807,914 results match your criteria study examined


[Childhood Cancer Patients in a Family-Oriented Rehabilitation Program: Goals and Change in Physical Functioning].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):124-131. Epub 2021 Apr 15.

Institut und Poliklinik für Medizinische Psychologie, Universitätsklinikum Hamburg-Eppendorf, Deutschland.

Purpose: Childhood cancer often leads to physical and psychosocial burdens that can persist beyond the end of treatment. Family-oriented rehabilitation programs (FOR) focus on long-term consequences and support families in returning to daily life. The objectives of this study were to describe rehabilitation goals and goal attainment, to analyze the relationship between physical functioning and physical well-being and to examine predictors of changes in physical functioning during the FOR. Read More

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[Predictors of the Utilization and Waiting Period Before Starting an Oncological Rehabilitation after Breast Cancer].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):86-94. Epub 2021 Apr 15.

Forschungs- und Lehreinheit Medizinische Soziologie, Med. Hochschule Hannover.

Purpose: This study explores the sociodemographic, medical and work-related factors leading to a participation in an in-house rehabilitation measure after primary treatment for breast cancer.

Methods: The prospective multi-center study is based on a written survey with employed breast cancer patients who were recruited at 11 breast cancer centers in Lower Saxony, Germany. Predictors of participation were examined by logistic regression, predictors of the time period before starting the rehabilitation by linear regression. Read More

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Assessing Left Ventricular Early Diastolic Velocities With Tissue Doppler and Speckle Tracking by Transesophageal and Transthoracic Echocardiography.

Anesth Analg 2021 May;132(5):1400-1409

From the Department of Anesthesiology and Perioperative Medicine, Ghent University Hospital, Ghent, Belgium.

Background: Assessing diastolic dysfunction is essential and should be part of every routine echocardiography examination. However, clinicians routinely observe lower mitral annular velocities by transesophageal echocardiography (TEE) under anesthesia than described by awake transthoracic echocardiography (TTE). It would be important to know whether this difference persists under constant loading conditions. Read More

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Characteristics Associated With Functional Changes During Systemic Cancer Treatments: A Systematic Review Focused on Older Adults.

J Natl Compr Canc Netw 2021 Apr 15:1-8. Epub 2021 Apr 15.

2Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

Background: Maintaining functional status is important to older adults with cancer, but data are limited on how systemic treatments affect functional status. We systematically reviewed changes in functional status during systemic cancer treatments and identified characteristics associated with functional decline and improvement.

Methods: We searched PubMed, Embase, Web of Science, and Cochrane Register of Controlled Trials for articles examining characteristics associated with functional changes in older adults during systemic cancer treatment published in English between database inception and January 11, 2019 (PROSPERO CRD42019123125). Read More

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Stressful life events and the risk of primary progressive multiple sclerosis: A population-based case-control study.

Mult Scler Relat Disord 2021 Apr 7;51:102937. Epub 2021 Apr 7.

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The onset and presentation of primary progressive multiple sclerosis (PPMS) like any other autoimmune diseases can be triggered by unexpected lifetime stressful events, which require to be assessed in order to minimize our exposure to such events as much as possible.

Objective: The aim of the present study was to determine the possible role of socioeconomic status (SES) and stressful events in PPMS development METHODS: The present population-based case-control study recruited PPMS cases and healthy controls from the general population during 2019-2020 in Tehran, Iran. Clinical diagnosis of cases was based on the 2017 McDonald criteria and confirmed by a neurologist. Read More

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A comparison of the mechanisms and performances of Acorus calamus, Pontederia cordata and Alisma plantagoaquatica in removing nitrogen from farmland wastewater.

Bioresour Technol 2021 Apr 6;332:125105. Epub 2021 Apr 6.

College of Resources and Environment, Hunan Agricultural University, Changsha 410128, PR China; Hunan Provincial Key Laboratory of Farmland Pollution Control and Agricultural Resources Use, Hunan Provincial Key Laboratory of Nutrition in Common University, National Engineering Laboratory on Soil and Fertilizer Resources Efficient Utilization, Changsha 410128, PR China. Electronic address:

This study examined the performances of Acorus calamus, Pontederia cordata, and Alisma plantagoaquatica in removing nitrogen (N) from farmland wastewater. P. cordata showed the fastest rate of N removal, followed by A. Read More

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Postoperative extremity compartment syndrome in a cancer center: Incidence and risk factors.

Surg Oncol 2021 Apr 3;38:101563. Epub 2021 Apr 3.

Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Objective: Postoperative compartment syndrome is a reported complication with known patient- and treatment-specific risk factors. Cancer patients carry unique risk factors associated with their underlying disease and long, complex procedures. While elevated serum lactate in traumatic and intensive care settings portends higher risk, no laboratory parameter has demonstrated utility in postoperative risk stratification. Read More

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Sepsis-induced acute lung injury in young rats is relieved by calycosin through inactivating the HMGB1/MyD88/NF-κB pathway and NLRP3 inflammasome.

Int Immunopharmacol 2021 Apr 12;96:107623. Epub 2021 Apr 12.

Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China. Electronic address:

Purpose: Sepsis is the primary cause for children's death worldwide. Calycosin (CAL) is an astragalus extract with anti-inflammatory, antioxidant and anti-tumor functions. This study aims to probe the role of CAL in alleviating sepsis-induced acute lung injury (ALI). Read More

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Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group.

Neuroimage Clin 2021 Mar 22;30:102636. Epub 2021 Mar 22.

Neuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural & Health Sciences, Faculty of Health Sciences, Australian Catholic University, Melbourne, VIC, Australia. Electronic address:

Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i. Read More

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Evidence for dissociable cognitive and neural pathways from poverty versus maltreatment to deficits in emotion regulation.

Dev Cogn Neurosci 2021 Apr 8;49:100952. Epub 2021 Apr 8.

Department of Psychological & Brain Sciences at Washington University in St. Louis, United States; Department of Psychiatry at Washington University in St. Louis, United States; Department of Radiology at Washington University in St. Louis, United States.

Poverty and threat exposure (TE) predict deficits in emotion regulation (ER). Effective cognitive ER (i.e. Read More

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Human Papillomavirus (HPV): unawareness of causal role HPV infection in cervical cancer, HPV vaccine availability and HPV vaccine uptake among female schoolteachers in a Middle Eastern country.

J Infect Public Health 2021 Feb 8;14(5):661-667. Epub 2021 Feb 8.

Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Box: 24923, 13110 Safat, Kuwait. Electronic address:

Background: Human papillomavirus (HPV) is the most common viral infection of the reproductive tract. This cross-sectional study among female schoolteachers assessed the prevalence of i) unawareness of HPV infection's causal role in cervical cancer; ii) unawareness of HPV vaccine availability and iii) examined the sociodemographic variables associated both the outcome variables.

Methods: This cross-sectional study was conducted among female schoolteachers employed in public and private sectors schools in Kuwait using a structured questionnaire for data collection. Read More

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February 2021

Temporal accuracy of gait after metronome practice.

Hum Mov Sci 2021 Apr 12;77:102798. Epub 2021 Apr 12.

Sargent College of Health and Rehabilitation Sciences, Boston University, USA. Electronic address:

Humans readily entrain their movements to a beat, including matching their gait to a prescribed tempo. Rhythmic auditory cueing tasks have been used to enhance stepping behavior in a variety of clinical populations. However, there is limited understanding of how temporal accuracy of gait changes over practice in healthy young adults. Read More

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Evaluation of Pathologic Response in Lymph Nodes of Lung Cancer Patients Receiving Neoadjuvant Chemotherapy.

J Thorac Oncol 2021 Apr 12. Epub 2021 Apr 12.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Introduction: Major pathologic response (MPR), defined as ≤10% residual viable tumor, currently serves as a surrogate endpoint for survival for patients with resectable non-small cell lung cancer (NSCLC) after neoadjuvant chemotherapy. However, the significance of pathologic response in lymph nodes harboring metastatic tumor in such patients remains uncertain. Therefore, we studied the effect of neoadjuvant chemotherapy on resected positive lymph nodes and determined if the degree of pathologic response in the lymph nodes alone (LN-MPR) or in combination with that of the primary tumor (PT-MPR) was able to predict outcome. Read More

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Potential of antibody test using Schistosoma mansoni recombinant serpin and RP26 to detect light-intensity infections in endemic areas.

Parasitol Int 2021 Apr 12:102346. Epub 2021 Apr 12.

Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; The Joint Usage/Research Center on Tropical Disease, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan; Nagasaki University, Kenya Research Station, NUITM-KEMRI Project, Nairobi, Kenya. Electronic address:

Schistosomiasis remains a worldwide public health problem, especially in sub-Saharan Africa. The World Health Organization targets the goal for its elimination as a public health problem in the 2030 Neglected Tropical Diseases (NTD) Roadmap. Concerted action and agile responses to challenges will be necessary to achieve the targets. Read More

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ERα-agonist and ERβ-antagonist bifunctional next-generation bisphenols with no halogens: BPAP, BPB, and BPZ.

Toxicol Lett 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemistry, Faculty of Science, Kyushu University, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan; Risk Science Research Institute, Ikimatsudai 3-7-5, Nishi-ku, Fukuoka, 819-0044, Japan. Electronic address:

As demonstrated for bisphenol AF (BPAF), the electrostatic halogen bond based on the London dispersion force of halogen atoms was found to be a major driving force of their bifunctional ERα-agonist and ERβ-antagonist activities. Because similar electronic effects are anticipated for hydrocarbon groups (alkyl or aryl groups), we hypothesized that bisphenol compounds consisting of such groups also work bifunctionally. In the present study, we examined bisphenol AP (BPAP), B (BPB), and Z (BPZ). Read More

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The differential calibration of the HPA axis as a function of trauma versus adversity: A systematic review and p-curve meta-analyses.

Neurosci Biobehav Rev 2021 Apr 12. Epub 2021 Apr 12.

Cognitive Development and Neuroimaging Laboratory, The Brain and Mind Institute, Western University, London, ON, Canada. Electronic address:

Although there is an abundance of evidence linking the function of the hypothalamic-pituitary-adrenal (HPA) axis to adverse early-life experiences, the precise nature of the association remains unclear. Some evidence suggests early-life adversity leads to cortisol hyper-reactivity, while other evidence suggests adversity leads to cortisol hypo-reactivity. Here, we distinguish between trauma and adversity, and use p-curves to interrogate the conflicting literature. Read More

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Study of ER Stress and Apoptotic Proteins in the Heart and Tumor Exposed to Doxorubicin.

Biochim Biophys Acta Mol Cell Res 2021 Apr 12:119039. Epub 2021 Apr 12.

Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. Electronic address:

Although a high cumulative dose of Doxorubicin (Dox) is known to cause cardiotoxicity, there is still a lack of understanding of the subcellular basis of this drug-induced cardiomyopathy. Differential effects of Dox on mitochondria and endoplasmic reticulum (ER) were examined in cardiomyocytes, tumor cells, implanted tumors and hearts of normal as well as tumor-bearing animals. Dox increased mitochondrial (Mito) Bax activation at 3h in the cardiomyocyte without change in the DNA damage inducible transcriptor-3 (DDIT3) expression in the ER. Read More

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Provider communication and HPV vaccine uptake: A meta-analysis and systematic review.

Prev Med 2021 Apr 12:106554. Epub 2021 Apr 12.

Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, United States of America. Electronic address:

Provider communication can be critically important to families as they consider HPV vaccination. We sought to characterize the association of provider communication and HPV vaccine uptake, including when communication better motivates vaccination. We searched four databases for studies published between 2006 and 2019. Read More

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Adverse childhood experiences in a low-income black cohort: The importance of context.

Prev Med 2021 Apr 12:106557. Epub 2021 Apr 12.

Institute of Child Development, University of Minnesota, Minneapolis, MN, United States of America.

Adverse Childhood Experiences (ACEs) have been definitively linked with cross-domain life course well-being. While scales measuring the ten "Conventional" ACEs (ACEs-C; intrafamilial experiences of abuse, neglect, and household dysfunction) are parsimonious, use of such scales alone may fail to capture crucial information about adversity, particularly in youth growing up in high-crime areas. Patterns and disparities in Conventional and Expanded (ACEs-E; experiences more common in impoverished and densely populated areas) ACEs were examined in the large, primarily Black Chicago Longitudinal Study cohort. Read More

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Accuracy of Peridialytic, Intradialytic, and Scheduled Interdialytic Recordings in Detecting Elevated Ambulatory Blood Pressure in Hemodialysis Patients.

Am J Kidney Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Greece.

Rationale And Objective: Current recommendations suggest the use of ambulatory-BP-monitoring (ABPM) as the gold-standard for hypertension diagnosis and management in hemodialysis patients. This study assesses the accuracy of peridialytic, intradialytic, and scheduled interdialytic recordings in detecting abnormally elevated 44-h interdialytic BP.

Study Design: Diagnostic test study. Read More

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The Impact of Center Volume on Outcomes in Lung Transplantation.

Ann Thorac Surg 2021 Apr 12. Epub 2021 Apr 12.

Washington University School of Medicine, Division of Cardiothoracic Surgery. Electronic address:

Background: Studies in lung transplantation have shown variable association between hospital volume and clinical outcomes. We aimed to identify the pattern of effect of hospital volume on individual survival after lung transplantation.

Methods: We performed a retrospective analysis using the United Network for Organ Sharing national thoracic organ transplantation database. Read More

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Licoricidin Abrogates T Cell Activation by Modulating PTPN1 Activity and Attenuates Atopic Dermatitis In Vivo.

J Invest Dermatol 2021 Apr 12. Epub 2021 Apr 12.

School of Life Sciences, Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.

Licoricidin, the fifth-highest fraction among the isolated 48 molecules from Glycyrrhiza uralensis extracts, has been known as anti-inflammatory bioactive molecules, however, few studies have shown its inhibitory effect on T cell activation and atopic dermatitis. The present study examined the therapeutic potential of licoricidin in atopic dermatitis by modulating T cell activation with molecular mechanism. Licoricidin attenuated the expression of IL-2 mRNA in stimulated T cells without cytotoxicity. Read More

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Access to male sexual and reproductive health services in publicly funded California clinics in 2018.

Contraception 2021 Apr 12. Epub 2021 Apr 12.

Section of Family Planning, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Objectives: To characterize the sexual and reproductive health (SRH) services available to men from publicly-funded family planning clinics in California.

Study Design: We conducted a cross-sectional telephone survey in 2018 to compare the accessibility of SRH services for male clients at Planned Parenthood clinics in California to those visiting a random sample of 200 other publicly-funded family planning clinics, selected from a California Department of Health Care Services list of 773 that had served at least 15 male clients in the prior year. A representative at each clinic answered questions about provision of 20 clinical services. Read More

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Temperature and place associations with Inuit mental health in the context of climate change.

Environ Res 2021 Apr 12:111166. Epub 2021 Apr 12.

Department of Population Medicine, University of Guelph, 50 Stone Road E, Guelph, Ontario, N1G 2W1, Canada; School of Public Health, University of Alberta, 116 St. and 85 Ave., Edmonton, Alberta, T6G 2R3, Canada. Electronic address:

Background: Climate change has important implications for mental health globally. Yet, few studies have quantified the magnitude and direction of associations between weather and mental health-related factors, or assessed the geographical distribution of associations, particularly in areas experiencing rapid climatic change. This study examined the associations between air temperature variables and mental health-related community clinic visits across Nunatsiavut, Labrador, Canada, and the place-specific attributes of these associations. Read More

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Effect of alternative income assistance schedules on drug use and drug-related harm: a randomised controlled trial.

Lancet Public Health 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Centre on Substance Use, Vancouver, BC, Canada.

Background: The synchronised monthly disbursement of income assistance, whereby all recipients are paid on the same day, has been associated with increases in illicit drug use and serious associated harms. This phenomenon is often referred to as the cheque effect. Because payment variability can affect consumption patterns, this study aimed to assess whether these harms could be mitigated through a structural intervention that varied income assistance payment timing and frequency. Read More

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Safety of Tranexamic Acid in Hip and Knee Arthroplasty in High-risk Patients.

Anesthesiology 2021 Apr 15. Epub 2021 Apr 15.

Background: With increasing use of tranexamic acid in total hip and knee arthroplasties, safety concerns remain. Using national claims data, this study examined tranexamic acid use in patients with preexisting comorbidities. The hypothesis was that tranexamic acid use is not associated with increased complication risk in hip and knee arthroplasty patients with comorbidities. Read More

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Systems epidemiology and cancer: A review of the National Institutes of Health extramural grant portfolio 2013-2018.

PLoS One 2021 15;16(4):e0250061. Epub 2021 Apr 15.

Genomics Epidemiology Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, United States of America.

Objectives: Systems epidemiology approaches may lead to a better understanding of the complex and dynamic multi-level constellation of contributors to cancer risk and outcomes and help target interventions. This grant portfolio analysis aimed to describe the National Institutes of Health (NIH) and the National Cancer Institute (NCI) investments in systems epidemiology and to identify gaps in the cancer systems epidemiology portfolio.

Methods: The analysis examined grants funded (2013-2018) through seven NIH systems science Funding Opportunity Announcements (FOAs) as well as cancer-specific systems epidemiology grants funded by NCI during that same time. Read More

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CpG content-dependent associations between transcription factors and histone modifications.

PLoS One 2021 15;16(4):e0249985. Epub 2021 Apr 15.

Max Planck Institute for Informatics, Computational Biology and Applied Algorithmics, Saarbrücken, Germany.

Understanding the factors that underlie the epigenetic regulation of genes is crucial to understand the gene regulatory machinery as a whole. Several experimental and computational studies examined the relationship between different factors involved. Here we investigate the relationship between transcription factors (TFs) and histone modifications (HMs), based on ChIP-seq data in cell lines. Read More

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Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice.

PLoS One 2021 15;16(4):e0249932. Epub 2021 Apr 15.

Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan.

In the present study, we examined the importance of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in the regulation of cardiac function using genetically modified CaMKIV-null mice. RT-PCR analysis revealed decreased expression of voltage-dependent calcium channels in the cardiac myocytes of CaMKIV-null mice compared with wild-type mice. CaMKIV-null mice showed shortened QT time on electrocardiograms. Read More

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L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH4.

PLoS One 2021 15;16(4):e0250126. Epub 2021 Apr 15.

College of Animal Sciences, Zhejiang University, Hangzhou, China.

Amino acid metabolism plays an important role in controlling blood pressure by regulating the production of NO and ROS. The present study examined amino acid levels in the serum of Dahl SS rats and SS.13BN rats fed a low or high salt diet. Read More

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