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Dynamic evolution of hyperuniformity in a driven dissipative colloidal system.

J Phys Condens Matter 2021 Apr 20. Epub 2021 Apr 20.

UNAM-National Nanotechnology Research Center & Institute of Materials Science and Nanotechnology, Bilkent Universitesi, UNAM-National Nanotechnology Research Center & Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, 06800, Turkey, Ankara, 06800, TURKEY.

Hyperuniformity is evolving to become a unifying concept that can help classify and characterize equilibrium and nonequilibrium states of matter. Therefore, understanding the extent of hyperuniformity in dissipative systems is critical. Here, we study the dynamic evolution of hyperuniformity in a driven dissipative colloidal system. Read More

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Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors.

J Natl Compr Canc Netw 2021 Apr 20:1-7. Epub 2021 Apr 20.

3Division of Medical Oncology, and.

Background: Bone metastases and skeletal-related events (SREs) are a frequent cause of morbidity in patients with metastatic non-small cell lung cancer (mNSCLC). Data are limited on bone metastases and SREs in patients with mNSCLC treated using immune checkpoint inhibitors (ICIs), and on the efficacy of bone-modifying agents (BMAs) in this setting. Here we report the incidence, impact on survival, risk factors for bone metastases and SREs, and impact of BMAs in patients with mNSCLC treated with ICIs in a multi-institutional cohort. Read More

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Effect of sample thinning on strains and lattice rotations measured from Transmission Kikuchi diffraction in the SEM.

Ultramicroscopy 2021 Apr 9;225:113267. Epub 2021 Apr 9.

Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United Kingdom.

Cross correlation based high angular resolution EBSD (or HR-EBSD) has been developed for measurement of elastic strains, lattice rotations (and estimating GND density). Recent advances in Transmission Kikuchi diffraction (TKD), especially the on-axis geometry allows the possibility of acquiring patterns at higher spatial resolution. However, some controversy remains as to whether stresses/strains measured after the sample thinning process are still representative of the bulk sample. Read More

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A procedure for method development and protein binding ratio as the indicator of sensitivity with anticancer agents on MALDI mass spectrometry imaging.

Drug Metab Pharmacokinet 2021 Jan 30;38:100385. Epub 2021 Jan 30.

Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Department of Medical Oncology and Translational Research, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:

The concentration and distribution of a drug and its metabolites in tissues are key factors for elucidating both drug efficacy and toxicity in drug development. In this study we developed a pharamaco-imaging procedure for 12 agents and investigated the relationship between the properties of target compounds and the sensitivities of detection in matrix-assisted laser desorption/ionization-mass spectrometer imaging (MALDI-MSI). We prepared mock samples with mouse liver homogenates diluted with gelatin solution, limit of detection concentrations of each compound was confirmed. Read More

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January 2021

Tuberculosis in Myasthenia Gravis patients on immunosuppressive therapy in a high-risk area: Implications for preventative therapy.

J Neurol Sci 2021 Apr 17;425:117447. Epub 2021 Apr 17.

Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Neurology Research Group, UCT Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Electronic address:

Data regarding the risk of tuberculosis (TB) in myasthenia gravis (MG) patients receiving immunosuppressive therapy is limited, and the benefit of TB preventative therapy in these patients is uncertain. We audited observational data collected at an MG clinic in South Africa over a ~ 10-year period, of cases who received immunosuppressive therapy. The total time that the cohort was at risk (patient-years) was used as the denominator to calculate TB incidence after immunosuppressive therapy initiation. Read More

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Adverse childhood experiences in New Zealand and subsequent victimization in adulthood: Findings from a population-based study.

Child Abuse Negl 2021 Apr 17;117:105067. Epub 2021 Apr 17.

School of Māori Studies and School of Pacific Studies, Faculty of Arts, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

Background: Adverse childhood experiences (ACEs) are widespread and are associated with adverse outcomes in later life, yet few studies have explored their prevalence and consequences in New Zealand.

Objectives: To provide prevalence estimates of ACEs in New Zealand using a large sample of adults, and to explore the associations between ACEs and experience of violence by intimate partners and non-partners in adulthood.

Participants And Setting: 2,887 participants (1464 female, 1423 male) from the 2019 New Zealand Family Violence Survey, a population based study conducted in New Zealand between March 2017-March 2019. Read More

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Quantitative evaluation of the sacroiliac joint fixation in stress reduction on both sacroiliac joint cartilage and ligaments: A finite element analysis.

Clin Biomech (Bristol, Avon) 2021 Apr 17;85:105350. Epub 2021 Apr 17.

Division of Mechanical and Aerospace Engineering, Faculty of Engineering, Hokkaido University, Sapporo, Japan. Electronic address:

Background: The sacroiliac joint fixation is the last resort for patients with prolonged and severe joint pain. Although the clinical results of anterior fixations are conclusive, there exist several inevitable drawbacks with the surgical method such as the difficulty performing the surgery due to the presence of many organs. The posterior fixation technique has thus been developed to overcome those inconveniences. Read More

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Residue analytical method for the determination of trifluoroacetic acid and difluoroacetic acid in plant matrices by capillary electrophoresis tandem mass spectrometry (CE-MS/MS).

J Chromatogr A 2021 Mar 22;1646:462096. Epub 2021 Mar 22.

Sciex, Darmstadt, Germany; Horváth Csaba Memorial Laboratory, University of Pannonia, Veszprém, Hungary. Electronic address:

In the past years, the technology for trace residue analysis of plant protection compounds in plant and animal matrices, soil, and water has gradually changed to meet changing regulatory demands. Generally, from the '70s to the '90s of the last century, the active compounds and only a few major metabolites had to be determined in a typical "residue definition". Step by step and within the framework of product safety assessments of the enforcement of residues in dietary matrices and in the environment, further metabolites have come into the authorities focus. Read More

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A "Co-CREATES" framework to foster a positive learning environment for nursing students' professional development in Rwanda.

Nurse Educ Pract 2021 Apr 7;53:103053. Epub 2021 Apr 7.

Western University, Arthur Labatt Family School of Nursing, Faculty of Health Sciences, Western University, London, ON N6A 5B9, Canada. Electronic address:

Aim: The future of the nursing profession in Rwanda in large part depends on the students who join the workforce and the education they have received. Preparing students with the necessary knowledge, values and judgement requires practice settings to be learner-centered. This study aimed at exploring strategies that might improve the current practice-based learning environment. Read More

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Early Clinical and Patient-Reported Outcomes of a New Hybrid Mesh for Incisional Hernia Repair.

J Surg Res 2021 Apr 17;265:49-59. Epub 2021 Apr 17.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Introduction: Consensus on the safety and efficacy of various types of mesh in reconstructing the abdomen has yet to be reached. Hybrid mesh products have been designed to address the need for a cost-effective mesh leveraging the tensile strength of a synthetic mesh while minimizing the prosthetic footprint within the abdominal wall through resorbable materials. In this study we evaluate early clinical outcomes and health related quality of life (HR-QOL) of a new Hybrid mesh, Synecor, for Ventral Hernia Repair (VHR). Read More

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Benefit of adjuvant chemotherapy in patients with lobular breast cancer: A systematic review of the literature and metanalysis.

Cancer Treat Rev 2021 Apr 9;97:102205. Epub 2021 Apr 9.

Division of New Drugs and Early Drug Development, European Institute of Oncology IRCCS, Milan, Italy; Departement of Hematology and Oncology (DIPO), University of Milan, Milan, Italy. Electronic address:

The role of adjuvant chemotherapy (aCT) for patients with localized lobular breast cancer (ILC) is still controversial. It is unclear what is the magnitude of benefit of the CT in this setting. In this systematic review of the literature and metanalysis, we aimed to estimate the benefit of aCT in addition to the standard treatments in the early ILC setting. Read More

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Alberta Stroke Program Early CT Score Calculation Using the Deep Learning-Based Brain Hemisphere Comparison Algorithm.

J Stroke Cerebrovasc Dis 2021 Apr 17;30(7):105791. Epub 2021 Apr 17.

Department of Neurology, Saiseikai Kumamoto Hospital, Chikami 5-3-1, Minami-ku, Kumamoto, Japan. Electronic address:

Objectives: The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a promising tool for the evaluation of stroke expansion to determine suitability for reperfusion therapy. The aim of this study was to validate deep learning-based ASPECTS calculation software that utilizes a three-dimensional fully convolutional network-based brain hemisphere comparison algorithm (3D-BHCA).

Materials And Methods: We retrospectively collected head non-contrast computed tomography (CT) data from 71 patients with acute ischemic stroke and 80 non-stroke patients. Read More

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Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels.

Bone 2021 Apr 17:115963. Epub 2021 Apr 17.

Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Medicine - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Biomedical Engineering, Indiana University Purdue University of Indianapolis, Indianapolis, IN, United States; Roudebush Veterans Administration Medical Center, Indianapolis, IN, United States. Electronic address:

Chronic kidney disease (CKD) leads to loss of cortical bone through cortical thinning and the development of cortical porosity. The goal of this current study was to assess cortical bone alterations to adenine-induced chronic kidney disease (CKD) in two strains of mice with known genetic differences in cortical thickness. We hypothesized that C3H mice with thicker cortices and baseline levels of intracortical remodeling would have greater cortical porosity in response to adenine-induced CKD compared to B6 animals. Read More

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Highly interconnected inverse opal extracellular matrix scaffolds enhance stem cell therapy in limb ischemia.

Acta Biomater 2021 Apr 17. Epub 2021 Apr 17.

College of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education), State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. Electronic address:

The therapeutic effectiveness of cell transplantation in treatment of diseases and injuries is often limited by low cell retention, survivability, and engraftment. Extracellular matrix (ECM)-derived scaffolds are capable of controlling cell responses, thereby offering potential solutions to current challenges associated with cell therapy. However, it remains a technical challenge to produce ECM scaffolds with highly interconnected porous structure specifically required for cell transplantation. Read More

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Epidemiological and Clinical Presentations of Hospitalized COVID-19 patients in Libya: an initial report from Africa.

Travel Med Infect Dis 2021 Apr 17:102064. Epub 2021 Apr 17.

Faculty of Medicine, University of Tripoli, Tripoli, Libya. Electronic address:

Background: The first case of the novel coronavirus disease 2019 (COVID-19) in Libya was diagnosed in March 2020. We aimed to determine the epidemiological, clinical, and laboratory characteristics of COVID-19 in Libya.

Method: In this retrospective descriptive study, we analyzed the demographics, initial clinical presentation, history, comorbidities, laboratory findings, complications, and outcomes of hospitalized patients with COVID-19 at several centers in the Western part of Libya between March 24, 2020, and December 3, 2020. Read More

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Adverse associations of sedentary behavior with cancer incidence and all-cause mortality: A prospective cohort study: Sedentary behavior, cancer and mortality.

J Sport Health Sci 2021 Apr 17. Epub 2021 Apr 17.

Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Background: Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality, but evidence from the Chinese population is scarce. This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity (MVPA) on these relationships.

Methods: We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire. Read More

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A three-time point longitudinal investigation of the arcuate fasciculus throughout reading acquisition in children developing dyslexia.

Neuroimage 2021 Apr 17:118087. Epub 2021 Apr 17.

Parenting and Special Education Research Unit, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium; Research Group ExpORL, Department of Neurosciences, KU Leuven, Belgium; Psychological Sciences Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Institute of Neuroscience, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium. Electronic address:

Although the neural basis of dyslexia has intensively been investigated, results are still unclear about the existence of a white matter deficit in the arcuate fasciculus (AF) throughout development. To unravel this ambiguity, we examined the difference in fractional anisotropy (FA) of the AF between children developing dyslexia and children developing typical reading skills in a longitudinal sample with three MRI time points throughout reading development: the pre-reading stage (5-6 years old), the early reading stage (7-8 years old) and the advanced reading stage (9-10 years old). Applying along-the-tract analyses of white matter organization, our results confirmed that a white matter deficit existed in the left AF prior to the onset of formal reading instruction in children who developed dyslexia later on. Read More

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Eradication of large established tumors by drug-loaded bacterial particles via a neutrophil-mediated mechanism.

J Control Release 2021 Apr 17. Epub 2021 Apr 17.

State Key Laboratory of Biotherapy and Cancer center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China; Experimental and Research Animal Institute, Sichuan University, Chengdu 610041, China. Electronic address:

The treatment of large established tumors remains a significant challenge and is generally hampered by poor drug penetration and intrinsic drug resistance of tumor cells in the central tumor region. In the present study, we developed bacterial particles (BactPs) to deliver chemotherapeutics into the tumor mass by hijacking neutrophils as natural cell-based carriers. BactPs loaded with doxorubicin, 5-fluorosuracil, or paclitaxel induced significantly greater tumor regression than unconjugated drugs. Read More

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Development and characterization of chitosan and acrylic acid-based novel biodegradable polymeric films for soil conditioning.

Int J Biol Macromol 2021 Apr 17. Epub 2021 Apr 17.

School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China. Electronic address:

In this study, biodegradable polymeric films (BPFs) based on chitosan and acrylic acid cross-linked with 3-aminopropyl triethoxysilane (APTES) were developed for water retention and soil-conditioning applications in areas sufferings from water scarcity. A series of BPFs were prepared by varying the amount of silica nanoparticles (SiNPs) (0.67% to 2. Read More

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Compression stockings for preventing deep vein thrombosis in airline passengers.

Cochrane Database Syst Rev 2021 Apr 20;4:CD004002. Epub 2021 Apr 20.

UK Cochrane Centre, Oxford, UK.

Background: Air travel might increase the risk of deep vein thrombosis (DVT). It has been suggested that wearing compression stockings might reduce this risk. This is an update of the review first published in 2006. Read More

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Intra-Operative Vascular Injury and Control During Laparoscopic and Robotic Mesh Explantation for Chronic Post Herniorrhaphy Inguinal Pain (CPIP).

Surg Technol Int 2021 Apr 20;38. Epub 2021 Apr 20.

Department of Surgery, David Geffen School of Medicine, Lichtenstein Amid Hernia Institute at UCLA Santa Monica, CA, USA.

Introduction: Chronic postherniorrhaphy inguinal pain (CPIP) is common following inguinal hernia repair. As even primary minimally-invasive inguinal hernia repairs carry a risk of significant intra-operative bleeding, it is unsurprising that reoperative groin exploration and mesh explantation for chronic post-inguinal herniorrhaphy pain confers an even higher risk of arteriotomy or venotomy due to a distorted anatomy and the presence of adhesions. In this report, we present a single institution's experience with the management of intra-operative vascular injury encountered during minimally invasive groin exploration and mesh explantation for CPIP. Read More

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Extracellular histones are a target in myocardial ischaemia reperfusion injury.

Cardiovasc Res 2021 Apr 20. Epub 2021 Apr 20.

The Hatter Cardiovascular Institute, University College London, WC1E 6HX, United Kingdom.

Acute myocardial infarction causes lethal cardiomyocyte injury during ischaemia and reperfusion (I/R). Histones have been described as important Danger Associated Molecular Proteins (DAMPs) in sepsis. Aims The objective of this study was to establish whether extracellular histone release contributes to myocardial infarction. Read More

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Thyroid immune-related adverse events following immune checkpoint inhibitor treatment.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background: Thyroid dysfunction occurs commonly following immune checkpoint inhibition. The etiology of thyroid immune-related adverse events (irAEs) remains unclear and clinical presentation can be variable. This study sought to define thyroid irAEs following immune checkpoint inhibitor (ICI) treatment and describe their clinical and biochemical associations. Read More

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A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats.

PLoS One 2021 20;16(4):e0250352. Epub 2021 Apr 20.

Cancer Research and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing. The purpose of this preliminary study was to test the efficacy and safety of calcipotriol, vitamin D analog, as a treatment for a fully-developed knee arthritis in Zymosan-induced arthritis (ZIA) model. Forty 5-month-old male Sprague-Dawley rats were randomized into three arthritis groups and a non-arthritic control group with no injections (10 rats/group). Read More

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Development of an integrated, holistic care package for people with lymphoedema for use at the level of the Primary Health Care Unit in Ethiopia.

PLoS Negl Trop Dis 2021 Apr 20;15(4):e0009332. Epub 2021 Apr 20.

Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.

Background: Neglected Tropical Diseases (NTDs) are a group of several communicable and non-communicable diseases prevalent in tropical and subtropical areas. The co-endemicity of these diseases, the similarity of their clinical signs, and the need to maximize limited financial and human resources suggest the importance of adoptingan integratedapproach to their prevention and treatment.

Aims: This study describes the development of a comprehensive package of physical, mental health and psychosocial care for people with lower-limb lymphoedema caused bypodoconiosis, lymphatic filariasis (LF)or leprosy as part of the EnDPoINT program in Ethiopia. Read More

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Analysis of the sources of COVID-19 transmission in France by Self-assessment Web-application before and after the partial autumnal lockdown: Observational Study.

J Med Internet Res 2021 Apr 16. Epub 2021 Apr 16.

APHP, Bichat-Claude Bernard University Hospital, Infectious and Tropical Diseases Department, Paris, FR.

Background: We developed a questionnaire on a web-application for COVID-19 circumstances of contamination analysis in France during the 2nd wave of pandemic.

Objective: OBJECTIVE To analyze the impact on contaminations characteristics before and after the second partial lockdown in France to adapt health public restrictions to further pandemic surges.

Methods: Between 12/15/2020 and 12/24/2020, after a national media campaign, users of sourcecovid. Read More

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Characterization and Comparison of Public, Medical Professionals and Technical Communities Utilization of Facebook Groups to Facilitate Idea Sharing and Crowdsourcing During the COVID-19 Pandemic: A Cross-Sectional Observational Study.

JMIR Form Res 2021 Apr 13. Epub 2021 Apr 13.

Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, US.

Background: Strict social distancing measures resulting from the COVID-19 pandemic have led people to rely more heavily on social media, such as Facebook Groups, as a means of communication and information sharing. Multiple Facebook Groups have been developed by medical professionals, lay people, and engineering or technical groups to discuss current issues and possible solutions to the medical crisis.

Objective: To characterize Facebook groups created by laypersons, medical professionals, and technical professionals, with specific focus on information dissemination and requests for crowdsourcing. Read More

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Learning Methodologies to Generate Kernel-learning-based Image Downscaler for Arbitrary Scaling Factors.

IEEE Trans Image Process 2021 Apr 20;PP. Epub 2021 Apr 20.

Displays and content have various resolutions and aspect ratios, requiring an image downscaler to adaptively reduce the image resolution. However, research on downscaling has garnered less attention than upscaling, including super-resolution. In practical display systems, simple interpolation, such as a bicubic filter that cannot preserve image details well, is still widely used for image downscaling rather than frame optimization-based or learning-based methods because of following reasons: frame optimization-based methods can effectively preserve image details after downscaling but are difficult to implement due to hardware costs. Read More

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Integrating theory-based and data-driven methods to case conceptualization: A functional analysis approach with ecological momentary assessment.

Psychother Res 2021 Apr 20:1-13. Epub 2021 Apr 20.

Pain and Psychotherapy Research Lab, Universität Koblenz-Landau, Landau in der Pfalz, Germany.

Ecological momentary assessment (EMA) and network analysis are promising empirical developments for psychotherapy research and practice, but they lack a therapeutic rationale that could guide case conceptualization and treatment planning. We developed an assessment strategy that aims to assess functional analysis with EMA. The assessment strategy was applied to a series of three N-of-1 assessments in a proof-of-concept study. Read More

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Toward the Development of a Perceived IRB Violation Scale.

Account Res 2021 Apr 20. Epub 2021 Apr 20.

School of Criminology & Criminal Justice, Arizona State University.

This study introduces survey items that can be used to assess the perceived prevalence of specific IRB violations by researchers or to gauge the perceived seriousness of such infractions. Using survey data from tenured and tenure-track faculty at research-intensive universities, the descriptive findings showed that the failure to properly store data and neglecting to maintain project records were perceived to be the most widespread violations by sample members. Although comparatively less definitive, the results also showed that problems with data storage and record keeping were perceived to be relatively serious violations. Read More

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