849,222 results match your criteria study period


Inflammatory Bowel Disease as a Precondition for Stroke or TIA: A Matter of Crohn's Disease Rather than Ulcerative Colitis.

J Stroke Cerebrovasc Dis 2021 Apr 14;30(7):105787. Epub 2021 Apr 14.

Epidemiology, IQVIA, Frankfurt am Main, Germany.

Background: As a chronic systemic inflammation may be associated with an increased risk of vascular events, the aim of the present study was to assess the incidence of stroke and transient ischemic attack (TIA) in patients with inflammatory bowel disease over a period of 15 years.

Methods: This cohort study included patients for whom the initial diagnosis of an inflammatory bowel disease (IBD) (Crohn's disease: CD and ulcerative colitis: UC) was documented anonymously between 2000 and 2015 in 1,262 general practices in Germany. IBD patients were matched to patients without IBD using propensity scores based on age, sex, physician, co-diagnoses and co-therapies. Read More

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Impact of Immunoablation and Autologous Hematopoietic Stem Cell Transplantation (AHSCT) on Treatment Cost of Multiple Sclerosis: Real-World Nationwide Study.

Value Health Reg Issues 2021 Apr 14;25:104-107. Epub 2021 Apr 14.

Medical University of Warsaw, Hematology, Oncology, and Internal Diseases, Warsaw, Poland. Electronic address:

Objectives: To provide real-world data on the impact of autologous hematopoietic stem cell transplantation (AHSCT) on treatment costs of patients with multiple sclerosis (MS) in Poland.

Methods: Medical data of 105 patients who underwent AHSCT in the years 2011 to 2016 were obtained from the National Health Fund (NHF) database. Treatment costs were calculated from the public payer's perspective per patient-year for the total available period as well as 12 months before and after AHSCT. Read More

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Complications of intrathecal drug delivery therapy (ITDD): A retrospective study of 231 implantations between 1999 and 2014.

Clin Neurol Neurosurg 2021 Apr 2;205:106630. Epub 2021 Apr 2.

Department of Rehabilitation Medicine, Region Östergötland & Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Objective: Determination of types and frequencies of complications related to ITDD therapy, and assessment of possible risk factors for such complications.

Methods: Retrospective study (1999-2014) including all ITDD-implantations at one regional center in Sweden. Descriptors comprised: sex; age; medical condition; body weight index; preoperative ASA-grade; presence of indwelling urinary catheters, feeding tubes, and/or daily urinary or anal incontinence; primary or re-implantation; type of pump and catheter; drug delivered; weekday of surgery; surgical procedure time; surgeon; experience of surgeon; surgical theater; and type of antibiotic prophylaxis. Read More

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Real-world experience with botulinum toxin A for the treatment of hemifacial spasm: A study of 1138 injections.

Clin Neurol Neurosurg 2021 Apr 2;205:106632. Epub 2021 Apr 2.

Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines; Movement Disorders Service and Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines; Department of Neurosciences, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Philippines; Movement Disorders Service and Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Global City, Philippines. Electronic address:

Background: Hemifacial spasm (HFS) is a chronic, potentially disabling disorder that often requires long-term management with botulinum toxin (BoNT). In a country where healthcare costs limit compliance to medical follow-up and treatment, the study aims to provide a real-world experience on the use of BoNT for HFS among Filipinos.

Methods: We retrospectively collected data from 162 HFS patients who received 1138 botulinum toxin (BoNT) injections from 2006 to 2019 in our movement disorders center in the Philippines. Read More

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Trends in substances involved in polysubstance overdose fatalities in Maryland, USA 2003-2019.

Drug Alcohol Depend 2021 Apr 12;223:108700. Epub 2021 Apr 12.

Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Baltimore, MD, 21205, USA.

Background: The substances driving the overdose epidemic in the United States have changed over time. Since 2013, fentanyl-analogues have become the primary opioids driving the epidemic. Recently, polysubstance related deaths have come to the forefront of the epidemic. Read More

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Rare earth real wastewater treatment by pilot scale using new concept continuous treatment process.

Chemosphere 2021 Apr 12;279:130523. Epub 2021 Apr 12.

School of Civil, Environmental, and Architectural Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. Electronic address:

Rare earth (RE) containing radioactive species and a variety of toxic pollutants The treatment of real wastewater is very important for environmental protection. In this study, a new concept of continuous process consisting of precipitation, adsorption, and oxidation was developed without the use of chemicals. In the sedimentation step, waste oyster shell(WOS) and a PE tube diffuser(PE250) containing NaS (PE), PE were prepared, which were used to precipitate heavy metals with a removal efficiency of 97% or more. Read More

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Seeking sustainable development policies at the municipal level based on the triad of city, economy and environment: evidence from Hunan province, China.

J Environ Manage 2021 Apr 14;290:112554. Epub 2021 Apr 14.

State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences, Beijing, 100875, China; Beijing Engineering Research Center for Global Land Remote Sensing Products, Institute of Remote Sensing Science and Engineering, Faculty of Geographical Science, Beijing Normal University, Beijing, 100875, China.

Keeping urbanization, economy and eco-environment in harmony is a core issue for attaining Sustainable Development Goals (SDGs) in any complex geographical regions. Previous studies mainly focused on seeking the balance between urban expansion levels, eco-environment quality and socioeconomic degree. But the challenges still exist in solving the negative influence of urban expansion that affects eco-environmental and economic development. Read More

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Fate of antibiotic resistance genes in farmland soil applied with three different fertilizers during the growth cycle of pakchoi and after harvesting.

J Environ Manage 2021 Apr 14;289:112576. Epub 2021 Apr 14.

State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address:

The increasing prevalence of antibiotic resistance genes (ARGs) in the soil environment poses a serious threat to crop safety and even public health. In this study, the fate of ARGs in the soil was investigated during the growth period of pakchoi and after harvesting with the application of different kinds of fertilizers. The result showed that increasing rate of soil ARGs during the growth period of pakchoi followed the order of composted manure > commercial fertilizer > mineral fertilizer. Read More

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How does e-commerce city pilot improve green total factor productivity?Evidence from 230 cities in China.

J Environ Manage 2021 Apr 14;289:112520. Epub 2021 Apr 14.

School of Economics, Shanghai University of Finance and Economics, Shanghai, 200433, China.

This paper presents a feasible road to achieving green development through the e-commerce model. We employ the data of 230 cities data in China from 2003 to 2017 as a research sample and use the Multi-period DID method to test the policy shock of National E-commerce Demonstration Cities (NEDC) pilots on the green total factor productivity (GTFP). The basic results show that urban GTFP increases by about 1. Read More

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Prediction of minimum postmortem submersion interval (PMSI) based on eukaryotic community succession on skeletal remains recovered from a lentic environment.

Forensic Sci Int 2021 Apr 14;323:110784. Epub 2021 Apr 14.

Department of Forensic Science, Virginia Commonwealth University, Richmond, VA 23284, United States. Electronic address:

Although recent studies explored using microbial succession during decomposition to estimate the postmortem interval (PMI) and postmortem submersion interval (PMSI), there is currently no published research using aquatic eukaryotic community succession to estimate the minimum postmortem submersion interval (PMSI). The goals of this study were to determine whether eukaryotic community succession occurs on porcine skeletal remains in a lentic environment, and, if so, to develop a statistical model for PMSI prediction. Fresh porcine bones (rib N = 100, scapula N = 100) were placed in cages (10'' x 10'') attached to floatation devices and submerged in a fresh water lake (Crozet, VA), using waterproof loggers and a YSI Sonde to record temperature and water quality variables, respectively. Read More

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An Optimized Model of Hypertrophic Preconditioning Confers Cardioprotection in the Mouse.

J Surg Res 2021 Apr 14;264:544-552. Epub 2021 Apr 14.

Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an Shaanxi, China. Electronic address:

Background: Conventional models of hypertrophic preconditioning (C-HP) can be established surgically through transverse aortic constriction (TAC) → deconstriction (De-TAC) → reconstriction (Re-TAC) characterized by dynamic afterload while it exerts technical difficulty on operators and poses high mortality during perioperative period in mice. We aimed to introduce an optimized method for obtaining a hypertrophic preconditioning (O-HP) model for further study on cardiac hypertrophy.

Methods: Ninety mice were divided into four groups: sham, TAC, C-HP, and O-HP. Read More

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Transjugular intrahepatic portosystemic shunt creation for the prevention of gastric variceal rebleeding in patients with hepatocellular carcinoma: a multicenter retrospective study.

J Vasc Interv Radiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Purpose: To evaluate the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) creation for the prevention of gastric variceal rebleeding in patients with Hepatocellular carcinoma (HCC).

Materials And Methods: This multicenter retrospective study included 126 cirrhotic patients (mean age, 54.1 ± 10. Read More

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Binge sucrose-induced neuroadaptations: A focus on the endocannabinoid system.

Appetite 2021 Apr 14:105258. Epub 2021 Apr 14.

Université de Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Centre de La Recherche Nationale Scientifique, 12 Rue Goethe, F-67000, Strasbourg France. Electronic address:

Binge eating, the defining feature of binge eating disorder (BED), is associated with a number of adverse health outcomes as well as a reduced quality of life. Animals, like humans, selectively binge on highly palatable food suggesting that the behaviour is driven by hedonic, rather than metabolic, signals. Given the links to both reward processing and food intake, this study examined the contribution of the endocannabinoid system (ECS) to binge-like eating in rats. Read More

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Relationship between ambient temperature and severe acute poisoning by alcohol and drugs.

Alcohol 2021 Apr 14. Epub 2021 Apr 14.

Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Asklepios Klinikum Harburg, Eißendorfer Pferdeweg 52, 21075 Hamburg, Germany. Electronic address:

Aim: To test the hypothesis that severe acute poisoning by alcohol and drugs is more frequent at higher rather than at lower ambient temperatures.

Method: This was a prospective observational study performed in a prehospital setting under marine west coast climate conditions. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Read More

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Effects of 5-aminolevulinic acid with iron supplementation on respiratory responses to graded cycling and interval walking training achievement in older women over 75 yrs.

Exp Gerontol 2021 Apr 14:111356. Epub 2021 Apr 14.

Departments of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan; Departments of e-Health Sciences, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan.

Background: Exercise training above a given intensity is necessary to prevent age-associated physical disability and diseases; however, the physical and psychological barriers posed by deteriorated physical fitness due to aging may hinder older people from performing daily exercise training. Because 5-aminolevulinic acid (ALA), a precursor of heme, reportedly improves mitochondrial function, we examined whether ALA, combined with sodium ferrous citrate (SFC) for enhancement, improved aerobic capacity and voluntary exercise training achievement in older women aged over 75 yrs.

Methods: The study was conducted using a placebo-controlled, double-blind crossover design. Read More

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A morphovolumetric analysis of aneurysm sac evolution after elective endovascular abdominal aortic repair.

J Vasc Surg 2021 Apr 14. Epub 2021 Apr 14.

Objectives: Abdominal aortic aneurysm (AAA) sac shrinkage after endovascular repair (EVAR) has been regarded as positive marker of EVAR success durability. The purpose of this study was to describe the morphovolumetric changes of the AAA sac during follow-up after elective EVAR, and to analyze sac shrinkage related variables.

Methods: This is a single center, retrospective, observational cohort study from a tertiary referral university hospital. Read More

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Detection of acute stress by smooth muscle electromyography: A translational study on rat and human.

Life Sci 2021 Apr 14:119492. Epub 2021 Apr 14.

Department of Psychiatry, Faculty of Medicine, University of Szeged, Szeged, Hungary. Electronic address:

Aims: Non-invasive and simultaneous recording of gastrointestinal (GI) activity during stress induction is still an unexplored field. In our previous investigation, the stress-induced alteration of the gastrointestinal tract was explored in rats. Our aims were to expand our previous rat experiment and to induce stress response in rats (Study 1) and humans (Study 2) to detect the GI tract activity, heart rate and body temperature. Read More

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Post-exercise recovery for the endurance athlete with type 1 diabetes: a consensus statement.

Lancet Diabetes Endocrinol 2021 May;9(5):304-317

Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:

There has been substantial progress in the knowledge of exercise and type 1 diabetes, with the development of guidelines for optimal glucose management. In addition, an increasing number of people living with type 1 diabetes are pushing their physical limits to compete at the highest level of sport. However, the post-exercise recovery routine, particularly with a focus on sporting performance, has received little attention within the scientific literature, with most of the focus being placed on insulin or nutritional adaptations to manage glycaemia before and during the exercise bout. Read More

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[Engagement of students enrolled in fifth year of pharmacy studies in their academic or salaried pharmaceutical activities during the first period of lockout due to the COVID-19 pandemic (16 March - 11 May 2020)].

Ann Pharm Fr 2021 Apr 14. Epub 2021 Apr 14.

Département Pharmacie, Faculté de Santé, Université d'Angers, 16, Boulevard Daviers, 49045 Angers, France. Electronic address:

Objectives: To characterize the engagement of students enrolled in the fifth year of pharmaceutical studies in the management of the health crisis due to the COVID-19 pandemic, and to identify some determinants of this engagement during this period.

Methods: With the health crisis, new missions have been entrusted during hospital internships, whereas certain internship sites were removed in hospitals and as part of the health service organization. In addition, some students who were no longer in internship returned to the hospital setting for helping in critical activities. Read More

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Intraoperative methylprednisolone and neurodevelopmental outcomes in infants after cardiac surgery.

Ann Thorac Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Pediatrics, Medical University of South Carolina, Charleston, SC.

Background: Neurodevelopmental impairment is a significant consequence for survivors of surgery for critical congenital heart disease. This study sought to determine if intraoperative methylprednisolone during neonatal cardiac surgery is associated with neurodevelopmental outcomes at 12 months of age and to identify early prognostic variables associated with neurodevelopmental outcomes.

Methods: A planned secondary analysis of a two-center, double-blind, randomized, placebo-controlled trial of intraoperative methylprednisolone in neonates undergoing cardiac surgery was performed. Read More

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Characterization of chronic active multiple sclerosis lesions with sodium ( Na) MRI - preliminary observations.

Eur J Neurol 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, 68167, Mannheim, Germany.

Background: There has been an increasing interest in chronic active multiple sclerosis (MS) lesions as a new magnetic resonance imaging (MRI) marker of disease progression. Chronic active lesions are characterized by progressive tissue matrix damage, axonal loss and chronic inflammation. Sodium ( Na) MRI provides a biochemical marker of cell integrity and tissue viability in a quantitative manner. Read More

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The role of ThyroSeq V3 testing in the management of patients with indeterminate thyroid nodules on fine needle aspiration.

Diagn Cytopathol 2021 Apr 17. Epub 2021 Apr 17.

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Background: The multigene genomic classifier ThyroSeq V3 has proven to be an effective triage modality in the management of indeterminate thyroid nodules. This study reports on the clinical management of patients with indeterminate thyroid nodules.

Methods: ThyroSeq V3 testing at our institution was implemented April 1, 2019. Read More

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Autochthonous and imported tegumentary leishmaniasis in Catalonia (Spain): aetiological evolution in the last four decades and usefulness of different typing approaches based on biochemical, molecular and proteomic markers.

Transbound Emerg Dis 2021 Apr 17. Epub 2021 Apr 17.

Secció de Parasitologia, Departament de Biologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Sanitat i Medi Ambient, Barcelona, Spain.

Leishmaniasis is a transmissible disease caused by Leishmania protozoa. Spain is endemic for both visceral and cutaneous leishmaniasis, the autochthonous aetiological agent being Leishmania infantum. Around the world, the L. Read More

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Production and outmigration of young-of-year northern pike Esox lucius from natural and modified waterways connected to Lower Green Bay, Wisconsin.

J Fish Biol 2021 Apr 17. Epub 2021 Apr 17.

Department of Natural and Applied Sciences, Aquatic Ecology and Fisheries Laboratory, University of Wisconsin-Green Bay, Green Bay, WI, United States.

Production and outmigration of young-of-year (YOY) northern pike from natal sites in Lower Green Bay were documented over three consecutive years (2013-2015). We tested the hypothesis that spawning success and outmigration characteristics of YOY northern pike would vary among natural and anthropogenically modified habitats. Sixteen focal study locations were surveyed including a restored natural wetland, agricultural drainage ditches, a flooded forested wetland and several unimpounded tributaries. Read More

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[Combined cerebral revascularization for moyamoya disease].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):47-59

Burdenko Neurosurgical Center, Moscow, Russia.

Introduction: Combined cerebral revascularization with direct and indirect components is recognized as the most appropriate method for treating patients with Moyamoya disease all over the world, however, large studies on its effectiveness in Russia have not yet been conducted.

The Aim Of The Study: Was to evaluate the results of combined cerebral revascularization in patients with Moyamoya disease with an analysis of the clinical state and perfusion and angiographic features of neoangiogenesis.

Material And Methods: For the period from 2013 to 2020 in N. Read More

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January 2021

[Influence of resection quality on postoperative outcomes in children with atypical teratoid-rhabdoid tumor of the central nervous system].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):17-25

Voino-Yasenetsky Research and Practical Center for Specialized Medical Care, Moscow, Russia.

The purpose of this study was to assess the influence of resection quality on overall survival and disease-free survival in children with atypical teratoid-rhabdoid tumors (ATRT). The study included children younger than 18 years old for the period from 2008 to 2019. There were 134 interventions in 105 patients with ATRT including 11 redo resections («second-look» surgery) and 18 procedures for tumor recurrence. Read More

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January 2021

[Central neurocytomas: long-term treatment outcomes].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):5-16

Burdenko Neurosurgical Center, Moscow, Russia.

Central neurocytoma is a rare benign brain tumor. These tumors may be giant and accompanied by compression of ventricular system and surrounding structures. Modern treatment of brain neurocytoma includes extended resection and restoration of normal CSF circulation. Read More

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January 2021

Clinical Features of Essential Voice Tremor and Associations with Tremor Severity and Response to Octanoic Acid Treatment.

Laryngoscope 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, SUNY Upstate Medical University, Syracuse, New York, U.S.A.

Objectives/hypothesis: The purpose of this study was to characterize the clinical features, tremor variability, and factors related to octanoic acid (OA) treatment response in essential voice tremor (EVT).

Study Design: Prospective, double blind, placebo-controlled, crossover study with secondary analysis.

Methods: Clinical tremor features in 16 individuals with EVT were comprehensively assessed, and correlations with acoustic tremor severity were determined. Read More

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Improving memory effect correction to achieve high precision analysis of δ O, δ O δ H, O-excess and d-excess in water using cavity ring-down laser spectroscopy.

Rapid Commun Mass Spectrom 2021 Apr 17:e9108. Epub 2021 Apr 17.

CEREGE, Aix Marseille Univ, CNRS, IRD, INRA, Coll France, Aix-en-Provence, France.

Rationale: The precision obtained in routine isotope analysis of water (δ O, δ O, δ H, O-excess and d-excess values) by Cavity Ring-Down Spectroscopy is usually below the instrument specifications provided by the manufacturer. This study aimed at reducing this discrepancy, with particular attention paid to mitigating the memory effect (ME).

Methods: We used a Picarro L2140i analyzer coupled with a high-precision A0211 vaporizer and an A0325 autosampler. Read More

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Treatment Patterns and Persistence With GLP-1 RA Treatments Among Patients With Type 2 Diabetes in France: A Retrospective Cohort Analysis.

Diabetes Ther 2021 Apr 17. Epub 2021 Apr 17.

Department of Endocrinology, Diabetology and Nutrition, Brabois Hospital and University of Lorraine, Vandoeuvre-Lès-Nancy, France.

Introduction: In type 2 diabetes (T2D), persistence with injectable glucose-lowering therapy is associated with better outcomes. This study used real-world pharmacy data to report on persistence with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in patients with T2D in France.

Methods: This retrospective cohort analysis presents longitudinal data from approximately 7500 French retail pharmacies that filled GLP-1-RA prescriptions for GLP-1 RA-naïve patients with T2D ('index therapy': dulaglutide; once-weekly exenatide [exenatide QW]; twice-daily exenatide [exenatide BID]; liraglutide) between January 2015 and December 2016 (follow-up ≥ 12 months). Read More

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