173,020 results match your criteria study ten


The effect of musculoskeletal model scaling methods on ankle joint kinematics and muscle force prediction during gait for children with cerebral palsy and equinus gait.

Comput Biol Med 2021 May 5;134:104436. Epub 2021 May 5.

Department of Exercise Sciences, The University of Auckland, Auckland, New Zealand. Electronic address:

Clinical gait analysis incorporated with neuromusculoskeletal modelling could provide valuable information about joint movements and muscle functions during ambulation for children with cerebral palsy (CP). This study investigated how imposing pre-calculated joint angles during musculoskeletal model scaling influence the ankle joint angle and muscle force computation. Ten children with CP and equinus gait underwent clinical gait analysis. Read More

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Ethnopharmacology, biological activities and chemical compounds of Canarium strictum: An important resin-yielding medicinal tree in India.

Fitoterapia 2021 May 10:104920. Epub 2021 May 10.

Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, P.O. Box 1068, 0316 Oslo, Norway. Electronic address:

The resin of Canarium strictum Roxb. is used for rheumatism and asthma; the bark is used as a mosquito repellent. The major compounds in the resin are triterpenoids, but as no studies have been performed on the bark, this study investigated this economically important resource. Read More

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Mental-physical multimorbidity treatment adherence challenges in Brazilian primary care: A qualitative study with patients and their healthcare providers.

PLoS One 2021 13;16(5):e0251320. Epub 2021 May 13.

Public Health Postgraduate Program, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

Improved understanding of multimorbidity (MM) treatment adherence in primary health care (PHC) in Brazil is needed to achieve better healthcare and service outcomes. This study explored experiences of healthcare providers (HCP) and primary care patients (PCP) with mental-physical MM treatment adherence. Adults PCP with mental-physical MM and their primary care and community mental health care providers were recruited through maximum variation sampling from nine cities in São Paulo State, Southeast of Brazil. Read More

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Correlation between the immuno-virological response and the nutritional profile of treatment-experienced HIV-infected patients in the East region of Cameroon.

PLoS One 2021 13;16(5):e0229550. Epub 2021 May 13.

Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon.

Background: HIV management remains concerning and even more challenging in the frame of comorbidities like malnutrition that favors disease progression and mortality in resource-limited settings (RLS).

Objective: To describe the nutritional parameters of antiretroviral therapy (ART) recipients (without nutritional support) with respect to CD4 count and virological failure.

Methods: A cross-sectional study was conducted from October to December 2018 among 146 consenting participants enrolled in two health facilities of the East-Region of Cameroon. Read More

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3D whole-brain metabolite imaging to improve characterization of low-to-intermediate grade gliomas.

J Neurooncol 2021 May 13. Epub 2021 May 13.

Department of Radiology and Imaging Sciences, Winship Cancer Institute of Emory University, Emory University School of Medicine, 1701 Uppergate Drive, C5018, Atlanta, GA, 30322, USA.

Purpose: MRI is the standard imaging modality used for diagnosis, treatment planning, and post-treatment management of gliomas. Contrast-enhanced T1-weighted (CE-T1w) MRI is used to plan biopsy and radiation for grade IV gliomas but is less effective for grade II and III gliomas (i.e. Read More

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Predicting Mycoplasma pneumoniae and Chlamydophila pneumoniae in community-acquired pneumonia (CAP) pneumonia: epidemiological study of respiratory tract infection using multiplex PCR assays.

Intern Emerg Med 2021 May 13. Epub 2021 May 13.

Department of Primary Care and Medical Education, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Community-acquired pneumonia (CAP) is a common illness that can lead to mortality. β-lactams are ineffective against atypical pathogen including Mycoplasma pneumoniae. We used molecular examinations to develop a decision tree to predict atypical pathogens with CAP and to examine the prevalence of macrolide resistance in Mycoplasma pneumoniae. Read More

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Evaluation of the Allied Health Rural Generalist Program 2017-2019.

Aust J Rural Health 2021 Apr;29(2):158-171

James Cook University, Cairns, QLD, Australia.

Objective: To evaluate the development and implementation of the Allied Health Rural Generalist Program, a two-level online post-graduate education program, which includes Level 1, an entry-level non-award pathway program, and Level 2, a Graduate Diploma in Rural Generalist Practice.

Design: A convergent mixed methodology evaluation in two overlapping stages: a process evaluation on quality and reach, together with a mixed method case study evaluation on benefits, of the program.

Setting: Rural and remote Australia across ten sites and seven allied health professions: dietetics; occupational therapy; pharmacy; physiotherapy; podiatry; radiography; speech pathology. Read More

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Identification of potential core genes and pathways predicting pathogenesis in head and neck squamous cell carcinoma.

Biosci Rep 2021 May 13. Epub 2021 May 13.

China Medical University, Shenyang, China.

Head and neck squamous cell carcinoma (HNSCC) is the most common subtype of head and neck cancer; however, its pathogenesis and potential therapeutic targets remain largely unknown. In this study, we analyzed three gene expression profiles and screened differentially expressed genes (DEGs) between HNSCC and normal tissues. The DEGs were subjected to gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG), protein-protein interaction (PPI), and survival analyses, while the connectivity map (CMap) database was used to predict candidate small molecules that may reverse the biological state of HNSCC. Read More

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The anti-osteoporosis effects of Vitamin K in postmenopausal women.

Curr Stem Cell Res Ther 2021 May 11. Epub 2021 May 11.

Honghui Hospital Affiliated to Xi Spine surgery, China.

As a common systemically muscular-skeleton disorder in aging, osteoporosis is characterized by the uninterrupted deconstruction in osseous microarchitecture. Osteoporosis can consequently lead to a significantly high risk of osteoporotic fractures, such as osteoporotic vertebral compressive fractures [OVCF] in the spine and osteoporotic femoral neck fractures, which can significantly increase the numbers of mortality and morbidity in aging people, especially in postmenopausal women. In addition, vitamin K has been demonstrated to play a key role in inhibiting osteoporotic fractures among postmenopausal women, but its long-term benefits, potential harms, and effects of the combination between vitamin K and other anti-osteoporosis medicines such as bisphosphonates or teriparatide were just extensively studied. Read More

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Effect of arm position on spatial distribution of upper trapezius muscle activity during simulated car driving.

Int J Occup Saf Ergon 2021 May 13:1-25. Epub 2021 May 13.

Laboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences and School of International Liberal Studies, Chukyo University, Nagoya, Japan.

The present study aimed to investigate the upper trapezius muscle activity during simulated car driving while adopting three different arm positions. Ten participants were instructed to maintain the following positions: hands on the steering wheel (Hands-On), hands not on the steering wheel (Hands-Off), and hands not on the steering wheel but arms on armrests (Armrests). During the tasks, multi-channel surface electromyography (EMG) was recorded from the upper trapezius muscle with 64 two-dimensionally distributed electrodes. Read More

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Structural Vulnerability and Occupational Injury Among Latinx Child Farmworkers in North Carolina.

New Solut 2021 May 13:10482911211017556. Epub 2021 May 13.

Department of Family and Community Medicine-Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Children as young as ten-years-old can legally work as hired farm labor in the United States. In North Carolina, many hired children are part of the Latinx farmworker community. Agriculture is a hazardous industry, and child workers experience high rates of injury, illness, and mortality. Read More

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Laryngopharyngeal reflux management in clinical practice.

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):55-59

UOC di Otorinolaringoiatria, Dipartimento Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della testa collo. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of the pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the esophagus. LPR is considered a relatively new clinical entity with a vast number of clinical manifestations that are sometimes treated empirically and without a correct diagnosis. Alginate is a reasonable therapeutic option as a first-line or add-on option. Read More

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[Advance on pharmacokinetics study of traditional Chinese medicine injections in recent ten years].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1752-1762

Medical College of Jiaxing University Jiaxing 314001, China.

Traditional Chinese medicine(TCM) injections boast a definite efficacy and have been widely used in clinic. However, the problems in medication safety have been attracted increasing attention. Pharmacokinetics is of significance to guiding TCM injection administration regimen design and improving safety and effectiveness in clinical use. Read More

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[Critical quality attribute assessment of big brand traditional Chinese medicine: quality control method of Huangjing Zanyu Capsules based on chemical properties of characteristic components].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1629-1635

School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Engineering Research Center of Chinese Medicine Production and New Drug Development, Ministry of Education Beijing 102488, China.

The chemical properties of characteristic components are significant to the manufacturing quality control of big brand traditional Chinese medicine. In this study, the Huangjing Zanyu Capsules were used as the research carrier to determine the content of five characteristic components including icraiin, emodin, schisandrin A, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, and osthole simultaneously by high-performance liquid chromatography(HPLC). The results showed that the chemical properties of five cha-racteristic components had a good linear relationship(r>0. Read More

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Fungal Ice2p is in the same superfamily as SERINCs, restriction factors for HIV and other viruses.

Proteins 2021 May 13. Epub 2021 May 13.

UCL Institute of Ophthalmology, London, United Kingdom.

Ice2p is an integral endoplasmic reticulum (ER) membrane protein in budding yeast S. cerevisiae named ICE because it is required for Inheritance of Cortical ER. Ice2p has also been reported to be involved in an ER metabolic branch-point that regulates the flux of lipid either to be stored in lipid droplets or to be used as membrane components. Read More

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Freezing stress damage and growth viability in Vaccinium macrocarpon Ait. bud structures.

Physiol Plant 2021 May 13. Epub 2021 May 13.

Department of Horticulture, University of Wisconsin-Madison 1575 Linden Dr., Madison, Wisconsin.

After a freezing event, it can be challenging to extrapolate levels of freezing damage to plant growth viability based on the presence or absence of symptoms in specific bud tissues. This study investigated the relationship between freezing damage in terminal buds during ecodormancy and their viability during the subsequent growing season. We identified the bud structure that best explained this relationship, and developed a model to explain the changes in bud cold hardiness. Read More

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Effects of heavy metal contamination released by petrochemical plants on marine life and water quality of coastal areas.

Environ Sci Pollut Res Int 2021 May 13. Epub 2021 May 13.

Young Researchers and Elite Club, Islamic Azad University of Bushehr, Bushehr, Iran.

The present study attempts to assess the threat of water contamination in Persian Gulf by heavy metals (Fe, Cr, Pb, Cu, Zn, Cd, Se, and Ni) and its subsequent effects on five fish species including Scomberomorus guttatus (S. guttatus), Lethrinus nebulosus (L. nebulosus), Brachirus orientalis (B. Read More

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Autocrine and paracrine purinergic signaling in the most lethal types of cancer.

Purinergic Signal 2021 May 12. Epub 2021 May 12.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Querétaro, México.

Cancer comprises a collection of diseases that occur in almost any tissue and it is characterized by an abnormal and uncontrolled cell growth that results in tumor formation and propagation to other tissues, causing tissue and organ malfunction and death. Despite the undeniable improvement in cancer diagnostics and therapy, there is an urgent need for new therapeutic and preventive strategies with improved efficacy and fewer side effects. In this context, purinergic signaling emerges as an interesting candidate as a cancer biomarker or therapeutic target. Read More

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Validity assessment of the laparoscopic radical nephrectomy module of the LapVision virtual reality simulator.

Surg Open Sci 2020 Jan 1;2(1):51-56. Epub 2019 Nov 1.

Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Virtual reality simulators allow trainees to perform repeated practice and provide objective dexterity metrics regarding their performance, which means that virtual reality-based surgical training is becoming a vital part of initial learning of basic laparoscopic surgical skills. However, its educational role in learning advanced procedures remains undetermined. We evaluated the validity of the laparoscopic radical nephrectomy module of the LapVision virtual reality simulator. Read More

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January 2020

, , and genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients.

Heliyon 2021 Apr 20;7(4):e06852. Epub 2021 Apr 20.

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.

Antituberculosis drug-induced liver injury (ATDILI) is the common adverse reaction of antituberculosis drugs. Glutathione S-transferases (GSTs), which are phase II metabolizing enzymes for detoxification, are recognized as potential mediators of hepatotoxicity. However, role of s polymorphisms in ATDILI pathogenesis has never been observed in Thais. Read More

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antimicrobial activity of De Wild and Banks ex C. F. Gaertn on selected foodborne pathogens associated to gastroenteritis.

Heliyon 2021 Apr 19;7(4):e06830. Epub 2021 Apr 19.

Centre for Food and Nutrition Research, Institute of Medical Research and Medicinal Plants Studies, POBOX 13033, Yaoundé Cameroon.

This study aimed at evaluating the antimicrobial potential of aqueous, ethanolic and methanolic extracts of two Cameroonian plants against selected foodborne pathogens. Bioactive compounds were extracted from De Wild seeds and Banks ex. C. Read More

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Barriers and facilitators to the adoption of artificial intelligence in radiation oncology: A New Zealand study.

Tech Innov Patient Support Radiat Oncol 2021 Jun 21;18:16-21. Epub 2021 Apr 21.

Waikato Hospital, Regional Cancer Centre Selwyn Street Level 1 Lomas Street Hamilton, Waikato 3240 New Zealand.

Introduction: Advances in computing capabilities and automated data collection have led to an increase in the use of Artificial Intelligence (AI) in radiation therapy. This has implications to workflow and workforce planning in radiation oncology departments. A survey was conducted in New Zealand to determine the likelihood of departments adopting AI into their practice. Read More

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Efficacy of Antibiotic-Loaded Cement Augmentation for Correcting Low Grade Pedicle Screw Loosening.

Korean J Neurotrauma 2021 Apr 18;17(1):41-47. Epub 2021 Mar 18.

Department of Neurosurgery, College of Medicine, Chosun University, Gwangju, Korea.

Objective: Altered biomechanics and bone fragility can contribute to pedicle screw loosening. This study aimed to evaluate the efficacy of antibiotic-loaded cement augmentation for correcting symptomatic screw loosening as a minimally invasive alternative to open revision surgery.

Methods: Ten consecutive patients who underwent percutaneous cement augmentation for pedicle screw loosening were included in this study. Read More

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Preliminary evaluation of probiotic effects on gastrointestinal signs in dogs with multicentric lymphoma undergoing multi-agent chemotherapy: A randomised, placebo-controlled study.

Vet Rec Open 2021 Dec 29;8(1):e2. Epub 2021 Mar 29.

Department of Clinical Sciences College of Veterinary Medicine Kansas State University Manhattan Kansas USA.

Background: Gastrointestinal (GI) toxicity is a major dose-limiting factor in dogs undergoing chemotherapy. A proposed mechanism of GI toxicity includes chemotherapy-driven GI dysbiosis. This study was designed to determine the effects of probiotic administration on GI side-effects in dogs receiving multi-agent chemotherapy. Read More

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December 2021

Current Pharmacogenetic Perspective on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Authors:
Lin Cheng

Front Pharmacol 2021 26;12:588063. Epub 2021 Apr 26.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Adverse drug reactions are a public health issue that draws widespread attention, especially for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) which have high mortality and lack of efficacious treatment. Though T-cell-mediated HLA-interacted immune response has been extensively studied, our understanding of the mechanism is far from satisfactory. This review summarizes infection (virus, bacterial, and mycoplasma infection), an environmental risk factor, as a trigger for SJS/TEN. Read More

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Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease.

Front Hum Neurosci 2021 26;15:651168. Epub 2021 Apr 26.

Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.

: Freezing of gait (FOG) is a common symptom in Parkinson's disease (PD) and can be difficult to treat with dopaminergic medications or with deep brain stimulation (DBS). Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation (BCDBS) delivers current in various frequencies of bursts (e. Read More

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Pain Perception in Cataract Surgery: Topical versus Peribulbar Anaesthesia.

Nepal J Ophthalmol 2021 Jan;13(25):50-58

Himalaya Eye Hospital, Gharipatan, Pokhara.

Introduction: The requirement for very deep akinesia has decreased with the use of modern phacoemulsification technique for cataract surgery. The use of topical anesthesia has increased as a way to reduce complications associated with anaesthesia with injection and to allow the most rapid visual recovery. The objective of this study was to assess the patient reported pain in phacoemulsification cataract surgery under topical anaesthesia versus peribulbar anaesthesia administered using an injection. Read More

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January 2021

Prevalence and Causes of Visual Impairment and Blindness in Three Ecological Regions of Nepal.

Nepal J Ophthalmol 2021 Jan;13(25):4-12

Tilganga Institute of Ophthalmology, Kathmandu, Nepal.

Introduction: Visual impairment and blindness are significant public health issues worldwide. The objective of this study was to estimate the prevalence and causes of moderate to severe visual impairment (MSVI) and blindness in people aged 15 years and above across three ecological regions of Nepal.

Materials And Methods: A comparative cross-sectional study was conducted in one district in each of the three ecological regions of Nepal. Read More

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January 2021

Scaffolding depth cues and perceptual learning in VR to train stereovision: a proof of concept pilot study.

Sci Rep 2021 May 12;11(1):10129. Epub 2021 May 12.

School of Optometry, University of California, Berkeley, USA.

Stereopsis is a valuable feature of human visual perception, which may be impaired or absent in amblyopia and/or strabismus but can be improved through perceptual learning (PL) and videogames. The development of consumer virtual reality (VR) may provide a useful tool for improving stereovision. We report a proof of concept study, especially useful for strabismic patients and/or those with reduced or null stereoacuity. Read More

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Next-Generation Sequencing for Congenital Nephrotic Syndrome: A Multi-Center Cross-Sectional Study from India.

Indian Pediatr 2021 May;58(5):445-451

Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi; India. Correspondence to: Professor Arvind Bagga, Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Objective: Information on etiology of congenital nephrotic syndrome in non-Caucasian populations is limited. This study aimed to determine the genetic basis of congenital nephrotic syndrome in Indian patients.

Methods: In this observational, cross-sectional study, whole exome sequencing was performed on samples from all children diagnosed with congenital nephrotic syndrome, presenting at centers collaborating in a nationwide registry and biorepository. Read More

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