1,334,666 results match your criteria study performed

Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models.

J Basic Clin Physiol Pharmacol 2021 Apr 20. Epub 2021 Apr 20.

Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Objectives: The present work was designed to study the modulatory effects of algogen-induced vasosensory reflex responses on short-term heart rate variability (HRV) parameters in naïve and vagotomized rat models.

Methods: In this study, vasosensory reflex responses were elicited by instilling algogens (bradykinin/histamine), a component of inflammatory mediators into a local segment of medium-sized peripheral blood vessel (femoral artery) while a continuous electrocardiogram (ECG) was recorded. Short-term (5 min) ECG segments obtained from original recordings were examined in detail and relevant data of HRV parameters were pooled. Read More

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Radiographic Results after Vertebral Body Tethering.

Z Orthop Unfall 2021 Apr 19. Epub 2021 Apr 19.

Klinik für Orthopädie, Uniklinik RWTH Aachen, Germany.

Vertebral body tethering (VBT), otherwise known as fusion-less anterior scoliosis correction (ASC), is a new and increasingly interesting therapeutic option for selected scoliosis patients. The available data on this surgical technique are still limited and guidelines on patient selection or surgical timing are not available. The aim of this study was to conduct a systematic review of the available literature on VBT. Read More

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How Safe and Time Consuming is the Surgical Training of Young Orthopaedic Surgeons? A Retrospective Analysis of Proximal Femur Fractures.

Z Orthop Unfall 2021 Apr 19. Epub 2021 Apr 19.

Department of Trauma, Hand and Reconstructive Surgery, University of Ulm, Germany.

Background: Fractures of the proximal femur in the elderly population are rising. Teaching the appropriate surgical treatment of these fractures is of paramount importance. The aim of the study was to evaluate differences in outcome of surgical procedures between supervised trainees and senior surgeons. Read More

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Prevalence of "Reversal Nystagmus" in Benign Paroxysmal Positional Vertigo.

J Am Acad Audiol 2021 Jan 19;32(1):35-38. Epub 2021 Apr 19.

Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, La Crosse, Wisconsin.

Purpose:  To investigate the prevalence of reversal nystagmus in individuals with benign paroxysmal positional vertigo (BPPV).

Study Design:  Prevalence of reversal nystagmus was assessed in 28 subjects with unilateral posterior canal BPPV, canalithiasis type. Six trials of Dix-Hallpike testing were completed for each subject. Read More

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January 2021

Evaluation of Allergic Disease Prevalence and Related Risk Factors in Children with Autoimmune Thyroiditis.

Int Arch Allergy Immunol 2021 Apr 19:1-9. Epub 2021 Apr 19.

Department of Pediatric Allergy and Immunology, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Background: Allergic and autoimmune diseases are caused by an impaired immunological response resulting from different types of T-helper (Th) cells. Since the Th cell production is in a certain balance, an inverse relationship between the 2 disease groups may exist. In this study, we aimed to investigate the frequency of allergic diseases in children with autoimmune thyroiditis (AT). Read More

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Systematic Review of Microthrombi in COVID-19 Autopsies.

Acta Haematol 2021 Apr 19:1-8. Epub 2021 Apr 19.

Instituto de Patologia Mejia Jimenez, Department of Pathology, Cali, Colombia.

Background: Histopathological analysis can provide additional clues in COVID-19 understanding. During the last year, autopsy reports have revealed that diffuse alveolar damage (DAD) is the most significant observed finding. The aim of this study is to review cases in the literature about COVID-19 autopsies that reported microthrombi in different organs. Read More

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Fabrication of a dual-layer cell-laden tubular scaffold for nerve regeneration and bile duct reconstruction.

Biofabrication 2021 Apr 19. Epub 2021 Apr 19.

Zhejiang University, School of Mechanical Engineering, Zhejiang University, Hangzhou, Hangzhou, 310058, CHINA.

Tubular scaffolds serve as a controllable extracellular environment to guide the repair and regeneration of tissues. But it is still a challenge to achieve both excellent mechanical properties and cell compatibility of artificial scaffolds for long-term structural and biological stability. In this study, a four-step solution casting method was developed to fabricate dual-layer cell-laden tubular scaffolds for nerve and bile duct regeneration. Read More

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Hydrogel from acellular porcine adipose tissue promotes survival of adipose tissue transplantation.

Biomed Mater 2021 Apr 19. Epub 2021 Apr 19.

Department of Breast Surgery, Clinical Research Center for Breast, Sichuan University West China Hospital, No.37 Guoxuexiang, Chengdu, Sichuan, China, Chengdu, Sichuan, 610041, CHINA.

Lipofilling is a popular technique for soft tissue augmentation, limited by unpredictable graft survival. This study aimed at exploring the effect of hydrogel from acellular porcine adipose tissue (HAPA) on angiogenesis and survival of adipose tissue used for lipofilling. The effect of HAPA on adipose-derived stem cells (ADSCs) proliferation, adipogenic differentiation, and vascular endothelial growth factor (VEGF) secretion were evaluated in hypoxia and normoxia in vitro. Read More

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Using SHRP2 NDS data to examine infrastructure and other factors contributing to older driver crashes during left turns at signalized intersections.

Accid Anal Prev 2021 Apr 16;156:106141. Epub 2021 Apr 16.

Department of Civil & Environmental Engineering, University of Massachusetts Amherst, 214 Marston Hall, 130 Natural Resources Road, Amherst, MA, 01003, USA.

Drivers age 65 and over have higher rates of crashes and crash-related fatalities than other adult drivers and are especially over-represented in crashes during left turns at intersections. This research investigated the use of SHRP2 Naturalistic Driving Study (NDS) data to assess infrastructure and other factors contributing to left turn crashes at signalized intersections, and how to improve older driver safety during such turns. NDS data for trips involving signalized intersections and crash or near-crash events were obtained for two driver age groups: drivers age 65 and over (older drivers) and a sample of drivers age 30-49, along with NDS pre-screening and questionnaire data. Read More

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A comprehensive approach for the validation of lumbar spine finite element models investigating post-fusion adjacent segment effects.

A Azadi N Arjmand

J Biomech 2021 Apr 15;121:110430. Epub 2021 Apr 15.

Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran. Electronic address:

Spinal fusion surgery is usually followed by accelerated degenerative changes in the unfused segments above and below the treated segment(s), i.e., adjacent segment disease (ASD). Read More

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Bronchodilator reversibility testing in post-COVID-19 patients undergoing pulmonary rehabilitation.

Respir Med 2021 Apr 13;182:106401. Epub 2021 Apr 13.

Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy. Electronic address:

Background: The usefulness of bronchodilators in coronavirus diseases 2019 (COVID-19) survivors is still uncertain, especially for patients with a concomitant obstructive lung disease. We aimed at verifying the level of bronchodilator reversibility in COVID-19 patients undergoing multidisciplinary pulmonary rehabilitation after the acute phase.

Methods: We enrolled 105 consecutive patients referring to the Pulmonary Rehabilitation Unit of Istituti Clinici Scientifici Maugeri Spa SB, IRCCS of Telese Terme, Benevento, Italy after being discharged from the COVID-19 acute care ward and after recovering from acute COVID-19 pneumonia. Read More

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Artificial intelligence (AI) in the detection of rectosigmoid deep endometriosis.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 14;261:29-33. Epub 2021 Apr 14.

Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

Objectives: The aim of this study was to compare the accuracy of seven classical Machine Learning (ML) models trained with ultrasound (US) soft markers to raise suspicion of endometriotic bowel involvement.

Materials And Methods: Input data to the models was retrieved from a database of a previously published study on bowel endometriosis performed on 333 patients. The following models have been tested: k-nearest neighbors algorithm (k-NN), Naive Bayes, Neural Networks (NNET-neuralnet), Support Vector Machine (SVM), Decision Tree, Random Forest, and Logistic Regression. Read More

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Demographic risk factors for pelvic organ prolapse: Do smoking, asthma, heavy lifting or family history matter?

Eur J Obstet Gynecol Reprod Biol 2021 Apr 12;261:25-28. Epub 2021 Apr 12.

Sydney Medical School Nepean, University of Sydney, Sydney, NSW, Australia.

Objective: Our objective was to identify non-obstetric risk factors for pelvic organ prolapse in women attending a urogynecology clinic.

Study Design: A retrospective study of 662 women referred for pelvic floor dysfunction between January 2017 and August 2018. Participants underwent a standardized interview, clinical exam including Pelvic Organ Prolapse Qualification (POP-Q) assessment, and four-dimensional transperineal ultrasound. Read More

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Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA): Early diagnosis, treatment and outcomes.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 16;261:12-16. Epub 2021 Apr 16.

Department of Urology, Children's Medicine Affiliated to Chongqing Medical University, Chongqing, PR China; Paediatrics Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Centre for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China; Chongqing Key Laboratory of Paediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, PR China. Electronic address:

Objective: To describe and summarize the early diagnosis, treatment and outcomes of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA).

Methods: Data from patients with OHVIRA treated at the study centre over the last decade were analysed retrospectively, including demographic characteristics, symptoms, diagnosis, treatment and outcomes. Relevant published literature was also reviewed in this study. Read More

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Calibration of silicone for passive sampling of semivolatile organic contaminants in indoor air.

Chemosphere 2021 Apr 8;279:130536. Epub 2021 Apr 8.

RECETOX, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic. Electronic address:

Semivolatile organic compounds (SVOCs) are mostly man-made chemicals that distribute between the gas and solid phase in the environment. Many of them could pose harm to people and therefore it is important to know their concentrations in the indoor environment to evaluate the related risks. Inhalation exposure can be assessed using passive sampling. Read More

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The utility of Vibratip in accurate identification of loss of protective sensation in the contralateral foot of patients admitted with a diabetic foot ulcer.

Diabetes Metab Syndr 2021 Apr 7;15(3):857-862. Epub 2021 Apr 7.

Department of Endocrinology, St. Johns Medical College Hospital, Sarjapur Road, Bangalore, 560034, India. Electronic address:

Background And Aims: Diabetic foot ulcer (DFU) is a debilitating complication of type 2 DM. Complexity of foot examination often precludes proper clinical assessment of the foot during routine evaluation. We assessed the utility of novel device, vibratip, both singly and in combination with standard bedside tools for assessment of loss of protective sensation. Read More

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Coordination compounds with heterocyclic ester derivatives. Structural characterization and anti-proliferative activity.

J Inorg Biochem 2021 Mar 23;219:111432. Epub 2021 Mar 23.

Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, 04510 Ciudad de México, Mexico. Electronic address:

A series of new coordination compounds of cobalt(II), copper(II) and zinc(II) with heterocyclic ester derivatives (ethyl 4-methyl-5-imidazole-carboxylate (emizco), 1-(2-(phenylsulphonyl)ethyl)-4-imidazole carboxylate (semizco)) and methyl 5-(propylthio)-2-benzimidazolecarbamate (albendazole, abz) were synthesized. They were fully characterized by different techniques such as IR, UV-Vis-NIR, elemental analysis, molar conductivity and magnetic susceptibility. Additionally, X-ray crystal structures of semizco and its [Co(semizco)Cl]·2CHCN 10, [Co(smmizco)Br]·2CHCN 11 and [Cu(semizco)Br] 15 coordination compounds are analyzed. Read More

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Olfactory dysfunction in SARS-CoV-2 infection: Focus on odorant specificity and chronic persistence.

Am J Otolaryngol 2021 Apr 13;42(5):103014. Epub 2021 Apr 13.

Department of Physics and Chemistry of Materials, Faculty of Medicine/Dental Medicine, Danube Private University, Krems, Austria; Institute of Chemical Technology of Inorganic Materials, Johannes Kepler University Linz, Linz, Austria.

Background: Smell dysfunction has been recognized as an early symptom of SARS-CoV-2 infection, often occurring before the onset of core symptoms of the respiratory tract, fever or muscle pain. In most cases, olfactory dysfunction is accompanied by reduced sense of taste, is partial (microsmia) and seems to normalize after several weeks, however, especially in cases of virus-induced complete smell loss (anosmia), there are indications of persisting deficits even 2 months after recovery from the acute disease, pointing towards the possibility of chronic or even permanent smell reduction for a significant part of the patient population. To date, we have no knowledge on the specificity of anosmia towards specific odorants or chemicals and about the longer-term timeline of its persistence or reversal. Read More

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Towards using convolutional neural network to locate, identify and size defects in phased array ultrasonic testing.

Ultrasonics 2021 Apr 16;115:106436. Epub 2021 Apr 16.

PULÉTS, École de technologie supérieure, 1100 Notre-Dame Ouest, Montréal, Québec, Canada, H3C 1K3.

Machine learning algorithms are widely used in image recognition. In Phased Array Ultrasonic Testing (PAUT), images are typically formed through constructive and destructive superpositions of signals backscattered from flaws or geometric features. However, all PAUT data acquisition schemes require several emissions and the duration of the acquisition may be too slow in high-speed manufacturing. Read More

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Nonadherence after hospital discharge in patients with schizophrenia or schizoaffective disorder: A six-month naturalistic follow-up study.

Compr Psychiatry 2021 Apr 16;108:152240. Epub 2021 Apr 16.

Department of Mathematics, University of Las Palmas de Gran Canaria, The Canary Islands, Spain.

Background: Despite a wealth of studies seeking to identify factors associated with nonadherence few consistent predictors have been determined, and several gaps still exist in the literature.

Method: We assessed 110 consecutively admitted patients diagnosed with schizophrenia or schizoaffective disorder according to ICD-10 criteria. Assessments were performed during hospitalization and at six-months follow-up. Read More

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Current perceptions of cancer nurses in France about their role and the evolution of nursing practices: Findings and perspectives.

Soc Sci Med 2021 Apr 3;277:113896. Epub 2021 Apr 3.

University of Saint-Etienne, Centre Hygée, Institut Presage, CIC-EC Inserm 1408, Saint-Etienne, France. Electronic address:

Background: Florence Nightingale lamented that nurses were seen as merely obedient and devoted. Our two previous oncology studies demonstrated the continuum of strictly curative care and paternalistic care practices among healthcare professionals. At a time when France has just formalized the nursing sciences, this article seeks to shed light on the specifics of the nursing role in oncology and the evolution of standard nursing practices in a rapidly changing environment. Read More

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Kinetic modeling of hydrogen and L-lactic acid production by Thermotoga neapolitana via capnophilic lactic fermentation of starch.

Bioresour Technol 2021 Apr 6;332:125127. Epub 2021 Apr 6.

Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy; Department of Biology, University of Napoli "Federico II", Via Cupa Nuova Cinthia 21, 80126 Napoli, Italy. Electronic address:

This study investigated the feasibility of hydrogen (H) and L-lactic acid production from starch under capnophilic lactic fermentation (CLF) conditions by using Thermotoga neapolitana. Batch experiments were performed in 120 mL serum bottles and a 3 L pH-controlled continuous stirred-tank reactors (CSTR) system with potato and wheat starch as the substrates. A H yield of 3. Read More

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Effect of dexmedetomidine on hemodynamic responses to tracheal intubation: A meta-analysis with meta-regression and trial sequential analysis.

J Clin Anesth 2021 Apr 16;72:110287. Epub 2021 Apr 16.

UOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy; UOC Anesthesia and Intensive Care Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy.

Study Objective: An uncontrolled adrenergic response during tracheal intubation may lead to life-threatening complications. Dexmedetomidine binds to α2-receptors and may attenuate this response. The primary aim of our meta-analysis is to investigate dexmedetomidine efficacy in attenuating sympathetic response to tracheal intubation, compared with placebo or no dexmedetomidine, in terms of heart rate and blood pressure at intubation. Read More

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Liquid triphasic systems as sustainable downstream processing of Chlorella sp. biorefinery for potential biofuels and feed production.

Bioresour Technol 2021 Mar 31;333:125075. Epub 2021 Mar 31.

Department of Chemical and Materials Engineering, College of Engineering, Tunghai University, Taichung 407, Taiwan; Research Centre for Smart Sustainable Circular Economy, Tunghai University, Taichung 407, Taiwan; Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan. Electronic address:

Microalgae are potential sustainable renewable sources of energy but are highly underutilized due to the expensive and time-consuming downstream processing. This study aims at curbing these obstacles by extracting multiple components with a single processing unit. In this work, an ultrasound-assisted liquid triphasic flotation system was incorporated to extract proteins, lipids, and carbohydrates by phase separation. Read More

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KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.

Biochem Biophys Res Commun 2021 Apr 16;557:192-198. Epub 2021 Apr 16.

Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China. Electronic address:

Kinesin family member 18A (KIF18A) is significantly overexpressed and is related to the poor prognosis of human cancers. However, the function of KIF18A in esophageal cancer (EC) is still unclear. Human EC cell lines were used in this study. Read More

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Case study of pipeline failure analysis from two automated vacuum collection system.

Waste Manag 2021 Apr 16;126:643-651. Epub 2021 Apr 16.

Departament de Ciència de Materials i Química Física, Universitat de Barcelona, C/ Martí i Franquès 1, 08028 Barcelona, Spain. Electronic address:

Conventional municipal waste management systems based on collecting and storing waste for future management are cost-effective and flexible. These systems present significant problems such as odours, plagues and hygiene problems caused by their storage and greenhouse gas emissions from garbage trucks used for the transport of waste. The Automated Waste Collection System (AWCS) and Automated Vacuum Waste Collection (AVWC) systems, in which waste is transported directly underground to the processing plants, are efficient collection systems and respectful of the environment as alternatives to traditional systems. Read More

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A unique view of SARS-COV-2 through the lens of ORF8 protein.

Comput Biol Med 2021 Apr 15;133:104380. Epub 2021 Apr 15.

School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK. Electronic address:

Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective concerning the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Read More

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Detection and removal of pacing artifacts prior to automated analysis of 12-lead ECG.

Comput Biol Med 2021 Apr 16;133:104396. Epub 2021 Apr 16.

Oregon Health & Science University, Knight Cardiovascular Institute, Portland, OR, USA. Electronic address:

Background: Pacing artifacts must be excluded from the analysis of paced ECG waveform. This study aimed to develop and validate an algorithm to identify and remove the pacing artifacts on ECG and vectorcardiogram (VCG).

Methods: We developed a semi-automatic algorithm that identifies the onset and offset of a pacing artifact based on the VCG signal slope steepness and designed a graphical user interface that permits quality control and fine-tuning the constraining threshold values. Read More

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CT-based structural analyses of vertebral fractures with polymeric augmentation: A study of cadaveric three-level spine segments.

Comput Biol Med 2021 Apr 16;133:104395. Epub 2021 Apr 16.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Pathologic vertebral fractures due to metastasis can occur under normal physiologic activities, leading to pain and neurologic deficit. Prophylactic vertebroplasty is a technique used to augment vertebral strength and reduce the risk of fracture. Currently, no technique is available to objectively assess vertebral fracture risk in metastatically-involved vertebral bodies. Read More

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