

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September 2021

Nurse-led normalised advance care planning service in hospital and community health settings: a qualitative study.

BMC Palliat Care 2021 Sep 9;20(1):139. Epub 2021 Sep 9.

Department of Aged Care Services, Wyong Hospital, PO Box 4200, Central Coast Local Health District, Lakehaven, NSW, 2263, Australia.

Background: Advance Care Planning (ACP) by Registered Nurses (RNs) has been emerging. However, there is limited understanding about what RNs experience as they incorporate ACP into their practice. This study aimed to elicit the experiences of ACP RNs with the implementation of a normalised ACP (NACP) service in hospital and community care settings. Read More

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September 2021

Decision-Making Strategy for the Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD).

J Clin Med 2021 Aug 25;10(17). Epub 2021 Aug 25.

Department of Internal Medicine, Division of Respiratory Diseases, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.

Rheumatoid arthritis (RA) is a common type of autoimmune arthritis. Patient clinical outcomes might be influenced by numerous respiratory diseases, but interstitial lung disease (ILD) is the most important comorbidity. RA-associated ILD (RA-ILD) is divided into acute/subacute and chronic forms. Read More

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Role of Cerebrolysin® in Rehabilitation in Ischemic Stroke: A Case Report.

Am J Case Rep 2021 Sep 8;22:e932365. Epub 2021 Sep 8.

Department of Radiology, Neurological Institute of Thailand, Bangkok, Thailand.

BACKGROUND The criterion standard treatments for ischemic stroke patients, starting from systemic thrombolysis and/or undergoing endovascular recanalization therapy to intensive rehabilitation, are the best options available nowadays, but still cannot achieve total recovery. Neuroprotective and neurotrophic agents seem to be promising therapeutic targets in stroke, even in ischemic and/or hemorrhagic stroke, either in the acute stage or to support neuro-recovery in subacute to chronic stages. Therefore, new therapies are needed as adjuvants in the rehabilitation phase for promoting the recovery and monitoring adverse effects of treatment. Read More

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September 2021

Subacute Herpes Simplex Type 1 Encephalitis: Case Report With Literature Review.

Neurologist 2021 Sep 7;26(5):178-184. Epub 2021 Sep 7.

Department of Neurology/Internal Medicine, Security Forces Hospital, Makkah, Saudi Arabia.

Introduction: The typical herpes simplex viral encephalitis (HSVE) course is an acute illness, less commonly it may present as a chronic course, mainly in children, and rarely may it be subacute. Subacute HSVE is rarely described in the literature being reported 4 times only.

Case Report: We here report 2 cases of subacute HSV1 encephalitis diagnosed based on cerebrospinal fluid polymerase chain reaction and magnetic resonance imaging findings and review the literature trying to find any specific clinical, laboratory, radiologic diagnostic or prognostic criteria regarding this subacute form of HSVE. Read More

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September 2021

Who recovers independent bowel management during the first year following a traumatic spinal cord injury? A case-control study.

Am J Phys Med Rehabil 2021 Sep 2. Epub 2021 Sep 2.

Faculty of Medicine, University of Montreal, Pavillon Roger-Gaudry, S-749, C.P. 6128, succ. Centre-ville, Montreal, Quebec, H3C 3J7, Canada Hôpital du Sacré-Cœur de Montréal, 5400 Gouin Boul. West, Montreal, Quebec, H4J 1C5, Canada Sainte-Justine University Hospital Research Center, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada.

Objectives: 1) document the characteristics of patients with impaired bowel functioning during the subacute and chronic phases; 2) identify factors associated with recovery of independent bowel functioning during the first year following TSCI in patients who present impaired bowel functioning during the subacute phase, when bowel rehabilitation is completed.

Design: Case-control study on 123 adult TSCI patients. Bowel function assessments using item 7 of the SCIM-III were obtained 3-months following TSCI and during the early chronic phase. Read More

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September 2021

Effect of ankle-foot orthoses on functional outcome measurements in individuals with stroke: a systematic review and meta-analysis.

Disabil Rehabil 2021 Sep 5:1-16. Epub 2021 Sep 5.

Proteomics Research Center, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To determine and compare the effect of ankle-foot orthosis (AFOs) types on functional outcome measurements in individuals with (sub)acute or chronic stroke impairments.

Methods: PubMed, Web of Knowledge, Embase, Scopus, ProQuest, and Cochrane were searched from inception until September 2020. Methodological quality assessment of 30 studies was conducted based on the Downs and Black checklist. Read More

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September 2021

Scalable culture techniques to generate large numbers of purified human Schwann cells for clinical trials in human spinal cord and peripheral nerve injuries.

J Neurosurg Spine 2021 Sep 3:1-10. Epub 2021 Sep 3.

1The Miami Project to Cure Paralysis.

Objective: Schwann cells (SCs) have been shown to play an essential role in axon regeneration in both peripheral nerve injuries (PNIs) and spinal cord injuries (SCIs). The transplantation of SCs as an adjunctive therapy is currently under investigation in human clinical trials due to their regenerative capacity. Therefore, a reliable method for procuring large quantities of SCs from peripheral nerves is necessary. Read More

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September 2021

Organizing a Rational Approach to Treatments of Disorders of Consciousness Using the Anterior Forebrain Mesocircuit Model.

J Clin Neurophysiol 2021 Aug 30. Epub 2021 Aug 30.

Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, U.S.A.

Summary: Organizing a rational treatment strategy for patients with multifocal structural brain injuries and disorders of consciousness (DOC) is an important and challenging clinical goal. Among potential clinical end points, restoring elements of communication to DOC patients can support improved patient care, caregiver satisfaction, and patients' quality of life. Over the past decade, several studies have considered the use of the anterior forebrain mesocircuit model to approach this problem because this model proposes a supervening circuit-level impairment arising across DOC of varying etiologies. Read More

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Efficacy of Normalisation of Advance Care Planning (NACP) for people with chronic diseases in hospital and community settings: a quasi-experimental study.

BMC Health Serv Res 2021 Sep 1;21(1):901. Epub 2021 Sep 1.

Hunter Medical Research Institute, Lot 1, Kookaburra Circuit, New Lambton Heights, Newcastle, NSW, 2305, Australia.

Background: Advance Care Planning (ACP) has emerged to improve end-of-life processes and experiences. However, the available evidence presents the gloomy picture of increasing number of older people living with chronic diseases and the mismatch between their preferences for and the actual place of death. The study aimed to investigate the efficacy of normalisation of an Advance Care Planning (NACP) service delivered by specially trained Registered Nurses (RNs) in hospital and community settings. Read More

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September 2021

Automated Detection of Ischemic Stroke and Subsequent Patient Triage in Routinely Acquired Head CT.

Clin Neuroradiol 2021 Aug 31. Epub 2021 Aug 31.

Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.

Purpose: Advanced machine-learning (ML) techniques can potentially detect the entire spectrum of pathology through deviations from a learned norm. We investigated the utility of a weakly supervised ML tool to detect characteristic findings related to ischemic stroke in head CT and provide subsequent patient triage.

Methods: Patients having undergone non-enhanced head CT at a tertiary care hospital in April 2020 with either no anomalies, subacute or chronic ischemia, lacunar infarcts of the deep white matter or hyperdense vessel signs were retrospectively analyzed. Read More

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Effectiveness of deep cervical fascial manipulation and yoga postures on pain, function, and oculomotor control in patients with mechanical neck pain: study protocol of a pragmatic, parallel-group, randomized, controlled trial.

Trials 2021 Aug 28;22(1):574. Epub 2021 Aug 28.

Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.

Introduction: Mechanical neck pain (MNP) is a commonly occurring musculoskeletal condition that is usually managed using electrical modalities, joint mobilization techniques, and therapeutic exercises, but has limited evidence of their efficacy. Pathology (densification) of the deep cervical fascia that occurs due to the increased viscosity of hyaluronic acid (HA) may induce neck pain and associated painful symptoms of the upper quarter region. Fascial manipulation (FM) and yoga poses are considered to reduce the thixotropy of the ground substances of the deep fascia and improve muscle function. Read More

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COVID-19 and exacerbation of dermatological diseases: A review of the available literature.

Dermatol Ther 2021 Aug 27:e15113. Epub 2021 Aug 27.

Network of Dermatology Research (NDR), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Since the emergence of the new coronavirus disease 19 (COVID-19) pandemic, there has been a concern for the patients with chronic autoimmune diseases including dermatological conditions over the potential exacerbation of these underlying conditions after infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV2). We performed a systematic review to evaluate presentations, postinfection change in the manifestation, diagnosis, and management of flare-ups of underlying dermatologic disease in patients with COVID-19. A total of 17 articles were recovered reporting on flare-ups of dermatological disease including pemphigus vulgaris, psoriasis, subacute cutaneous lupus erythematosus, acrodermatitis continua of Hallopeau, systemic sclerosis sine scleroderma, and Sézary syndrome (SS). Read More

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Neurological and psychiatric effects of hepatitis C virus infection.

World J Gastroenterol 2021 Aug;27(29):4846-4861

Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome 00185, Italy.

Hepatitis C virus (HCV) infection is widespread and affects 71 million people worldwide. Although hepatic manifestations are the most frequent, ranging from chronic hepatitis to cirrhosis and hepatocellular carcinoma, it is also associated with several extrahepatic manifestations. Infected patients may present non-specific neurological symptoms, regardless of the presence of liver cirrhosis. Read More

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A Retrospective Analysis of Pain Etiology in Middle-Aged Patients with Peripheral Neuropathy.

Medicina (Kaunas) 2021 Jul 31;57(8). Epub 2021 Jul 31.

Department of Neurology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland.

: Correct assessment and a multidisciplinary approach appear to be extremely important in preventing peripheral neuropathy and its complications. The purpose of this study was to find the correlations and dissimilarities between different types of peripheral neuropathy, the occurrence of pain, and laboratory results. : This retrospective study assessed 124 patients who were hospitalized in our neurology department due to various types of sensory or motor disturbances. Read More

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Negative impacts of microcystin-LR and glyphosate on zebrafish intestine: Linked with gut microbiota and microRNAs?

Environ Pollut 2021 Oct 1;286:117685. Epub 2021 Jul 1.

College of Life Science, Henan Normal University, Xinxiang, Henan, 453007, China.

Microcystin-LR (MC-LR) and glyphosate (GLY) have been classified as a Group 2B and Group 2A carcinogens for humans, respectively, and frequently found in aquatic ecosystems. However, data on the potential hazard of MC-LR and GLY exposure to the fish gut are relatively scarce. In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 μg L) and GLY (3. Read More

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October 2021

Prurigo Simplex or "Itchy Red Bump" Disease: Review and Case Series.

Acta Derm Venereol 2021 Sep 3;101(9):adv00539. Epub 2021 Sep 3.

Department of Clinical Sciences Lund, Dermatology and Venereology, Lund University, Skane University Hospital, SE-221 85 Lund, Sweden.

Prurigo simplex or "itchy red bump" disease is a controversial pruritic papular eruption. The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: "prurigo simplex", "prurigo simplex subacuta", "subacute prurigo", "chronic papular dermatitis in adults" and "itchy red bump disease". Read More

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September 2021

A Case-Control Study of Paracoccidioidomycosis in Women: The Hormonal Protection Revisited.

J Fungi (Basel) 2021 Aug 13;7(8). Epub 2021 Aug 13.

Laboratorio de Investigacao em Imunologia e Dermatologia (LIM56), Departamento de Dermatologia and Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de Sao Paulo, SP, R. Dr. Enéas de Carvalho Aguiar 470, São Paulo 05403-000, Brazil.

Clinical observations have long suggested that women are protected against paracoccidioidomycosis. 17β-estradiol, the main female estrogen, inhibits conidia-to-yeast transformation (C-to-Y), which is required for the infection establishment. However, experiments in murine models have yielded conflicting results, suggesting that C-to-Y inhibition, alone, fails to explain the female-associated protection and that sexual hormones may also act by modulating the host's immune responses. Read More

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Acute and Chronic Effects of Multiple Concussions on Midline Brain Structures.

Neurology 2021 Aug 25. Epub 2021 Aug 25.

Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada

Objective: To test the hypothesis that a history of concussion (HOC) causes greater disturbances in cerebral blood flow (CBF) and white matter microstructure of midline brain structures after subsequent concussions, during the acute and chronic phases of recovery.

Methods: In this longitudinal magnetic resonance imaging (MRI) study, 61 athletes with uncomplicated concussion (36 with HOC) were imaged at the acute phase of injury (1 to 7 days post-injury), the subacute phase (8 to 14 days), medical clearance to return to play (RTP), one month post-RTP and one year post-RTP. A normative group of 167 controls (73 with HOC) were also imaged. Read More

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Combining K-72 Hepatic Failure with 15 Individual T-Codes to Identify Patients with Idiosyncratic Drug-Induced Liver Injury in the Electronic Medical Record.

Dig Dis Sci 2021 Aug 24. Epub 2021 Aug 24.

Division of Gastroenterology and Hepatology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI, 48109, USA.

Background: The aim of this study was to determine the utility of combining three K72 codes (hepatic failure) with 15 individual T-Codes (drug toxicity/poisoning) to identify potential DILI cases.

Methods: The EMR was searched for encounters that had a K72 code combined with a T-code that also met minimal liver injury laboratory criteria between 10/1/15 and 9/30/18. After manual chart review, a DILIN expert opinion causality score (1-5) was assigned to each case. Read More

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Not All Lesioned Tissue Is Equal: Identifying Pericavitational Areas in Chronic Stroke With Tissue Integrity Gradation T2w T1w Ratio.

Front Neurosci 2021 5;15:665707. Epub 2021 Aug 5.

Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, GA, United States.

Stroke-related tissue damage within lesioned brain areas is topologically non-uniform and has underlying tissue composition changes that may have important implications for rehabilitation. However, we know of no uniformly accepted, objective non-invasive methodology to identify pericavitational areas within the chronic stroke lesion. To fill this gap, we propose a novel magnetic resonance imaging (MRI) methodology to objectively quantify the lesion core and surrounding pericavitational perimeter, which we call tissue integrity gradation T2w T1w ratio (TIGR). Read More

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A Self-Limited Facial Rash in a Lupus Patient: The Case of Primary Facial Raynaud's Phenomenon.

Case Rep Dermatol 2021 May-Aug;13(2):366-371. Epub 2021 Jul 16.

Department of Medicine, Nephrology Unit, Amiri Hospital, Ministry of Health, Kuwait City, Kuwait.

Skin is involved in 80% of systemic lupus erythematosus (SLE) and the second most affected after joint disease. Lupus-specific lesions include (a) acute ones viz. malar rash (80%), (b) subacute ones viz. Read More

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Budd-Chiari syndrome computed tomographic imaging: Elucidating the devil in the details.

J Pak Med Assoc 2021 Jul;71(7):1889-1892

Department of Cardiovascular Medicine, Oxford University, Oxford, United Kingdom.

Hepatic venous outflow obstruction, due to hepatic venous thrombosis is the hallmark of Budd-Chiari Syndrome (BCS), a relatively uncommon disorder. The aim of this study was to explore imaging details and causes, and define invasive and non-invasive interventions for achieving successful portosystemic shunting (PSS). The variations in imaging topology and associated risk factors in BCS cases, diagnosed during the past 20 months, were studied. Read More

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RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury.

Acta Neuropathol Commun 2021 08 17;9(1):138. Epub 2021 Aug 17.

Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig-Maximilians University Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.

Traumatic brain injury (TBI) causes acute and subacute tissue damage, but is also associated with chronic inflammation and progressive loss of brain tissue months and years after the initial event. The trigger and the subsequent molecular mechanisms causing chronic brain injury after TBI are not well understood. The aim of the current study was therefore to investigate the hypothesis that necroptosis, a form a programmed cell death mediated by the interaction of Receptor Interacting Protein Kinases (RIPK) 1 and 3, is involved in this process. Read More

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