Acta Biomater 2021 May 31. Epub 2021 May 31.
Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.; Institute of Digital Intelligence of Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, China.; Guangdong Provincial Clinical and Engineering Technology Center of Digital Medicine, Guangzhou, 510280, China.. Electronic address:
Effective and noninvasive diagnosis and prompt treatment of early-stage hepatocellular carcinoma (HCC) are urgently needed to reduce its mortality rate. Herein, the integration of high-resolution diagnostic second near-infrared (NIR-II) photoacoustic computed tomography (PACT) and imaging-guided targeted photothermal ablation of orthotopic small HCC (SHCC) is presented for the first time, which was enabled by a plasmonic platinum (Pt)-doped polydopamine melanin-mimic nanoagent. As designed, an antibody-modified nanoagent (designated [email protected]) with a plasmonic blackbody-like NIR absorption and superior photothermal conversion efficiency (71. Read More