J Neurosurg Anesthesiol 2021 Jun 10. Epub 2021 Jun 10.
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA Department of Anesthesiology, MMIMSR, MM (DU), Mullana, Haryana, India Bernard Becker Medical Library Department of Anesthesiology, Perioperative and Pain Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO.
One of the main concerns of intraoperative hypotension is adequacy of cerebral perfusion, as cerebral blood flow decreases passively when mean arterial pressure falls below the lower limit of cerebral autoregulation. Treatment of intraoperative hypotension includes administration of drugs, such as inotropes and vasopressors, which have different pharmacological effects on cerebral hemodynamics; there is no consensus on the preferred drug to use. We performed a network meta-analysis (NMA) to pool and analyze data comparing the effect on cerebral oxygen saturation (ScO2) measured by cerebral oximetry of various inotropes/vasopressors used to treat intraoperative hypotension. Read More