2,236 results match your criteria study ptt


A versatile nanoagent for multimodal imaging-guided photothermal and anti-inflammatory combination cancer therapy.

Biomater Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Ultrasonography, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangzhou 510515, Guangdong Province, P. R. China.

Photothermal therapy (PTT) has drawn great attention in cancer treatment because of its minimal invasiveness and high spatiotemporal selectivity, but it still encounters severe obstacles like heat-resistance, metastasis and recurrence. A key reason for the treatment failure is the highly inflammatory tumor microenvironment caused by hyperthermia. A simultaneous anti-inflammatory therapy alongside the PTT has great potential for overcoming the drawbacks of PTT; however, it has been less reported and further study is urgently needed. Read More

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Operation Blood Rain: The Effect of Airdrop on Fresh Whole Blood.

J Spec Oper Med 2021 ;21(2):29-33

Background: Administration of fresh whole blood (FWB) is a life-saving treatment that prolongs life until definitive surgical intervention can be performed; however, collecting FWB is a time-consuming and resource-intensive process. Furthermore, it may be difficult to collect sufficient FWB to treat critically wounded patients or multiple-hemorrhaging casualties. This study describes the effect of airdrop on FWB and explores the possibility of using airdrop to deliver FWB to combat medics treating casualties in the prehospital setting when FDA-approved, cold-stored blood products are not readily available and timely casualty evacuation (CASEVAC) is not feasible. Read More

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Facile fabricating of rGO and Au/rGO nanocomposites using Brassica oleracea var. gongylodes biomass for non-invasive approach in cancer therapy.

Sci Rep 2021 Jun 7;11(1):11900. Epub 2021 Jun 7.

Faculty of Physics, University of Tabriz, Tabriz, Iran.

In this study, we report a facile green-synthesis route for the fabrication of reduced graphene oxide (rGO) using biomass of Brassica oleracea var. gongylodes (B. oleracea). Read More

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Unbiased identification of clinical characteristics predictive of COVID-19 severity.

Clin Exp Med 2021 Jun 5. Epub 2021 Jun 5.

Harvard Medical School, Boston, MA, 02115, USA.

There is currently limited clinical ability to identify COVID-19 patients at risk for severe outcomes. To unbiasedly identify metrics associated with severe outcomes in COVID-19 patients, we conducted a retrospective study of 835 COVID-19 positive patients at a single academic medical center between March 10, 2020 and October 13, 2020. As of December 1, 2020, 656 (79%) patients required hospitalization and 149 (18%) died. Read More

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Gold-iron selenide nanocomposites for amplified tumor oxidative stress-augmented photo-radiotherapy.

Biomater Sci 2021 Jun;9(11):3979-3988

Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. and State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

The radio-resistance of tumor tissues has been considered a great challenge for cancer radiotherapy (RT).The development of nanoparticle (NP)-based radio-sensitizers can enhance the radio-sensitization of tumor tissues while reducing the side effects to surrounding tissues. However, most of the nano-radiosensitizers show increased radiation deposition with a high-Z element but achieve limited enhancement. Read More

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Plasmonic-Doped Melanin-Mimic for CXCR4-Targeted NIR-II Photoacoustic Computed Tomography-Guided Photothermal Ablation of Orthotopic Hepatocellular Carcinoma.

Acta Biomater 2021 May 31. Epub 2021 May 31.

Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.; Institute of Digital Intelligence of Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, China.; Guangdong Provincial Clinical and Engineering Technology Center of Digital Medicine, Guangzhou, 510280, China.. Electronic address:

Effective and noninvasive diagnosis and prompt treatment of early-stage hepatocellular carcinoma (HCC) are urgently needed to reduce its mortality rate. Herein, the integration of high-resolution diagnostic second near-infrared (NIR-II) photoacoustic computed tomography (PACT) and imaging-guided targeted photothermal ablation of orthotopic small HCC (SHCC) is presented for the first time, which was enabled by a plasmonic platinum (Pt)-doped polydopamine melanin-mimic nanoagent. As designed, an antibody-modified nanoagent (designated [email protected]) with a plasmonic blackbody-like NIR absorption and superior photothermal conversion efficiency (71. Read More

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Decreased Transfusion Requirements with Use of Acute Normovolemic Hemodilution in Open Aortic Aneurysm Repair.

J Vasc Surg 2021 May 31. Epub 2021 May 31.

Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH. Electronic address:

Objectives: Acute normovolemic hemodilution (ANH) is an operative blood conservation technique involving the removal and storage of patient blood after induction of anesthesia, while maintaining normovolemia with crystalloid and/or colloid replacement. Developed and used predominately in cardiac surgery, ANH has been applied to the vascular surgery population but data regarding impact on transfusion requirements in this population is limited. The objective of this study is to compare transfusion requirements and coagulopathy in patients undergoing open abdominal aortic aneurysm repair (oAAA) employing ANH to those receiving only product replacement as clinically indicated. Read More

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Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours.

Dermatopathology (Basel) 2021 May 25;8(2):147-158. Epub 2021 May 25.

Pathology Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain.

Proliferating trichilemmal tumours (PTT) are defined by a benign squamous cell proliferation inside a trichilemmal cystic (TC) cavity. A possible explanation of this proliferative phenomenon within the cyst may be molecular alterations in genes associated to cell proliferation, which can be induced by ultraviolet radiation. Among other genes, alterations on and DNA mismatch repair proteins (MMR) may be involved in the cellular proliferation observed in PTT. Read More

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Hyalase-Mediated Cascade Degradation of a Matrix Barrier and Immune Cell Penetration by a Photothermal Microneedle for Efficient Anticancer Therapy.

ACS Appl Mater Interfaces 2021 Jun 1. Epub 2021 Jun 1.

Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, P.R. China.

For melanoma with high lethality and metastasis rate, traditional therapy has limited effects; local photothermal therapy (PTT) synergetic with immune therapy for cancer treatment can perhaps improve the situation. However, because of the natural existence of the tumor matrix barrier, the penetration depth of drugs and immune cells often dampens the efficacy of cancer treatment. Herein, we report an innovative synergetic PTT and immune therapy through dissolving microneedles for the codelivery of the hyaluronidase-modified semiconductor polymer nanoparticles containing poly(cyclopentadithiophene--benzothiadiazole) and immune adjuvant polyinosinic-polycytidylic acid (PIC). Read More

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Construction of Smart Nanotheranostic Platform [email protected]: Multimodal CT/PA Imaging-Guided PDT/PTT for Cancer Therapy.

ACS Omega 2021 Apr 14;6(16):10723-10734. Epub 2021 Apr 14.

School of Medicine, Xiamen University, Xiamen 361005, China.

High-efficiency nanotheranostic agents with multimodal imaging guidance have attracted considerable interest in the field of cancer therapy. Herein, novel silver-decorated bismuth-based heterostructured polyvinyl pyrrolidone nanoparticles (NPs) with good biocompatibility ([email protected] NPs) were synthesized for accurate theranostic treatment, which can integrate computed tomography (CT)/photoacoustic (PA) imaging and photodynamic therapy/photothermal therapy (PDT/PTT) into one platform. The [email protected] NPs can enhance light absorption and achieve a better photothermal effect than bismuth NPs. Read More

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A Push-to-Talk Application as an Inter-Professional Communication Tool in an Emergency Department During the COVID-19 Pandemic.

Open Access Emerg Med 2021 20;13:189-199. Epub 2021 May 20.

Clinical Sciences Department, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Objective: To assess the effects of using a smartphone-based push-to-talk (PTT) application on communication, safety, and clinical performance of emergency department (ED) workers during the COVID-19 outbreak.

Design: An observational, cross-sectional study.

Setting: ED in an academic medical center. Read More

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Investigating mating preference between or within the two forms of and its hybrids.

Phytopathology 2021 May 25. Epub 2021 May 25.

University of Southern Queensland, Centre for Crop Health, Toowoomba, Queensland, Australia;

Net blotch diseases result in significant yield losses to barley industries worldwide. They occur as net-form and spot-form net blotch caused by f. () and f. Read More

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Disseminated Intravascular Coagulopathy in Critically Ill Patients in Amman, Jordan.

Biol Res Nurs 2021 May 25:10998004211017241. Epub 2021 May 25.

Clinical Nursing Department, School of Nursing, 54658The University of Jordan, Amman, Jordan.

Background: The disseminated intravascular coagulation (DIC) is under-recognized in critically ill patients. The International Society of Thrombosis and Haemostasis (ISTH; DIC) provides a useful scoring system for accurate DIC identification. The study investigated the period prevalence of ISTH DIC from 2015 to 2017 in critically ill patients. Read More

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A mitochondria-targeted thiazoleorange-based photothermal agent for enhanced photothermal therapy for tumors.

Bioorg Chem 2021 Apr 30;113:104954. Epub 2021 Apr 30.

Allan H. Conney Laboratory for Anticancer Research, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China. Electronic address:

Organic small molecules with near-infrared (NIR) absorption hold great promise as the phototheranostic agents for clinical translation by virtue of their inherent merits such as well-defined chemical structure, high purity and good reproducibility. Probes that happen to be based on cyanine dyes exhibit strong NIR-absorbing and efficient photothermal conversion, representing a new class of photothermal agents (PAs) for photothermal therapy (PTT), and taking into account the heat susceptibility of Mitochondria (Mito), we designed and prepared a mitochondria-targeted organic small molecule (Mito-BWQ) based on thiazole orange maternal unit that can effectively kill tumor cells through the hyperpyrexia generated in the lesions under exogenous laser irradiation. The Confocal laser scanning microscope was employed to determine the preferential targeting of Mito-BWQ to the mitochondria of MCF-7 cells and U87 cells. Read More

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Prognostic Value of Pulmonary Transit Time and Pulmonary Blood Volume Estimation Using Myocardial Perfusion CMR.

JACC Cardiovasc Imaging 2021 May 12. Epub 2021 May 12.

National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA. Electronic address:

Objectives: The purpose of this study was to explore the prognostic significance of PTT and PBVi using an automated, inline method of estimation using CMR.

Background: Pulmonary transit time (PTT) and pulmonary blood volume index (PBVi) (the product of PTT and cardiac index), are quantitative biomarkers of cardiopulmonary status. The development of cardiovascular magnetic resonance (CMR) quantitative perfusion mapping permits their automated derivation, facilitating clinical adoption. Read More

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One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy.

Biomaterials 2021 Jul 11;274:120892. Epub 2021 May 11.

Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong, China. Electronic address:

Construction of single component theranostic agent with one-for-all features to concurrently afford both multi-modality imaging and therapy is an appealing yet significantly challenging task. Herein, a type of luminogens with aggregation-induced emission (AIE) characteristics are tactfully designed and facilely synthesized. These AIE luminogens (AIEgens) exhibit long emission wavelengths, good photostability, remarkable biocompatibility, good reactive oxygen species (ROS) generation performance and excellent photothermal conversion efficiency, which allow them to be powerfully utilized for in vitro and in vivo cancer phototheranostics. Read More

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Low-work-function LaB for realizing photodynamic-enhanced photothermal therapy.

J Mater Chem B 2021 Jun;9(21):4380-4389

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.

There is great potential for photodynamic therapy (PDT)-enhanced photothermal therapy (PTT) to be used for tumor therapy, especially for the single material-mediated process that could greatly simplify the experimental arrangements. This study presents a new cancer phototherapeutic agent consisting of low-work-function lanthanum hexaboride particles, which are excellent light absorbers in the near-infrared (NIR) region. The photothermal effect and reactive oxygen species production were realized by LaB6 under NIR light irradiation. Read More

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Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP).

J Nanobiotechnology 2021 May 19;19(1):146. Epub 2021 May 19.

Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Background: Paclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead to drug resistance by pumping PTX out of GC cells. Consequently, it might be a hopeful way to combat drug resistance by inhibiting the out-pumping function of P-gp.

Results: In this study, we developed a drug delivery system incorporating PTX onto polyethylene glycol (PEG)-modified and oxidized sodium alginate (OSA)-functionalized graphene oxide (GO) nanosheets (NSs), called [email protected] Read More

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Hyaluronidase-responsive phototheranostic nanoagents for fluorescence imaging and photothermal/photodynamic therapy of methicillin-resistant infections.

Biomater Sci 2021 Jun;9(12):4484-4495

State Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Infectious diseases associated with antibiotic-resistant bacteria are ever-growing threats to public health. Effective treatment and detection methods of bacterial infections are in urgent demand. Herein, novel phototheranostic nanoagents ([email protected] nanosheets, MHC NSs) with hyaluronidase (HAase)-responsive fluorescence imaging (FLI) and photothermal/photodynamic therapy (PTT/PDT) functions were prepared. Read More

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A Homotypic Membrane-Camouflaged Biomimetic Nanoplatform with Gold Nanocrystals for Synergistic Photothermal/Starvation/Immunotherapy.

ACS Appl Mater Interfaces 2021 May 17;13(20):23469-23480. Epub 2021 May 17.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.

Although photothermal therapy (PTT) has great potential for tumor inhibition, this single mode of action frequently encounters recurrence and metastasis, highlighting the urgent need for developing combination therapy. Inspired by established evidence that PTT could induce efficient immunogenic cell death (ICD), we here developed a versatile biomimetic nanoplatform (denoted as AuDRM) for the synergism of photothermal/starvation/immunotherapy against cancer. Specifically, dendritic mesoporous silica nanoparticles (NPs) were successfully constructed followed by the synthesis of Au NPs in the mesopores. Read More

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Heterobifunctional PEG-grafted black phosphorus quantum dots: "Three-in-One" nano-platforms for mitochondria-targeted photothermal cancer therapy.

Asian J Pharm Sci 2021 Mar 18;16(2):222-235. Epub 2020 Oct 18.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.

Black phosphorus (BP) nano-materials, especially BP quantum dots (BPQDs), performs outstanding photothermal antitumor effects, excellent biocompatibility and biodegradability. However, there are several challenges to overcome before offering real benefits, such as poor stability, poor dispersibility as well as difficulty in tailoring other functions. Here, a "three-in-one" mitochondria-targeted BP nano-platform, called as BPQD-PEG-TPP, was designed. Read More

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Continuous Renal Replacement Therapy with Low Dose Systemic Heparin in Liver Transplant Recipients.

Iran J Kidney Dis 2021 May;15(3):229-234

Taleghani Hospital, Department of Transplant and Hepatobiliary Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Continuous renal replacement therapy (CRRT) is an effective dialysis method in critically ill patients. Citrate and heparin are commonly used as anticoagulants to prevent premature circuit clotting. The aim of this study was to evaluate the safety and efficacy of using low dose systemic heparin while on CRRT in liver transplant recipients. Read More

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Strength training in addition to neuromuscular exercise and education in individuals with knee osteoarthritis-the effects on pain and sensitization.

Eur J Pain 2021 May 15. Epub 2021 May 15.

The Research Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Naestved-Slagelse-Ringsted Hospitals, Slagelse, Denmark.

Background: There is a lack of evidence of the relative effects of different exercise modes on pain sensitization and pain intensity in individuals with knee osteoarthritis (KOA).

Methods: Ninety individuals with radiographic and symptomatic KOA, ineligible for knee replacement surgery, were randomized to 12 weeks of twice-weekly strength training in addition to neuromuscular exercise and education (ST+NEMEX-EDU) or neuromuscular exercise and education alone (NEMEX-EDU). Outcomes were bilateral, lower-leg, cuff pressure pain- and tolerance thresholds (PPT, PTT), temporal summation (TS), conditioned pain modulation (CPM), self-reported knee pain intensity and number of painful body sites. Read More

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Differential effects of the blood pressure state on pulse rate variability and heart rate variability in critically ill patients.

NPJ Digit Med 2021 May 14;4(1):82. Epub 2021 May 14.

Research Centre for Biomedical Engineering, City, University of London, London, United Kingdom.

Heart rate variability (HRV) utilizes the electrocardiogram (ECG) and has been widely studied as a non-invasive indicator of cardiac autonomic activity. Pulse rate variability (PRV) utilizes photoplethysmography (PPG) and recently has been used as a surrogate for HRV. Several studies have found that PRV is not entirely valid as an estimation of HRV and that several physiological factors, including the pulse transit time (PTT) and blood pressure (BP) changes, may affect PRV differently than HRV. Read More

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Dual mitigation of immunosuppression combined with photothermal inhibition for highly effective primary tumor and metastases therapy.

Biomaterials 2021 Jul 7;274:120856. Epub 2021 May 7.

Department of Ultrasound, The Third Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, PR China. Electronic address:

T-cell based immune response can attack cancer cells formidably when certain immune checkpoint (e.g., PD-1/PD-L1) is blocked. Read More

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Characteristics of Thermosensitive and Targeted F127-Triethoxysilane/Gold Nanorod Combined with Photothermal Therapy in Tumor Model Mice.

J Nanosci Nanotechnol 2021 Nov;21(11):5688-5693

Division of Isotope Application, Institute of Nuclear Energy Research, Taoyuan, Taiwan, 325, ROC.

Even with all the recent technological improvements, cancer remains to be the disease with the highest impact on global health. Due to obviously disadvantages or limitations on traditional therapy, researchers are engaged to search for safely and effective methods in cancers' therapy. Photothermal therapy (PTT) has been employed in treating cancers and several of other diseases. Read More

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November 2021

Nutritional Predictors of Wound Infection in Patients with Lower Extremity Soft Tissue Sarcoma.

Ann Surg Oncol 2021 May 12. Epub 2021 May 12.

Department of Orthopaedic Surgery, Division Musculoskeletal Oncology, Massachusetts General Hospital, Boston, MA, USA.

Background: Soft tissue sarcoma (STS) frequently requires high-risk surgery that predisposes patients to complex wounds. Past studies have identified a variety of tumor characteristics as risk factors for wound infection (WI); however, physiologic characteristics have not yet been studied in this population. Thus, the objective of this study is to identify any nutritional indicators and physiologic characteristics associated with the development of WI. Read More

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Paper towel test as independently self-administered to quantify cough-related urine loss: Compliance and comparisons with survey-only data in SWAN.

Neurourol Urodyn 2021 May 11. Epub 2021 May 11.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Aims: The epidemiologic Study of Women's Health Across the Nation (SWAN) includes urinary incontinence (UI) questionnaire items. We introduced an independently self-administered paper towel test (PTT-ISA; invention disclosure #2021-347) to objectively demonstrate UI. Aims were to determine: (1) PTT-ISA compliance and (2) relationship to questionnaire results. Read More

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Structure and properties of in situ reactive blend of polylactide and thermoplastic starch.

Int J Biol Macromol 2021 May 7;182:1238-1247. Epub 2021 May 7.

The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand; Bioresources Advanced Materials (B2A), The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

In this study, in situ reactive extrusion of polylactide and thermoplastic starch modified with chloropropyl trimethoxysilane coupling agent (PLA/mTPS) is proposed. The success of covalent bond formation between PLA matrix and mTPS phase is clarified by two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy with HH TOCSY mode. This chemically bound PLA with starch gives the remarkable compatibility in the PLA/mTPS film, with not only a decreased glass transition temperature (47 °C) but also an increased crystallinity of PLA (Χ of 50%). Read More

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Chronological Skin Changes Through Postmastectomy Radiotherapy Based on Radiotherapy Techniques: Using Quantitative Dermatological Measurements.

Skin Pharmacol Physiol 2021 May 7:1-10. Epub 2021 May 7.

Skin Research Institute, AMOREPACIFIC Corporation R&D Center, Youngin, Republic of Korea.

Background: There has been few research on how to measure skin status quantitatively throughout the course of radiotherapy (RT). We evaluated the changes in the skin induced by 2 different RT techniques using objective measurements in breast cancer patients.

Methods: In this prospective study, between August 2015 and March 2019, serial measurements of the dermatological factors during and after postmastectomy radiotherapy (PMRT) were made in 40 breast cancer patients. Read More

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