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Neonatal Lymphopenia Screening Is Important For Early Diagnosis of Severe Combined Immunodeficiency.

Am J Perinatol 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology and Oncology, Immunology, Department of Pediatrics, Erciyes University, School of Medicine, Kayseri, Turkey.

Objective:  T-cell receptor excision circles are expensive for neonatal severe combined immunodeficiency screening in developing countries. We aimed to detect immunodeficiencies presenting with lymphopenia to enable screening in the general population and to improve awareness regarding lymphopenia among clinicians.

Study Design:  This study was conducted prospectively. Read More

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The interaction effect between comorbidity and venous thromboembolism on mortality rates after venous thromboembolism: A 5-year cohort study.

Thromb Haemost 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: Comorbidity influences venous thromboembolism (VTE) mortality, but it is unknown whether this is due to comorbidity alone or whether biological interaction exists.

Objectives: We examined whether comorbidity and VTE interact to increase VTE mortality beyond their individual effects.

Methods: This register-based 5-year cohort study included all VTE patients ≥18 years during 2000-2016, and an age-, sex-, and comorbidity-matched comparison cohort of individuals without VTE. Read More

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Use of a Transarticular Calcaneo-Tibial Locking Plate for Temporary Immobilization of the Tarsocrural Joint following Surgical Repair of Common Calcaneal Tendon Rupture in Eight Dogs.

Vet Comp Orthop Traumatol 2021 Jun 11. Epub 2021 Jun 11.

Dipartimento di Scienze Veterinarie, Università di Torino, Grugliasco (To), Italy.

Objective:  The purpose of this clinical communication is to report the management of common calcaneal tendon rupture in dogs using a transarticular calcaneo-tibial locking plate as a method of temporary immobilization of the tarsocrural joint to support primary repair of the common calcaneal tendon.

Study Design:  Dogs presented with partial or complete common calcaneal tendon rupture treated with primary tendon repair supported by the transarticular calcaneo-tibial locking plate technique from July 2016 to December 2019 were included. The tarsus was placed at a standing angle of 150 degrees and the pre-contoured Fixin locking 'L' or 'T' plate was medially applied with two locking screws inserted in the calcaneus and two screws inserted in the distal tibia. Read More

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Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.

Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. Read More

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Experiencing Bullying Is Associated With Firearm Access, Weapon Carriage, Depression, Marijuana Use, and Justice Involvement in Adolescents.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Emergency Medicine, Children's National Hospital, Washington, DC.

Objectives: The aims of this study were to assess whether bullying experience among youths is associated with firearm access and to evaluate assault perpetration risk factors between bullied and nonbullied adolescents.

Methods: This was a secondary analysis of a cross-sectional survey designed to measure self-reported social determinants of health and behavioral health risks among adolescents (13-21 years) in a pediatric emergency department between July 2017 and August 2019. Participants were included in this subanalysis if they responded to a survey item that assessed bullying. Read More

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Pediatric Ocular Injury Due to Hand Sanitizer Exposure An Emerging Hazard.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer Pediatric Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Objectives: The objective of this study was to describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children presenting to a tertiary medical center during the severe acute respiratory syndrome coronavirus 2 pandemic.

Methods: A retrospective single-center observational study conducted from February 21, 2020, to October 11, 2020. Subjects 10 years or younger who presented with ABHR-induced ocular injury were included. Read More

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Mixed Methods Study of Nurse Assessment of Patient Preferences for Engagement During Hospitalization.

Nurs Res 2021 Jun 11. Epub 2021 Jun 11.

Marquette University College of Nursing, Milwaukee, WI University of Wisconsin-Madison Research Design and Statistics Unit, Madison, WI.

Background: Global health care initiatives emphasize the importance of engaging patients in their health care to improve the patient's experience and outcomes. Assessing patient preferences for engagement is critical, as there are many ways patients can engage in their care and preferences vary across individuals.

Objective: The primary purpose of this study was to evaluate the effect of implementation of the Patient Preferences for Engagement Tool 13-Item Short Form (PPET13) during hospitalization on patient and nurse experience of engagement. Read More

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The Regional Cerebral Oxygen Saturation Effect of Inotropes/Vasopressors Administered to Treat Intraoperative Hypotension: A Bayesian Network Meta-analysis.

J Neurosurg Anesthesiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA Department of Anesthesiology, MMIMSR, MM (DU), Mullana, Haryana, India Bernard Becker Medical Library Department of Anesthesiology, Perioperative and Pain Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO.

One of the main concerns of intraoperative hypotension is adequacy of cerebral perfusion, as cerebral blood flow decreases passively when mean arterial pressure falls below the lower limit of cerebral autoregulation. Treatment of intraoperative hypotension includes administration of drugs, such as inotropes and vasopressors, which have different pharmacological effects on cerebral hemodynamics; there is no consensus on the preferred drug to use. We performed a network meta-analysis (NMA) to pool and analyze data comparing the effect on cerebral oxygen saturation (ScO2) measured by cerebral oximetry of various inotropes/vasopressors used to treat intraoperative hypotension. Read More

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Histopathological Characteristics of Limbal Stem Cell Deficiency Secondary to Chronic Vernal Keratoconjunctivitis.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India; Center for Ocular Regeneration (CORE), L V Prasad Eye Institute, Hyderabad, India; and Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the histopathological characteristics of limbal stem cell deficiency (LSCD) due to chronic vernal keratoconjunctivitis (VKC).

Methods: This retrospective study included 14 eyes of 13 patients who underwent simple limbal epithelial transplantation for total LSCD from 2017 to 2018. The histological characteristics of the excised fibrovascular pannus were compared between 2 groups of 7 eyes, each with LSCD due to VKC and chemical burns (CB). Read More

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Comparison of DMEK and DSAEK in Eyes With Endothelial Decompensation After Previous Penetrating Keratoplasty.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Purpose: Posterior lamellar keratoplasty is increasingly applied in patients with endothelial decompensation after penetrating keratoplasty (PK). The aim of this study was to compare the results of Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) after PK.

Methods: In this retrospective study, clinical data of 30 patients who received DMEK (n = 19) or DSAEK (n = 11) for endothelial decompensation after PK were evaluated. Read More

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Effectiveness of a Teleophthalmology Vision Center in Treating Corneal Disorders and Its Associated Economic Benefits.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Cornea and Refractive Surgery, Aravind Eye Care System, Madurai, India; Department of Cataract, S.V. Aravind Eye Hospital, Aravind Eye Care System, Tirupati, India.

Purpose: The aim of this study was to study the clinical and economic impact of a teleophthalmology-based vision center (VC) in the management of corneal diseases in rural south India.

Methods: Data of patients with corneal disorders who visited the VC in the year 2019 were analyzed for the total number of outpatient visits, the proportion of corneal cases that were treated at the VC, those referred to the base hospital (BH), and the costs of treatment.

Results: In 2019, 1131 (10%) of 10,850 patients who visited the VC were diagnosed with corneal disorders. Read More

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Obstructive sleep apnea prediction from electrocardiogram scalograms and spectrograms using convolutional neural networks.

Physiol Meas 2021 Jun 11. Epub 2021 Jun 11.

Biomedical Engineering, TOBB Ekonomi ve Teknoloji Universitesi, Sogutozu Cad. No:43, Cankaya, 06560, TURKEY.

Objective: In this study, we conducted a comparative analysis of deep convolutional neural network (CNN) models in predicting Obstructive Sleep Apnea (OSA) using electrocardiograms. Unlike other studies in the literature, this study automatically extracts time-frequency features by using CNNs instead of manual feature extraction from ECG recordings.

Approach: The proposed model generates scalogram and spectrogram representations by transforming preprocessed 30-sec ECG segments from time domain to the frequency domain using Continuous Wavelet Transform (CWT) and Short Time Fourier transform (STFT), respectively. Read More

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Predictors of progression in radiation-induced versus nonradiation-induced pediatric meningiomas: a large single-institution surgical experience.

J Neurosurg Pediatr 2021 Jun 11:1-7. Epub 2021 Jun 11.

1Department of Neurosurgery, Boston Children's Hospital.

Objective: The goal in this study was to outline unique differences between radiation-induced and nonradiation-induced pediatric meningiomas and to identify independent risk factors of tumor recurrence/progression.

Methods: This is a retrospective cohort study of all pediatric meningiomas diagnosed and surgically treated at the authors' institution between 1993 and 2017. Multivariable Cox regression was applied to identify independent risk factors for tumor recurrence/progression. Read More

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Radiosurgery as a microsurgical adjunct: outcomes after microsurgical resection of intracranial arteriovenous malformations previously treated with stereotactic radiosurgery.

J Neurosurg 2021 Jun 11:1-12. Epub 2021 Jun 11.

1Department of Neurosurgery and Stanford Stroke Center, Stanford University Medical Center, Stanford.

Objective: Microsurgical resection of arteriovenous malformations (AVMs) can be aided by staged treatment consisting of stereotactic radiosurgery followed by resection in a delayed fashion. This approach is particularly useful for high Spetzler-Martin (SM) grade lesions because radiosurgery can reduce flow through the AVM, downgrade the SM rating, and induce histopathological changes that additively render the AVM more manageable for resection. The authors present their 28-year experience in managing AVMs with adjunctive radiosurgery followed by resection. Read More

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Association Between Chronologic Age and Geriatric Assessment-Identified Impairments: Findings From the CARE Registry.

J Natl Compr Canc Netw 2021 Jun 11:1-6. Epub 2021 Jun 11.

1Institute for Cancer Outcomes and Survivorship.

Background: The NCCN Guidelines for Older Adult Oncology recommend that, when possible, older adults with cancer undergo a geriatric assessment (GA) to provide a comprehensive health appraisal to guide interventions and appropriate treatment selection. However, the association of age with GA-identified impairments (GA impairments) remains understudied and the appropriate age cutoff for using the GA remains unknown.

Patients And Methods: We designed a cross-sectional study using the Cancer and Aging Resilience Evaluation (CARE) registry of older adults with cancer. Read More

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Predicting feed intake using modelling based on feeding behaviour in finishing beef steers.

Animal 2021 Jun 8;15(7):100231. Epub 2021 Jun 8.

Scotland's Rural College, Beef and Sheep Research Centre, SRUC, West Mains Road, Edinburgh EH9 3JG, UK.

Current techniques for measuring feed intake in housed cattle are both expensive and time-consuming making them unsuitable for use on commercial farms. Estimates of individual animal intake are required for assessing production efficiency. The aim of this study was to predict individual animal intake using parameters that can be easily obtained on commercial farms including feeding behaviour, liveweight and age. Read More

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Systematic review of reproductive outcomes after High Intensity Focused Ultrasound treatment of uterine fibroids.

Eur J Radiol 2021 May 27;141:109801. Epub 2021 May 27.

Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB, Zwolle, the Netherlands.

Purpose: Myomectomy is currently the gold standard for the treatment of uterine fibroids in women who desire pregnancy. However, this surgical fibroid removal has a long convalescence. Promising alternatives may be non-invasive High Intensity Focused Ultrasound (HIFU) under either MRI (MR-HIFU) or ultrasound guidance (USgHIFU). Read More

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Accuracy of preoperative CT staging of acute colonic diverticulitis using the classification of diverticular disease (CDD) - Is there a beneficial impact of water enema and visceral obesity?

Eur J Radiol 2021 Jun 6;141:109813. Epub 2021 Jun 6.

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Center for Radiology and Endoscopy, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. Electronic address:

Purpose: We evaluated the accuracy of preoperative CT in staging colonic diverticulitis (ACD) by using the classification of diverticular disease (CDD) and investigated the diagnostic impact of water enema (WE) and visceral obesity.

Methods: In this retrospective study, the radiological and hospital information system was searched for patients who underwent CT for clinically suspected ACD prior to surgery between 2009 and 2019. From the initial population (n = 164), we included 155 patients (94. Read More

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Evaluation of IGF-1 as a novel theranostic biomarker for schizophrenia.

J Psychiatr Res 2021 Jun 2;140:172-179. Epub 2021 Jun 2.

Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey.

Objective: In the current study, we aimed to investigate fasting plasma levels of glucose, insulin, growth hormone, IGF-1, and lipid profile in remission schizophrenia patients, treatment resistant schizophrenia patients and healthy controls and to determine whether IGF-1 levels can be used as a theranostic biomarker in schizophrenia.

Methods: Sixty-two patients under remission from schizophrenia, sixty-five treatment-resistant patients with schizophrenia and sixty-two healthy controls were included in the study. All patients were recruited and evaluated over 11 months. Read More

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Thiol/disulfide homeostasis in medication-naive children and adolescents with obsessive-compulsive disorder.

J Psychiatr Res 2021 Jun 2;140:159-164. Epub 2021 Jun 2.

Department of Child and Adolescent Psychiatry, Manisa Celal Bayar University, Faculty of Medicine, Manisa, 45030, Turkey. Electronic address:

Obsessive-compulsive disorder (OCD) causes significant psychic distress and affects children's social and academic functioning. Approximately 80% of OCD cases begin in childhood. Earlier onset is associated with more severe OC symptoms, poorer treatment response, and a more unfavorable clinical course. Read More

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Feelings about pregnancy and mother-infant bonding as predictors of persistent psychological distress in the perinatal period: The Japan Environment and Children's Study.

J Psychiatr Res 2021 May 30;140:132-140. Epub 2021 May 30.

Hyogo Regional Center for the Japan Environment and Children's Study, Hyogo College of Medicine, Nishinomiya, Japan; Department of Public Health, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address:

Feelings about pregnancy and mother-infant bonding are associated with maternal mental health before and after childbirth. The current study examined factors associated with persistent distress at 12 months after childbirth among mothers with psychological distress in the first trimester, using data from the Japan Environment and Children's Study (JECS). Feelings about pregnancy were assessed using a questionnaire in the first trimester, and maternal mental health was assessed using the Kessler 6 (K6) in the first trimester and at 12 months after childbirth. Read More

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Composite psychosocial risk based on the fear avoidance model in patients undergoing anterior cruciate ligament reconstruction: Cluster-based analysis.

Phys Ther Sport 2021 Jun 2;50:217-225. Epub 2021 Jun 2.

Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Musculoskeletal Research, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physical Medicine and Rehabilitation, Osher Center for Integrative Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Objectives: To examine associations between preoperative fear-avoidance model (FAM) risk subgroup status and patient expectation of surgical success with postoperative outcomes at 6 and 12 months after anterior cruciate ligament reconstruction (ACLR).

Design: Cohort study.

Setting: Academic medical center. Read More

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Vitamin D supplementation reduces serum lipids of children with hypertriacylglycerolemia: A randomized, triple-masked, placebo-controlled crossover trial.

Nutrition 2021 Apr 28;89:111296. Epub 2021 Apr 28.

Laboratory of Physiology, Nutrition and Health, Faculty of Physical Education and Dance, Federal University of Goiás, Samambaia Campus, Goiânia, Goiás, Brazil.

Objectives: This study aimed to evaluate the effect of cholecalciferol supplementation on the body composition and metabolic profile of children with hypertriacylglycerolemia.

Methods: This is a randomized, triple-masked, placebo-controlled, crossover trial of 44 Brazilian children with hypertriacylglycerolemia, age 4 to 11 y. The sample included eutrophic and overweight/obese children according to body mass index for age, with sufficient and insufficient vitamin D basal levels. Read More

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A Fast-track Pathway for Emergency General Surgery at an Academic Medical Center.

J Surg Res 2021 Jun 8;267:1-8. Epub 2021 Jun 8.

Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address:

Background: Fast Track Pathways (FTP) directed at reducing length of stay (LOS) and overall costs are being increasingly implemented for emergency surgeries. The purpose of this study is to evaluate implementation of a FTP for Emergency General Surgery (EGS) at an academic medical center (AMC).

Methods: The study included 165 patients at an AMC between 2016 and 2018 who underwent laparoscopic appendectomy (LA), laparoscopic cholecystectomy (LC), or laparoscopic inguinal hernia repair (LI). Read More

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Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction.

Environ Int 2021 Jun 8;155:106666. Epub 2021 Jun 8.

Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, United States.

Background: Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.

Objective: To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth. Read More

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Evaluation of serum antioxidative status, immune status and intestinal condition of Linwu duck challenged by lipopolysaccharide with various dosages and replications.

Poult Sci 2021 Apr 20;100(7):101199. Epub 2021 Apr 20.

Hunan Institute of Animal and Veterinary Science, Changsha 410131, China. Electronic address:

The present study investigated the dosage and replication effects of lipopolysaccharide challenges on the serum oxidative and immune status, and the intestinal morphology and permeability of Linwu ducks at the growing stage. A total of 500 54-day-old Linwu ducks were randomly assigned into 10 treatments, which included a factorial arrangement of 2 levels of LPS challenge replications (1 and 2 times) × 5 levels of lipopolysaccharide challenging dosages (0, 0.1, 0. Read More

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Effect of azithromycin on bronchial wall thickness in severe persistent asthma: A double-blind placebo-controlled randomized clinical trial.

Respir Med 2021 Jun 2;185:106494. Epub 2021 Jun 2.

Department of Radiology, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran. Electronic address:

Background: Azithromycin reduced airway remodeling in animal models of asthma. However, its effect on human subjects has not been studied yet. This study aimed to investigate the effect of long-term treatment with azithromycin on airways wall thickness in patients with severe persistent asthma. Read More

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COPD maintenance medication is linked to left atrial size: Results from the COSYCONET cohort.

Respir Med 2021 May 29;185:106461. Epub 2021 May 29.

Department of Medicine, Pulmonary and Critical Care Medicine, University of Marburg (UMR), Germany, Member of the German Center for Lung Research (DZL), Marburg, Germany. Electronic address:

Background: Lung function impairment in COPD is known to be related to reductions of left heart size, while short-term interventional trials with bronchodilators showed positive effects on cardiac parameters. We investigated whether COPD maintenance therapy has analogous long-term effects.

Methods: Pooled data of GOLD grade 1-4 patients from visits 1 and 3 (1. Read More

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Middle ear effusion prevalence at time of tympanostomy before and during COVID-19 pandemic.

Int J Pediatr Otorhinolaryngol 2021 Jun 8;147:110785. Epub 2021 Jun 8.

Nemours Children's Hospital, Orlando, FL, USA.

Background: Management of pediatric otitis media with effusion (OME) and recurrent otitis media typically includes observation up to 3 months. Bilateral myringotomy and tube (BMT) placement is performed due to persistent effusion with associated symptoms such as decreased hearing. With the COVID-19 pandemic and mandatory stay at home orders (MSHO), children were quarantined at home and many remained home after MSHO. Read More

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