879,611 results match your criteria study investigated


Clinical predictors of poor 30-day headache outcomes after an emergency department visit for acute post-traumatic headache.

Am J Emerg Med 2021 Jun 9;49:158-162. Epub 2021 Jun 9.

Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore, 111 East 210th Street, Bronx, NY 10467, USA. Electronic address:

Purpose: We investigated clinical risk factors that predict poor 30-day headache outcomes among patients evaluated in the emergency department (ED) for post-traumatic headache (PTH).

Methods: This was an analysis of data from a randomized, placebo-controlled study of IV metoclopramide + diphenhydramine for acute PTH. Patients were enrolled during an ED visit and received telephone follow-up with a structured questionnaire 30 days later. Read More

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A computational pipeline for data augmentation towards the improvement of disease classification and risk stratification models: A case study in two clinical domains.

Comput Biol Med 2021 Jun 6;134:104520. Epub 2021 Jun 6.

Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, Ioannina, GR45110, Greece; Department of Biomedical Research, FORTH-IMBB, Ioannina, GR45110, Greece. Electronic address:

Virtual population generation is an emerging field in data science with numerous applications in healthcare towards the augmentation of clinical research databases with significant lack of population size. However, the impact of data augmentation on the development of AI (artificial intelligence) models to address clinical unmet needs has not yet been investigated. In this work, we assess whether the aggregation of real with virtual patient data can improve the performance of the existing risk stratification and disease classification models in two rare clinical domains, namely the primary Sjögren's Syndrome (pSS) and the hypertrophic cardiomyopathy (HCM), for the first time in the literature. Read More

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Soil applied Ca, Mg and B altered phyllosphere and rhizosphere bacterial microbiome and reduced Huanglongbing incidence in Gannan Navel Orange.

Sci Total Environ 2021 May 26;791:148046. Epub 2021 May 26.

College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China; Hubei Provincial Engineering Laboratory for New-Type Fertilizer, Wuhan 430070, China; Research Center of Trace Elements, Wuhan 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, Wuhan 430070, China. Electronic address:

Huanglongbing (HLB) caused by 'Ca. Liberibacter. Asiaticus (Clas)' is one of the destructive diseases for citrus, threatening the development of citrus industry. Read More

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Enhancing the retention of phosphorus through bacterial oxidation of iron or sulfide in the eutrophic sediments of Lake Taihu.

Sci Total Environ 2021 May 26;791:148039. Epub 2021 May 26.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:

Microbial activity can enhance the sequestration of phosphorus (P) in sediments, but little is known about the mechanisms behind it. In this study, sediment cores were sampled from the most eutrophic Meiliang Bay of Lake Taihu, and three treatments were set up in a laboratory incubation experiment, involving (a) the non-treated sediment cores, (b) inoculation, and (c) sterilization. The dissolved and labile iron (Fe) and P were obtained by high-resolution dialysis and the diffusive gradients in thin films (DGT) technique, respectively. Read More

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Driving mechanisms of gross primary productivity geographical patterns for Qinghai-Tibet Plateau lake systems.

Sci Total Environ 2021 Jun 5;791:148286. Epub 2021 Jun 5.

Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:

Being a fundamental property of aquatic systems, gross primary productivity (GPP) is affected by complex environmental factors, such as salinity, nutrients, pH, and sunlight. Under conditions of intensified anthropogenic activity and climate change, it is critical to understand the driving mechanisms of GPP in alpine lakes. In this study, we investigated GPP and associated environmental factors of 23 lake systems in the Qinghai-Tibet Plateau (QTP) along an altitudinal range (from 2500 m to 4500 m). Read More

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Assessment of dust trace elements in an e-waste recycling area and related children's health risks.

Sci Total Environ 2021 May 31;791:148154. Epub 2021 May 31.

Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, Guangdong, China. Electronic address:

Children from Guiyu, an electronic waste (e-waste) recycling town, are exposed to trace elements via dust. However, the source, pathways, and influence factors of house dust and the association of house dust with child inflammation in an e-waste recycling area are not well-known. This study investigated dust trace elements in children's living environment and the associations of house dust trace elements with influence factors and child inflammation. Read More

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Orally administered nano-polystyrene caused vitellogenin alteration and oxidative stress in the red swamp crayfish (Procambarus clarkii).

Sci Total Environ 2021 May 29;791:147984. Epub 2021 May 29.

Dept. Life Sciences, University of Trieste, via L. Giorgieri 5, 34127 Trieste, Italy. Electronic address:

Nanoplastics (≤100 nm) represent the smallest fraction of plastic litter and may result in the aquatic environment as degradation products of larger plastic material. To date, few studies focused on the interactions of micro- and nanoplastics with freshwater Decapoda. The red swamp crayfish (Procambarus clarkii, Girard, 1852) is an invasive species able to tolerate highly perturbed environments. Read More

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Pesticides are the dominant stressors for vulnerable insects in lowland streams.

Water Res 2021 May 17;201:117262. Epub 2021 May 17.

Department of River Ecology, Helmholtz Centre for Environmental Research, UFZ, 04318 Leipzig, Germany.

Despite elaborate regulation of agricultural pesticides, their occurrence in non-target areas has been linked to adverse ecological effects on insects in several field investigations. Their quantitative role in contributing to the biodiversity crisis is, however, still not known. In a large-scale study across 101 sites of small lowland streams in Central Europe, Germany we revealed that 83% of agricultural streams did not meet the pesticide-related ecological targets. Read More

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Simulated acid mine drainage treatment in iron oxidizing ceramic membrane bioreactor with subsequent co-precipitation of iron and arsenic.

Water Res 2021 May 27;201:117297. Epub 2021 May 27.

Environmental and Energy Systems Engineering Program, Istanbul Medeniyet University, Istanbul, 34700, Turkey; Department of Bioengineering, Istanbul Medeniyet University, Istanbul, 34700, Turkey. Electronic address:

Acid mine drainage (AMD), generated in the active and abandoned mine sites, is characterized by low pH and high metal concentrations. One AMD treatment possibility is biologically oxidizing Fe followed by precipitation through pH control. As compared to autotrophic iron oxidizing microbial community, a microbial community enriched in the presence of organic nutrients was hypothesized to yield higher biomass during commissioning the bioreactor. Read More

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Detection of ultrashort-chain and other per- and polyfluoroalkyl substances (PFAS) in U.S. bottled water.

Water Res 2021 May 27;201:117292. Epub 2021 May 27.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA. Electronic address:

Per- and polyfluoroalkyl substances (PFAS) are compounds of emerging concern due to their persistence in the global water cycle and detection in drinking water sources. However, PFAS have been poorly studied in bottled water, especially in the United States. This study investigated the occurrence of PFAS and related factors in 101 uniquely labelled bottled water products for sale in the U. Read More

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Removal trend of amoxicillin and tetracycline during groundwater recharging reusing: Redox sensitivity and microbial community response.

Chemosphere 2021 Jun 4;282:131011. Epub 2021 Jun 4.

State Key Laboratory of Urban Water Resources and Environment (SKLUWRE); School of Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

The abundant existence of antibiotics within the effluent of wastewater treatment plant seriously threatened their safety recharging. To investigate the fate and biodegradation of those toxic antibiotics within the soil aquifer system, typical antibiotics of amoxicillin (AMX) and tetracycline (TC) were selected and their removal mechanisms were investigated. Experimental results revealed that totally 93. Read More

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Speciation, controlling steps and pathways of silver release from the sludge generated from coagulation of wastewater spiked with silver nanoparticles.

Chemosphere 2021 Jun 4;282:131093. Epub 2021 Jun 4.

Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, PR China.

Sludge generated in wastewater treatment facilities is an integral part for the introduction of silver nanoparticles (AgNPs) to the terrestrial environment, which would cause some adverse ecosystem responses. The understanding of silver release process from the sludge is important to evaluate their risks. In this study, the amount and speciation of the released silver were investigated by taking the sludge generated by wastewater coagulation with AgNPs added (denoted as sludge) an example, and kinetic analysis and density functional theory (DFT) calculations were first used to explore the controlling steps and pathways about the silver release. Read More

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Mixed biochar obtained by the co-pyrolysis of shrimp shell with corn straw: Co-pyrolysis characteristics and its adsorption capability.

Chemosphere 2021 Jun 5;282:131116. Epub 2021 Jun 5.

College of Environment and Safety Engineering, Qingdao University of Science and Technology, Qingdao, 266042, PR China. Electronic address:

The co-pyrolysis characteristics of shrimp shell (SS) with corn straw (CS) were investigated by comprehensive characterization to reveal the synergistic effects and further discuss the adsorption capability. TGA results showed that pyrolysis behavior and reactivity were improved with the increase of heating rate and doping ratio of CS. Flynn-Wall-Ozawa (FWO) and distributed activation energy model (DAEM) indicated that co-pyrolysis can effectively reduce energy consumption and promote the decomposition of CaCO. Read More

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Evaluating the added value of multi-input atmospheric transport ensemble modeling for applications of the Comprehensive Nuclear Test-Ban Treaty organization (CTBTO).

J Environ Radioact 2021 Jun 9;237:106649. Epub 2021 Jun 9.

Comprehensive Nuclear Test-Ban Treaty Organization, Wagramerstrasse 5, 1400, Vienna, Austria.

The Comprehensive Nuclear Test-Ban Treaty Organization (CTBTO) runs to date operationally an atmospheric transport modeling chain in backward mode based on operational deterministic European Centre for Medium-Range Weather Forecasts-Integrated Forecasting System (ECMWF-IFS) and on National Centers for Environmental Prediction-Global Forecast System (NCEP-GFS) input data. Meanwhile, ensemble dispersion modeling is becoming more and more widespread due to the ever increasing computational power and storage capacities. The potential benefit of this approach for current and possible future CTBTO applications was investigated using data from the ECMWF-Ensemble Prediction System (EPS). Read More

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Depressive symptom trajectories and their relation to body mass index in women of child-bearing age: The Korea Nurses' Health Study.

J Affect Disord 2021 May 27;292:114-120. Epub 2021 May 27.

College of Nursing, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, South Korea. Electronic address:

Background: This study investigated the sub-trajectory groups of depressive symptoms in women of child-bearing age and the factors impacting latent class membership. Moreover, differences in body mass index (BMI) as an outcome variable were identified among the sub-trajectory groups.

Methods: Data from the Korea Nurses' Health Study (KNHS) were analyzed, comprising that from 6,918 participants who filled out surveys during modules 1, 5, and 7. Read More

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Rational construction of Ni(OH) nanoparticles on covalent triazine-based framework for artificial CO reduction.

J Colloid Interface Sci 2021 May 25;602:23-31. Epub 2021 May 25.

State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, 2 Xue Yuan Road, New Campus, Minhou, Fujian 350108, PR China.

Artificial photoreduction of CO to chemical fuel is an intriguing and reliable strategy to tackle the issues of energy crisis and climate change simultaneously. In the present study, we rationally constructed a Ni(OH)-modified covalent triazine-based framework (CTF-1) composites to serve as cocatalyst ensemble for superior photoreduction of CO. In particular, the optimal Ni(OH)-CTF-1 composites (loading ratio at 0. Read More

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Robotic-assisted total knee arthroplasty improves the outlier of rotational alignment of the tibial prosthesis using 3DCT measurements.

Knee 2021 Jun 9;31:64-76. Epub 2021 Jun 9.

Department of Orthopedic Surgery, Toho University School of Medicine, Japan. Electronic address:

Background: The aim of the present study was to compare the accuracy of prosthetic alignment with three-dimensional computed tomography (3DCT) measurements following total knee arthroplasty (TKA) performed using a robotic-assisted surgical technique versus a conventional TKA.

Methods: 41 TKAs were performed with a handheld robotic-assisted surgical procedure (Robot group) between 2019 and 2020. Another 41 patients underwent TKA with a conventional manual surgical procedure (Manual group) using the same prosthesis. Read More

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Relationship between volatile organic compounds, free amino acids, and sensory profile of smoked bacon.

Meat Sci 2021 Jun 5;181:108596. Epub 2021 Jun 5.

Universidade de São Paulo, Escola Superior de Agricultura "Luiz de Queiroz", Departamento de Agroindústria, Alimentos e Nutrição, Av. Pádua Dias, 11, Piracicaba, SP, Brazil. Electronic address:

Flavor is one of the most important characteristics of smoked bacon, strongly affecting its liking by consumers. The smoking process, lipid oxidation and proteolysis contribute to bacon quality through the generation of odors and flavor compounds. In this study, the relationships between free amino acids (FAAs), volatile organic compounds (VOCs) and sensory characteristics of smoked bacon stored for 60 days at 5 °C were investigated. Read More

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A retrospective cohort study of medication dispensing at pharmacies: Administration matters!

Drug Alcohol Depend 2021 May 29;225:108792. Epub 2021 May 29.

Norwegian Centre for Addiction Research (SERAF), University of Oslo, Bygg 45, Ullevål sykehus, Kirkeveien 166, 0450, Oslo, Norway. Electronic address:

Background: Opioid agonist treatment (OAT) for opioid use disorders may be delivered at treatment clinics or dispensed from pharmacies, however the type of delivery may be associated with different risks and benefits. The aim of the study was to investigate whether dispensing of methadone or buprenorphine at pharmacies during treatment for opioid use disorders was associated with adverse outcomes.

Methods: Retrospective cohort study using a national, linked, population-level data set from Denmark. Read More

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Occurrence and migration of phthalates in adhesive materials to fruits and vegetables.

J Hazard Mater 2021 Jun 2;418:126277. Epub 2021 Jun 2.

Beijing Advanced Innovation Centre for Food Nutrition and Human Health. Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, PR China. Electronic address:

Labels or tapes are widely used on fresh fruits and vegetables, which may contain phthalates (PAEs). There are few studies on the contamination pathway of PAEs from labels or tapes to food stuff. In this study, the concentrations of eleven PAEs in adhesive labels, tapes, labeled fruits and vegetables on the market were investigated. Read More

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Integrated mechanistic and data-driven modeling for risk assessment of greenhouse gas production in an urbanized river system.

J Environ Manage 2021 Jun 9;294:112999. Epub 2021 Jun 9.

Department of Animal Sciences, Ghent University, Gent, Belgium.

Surrounded by intense anthropogenic activities, urban polluted rivers have increasingly been reported as a significant source of greenhouse gases (GHGs). However, unlike pollution and climate change, no integrated urban water models have investigated the GHG production in urban rivers due to system complexity. In this study, we proposed a novel integrated framework of mechanistic and data-driven models to qualitatively assess the risks of GHG accumulation in an urban river system in different water management interventions. Read More

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Enhanced immune reconstitution of γδ T cells after allograft overcomes negative impact of pre-transplant MRD positive status in AML patients.: γδ T cells and MRD+ AML.

Transplant Cell Ther 2021 Jun 9. Epub 2021 Jun 9.

Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Background: Minimal residual disease (MRD) prior to allogeneic stem cell transplantation (allo-SCT) in AML is a poor risk factor for outcome. The γδ T cells represents a unique minority lymphocyte population which is preferentially located in peripheral tissues, can recognize antigens in non-MHC restricted manner and plays a "bridging" role between innate and adaptive immune system.

Objectives: In this study, we investigated a potential graft-vs-leukaemia effect of γδ T cells reconstitution post-transplant in AML patients with pre-transplant positive minimal/measurable disease status (MRD+). Read More

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Autoimmunity and COVID-19 - The microbiotal connection.

Autoimmun Rev 2021 Jun 9:102865. Epub 2021 Jun 9.

Department of Medicine C, Wolfson Medical Center, Holon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background And Aims: The novel SARS-CoV-2 has been rattling the world since its outbreak in December 2019, leading to the COVID-19 pandemic. The learning curve of this new virus has been steep, with a global scientific community desperate to learn how the virus is transmitted, how it replicates, what cause such a wide spectrum of disease manifestations, causing none or few symptoms in some. Others are burdened by an intense immune response that resembles the cytokine storm syndrome (CSS), which leads to severe disease manifestations, often complicated by fatal acute respiratory distress syndrome and death. Read More

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Widespread brain parenchymal HMGB1 and NF-κB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice.

Neurobiol Dis 2021 Jun 9:105424. Epub 2021 Jun 9.

Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey. Electronic address:

Neuroinflammatory changes involving neuronal HMGB1 release and astrocytic NF-κB nuclear translocation occur following cortical spreading depolarization (CSD) in wildtype (WT) mice but it is unknown to what extent this occurs in the migraine brain. We therefore investigated in familial hemiplegic migraine type 1 (FHM1) knock-in mice, which express an intrinsic hyperexcitability phenotype, the extent of neuroinflammation without and after CSD. CSD was evoked in one hemisphere by pinprick (single CSD) or topical KCl application (multiple CSDs). Read More

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Development of a novel model of intervertebral disc degeneration by the intradiscal application of monosodium iodoacetate (MIA) in rat Degenerative change in monosodium iodoacetate (MIA)-injected intervertebral disc.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Physiology, Korea University, Seoul, Republic of Korea. Electronic address:

Background Context: Low back pain is one of the most common musculoskeletal disorders. While the pathology of intervertebral disc (IVD) degeneration has been modeled using various biological methods, these models are inadequate for simulating similar pathological states in humans.

Purpose: This study investigated whether monosodium iodoacetate (MIA) injection into the IVD of rats could generate a reliable model of IVD degeneration. Read More

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Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules.

Eur J Pharm Sci 2021 Jun 9:105908. Epub 2021 Jun 9.

Laboratory of Pharmaceutical Technology, Faculty of Pharmacy and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama, 930-0194, Japan.

This study investigated an agglomeration of nanoparticles in a suspension using nuclear magnetic resonance (NMR) relaxation. The nanosuspension was prepared by wet bead milling using indomethacin and polyvinylpyrrolidone as an active pharmaceutical ingredient (API) and stabilizer, respectively. Transmission profiles using a dispersion analyzer based on multilight scattering technology confirmed that agglomeration occurred at 25 °C immediately after wet bead milling. Read More

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HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content.

Reprod Toxicol 2021 Jun 9;103:96-107. Epub 2021 Jun 9.

Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria; Department of Morbid Anatomy, Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Osun State, Nigeria.

Highly active anti-retroviral therapy (HAART) is an effective anti-retroviral cocktail. Similarly, anti-Koch is highly potent against Mycobacterium tuberculosis. However, these drugs have been shown to impair male fertility. Read More

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Spermine with Sodium Taurocholate Enhances Pulmonary Absorption of Macromolecules in Rats.

J Pharm Sci 2021 Jun 9. Epub 2021 Jun 9.

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, kita-ku, Okayama 700-8530, Japan.

The improvement effect of the combined use of spermine (SPM), a polyamine, with sodium taurocholate (STC) on the pulmonary drug absorption was investigated utilizing poorly absorbable drugs with various molecular sizes in rats. The pulmonary absorption of rebamipide, a low molecular but poorly absorbable drug after oral administration, was significantly improved by the combined use of SPM with STC (SPM-STC formulation), while poly- L-lysine did not show a significant change in rebamipide absorption from the lungs. Furthermore, the safety of the SPM-STC formulation for the lungs was assessed in rats by the histopathological study and any local toxicity was not observed while poly-L-lysine, a typical chemical causing the toxicity for the epithelial cells, provided several histopathological changes. Read More

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Effects of fermented organic fertilizer application on soil NO emission under the vegetable rotation in polyhouse.

Environ Res 2021 Jun 9:111491. Epub 2021 Jun 9.

School of Agriculture and Food, The University of Melbourne, Victoria, 3010, Australia.

Vegetable field is one of the main sources of soil nitrous oxide (NO) emission, yet soil NO emission from vegetable rotation with combined application of fermented organic fertilizer with inorganic fertilizer in polyhouse is not well evaluated. In this study, we investigated the soil NO emission in cabbage-tomato rotation management system under different treatments of fertilizer nitrogen (N) sources, including: 100% inorganic fertilizer (IF), 75% IF+25% fermented organic fertilizer (OF), 50% IF+50% OF, 75% IF+25% OF, 100% OF, and no fertilizer (CK). The fertilization amount of N was 180 kg ha to cabbage and 200 kg ha to tomato. Read More

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Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies.

Eur J Pharmacol 2021 Jun 9:174254. Epub 2021 Jun 9.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 492010, India. Electronic address:

Psoriasis is an autoimmune chronic inflammatory condition of skin affecting 125 million populaces around the globe. It is implicated as a result of multifaceted phenomena involving various cell and subcell activities with the aid of numerous cellular and molecular components including signaling aisle and regulatory proteins owing to the development of such hyperproliferative dermatological conditions. This involves a deeply complex and conflicting pathology owing to genetic and immunological deviations resulting from the unusual presentation of different signaling pathways and regulatory proteins. Read More

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