27,598 results match your criteria study revealing


Ferrate Self-Decomposition in Water Is Also a Self-Activation Process: Role of Fe(V) Species and Enhancement with Fe(III) in Methyl Phenyl Sulfoxide Oxidation by Excess Ferrate.

Water Res 2021 Mar 29;197:117094. Epub 2021 Mar 29.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China.

To reveal the role of ferrate self-decomposition and the fates of intermediate iron species [Fe(V)/Fe(IV) species] during ferrate oxidation, the reaction between ferrate and methyl phenyl sulfoxide (PMSO) at pH 7.0 was investigated as a model system in this study. Interestingly, the apparent second-order rate constants (k) between ferrate and PMSO was found to increase with ferrate dosage in the condition of excess ferrate in borate buffer. Read More

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Complex coacervate formation between hemp protein isolate and gum Arabic: Formulation and characterization.

Int J Biol Macromol 2021 Apr 6. Epub 2021 Apr 6.

Laboratory of Food Chemistry and Technology, School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. Electronic address:

In this study, intermolecular interactions and structure formation between hemp protein isolate (HPI) and gum Arabic (GA) were investigated to unravel their complexation mechanisms. For this purpose, structural transition as a function of pH (2.0-7. Read More

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Taking the body off the mind: Decreased functional connectivity between somatomotor and default-mode networks following Floatation-REST.

Hum Brain Mapp 2021 Apr 9. Epub 2021 Apr 9.

Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.

Floatation-Reduced Environmental Stimulation Therapy (REST) is a procedure that reduces stimulation of the human nervous system by minimizing sensory signals from visual, auditory, olfactory, gustatory, thermal, tactile, vestibular, gravitational, and proprioceptive channels, in addition to minimizing musculoskeletal movement and speech. Initial research has found that Floatation-REST can elicit short-term reductions in anxiety, depression, and pain, yet little is known about the brain networks impacted by the intervention. This study represents the first functional neuroimaging investigation of Floatation-REST, and we utilized a data-driven exploratory analysis to determine whether the intervention leads to altered patterns of resting-state functional connectivity (rsFC). Read More

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Satisfactory clinical results and low failure rate of medial collagen meniscus implant (CMI) at a minimum 20 years of follow-up.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 9. Epub 2021 Apr 9.

IIa Clinica Ortopedica e Traumatologica, IRCCS Istituto Ortopedico Rizzoli, via Cesare Pupilli 1, 40136, Bologna, Italy.

Purpose: The aim of the study was to evaluate the long-term clinical results, reoperations, surgical failure and complications at a minimum of 20 year of follow-up of the first 8 medial CMI scaffolds implanted by a single surgeon during a pilot European Prospective study.

Methods: Seven (88%) out of 8 patients were contacted. The Cincinnati Score, VAS, and Lysholm score were collected. Read More

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Antioxidant, Cytotoxicity and Cytoprotective Potential of Extracts of and Berries.

J Pharmacopuncture 2021 Mar;24(1):24-31

Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Palapye, Botswana.

Objectives: Accumulation of cellular reactive oxygen species (ROS) leads to oxidative stress. Increased production of ROS, such as superoxide anion, or a deficiency in their clearance by antioxidant defences, mediates cellular pathology. fruits are a source of bioactive compounds and have notable antioxidant activity. Read More

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Gut Immunity and Microbiota Dysbiosis Are Associated with Altered Bile Acid Metabolism in LPS-Challenged Piglets.

Oxid Med Cell Longev 2021 25;2021:6634821. Epub 2021 Mar 25.

National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, Hangzhou 310058, China.

Bacterial infections are among the major factors that cause stress and intestinal diseases in piglets. Lipopolysaccharide (LPS), a major component of the Gram-negative bacteria outer membrane, is commonly employed for inducing an immune response in normal organisms for convenience. The association between LPS stimulation and gut immunity has been reported. Read More

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Dynamical Mechanisms for Gene Regulation Mediated by Two Noncoding RNAs in Long-Term Memory Formation.

Neural Plast 2021 25;2021:6668389. Epub 2021 Mar 25.

School of Mathematics and Systems Science and LMIB, Beihang University, Beijing 100191, China.

Noncoding RNAs such as miRNAs and piRNAs have long-lasting effects on the regulation of gene expression involved in long-term synaptic changes. To characterize gene regulation mediated by small noncoding RNAs associated with long-term memory in , we consider two noncoding RNAs stimulated by 5-HT into a gene regulatory network motif model, including miR-124 that binds to and inhibits the mRNA of CREB1 and piR-F that facilitates serotonin-dependent DNA methylation to lead to repression of CREB2. Codimension-1 and -2 bifurcation analyses of 5-HT regulating both miR-124 and piR-F and a negative feedback strength for oscillation reveal rich dynamical properties of bistability and oscillations robust to variations in all other parameters. Read More

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Comparative Genomics, Evolutionary and Gene Regulatory Regions Analysis of Casein Gene Family in .

Front Genet 2021 23;12:662609. Epub 2021 Mar 23.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China.

Buffalo is a luxurious genetic resource with multiple utilities (as a dairy, draft, and meat animal) and economic significance in the tropical and subtropical regions of the globe. The excellent potential to survive and perform on marginal resources makes buffalo an important source for nutritious products, particularly milk and meat. This study was aimed to investigate the evolutionary relationship, physiochemical properties, and comparative genomic analysis of the casein gene family (, and ) in river and swamp buffalo. Read More

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Interactive Effects of Mycorrhizae, Soil Phosphorus, and Light on Growth and Induction and Priming of Defense in .

Front Plant Sci 2021 23;12:647372. Epub 2021 Mar 23.

Department of Terrestrial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Wageningen, Netherlands.

Increasing demands to reduce fertilizer and pesticide input in agriculture has triggered interest in arbuscular mycorrhizal fungi (AMF) that can enhance plant growth and confer mycorrhiza-induced resistance (MIR). MIR can be based on a variety of mechanisms, including induction of defense compounds, and sensitization of the plant's immune system (priming) for enhanced defense against later arriving pests or pathogens signaled through jasmonic acid (JA). However, growth and resistance benefits of AMF highly depend on environmental conditions. Read More

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Phenotypic differences between the Alzheimer's disease-related hAPP-J20 model and heterozygous knockout mice.

eNeuro 2021 Apr 8. Epub 2021 Apr 8.

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, 94158 USA

Diverse gene products contribute to the pathogenesis of Alzheimer's disease (AD). Experimental models have helped elucidate their mechanisms and impact on brain functions. Human amyloid precursor protein (hAPP) transgenic mice from line J20 (hAPP-J20 mice) are widely used to simulate key aspects of AD. Read More

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SNF5 promotes IL-1β Expression via H3K4me1 in Atherosclerosis induced by Homocysteine.

Int J Biochem Cell Biol 2021 Apr 5:105974. Epub 2021 Apr 5.

School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China; NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, 750004, China; Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, 750004, China. Electronic address:

Homocysteine (Hcy) is a strong and independent risk factor of atherosclerosis. It can accelerate atherosclerosis through increased production of inflammatory factors, especially interleukin-1 β (IL-1β), while the precise mechanisms remain to be well elucidated. In this study, we investigated the role of the tumor suppressor gene SNF5 related to Switch/Sucrose Non-Fermentable complex (SWI/SNF) in the occurrence and development of atherosclerosis induced by Hcy. Read More

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Exploring the Transmucosal Permeability of Cyclobenzaprine: A Comparative Preformulation by Standardized and Controlled Ex Vivo and In Vitro Permeation Studies.

Int J Pharm 2021 Apr 5:120574. Epub 2021 Apr 5.

Institute of Clinical Pharmacy and Pharmacotherapy, Heinrich Heine University, Dusseldorf, Germany.

As part of early drug development, preformulation studies are used to comprehensively explore the properties of new drugs. In particular, this includes the biopharmaceutical characterization and evaluation of impacting factors (e.g. Read More

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iTRAQ-Based Quantitative Proteomics and Network Pharmacology Revealing Hemostatic Mechanism Mediated by Zingiberis Rhizome Carbonisata in Deficiency-cold and Hemorrhagic Syndrome Rat Models.

Chem Biol Interact 2021 Apr 5:109465. Epub 2021 Apr 5.

Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, The Key Unit of Chinese Medicine Digitalization Quality Evaluation of State Administration of Traditional Chinese Medicine, The Research Center for Quality Engineering Technology of Traditional Chinese Medicine, Panyu District, No. 280, Waihuan East Road, Guangzhou, Guangdong Province 510006, China. Electronic address:

Zingiberis Rhizome Carbonisata (ZRC) has been used as a hemostatic agent in traditional Chinese medicine (TCM). However, the underlying molecular mechanism remains unclear. In this study, network pharmacology method was used to predict the potential mechanism of ZRC on hemostasis, based on the structures of the main compounds. Read More

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Distinct effects of the basal ganglia and cerebellum on the thalamocortical pathway in idiopathic generalized epilepsy.

Hum Brain Mapp 2021 Apr 8. Epub 2021 Apr 8.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

The aberrant thalamocortical pathways of epilepsy have been detected recently, while its underlying effects on epilepsy are still not well understood. Exploring pathoglytic changes in two important thalamocortical pathways, that is, the basal ganglia (BG)-thalamocortical and the cerebellum-thalamocortical pathways, in people with idiopathic generalized epilepsy (IGE), could deepen our understanding on the pathological mechanism of this disease. These two pathways were reconstructed and investigated in this study by combining diffusion and functional MRI. Read More

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[Population-based Study of the Effects of Adiponectin, Leptin and Soluble Leptin Receptor on Risks for Breast Cancer].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):259-266

Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the individual or combined effects of adiponectin, leptin, and soluble leptin receptor (sOB-R) on risks for premenopausal and postmenopausal breast cancer, and to provide evidence for revealing the molecular mechanism between obesity and breast cancer.

Methods: 469 newly-diagnosed breast cancer cases were sequentially recruited for the study and 469 age-frequency-matched healthy women were enrolled as the controls over the same period of time. The participant baseline information was collected with questionnaires, and plasmic levels of adiponectin, leptin and sOB-R were checked with ELISA. Read More

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Dermatological diseases in seamen's lower extremity: a prevalence study.

Int Marit Health 2021 ;72(1):18-25

University of A Coruña, A Coruña, Spain.

Background: Little is known about the impact of occupational seafaring on lower limb conditions. The aim of the study was to estimate the prevalence of dermatological diseases affecting the feet and lower extremities of seafarers, as well as the possible impact of working conditions on the development of the pathologies analysed.

Materials And Methods: A prevalence study was performed through self-completed questionnaires at the "Instituto Social de la Marina" (ISM) centres at A Coruña, Ribeira, Noya and Cádiz (Spain). Read More

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January 2021

Occurrence and molecular characterization of on rice in Central Punjab, Pakistan.

J Nematol 2020 16;52. Epub 2021 Jan 16.

Department of Plant Pathology, University of Agriculture Faisalabad, P.O. Box 38040, Pakistan.

threatens global rice production, yet is understudied for many areas where it is cultivated. To better understand the prevalence and incidence of in central Punjab, Pakistan, we carried out field surveys of rice fields in the districts of Faisalabad and Chiniot. isolates were recovered from soil and root samples and identified on the basis of perineal patterns and rDNA ITS-based sequencing. Read More

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January 2021

Multi-modal Mapping of the Face Selective Ventral Temporal Cortex-A Group Study With Clinical Implications for ECS, ECoG, and fMRI.

Front Hum Neurosci 2021 15;15:616591. Epub 2021 Mar 15.

g.tec Medical Engineering GmbH, Schiedlberg, Austria.

Face recognition is impaired in patients with prosopagnosia, which may occur as a side effect of neurosurgical procedures. Face selective regions on the ventral temporal cortex have been localized with electrical cortical stimulation (ECS), electrocorticography (ECoG), and functional magnetic resonance imagining (fMRI). This is the first group study using within-patient comparisons to validate face selective regions mapping, utilizing the aforementioned modalities. Read More

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Interoception primes emotional processing: Multimodal evidence from neurodegeneration.

J Neurosci 2021 Apr 6. Epub 2021 Apr 6.

Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Argentina.

Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-Intero and post-Extero facial emotion recognition (FER). Read More

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Biochemical and phylogenetic characterization of the wastewater tolerant Chlamydomonas biconvexa Embrapa|LBA40 strain cultivated in palm oil mill effluent.

PLoS One 2021 7;16(4):e0249089. Epub 2021 Apr 7.

Embrapa Agroenergia, Brasília, Distrito Federal, Brazil.

The increasing demand for water, food and energy poses challenges for the world´s sustainability. Tropical palm oil is currently the major source of vegetable oil worldwide with a production that exceeds 55 million tons per year, while generating over 200 million tons of palm oil mill effluent (POME). It could potentially be used as a substrate for production of microalgal biomass though. Read More

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Leprosy Screening Based on Artificial Intelligence: Development of a Cross-Platform App.

JMIR Mhealth Uhealth 2021 Apr 7;9(4):e23718. Epub 2021 Apr 7.

Multicentre Biochemistry and Molecular Biology Program, Federal University of Juiz de Fora, Governador Valadares-MG, Brazil.

Background: According to the World Health Organization, achieving targets for control of leprosy by 2030 will require disease elimination and interruption of transmission at the national or regional level. India and Brazil have reported the highest leprosy burden in the last few decades, revealing the need for strategies and tools to help health professionals correctly manage and control the disease.

Objective: The main objective of this study was to develop a cross-platform app for leprosy screening based on artificial intelligence (AI) with the goal of increasing accessibility of an accurate method of classifying leprosy treatment for health professionals, especially for communities further away from major diagnostic centers. Read More

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Sex differences in the meiotic behavior of an XX sex chromosome pair in males and females of the mole vole Ellobius tancrei: turning an X into a Y chromosome?

Chromosoma 2021 Apr 6. Epub 2021 Apr 6.

Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.

Sex determination in mammals is usually provided by a pair of chromosomes, XX in females and XY in males. Mole voles of the genus Ellobius are exceptions to this rule. In Ellobius tancrei, both males and females have a pair of XX chromosomes that are indistinguishable from each other in somatic cells. Read More

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Temporal dynamics of the plasma microbiome in recipients at early post-liver transplantation: a retrospective study.

BMC Microbiol 2021 Apr 6;21(1):104. Epub 2021 Apr 6.

Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Immunosuppression during liver transplantation (LT) enables the prevention and treatment of organ rejection but poses a risk for severe infectious diseases. Immune modulation and antimicrobials affect the plasma microbiome. Thus, determining the impact of immunosuppression on the microbiome may be important to understand immunocompetence, elucidate the source of infection, and predict the risk of infection in LT recipients. Read More

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Interface analysis after fatigue loading of adhesively luted bundled fiber posts to human root canal dentin.

J Mech Behav Biomed Mater 2021 Mar 27;119:104385. Epub 2021 Mar 27.

Dept. of Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, Aßmannshauserstraße 4-6, 14197, Berlin, Germany.

Objectives: The aim of this study was to assess the fatigue loading behavior and fracture resistance of endodontically treated teeth restored with adhesively luted bundled fiber posts in comparison to solid fiber posts. Image analysis (2D and 3D) was applied to evaluate modes of failure and to characterize susceptible parts of the post-and-core interface.

Method: Crowns of 72 human similar-sized central upper incisors were removed and roots received a conventional root canal filling prior to establishing 4 groups of core build-up: No Post group (nP) received a 4 mm deep filling made of composite inside the canal with no dental post, fiber post group (FP) received a conventional solid post, and two experimental groups received bundles of 6 (FB6) or 12 (FB12) 0. Read More

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Regnase-1 is essential for B cell homeostasis to prevent immunopathology.

J Exp Med 2021 May;218(5)

Tumor Microenvironment and Cancer Immunology Program, National Cancer Institute designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.

Regnase-1 is an emerging regulator of immune responses with essential roles in the posttranscriptional control of immune cell activation. Regnase-1 is expressed in B cells; however, its B cell-specific functions remain unknown. Here, we demonstrate that Regnase-1 prevents severe autoimmune pathology and show its essential role in maintaining B cell homeostasis. Read More

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An Examination of Retailers' Compliance with the Minimum Legal Drinking (purchasing) Age Law in Slovenia: A Quasi-experimental Intervention Study.

Zdr Varst 2021 Jun 18;60(2):105-113. Epub 2021 Mar 18.

University of Ljubljana, Faculty of Social Sciences, Kardeljeva ploscad 5, 1000 Ljubljana, Slovenia.

Introduction: Alcohol consumption among young people is strongly related to alcohol availability. The minimum legal drinking (purchasing) age (MLDA) is a legal measure that regulates alcohol availability to minors in Slovenia. This study examines (1) retailers' compliance with the MLDA law in Slovenia and (2) the effectiveness of two interventions directed at cashiers in off-premise stores. Read More

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Microstructure Maps of Complex Perovskite Materials from Extensive Monte Carlo Sampling Using Machine Learning Enabled Energy Model.

J Phys Chem Lett 2021 Apr 6:3591-3599. Epub 2021 Apr 6.

Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.

Revealing the process-structure-property (PSP) relationships of chemically complex mixed-ion perovskite requires comprehensive insights into correlations between microstructures and chemical compositions. However, experimentally determining the microstructural information about complex perovskites over the composition space is a challenging task. In this study, a machine learning enabled energy model was trained for MAFAPb(BrI) mixed-ion perovskite for fast and extensive sampling over the compositional/permutational spaces to map the ion-mixing energies, chemical ordering, and atomic strains. Read More

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Using Integrative Biology to Infer Adaptation from Comparisons of Two (or a Few) Species.

Physiol Biochem Zool 2021 May-Jun;94(3):162-170

AbstractPhylogenetic comparative methods represent a major advance in integrative and comparative biology and have allowed researchers to rigorously test for adaptation in a macroevolutionary framework. However, phylogenetic comparative methods require trait data for many species, which is impractical for certain taxonomic groups and trait types. We propose that the philosophical principle of severity can be implemented in an integrative framework to generate strong inference of adaptation in studies that compare only a few populations or species. Read More

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Distinct basal metabolism in three mouse models of neurodevelopmental disorders.

eNeuro 2021 Apr 5. Epub 2021 Apr 5.

Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada

Prevalence of metabolic disturbances is higher among individuals with neurodevelopmental disorders (NDDs), yet this association has been largely overlooked. Investigation into human disease remains challenging, as a complete pathophysiological understanding relies on accurate modeling and highly controlled variables. Genetically engineered mouse models are widely used to gain insight into the biology of human NDDs, but research focus has been on behavioral and neurophysiological abnormalities. Read More

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The administration of sertraline plus naltrexone reduces ethanol consumption and motivation in a long-lasting animal model of post-traumatic stress disorder.

Neuropharmacology 2021 Apr 2:108552. Epub 2021 Apr 2.

Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda. de Ramón y Cajal S/n, San Juan de Alicante, 03550, Alicante, Spain; Red Temática de Investigación Cooperativa en Salud (RETICS), Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain. Electronic address:

This study was aimed to evaluate the effects of sertraline (STR) and/or naltrexone (NTX) on ethanol consumption and motivation in an animal model of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD). Male C57BL/6J mice were submitted to an intermittent and progressively increasing stressful stimuli simulating PTSD behavioural features. Behavioural alterations were explored by the fear conditioning (FC), novelty suppressed feeding test (NSFT) and acoustic startle response (ASR) paradigms. Read More

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