108,833 results match your criteria study constructed


Treatment of oily wastewaters by highly porous whisker-constructed ceramic membranes: Separation performance and fouling models.

Water Res 2022 Jan 6;211:118042. Epub 2022 Jan 6.

Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China. Electronic address:

Efficient treatment of challenging oily emulsion wastewater can alleviate water pollution to provide more chances for water reuse and resource recovery. Despite their promising application potential, conventional porous ceramic membranes have challenging bottleneck issues such as high cost and insufficient permeance. This study presents a new strategy for highly efficient treatment of not only synthetic but real oily emulsions via unexpensive whisker-constructed ceramic membranes, exhibiting exceptional permeance and less energy input. Read More

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January 2022

An injectable superior depot of Telratolimod inhibits post-surgical tumor recurrence and distant metastases.

Acta Biomater 2022 Jan 12. Epub 2022 Jan 12.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

The clinical success of Toll-like receptor (TLR) agonists is based on their capacity to efficiently mobilize both innate and adaptive immunity. However, rapid distribution of TLR agonists into the systemic circulation may result in systemic cytokine storms. Telratolimod (Tel) is a TLR 7/8 agonist whose structure has a hydrophobic long chain that helps to prolong its release. Read More

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January 2022

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Reflect Disease Activity and Flares in Patients with Systemic Lupus Erythematosus - a Prospective Study.

Joint Bone Spine 2022 Jan 12:105342. Epub 2022 Jan 12.

Division of Rheumatology, University Medicine Cluster, National University Hospital, 5 Lower Ken Ridge Road, 119074, SINGAPORE; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, 117597, SINGAPORE. Electronic address:

Objectives: To determine the association between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with disease activity and flares in an inception cohort of patients with systemic lupus erythematosus (SLE) using a prospective study design.

Methods: Consecutive adult patients (age≥21) who fulfilled the 1997 American College of Rheumatology (ACR) or the 2012 Systemic Lupus International Collaboration Clinic Classification (SLICC) Criteria for SLE were followed every 3 months, with SLE disease activity assessed by using SLEDAI-2K, and disease flares defined and captured by the SELENA-SLEDAI Flare Index (SFI). NLR and PLR were computed from the automated machine-counted blood count differentials. Read More

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January 2022

Impact of sodium hypochlorite on organic tissue dissolution in the periapical region of immature permanent teeth: an ex vivo study.

J Endod 2022 Jan 12. Epub 2022 Jan 12.

Endodontics, Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo, Mandic, R. Dr. José Rocha Junqueira, 13, 13045755, Campinas, SP, Brazil.

Introduction: To evaluate the impact of different sodium hypochlorite irrigation protocols on organic tissue dissolution in the periapical region of simulated immature permanent teeth.

Methods: Eight single-rooted premolars and 48 samples of porcine palatal mucosa were used. Acrylic resin prototypes were constructed, placing the tissue in close contact with the dental apices. Read More

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January 2022

Prenatal Exposure to Teratogenic Medications in the Era of Risk Evaluation and Mitigation Strategies (REMS).

Am J Obstet Gynecol 2022 Jan 12. Epub 2022 Jan 12.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida; Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida; Center for Drug Evaluation and Safety (CoDES), University of Florida. Electronic address:

Background: Prevention of prenatal exposures to teratogenic drugs is a significant clinical and public health concern. With the enactment of the FDA Amendment Act in 2007, the Food and Drug Administration has begun to require manufacturers to implement Risk Evaluation and Mitigation Strategies (REMS) to prevent prenatal exposures. Among 12 REMS drugs, several had predecessor risk mitigation plans (e. Read More

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January 2022

Temporal variation in leachate composition of a newly constructed landfill site in Lahore in context to environmental pollution and risks.

Environ Sci Pollut Res Int 2022 Jan 15. Epub 2022 Jan 15.

College of Earth and Environmental Sciences, University of the Punjab, Lahore, 54590, Pakistan.

This study investigated the seasonal and temporal variations in the extent and source of physiochemical and toxic trace elements in the Lakhodair landfill site of Lahore, Pakistan. For this purpose, systematic composite samples were collected every month, consecutively for 1 year, and analyzed for different physiochemical parameters and trace elements. The results of TDS, TSS, COD, NH-N, BOD, sulfate, sulfides, phenolic compounds, and oil and grease were higher than the national environmental quality standard (NEQs). Read More

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January 2022

Using radiomics-based modelling to predict individual progression from mild cognitive impairment to Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2022 Jan 15. Epub 2022 Jan 15.

Department of Nuclear Medicine, University Hospital Bern, Bern, Switzerland.

Background: Predicting the risk of disease progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) has important clinical significance. This study aimed to provide a personalized MCI-to-AD conversion prediction via radiomics-based predictive modelling (RPM) with multicenter 18F-fluorodeoxyglucose positron emission tomography (FDG PET) data.

Method: FDG PET and neuropsychological data of 884 subjects were collected from Huashan Hospital, Xuanwu Hospital, and from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Read More

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January 2022

Synergistic antitumor efficacy of PD-1-conjugated PTX- and ZSQ-loaded nanoliposomes against multidrug-resistant liver cancers.

Drug Deliv Transl Res 2022 Jan 15. Epub 2022 Jan 15.

Department of Medical Oncology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, China.

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with poor chemotherapeutic efficiency due to multidrug resistance (MDR); it is very important to develop a targeted nanocarrier for the treatment of HCC. In this study, a programmed death ligand 1 (PD-L1)-conjugated nanoliposome was constructed for co-delivery of paclitaxel (PTX) and P-glycoprotein (P-gp) inhibitor zosuquidar (ZSQ) to overcome MDR in human HCC cells and tumors in vivo. Transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA) were used to examine the nanoparticles morphology and size; PD-1-conjugated PTX and ZSQ-loaded nanoliposomes (PD-PZLP) revealed a spherical shape with a size of 139. Read More

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January 2022

miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer.

Gastric Cancer 2022 Jan 15. Epub 2022 Jan 15.

Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, 52 Fucheng Road, Hai-Dian District, Beijing, 100142, China.

Background: Peritoneum, liver and lymph node are the most common metastatic sites of gastric cancer (GC). Biomarkers for GC's organo-tropic metastasis remained largely unknown, which was investigated in this study from the perspective of small extracellular vesicle (sEV)-derived miRNAs.

Methods: Plasma from treatment-naïve GC patients including no metastasis (M0), peritoneal metastasis (PM), hepatic metastasis (HM) and distant lymph node metastasis (dLNM)) were divided into one discovery (N = 40), one training (N = 40) and one validating cohort (N = 86), then assessed by sEV-miRNA-sequencing and sEV-miRNA-qPCR. Read More

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January 2022

Spatiotemporal change analysis of long time series inland water in Sri Lanka based on remote sensing cloud computing.

Sci Rep 2022 Jan 14;12(1):766. Epub 2022 Jan 14.

State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.

Sri Lanka is an important hub connecting Asia-Africa-Europe maritime routes. It receives abundant but uneven spatiotemporal distribution of rainfall and has evident seasonal water shortages. Monitoring water area changes in inland lakes and reservoirs plays an important role in guiding the development and utilisation of water resources. Read More

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January 2022

Xiaolangdi reservoir with UAV and satellite multispectral images.

Sci Total Environ 2022 Jan 11:153059. Epub 2022 Jan 11.

Henan Normal University, Xinxiang, Henan 453007, China.

Accurate and timely acquisition of plant diversity information downstream of the reservoir is helpful to understand the impact mechanism of reservoir operation on wetland plant diversity and formulate reasonable water and sediment regulation strategies. In this study, we conducted field surveys in two communities (Phragmites australis and Tamarix chinensis) at a typical wetland in the lower reaches of Xiaolangdi Reservoir on the Yellow River, and employed UAV and Gaofen 1B multispectral images to estimate the wetland plant diversity. Results showed that most diversity indexes had a higher correlation with the mean of spectral vegetation indexes (DVI, RVI, NDVI, SAVI, and MSAVI). Read More

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January 2022

Magnetic casein aggregates as an innovative support platform for laccase immobilization and bioremoval of crystal violet.

Int J Biol Macromol 2022 Jan 11. Epub 2022 Jan 11.

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran 1417614411, Iran. Electronic address:

In this study, [email protected] was fabricated through a green synthesis methodology and applied to immobilize laccase. The constructed [email protected] exhibited porous structures with distinct cavities and suitable magnetic properties. The abundance of aromatic functional groups on the surface renneted casein and possible π-type interaction between laccase and para-κ-casein resulted in a successful immobilization. Read More

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January 2022

Demographic and social determinants of cognitive dysfunction following hospitalization for COVID-19.

J Neurol Sci 2022 Jan 7:120146. Epub 2022 Jan 7.

Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address:

Background: Persistent cognitive symptoms have been reported following COVID-19 hospitalization. We investigated the relationship between demographics, social determinants of health (SDOH) and cognitive outcomes 6-months after hospitalization for COVID-19.

Methods: We analyzed 6-month follow-up data collected from a multi-center, prospective study of hospitalized COVID-19 patients. Read More

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January 2022

Orientation of medical trainees to a new clinical environment (the ready-steady-go model): a constructivist grounded theory study.

BMC Med Educ 2022 Jan 14;22(1):37. Epub 2022 Jan 14.

Medical Education Unit, School of Medicine, University College Cork, Cork, Ireland.

Background: High-quality orientation of trainees entering a new clinical workplace is essential to support education and patient safety. However, few consultants receive extensive formal training to support new trainees and must create their own ways of integrating newcomers into their clinical team and work environment. We aim to conceptualise the strategies consultants use in the early stages of working with new trainees that will be useful for future faculty development in this area. Read More

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January 2022

Association between plasma leptin and cesarean section after induction of labor: a case control study.

BMC Pregnancy Childbirth 2022 Jan 14;22(1):29. Epub 2022 Jan 14.

Department of Obstetrics & Gynecology, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, 463 MRF, Iowa City, IA, 52242, USA.

Background: Obesity in pregnancy is common, with more than 50% of pregnant women being overweight or obese. Obesity has been identified as an independent predictor of dysfunctional labor and is associated with increased risk of failed induction of labor resulting in cesarean section. Leptin, an adipokine, is secreted from adipose tissue under the control of the obesity gene. Read More

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January 2022

Polygenic risk prediction models for colorectal cancer: a systematic review.

BMC Cancer 2022 Jan 15;22(1):65. Epub 2022 Jan 15.

Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168, Roma, Italy.

Background: Risk prediction models incorporating single nucleotide polymorphisms (SNPs) could lead to individualized prevention of colorectal cancer (CRC). However, the added value of incorporating SNPs into models with only traditional risk factors is still not clear. Hence, our primary aim was to summarize literature on risk prediction models including genetic variants for CRC, while our secondary aim was to evaluate the improvement of discriminatory accuracy when adding SNPs to a prediction model with only traditional risk factors. Read More

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January 2022

Spectral detection of simplicial communities via Hodge Laplacians.

Phys Rev E 2021 Dec;104(6-1):064303

School of Mathematical Sciences, Queen Mary University of London, London, E1 4NS, United Kingdom and The Alan Turing Institute, London, NW1 2DB, United Kingdom.

While the study of graphs has been very popular, simplicial complexes are relatively new in the network science community. Despite being a source of rich information, graphs are limited to pairwise interactions. However, several real-world networks such as social networks, neuronal networks, etc. Read More

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December 2021

Symmetries and phase diagrams with real-space mutual information neural estimation.

Phys Rev E 2021 Dec;104(6-1):064106

Institute for Theoretical Physics, ETH Zurich, 8093 Zurich, Switzerland.

Real-space mutual information (RSMI) was shown to be an important quantity, formally and from a numerical standpoint, in finding coarse-grained descriptions of physical systems. It very generally quantifies spatial correlations and can give rise to constructive algorithms extracting relevant degrees of freedom. Efficient and reliable estimation or maximization of RSMI is, however, numerically challenging. Read More

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December 2021

System size synchronization.

Phys Rev E 2021 Dec;104(6-1):064204

Física Teórica, Universidad de Sevilla, Apartado de Correos 1065, Sevilla 41080, Spain.

In this paper we bring out the existence of a kind of synchronization associated with the size of a complex system. A dichotomic random jump process associated with the dynamics of an externally driven stochastic system with N coupled units is constructed. We define an output frequency and phase diffusion coefficient. Read More

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December 2021

Multifunctional amino acids empowering bifunctional biosensing platform for depression study.

Biosens Bioelectron 2022 Jan 6;201:113972. Epub 2022 Jan 6.

The Key Laboratory of Bioactive Materials Ministry of Education, College of Life Science, Nankai University, Weijin Road No.94, Tianjin, 300071, PR China. Electronic address:

Poor availability of objective approaches hinders effective diagnosis and treatment for depression. Biosensors provide a promising platform for the development of quantitative and practical methods for disease detection, as well as for drug discovery. Here, we developed an electrochemical biosensor has been established with the ability to simply and accurately detect the trace glucocorticoid receptor alpha (GRα), as a key biomarker of depression, in both hippocampus and blood cells. Read More

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January 2022

Electrochemical sensor based on a chitosan-molybdenum vanadate nanocomposite for detection of hydroxychloroquine in biological samples.

J Colloid Interface Sci 2022 Jan 10;613:1-14. Epub 2022 Jan 10.

Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P. O. Box.87317-51167, Islamic Republic of Iran. Electronic address:

In this study, we firstly introduce an ultra-high sensitive VMoO-chitosan (MV-CHT) nanocomposite for electrochemical hydroxychloroquine sulfate (HCQ) monitoring toward paracetamol (PCM) and pantoprazole (PPZ) in environmental and clinical diagnostics. The single-phase MV nanostructures are prepared via the sol-gel pechini route, followed by engineering maleic acid as a structure-directing agent. The stabilization of the MV electro-catalysts is adopted by varying critical factors such as calcination temperature, different chelating ligands, chelating molality and cross-linker concentration. Read More

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January 2022

The new horizon of biomarker in melanoma patients: A study based on autophagy-related long non-coding RNA.

Medicine (Baltimore) 2022 Jan;101(1):e28553

Department of Orthopedics, Affiliated Hospital of Chengde Medical College, Chengde, Hebei, China.

Abstract: Autophagy-related long non-coding RNAs (arlncRNAs) play a crucial role in the pathogenesis and development of the tumor. However, there is a lack of systematic analysis of arlncRNAs in melanoma patients.Melanoma data for analysis were obtained from The Cancer Genome Atlas (TCGA) database. Read More

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January 2022

Mechanistic insights into the use of rhubarb in diabetic kidney disease treatment using network pharmacology.

Medicine (Baltimore) 2022 Jan;101(1):e28465

Internal medicine of traditional Chinese Medicine, Traditional Chinese Medicine Hospital of Jilin Province, Changchun, China.

Abstract: In this study, we predicted the core active compounds of rhubarb used in the treatment of diabetic kidney disease (DKD) and the related core gene targets and pathways using network pharmacological approaches.The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to identify active compounds of rhubarb. PharmMapper was used to predict the gene targets of active compounds, which were subsequently provided a standard nomenclature using the UniProt database. Read More

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January 2022

Analysis of the active components and mechanism of Shufeng Jiedu capsule against COVID-19 based on network pharmacology and molecular docking.

Medicine (Baltimore) 2022 Jan;101(1):e28286

Department of Pharmacology, Xinjiang Medical University, Urumqi, Xinjiang, China.

Abstract: This study investigates the active components and mechanism of Shufeng Jiedu Capsules (SFJDC) against novel coronavirus through network pharmacology and molecular docking.The TCMSP, TCMID, and BATMAN-TCM databases were used to retrieve the components of SFJDC. The active components were screened by ADME (absorption, distribution, metabolism, and excretion) parameters, and identified by Pubchem, Chemical Book, and ChemDraw softwares. Read More

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January 2022

Consistency evaluation of lung adenocarcinoma tissue and circulating tumor cells related gene mutation detection based on multi-site immunomagnetic beads.

J Biomater Appl 2022 Jan 14:8853282211065861. Epub 2022 Jan 14.

519885Xiamen Medical College Affiliated Second Hospital, Xiamen, China.

This study was designed to investigate the feasibility of genetic testing using circulating tumor cells (CTCs) instead of tumor tissues in lung adenocarcinoma to break through its limitation. Separation system for epithelial cell adhesion molecule (EpCAM), epidermal growth factor receptor (EGFR), and Vimentin expressing CTCs was constructed and used to capture CTCs in the blood samples of 57 patients with lung adenocarcinoma. Genetic mutations of genes involved in targeted therapies were detected by next-generation sequencing (NGS) in tissues from these patients. Read More

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January 2022

Impact of micro- and macrovascular complications of type 2 diabetes on quality of life: Insights from the DISCOVER prospective cohort study.

Endocrinol Diabetes Metab 2022 Jan 14:e00321. Epub 2022 Jan 14.

Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.

Background: The key goals of management in patients with type 2 diabetes (T2D) are to prolong life and improve quality of life. Micro- and macrovascular complications of T2D not only increase the risk of morbidity and mortality, but cross-sectional studies indicate they may also worsen quality of life. We prospectively examined the association of complications that developed during the follow-up with concurrent changes in quality of life. Read More

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January 2022

Carbon emission efficiency measurement and influencing factor analysis of nine provinces in the Yellow River basin: based on SBM-DDF model and Tobit-CCD model.

Environ Sci Pollut Res Int 2022 Jan 13. Epub 2022 Jan 13.

School of Management, China University of Mining and Technology-Beijing, Beijing, 100083, China.

The Yellow River basin (YRB) is China's most critical energy consumption and coal production area. The improvement of carbon emission reduction efficiency in this area is the key for the Chinese government to achieve the 2030 carbon peak and 2060 carbon neutral ("30.60"). Read More

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January 2022

Disparities in demand for COVID-19 hospital care in the United States: Insights from a longitudinal hierarchical study.

Authors:
Wolfgang Messner

Health Sci Rep 2022 Mar 7;5(1):e441. Epub 2022 Jan 7.

Darla Moore School of Business University of South Carolina Columbia South Carolina USA.

Background And Aims: This study examined disparities in hospitalization for COVID-19 within the U.S. by racial and ethnic groups, health insurance status, and social support structure. Read More

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The complete mitochondrial genome and phylogenetic analysis of the reticulated swellshark: Chan, 1966.

Mitochondrial DNA B Resour 2022 10;7(1):180-181. Epub 2022 Jan 10.

Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, Guangzhou, China.

In the present study, the complete mitogenome of has been sequenced and assembled. The complete mitochondrial genome is 16,509 bp in length and contains 37 mitochondrial genes and a control region as other fishes. The nucleotide composition of . Read More

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January 2022

Brucellosis in India: Comparing exposure amongst veterinarians, para-veterinarians and animal handlers.

One Health 2022 Jun 21;14:100367. Epub 2021 Dec 21.

Sydney School of Veterinary Science, The University of Sydney, Camden 2570, NSW, Australia.

The exposure to species is an occupational hazard for veterinary personnel in India. In our previous study, paraveterinarians and animal handlers were found to be at higher risk of being seropositive. In the present study, we further investigate comparative exposure risk to brucellosis amongst the veterinary professionals, identify risk factors, and evaluate the perceptions and practices towards using adequate personal protective equipment (PPE) while attending high risk veterinary interventions. Read More

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