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Difficulties encountered by physicians and mental health professionals in evaluating and caring for affective and behavioral problems in pediatric brain tumor survivors.

Support Care Cancer 2021 May 14. Epub 2021 May 14.

Psycho-Oncology Unit, Gustave Roussy, 114, Rue Edouard Vaillant, 94805, Villejuif Cedex, France.

Background: Pediatric brain tumor survivors (PBTS) present a high risk for emotional and behavioral disorders. When addressing these difficulties, differences in study designs; variety of and disagreement about diagnoses; and intricate links of emotional, behavioral, and cognitive issues may complicate the interpretation of studies and probably also the work of clinicians. We aimed to survey the difficulties perceived by physicians and mental health professionals in their practice and their interest in developing a new evaluative tool. Read More

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Natalizumab discontinuation in a Dutch real-world cohort.

Mult Scler Relat Disord 2021 Apr 24;52:102974. Epub 2021 Apr 24.

Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Objective: To determine characteristics of multiple sclerosis patients that discontinued natalizumab treatment in a real-world cohort.

Methods: Data was collected from an ongoing observational cohort study of all natalizumab treated patients at the Amsterdam UMC.

Results: Of 253 patients who ever received natalizumab treatment, 147 have discontinued treatment. Read More

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Positive airway pressure (PAP) treatment reduces glycated hemoglobin (HbA1c) levels in obstructive sleep apnea patients with concomitant weight loss: Longitudinal data from the ESADA.

J Sleep Res 2021 May 14:e13331. Epub 2021 May 14.

Department of Chest Diseases, Ege University Faculty of Medicine, Izmir, Turkey.

Patients with obstructive sleep apnea (OSA) are at increased risk of developing metabolic disease such as diabetes. The effects of positive airway pressure on glycemic control are contradictory. We therefore evaluated the change in glycated hemoglobin (HbA1c) in a large cohort of OSA patients after long-term treatment with positive airway pressure. Read More

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A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States.

Sci Rep 2021 May 13;11(1):10231. Epub 2021 May 13.

Division of Cardiovascular Disease, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall B140, Birmingham, AL, 35294-0019, USA.

Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children. The reopening of schools underlines the importance of understanding the epidemiology of pediatric COVID-19 infections. Read More

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Zn-Imidazole Coordination Crosslinks for Elastic Polymeric Binders in High-Capacity Silicon Electrodes.

Adv Sci (Weinh) 2021 May 2;8(9):2004290. Epub 2021 Mar 2.

School of Chemical and Biological Engineering and Institute of Chemical Process Seoul National University 1 Gwanak-ro, Gwanak-gu Seoul 08826 Republic of Korea.

Recent research has built a consensus that the binder plays a key role in the performance of high-capacity silicon anodes in lithium-ion batteries. These anodes necessitate the use of a binder to maintain the electrode integrity during the immense volume change of silicon during cycling. Here, Zn-imidazole coordination crosslinks that are formed to carboxymethyl cellulose backbones in situ during electrode fabrication are reported. Read More

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A sequence analysis of hospitalization patterns and service utilization in patients with major psychiatric disorders in China.

BMC Psychiatry 2021 May 11;21(1):245. Epub 2021 May 11.

Department of Psychiatry and Behavioral Sciences, Emory University, 12 Executive Park Drive NE, Suite 300, Atlanta, GA, USA; Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA, USA.

Background: Understanding the long-term inpatient service cost and utilization of psychiatric patients may provide insight into service demand for these patients and guide the design of targeted mental health programs. This study assesses 3-year hospitalization patterns and quantifies service utilization intensity of psychiatric patients in Beijing, China.

Methods: We identified patients admitted for one of three major psychiatric disorders (schizophrenia, bipolar and depressive disorders) between January 1 and December 31, 2013 in Beijing, China. Read More

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The impact of severe rare chronic neurological disease in childhood on the quality of life of families-a study on MLD and PCH2.

Orphanet J Rare Dis 2021 May 10;16(1):211. Epub 2021 May 10.

Department of Child Neurology, Children's Hospital, University of Tübingen, Hoppe-Seyler-Str. 1, 72072, Tübingen, Germany.

Background: Rare and severe neurological disorders in childhood not only heavily affect the life perspective of the patients, but also their caregivers and families. The aim of this study was to investigate the impact of such diseases on the family, especially on the quality of life and life perspectives of parents, but also on the families' everyday life, based on the model of two diseases which have been well described in recent years with respect to symptoms and course: metachromatic leukodystrophy (MLD) and pontocerebellar hypoplasia type 2 (PCH2). PCH2 is a primary severe developmental disorder, while children with MLD initially develop normally and then progressively deteriorate. Read More

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Risk of Infection after Deep Brain Stimulation Surgery with Externalization and Local-Field Potential Recordings: Twelve-Year Experience from a Single Institution.

Stereotact Funct Neurosurg 2021 May 10:1-9. Epub 2021 May 10.

Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Introduction: Deep brain stimulation (DBS) has been an established surgical procedure in the field of functional neurosurgery for many years. The experimental electrophysiological method of local field potential (LFP) recordings in postsurgically externalized patients has made substantial contributions to the better understanding of pathophysiologies underlying movement disorders. As interest in LFP recordings for the development of improved stimulation strategies increases, this study's aim was to provide evidence concerning safety of this research method, in a major DBS center. Read More

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Sensitivity of bovine tuberculosis surveillance through intradermal tests in cattle in France: An evaluation of different scenarios.

Prev Vet Med 2021 Apr 24;191:105364. Epub 2021 Apr 24.

INRAE, Oniris, BIOEPAR, 44300, Nantes, France. Electronic address:

The current situation regarding bovine tuberculosis (bTB) in Europe is spatially heterogeneous, with stagnating or increasing trends in bTB prevalence in many European regions, underlying the challenge in controlling this disease. In France, in spite of the implementation of two control programs in 2010-2012 to eradicate the disease and maintain the bTB-free status, bTB prevalence has continued to increase, underlying the need to reinforce and adapt surveillance measures. The goal of this study was to evaluate the effectiveness of bTB surveillance in high-risk areas in metropolitan France, with an emphasis on the criteria to select herds and animals within herds in the context of programmed surveillance and movement testing. Read More

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Co-exposures of TiO nanoparticles and cadmium ions at non-lethal doses aggravates liver injury in mice with ConA-induced hepatitis.

Environ Toxicol Pharmacol 2021 May 6;86:103669. Epub 2021 May 6.

School of Environmental Sciences and Engineering, Shandong University, Qingdao, 266237, China; Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, 510006, China. Electronic address:

The wide applications of titanium dioxide nanoparticles (TNP) and ubiquitous cadmium (Cd) pollution increase the chances of their co-existence in the environment and also pose potential health risks to humans. However, toxicological understanding of effects of co-exposures of TNP and Cd to mammals is still lacking. In this study, non-lethal doses of TNP and CdCl were intravenously co-administered to healthy or Concanavalin A (ConA)-induced acute hepatitis mice. Read More

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Pathological Response and Survival after Neoadjuvant Therapy for Her-2 Positive Breast Cancer.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):91-97

Pathological complete response (pCR) after neoadjuvant systemic treatment represents a good surrogate marker for the prognosis of Her-2 positive Breast Cancer (BCs). The results improved after adding anti-Her-2 therapy to chemotherapy in neoadjuvant setting. Our retrospective study enrolled a cohort of 56 invasive Her-2 positive non-metastatic BCs treated with neoadjuvant systemic therapy between 2001 and 2018. Read More

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Disentangling substance use and related problems: urgency predicts substance-related problems beyond the degree of use.

BMC Psychiatry 2021 May 7;21(1):242. Epub 2021 May 7.

Institute of Clinical Psychology and Psychotherapy, Chair of Addiction Research, Faculty of Psychology, Technische Universität Dresden, Chemnitzer Str. 46a, 01187, Dresden, Germany.

Background: Substance use disorders are reliably associated with high impulsivity and sensation seeking. Importantly, both precede problematic substance use, implicating them as risk factors. Individuals with substance use disorders show variable degrees of substance use (combined quantity and frequency) and substance-related problems and differ in both aspects from healthy controls. Read More

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Lessons from the impact of COVID-19 on medical educational continuity and practices.

Adv Physiol Educ 2021 Jun;45(2):390-398

Faculté de Médecine, Sorbonne Université, Paris, France.

The COVID-19 crisis necessitated abrupt transition to remote learning in medical schools. We aimed to assess the impact of COVID-19 on French undergraduate students and teachers, to identify practice changes, and to evaluate successes and areas for improvement of this remote learning experience. Data from 2 online questionnaires were analyzed with 509 participants among students and 189 among teachers from Sorbonne University. Read More

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Color-dependent changes in humans during a verbal fluency task under colored light exposure assessed by SPA-fNIRS.

Sci Rep 2021 May 6;11(1):9654. Epub 2021 May 6.

University of Bern, Institute of Complementary and Integrative Medicine, Fabrikstrasse 8, 3012, Bern, Switzerland.

Light evokes robust visual and nonvisual physiological and psychological effects in humans, such as emotional and behavioral responses, as well as changes in cognitive brain activity and performance. The aim of this study was to investigate how colored light exposure (CLE) and a verbal fluency task (VFT) interact and affect cerebral hemodynamics, oxygenation, and systemic physiology as determined by systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS). 32 healthy adults (17 female, 15 male, age: 25. Read More

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Burden of disease and lifestyle habits in adolescents and young adults prone to frequent episodic migraine: A secondary comparative analysis.

J Child Health Care 2021 May 6:13674935211008712. Epub 2021 May 6.

Department of Pediatric Neurology and Developmental Medicine and LMU Center for Children with Medical Complexity, Dr von Hauner Children's Hospital, LMU Hospital, 54187Ludwig-Maximilians-Universität, Germany.

The objective of this study was to assess the burden of disease and prevalence of lifestyle factors for adolescents and young adults with frequent episodic migraine. We conducted a secondary comparative analysis of data collected during two previous studies. Inclusion criteria for this analysis were age 15-35 years, 15 to 44 migraine episodes within 12 weeks, and completeness of Migraine Disability Assessment and lifestyle questionnaire data. Read More

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How do healthcare providers respond to multiple funding flows? A conceptual framework and options to align them.

Health Policy Plan 2021 May 5. Epub 2021 May 5.

Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.

Provider payment methods are a key health policy lever because they influence healthcare provider behaviour and affect health system objectives, such as efficiency, equity, financial protection and quality. Previous research focused on analysing individual provider payment methods in isolation, or on the actions of individual purchasers. However, purchasers typically use a mix of provider payment methods to pay healthcare providers and most health systems are fragmented with multiple purchasers. Read More

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Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis.

Eur J Nucl Med Mol Imaging 2021 May 3. Epub 2021 May 3.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Purpose: Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT for treatment monitoring in LVV. Read More

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Are self-reported and self-monitored adherence good proxies for reaching relevant plasma concentrations?: Experiences from a study of anti-depressants in healthy volunteers.

Clin Trials 2021 May 2:17407745211012683. Epub 2021 May 2.

Department of Value Evidence Analytics, H. Lundbeck A/S, Copenhagen, Denmark.

Background: The use of electronic-based devices to measure and to improve adherence of subjects in clinical trials is increasing. AiCure has developed a mobile technology that is claimed to provide visual confirmation of drug ingestion. While there is evidence suggesting that including such self-monitoring device in a study increases adherence, the quality of the data produced by the device may be questionable. Read More

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Impact of Minimally Invasive Aesthetic Procedures on the Psychological and Social Dimensions of Health.

Darren J McKeown

Plast Reconstr Surg Glob Open 2021 Apr 28;9(4):e3578. Epub 2021 Apr 28.

Aesthetic Medicine Institute, Glasgow, United Kingdom.

Background: The impact on psychosocial health of injectable facial treatments such as hyaluronic acid fillers and botulinum toxin type A remains poorly defined. The aim of this study was to measure changes in psychosocial health following aesthetic intervention with injectables in routine clinical practice using the validated FACE-Q patient-reported outcome measure.

Methods: This was a prospective assessment of patients presenting at a single center for the first time for aesthetic treatment of the face with injectables in February 2020. Read More

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Multi-objective optimization to improve energy, economic and, environmental life cycle assessment in waste-to-energy plant.

Waste Manag 2021 Apr 29;127:147-157. Epub 2021 Apr 29.

Networked Value Systems, Department of Production, University of Vaasa, P.O. Box 700, FI-65100 Vaasa, Finland. Electronic address:

This paper presents a multi-objective optimization (MOO) of waste-to-energy (WtE) to investigate optimized solutions for thermal, economic, and environmental objectives. These objectives are represented by net efficiency, total cost in treating waste, and environmental impact. Integration of the environmental objective is conducted using life cycle assessment (LCA) with endpoint single score method covering direct combustion, reagent production and infrastructure, ash management, and energy recovery. Read More

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A Prospective Single-Arm Study Evaluating the Effects of a Multimodal Physical Therapy Intervention on Psychosexual Outcomes in Women With Dyspareunia After Gynecologic Cancer.

J Sex Med 2021 Apr 27. Epub 2021 Apr 27.

School of Rehabilitation, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada; Research Center of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. Electronic address:

Background: Dyspareunia affects most women after treatment for gynecologic malignancies. However, to date, evidence-based interventions remain limited and no study has examined the effects of multimodal physical therapy on psychosexual outcomes in these patients.

Aim: To assess the effects of multimodal physical therapy on psychosexual outcomes including sexual distress, body image concerns, pain anxiety, pain catastrophizing, pain self-efficacy and depressive symptoms in women with dyspareunia after treatment for gynecologic malignancies. Read More

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[Prospective Cohort Study of In-Hospital Patients Undergoing Ophthalmic Surgery for the Validation of ClassIntra: Classification of Intraoperative Adverse Events].

Klin Monbl Augenheilkd 2021 Apr 30;238(4):510-520. Epub 2021 Apr 30.

Anästhesie, Universitätsspital Basel, Schweiz.

Background: To the best of our knowledge, there is no validated classification to assess intraoperative adverse events (iAEs) in ophthalmic surgery. ClassIntra is a newly developed classification for surgery- and anaesthesia-related iAEs that has been recently validated in various surgical disciplines, but not in ophthalmic surgery. We aim to assess the validity and practicability of ClassIntra in patients undergoing ophthalmic surgery. Read More

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Cognitive emotion regulation withstands the stress test: An fMRI study on the effect of acute stress on distraction and reappraisal.

Neuropsychologia 2021 Apr 28;157:107876. Epub 2021 Apr 28.

Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany; Leibniz Institute for Resilience Research (LIR), Research Group Wessa, Mainz, Germany. Electronic address:

Cognitive emotion regulation is a key mechanism for the maintenance of mental health, but may fail, when individuals are exposed to acute stress. To date, it is not well understood whether and to what extent acute stress effects contribute to impairments in emotion regulation capacities as the sparse existing studies have yielded heterogeneous results, indicating that stress timing might be a crucial factor. In the present study, 81 healthy participants underwent either an acute stress task (ScanSTRESS-C; n = 40) or a control condition (n = 41) while lying in the MRI scanner. Read More

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Prevalence of depressive symptoms among older children and young adolescents: a longitudinal population-based study.

Scand J Child Adolesc Psychiatr Psychol 2021 23;9:64-72. Epub 2021 Apr 23.

Faculty of Nursing and Health Sciences, Nord University, Levanger.

Introduction: This paper investigates levels of depressive symptoms among older children and young adolescents, 11-14 years of age. The population-based sample was assessed twice during a 12-month period. Point-prevalence, 12-month prevalence, and 12-month incidence were measured by a validated self-reported scale (SFMQ) and are presented in this paper. Read More

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Adverse health manifestations in the hands of vibration exposed carpenters - a cross sectional study.

J Occup Med Toxicol 2021 Apr 29;16(1):16. Epub 2021 Apr 29.

Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.

Background: Despite EU regulatory standards, many workers suffer injury as a result of working with hand-held vibrating tools. Our aim of this study was to confirm whether carpenters, a highly exposed group, suffer more injuries to their hands than painters, a group assumed to be less exposed to vibration.

Methods: 193 carpenters (participation rate 100%) and 72 painters (participation rate 67%), all men, answered a questionnaire and underwent a clinical examination to identify manifestations of neural and vascular origin in the hands. Read More

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Scaffold-Type Structure Dental Ceramics with Different Compositions Evaluated through Physicochemical Characteristics and Biosecurity Profiles.

Materials (Basel) 2021 Apr 27;14(9). Epub 2021 Apr 27.

Department of Prostheses Technology and Dental Materials, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Ave., 300070 Timisoara, Romania.

The design and development of ceramic structures based on 3D scaffolding as dental bone substitutes has become a topic of great interest in the regenerative dentistry research area. In this regard, the present study focuses on the development of two scaffold-type structures obtained from different commercial dental ceramics by employing the foam replication method. At the same time, the study underlines the physicochemical features and the biological profiles of the newly developed scaffolds, compared to two traditional Cerabone materials used for bone augmentation, by employing both the in vitro Alamar blue proliferation test at 24, 48 and 96 h poststimulation and the in ovo chick chorioallantoic membrane (CAM) assay. Read More

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Using Exome Sequencing to Improve Prediction of FOLFIRINOX First Efficacy for Pancreatic Adenocarcinoma.

Cancers (Basel) 2021 Apr 13;13(8). Epub 2021 Apr 13.

Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-Unicancer, 1 rue du Professeur Marion, 21000 Dijon, France.

Purpose: The first line treatment of advanced pancreatic ductal adenocarcinoma cancer (PDAC) comprises a FOLFIRINOX regimen for most patients with good performance status. However, no biomarker to predict efficacy is currently available. We investigated whether exome sequencing could be used to predict progression-free and overall survival in patients undergoing FOLFIRINOX for PDAC. Read More

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Loneliness, Wellbeing, and Social Activity in Scottish Older Adults Resulting from Social Distancing during the COVID-19 Pandemic.

Int J Environ Res Public Health 2021 04 24;18(9). Epub 2021 Apr 24.

Faculty of Health Sciences and Sport, University of Stirling, Stirling FK9 4LA, UK.

This study examined the impact of social distancing during the COVID-19 pandemic on loneliness, wellbeing, and social activity, including social support, in Scottish older adults. A mixed methods online survey was used to examine these factors during social distancing mid-lockdown, July 2020. Participants were asked to state whether loneliness, wellbeing, social activity, and social support had changed since pre-social distancing, and to provide details of strategies used to keep socially active. Read More

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Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations.

Cancers (Basel) 2021 Apr 25;13(9). Epub 2021 Apr 25.

Department of Pediatric Hematology, Oncology and BMT, University Hospital Muenster, 48149 Münster, Germany.

Despite poor survival, controversies remain in the treatment for refractory or relapsed pediatric non-Hodgkin lymphoma (r/r NHL). The current project aimed to collect international experience on the re-induction treatment of r/r NHL, hematopoietic stem cell transplantation (HSCT), risk factors associated with outcome, and to suggest treatment recommendations. Inclusion criteria were (i) refractory disease, disease progression or relapse of any NHL subtype except anaplastic large cell lymphoma, (ii) age < 18 years at initial diagnosis, (iii) diagnosis in/after January 2000. Read More

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A Qualitative Evaluation of a Mother and Child Center Providing Psychosocial Support to Newly Arrived Female Refugees in a Registration and Reception Center in Germany.

Int J Environ Res Public Health 2021 Apr 23;18(9). Epub 2021 Apr 23.

Center for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, 69115 Heidelberg, Germany.

Female refugees are frequently exposed to sexualized, gender-based violence and harassment before, during, and after their flight. Yet female refugee-specific care and protection needs are rarely addressed in host countries. This study aimed to evaluate a mother and child center (MUKI) for female refugees in a reception and registration center in Germany. Read More

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