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Association between isotretinoin (Roaccutanne) use and changes in periodontal clinical parameters and MMP-8 and MMP-9 salivary levels.

Front Biosci (Landmark Ed) 2021 Jul;26(7):191-197

Department of Periodontics and Community Dentistry, Dental College, King Saud University, 11545 Riyadh, Saudi Arabia.

: to evaluate changes in clinical periodontal parameters, salivary levels of MMP-8 and MMP-9, in individuals taking Isotretinoin (INN), and compare with individuals not taking the medication and to compare findings among different stages of periodontal disease and healthy periodontium. : A case-control study was conducted with a total of 180 human adults divided into six groups. Clinical parameters, including pocket depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were measured at six sites per tooth. Read More

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Quantitative evaluation of trunk function and the StartReact effect during reaching in patients with cervical and thoracic spinal cord injury.

J Neural Eng 2021 Aug 2. Epub 2021 Aug 2.

Institut Guttmann, Camí de Can Ruti, s/n, Badalona, Catalunya, 08916, SPAIN.

Objective: Impaired trunk stability is frequent in spinal cord injury (SCI), but there is a lack of quantitative measures for assessing trunk function. Our objectives were to: 1) evaluate trunk muscle activity and movement patterns during a reaching task in SCI patients, 2) compare the impact of cervical (cSCI) and thoracic (tSCI) injuries in trunk function, and 3) investigate the effects of a startling acoustic stimulus (SAS) in these patients.

Approach: Electromyographic (EMG) and smartphone accelerometer data were recorded from 15 cSCI patients, 9 tSCI patients, and 24 healthy controls, during a reaching task requiring trunk tilting. Read More

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First report on embryonic and larval development of 2n/3n mosaic sterlet.

Animal 2021 Jul 30;15(9):100317. Epub 2021 Jul 30.

Department of Ichthyology and Aquaculture, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.

Mosaicism is frequently observed in aquaculture practices, and it adversely affects the production as well as the restoration programme of the sturgeon. The purpose of the present study was the induction of 2n/3n mosaic in sterlet, Acipenser ruthenus L., and compare their embryonic and larval development with diploid control sterlet. Read More

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UniPortal thoracoscopic pneumonectomy does not compromise perioperative and long-term survival in patients with NSCLC: A retrospective, multicenter, and propensity score matching study.

Lung Cancer 2021 Jul 24;159:135-144. Epub 2021 Jul 24.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, People's Republic of China. Electronic address:

Objectives: To compare the perioperative and oncologic outcomes following pneumonectomy performed by uniportal video-assisted thoracoscopic surgery (U-VATS) and thoracotomy in patients with centrally located non-small cell lung cancer (NSCLC).

Materials And Methods: Patients with NSCLC who underwent pneumonectomy at the Shanghai Pulmonary Hospital (SPH) and Sun Yat-sen University Cancer Center (SYUCC) with the U-VATS approach or open approach between 2011 and 2016 were selected. Propensity score matching (1:3) was performed to balance the baseline covariates. Read More

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Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm.

Pediatr Neurol 2021 Jul 10;123:21-29. Epub 2021 Jul 10.

Department of Pediatric Neurology, University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.

Background: Fine motor and coordination problems are frequently reported among adolescents born preterm. We aimed to assess performance in hand coordination tasks and to compare concurrent brain activation between adolescents born very preterm and at term at 13 years.

Methods: A total of 34 right-handed adolescents born very preterm (gestational age less than 32 weeks/birth weight ≤1500 grams) and 37 controls born at term during 2003 to 2006 in Turku University Hospital, Finland, were recruited. Read More

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Long-term effect of repeated deslorelin acetate treatment in bitches for reproduction control.

Theriogenology 2021 Jul 26;173:73-82. Epub 2021 Jul 26.

Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland. Electronic address:

Long-acting gonadotropin-releasing hormone (GnRH) analogs, which are approved for male dogs and ferrets, have been used off-label to suppress estrus in bitches predisposed to the side effects of spaying. Health data from the past 12 years were evaluated from bitches without progestogen pretreatment that received deslorelin acetate (DA) to suppress estrus for the first time before the age of 4.5 years. Read More

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Clinical outcomes for patients with lateral lumbar radiculopathy treated by percutaneous endoscopic transforaminal discectomy versus tubular microdiscectomy: A retrospective review.

Clin Neurol Neurosurg 2021 Jul 27;208:106848. Epub 2021 Jul 27.

Medical University of South Carolina, Department of Neurosurgery, Charleston, SC 29425, USA.

Background: Surgical management of lateral lumbar radiculopathy is evolving. TMD (Tubular microdiscectomy) and TELD (Transforaminal endoscopic lumbar discectomy) have emerged as viable MIS treatments. We aim to compare clinical outcomes of both techniques for the treatment of lateral lumbar radiculopathy in relation to pre-operative lumbar foraminal stenosis grade (LFS). Read More

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Expressive and Receptive Language in Russian Primary-School-Aged Children with Autism Spectrum Disorder.

Res Dev Disabil 2021 Jul 30;117:104042. Epub 2021 Jul 30.

Center for Language and Brain, HSE University, Moscow, Russia; Institute of Linguistics, Russian Academy of Sciences, Moscow, Russia.

Background: Abnormal language development in both expressive and receptive domains occurs in most children with Autism Spectrum Disorder (ASD), although the language deficit is not a core symptom of ASD. However, previous studies disagree on the difference in the degree of impairment between expressive and receptive language in ASD. Existing research has concentrated on vocabulary and 'global expressive and receptive language', often using parental reports for language assessment. Read More

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Differentiating Diagnosed and Undiagnosed Primary Angle-Closure Glaucoma and Open-Angle Glaucoma: A Population-Based Study.

Ophthalmol Glaucoma 2021 Jul 30. Epub 2021 Jul 30.

Kanto General Hospital of The Mutual Aid Association of Public School Teachers, Tokyo, Japan; Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan.

Purpose: To study and compare factors contributing to the differentiation of diagnosed and undiagnosed primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) in the same population.

Design: Population-based survey.

Participants: All residents aged 40 years and older in Kumejima, Japan. Read More

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Comparison of Efficacy of Dexmedetomidine and Clonidine Infusion to Produce Hypotensive Anesthesia in Patients Undergoing Orthognathic Surgery: A Randomized Controlled Trial.

J Oral Maxillofac Surg 2021 Jul 7. Epub 2021 Jul 7.

Professor, Department of Oral and Maxillofacial Surgery.

Purpose: The purpose of the study was to compare the efficacy of dexmedetomidine (DEX) and clonidine (CLON) infusion to produce hypotensive anesthesia in patients undergoing orthognathic surgery.

Material And Methods: The investigators designed a randomized controlled trial on patients undergoing orthognathic surgery. Patients were randomized into 2 groups (DEX and CLON group). Read More

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Can Alloplastic Total Temporomandibular Joint Reconstruction be Used in the Growing Patient? A Preliminary Report.

J Oral Maxillofac Surg 2021 Jun 23. Epub 2021 Jun 23.

Reichmann Professor and Chair, Department of Oral & Maxillofacial Surgery, The University of Oklahoma.

Introduction: Although primarily reserved for adult patients, temporomandibular joint (TMJ) total joint reconstructive (TJR) surgery is rarely used in the pediatric population due to its many challenges; it is only performed after all other non-invasive or invasive procedures have been exhausted. Although autogenous grafting has been discussed in the literature, there is very little regarding synthetic or alloplastic materials. In this study, we performed alloplastic TMJ reconstruction on 5 patients with severe ankylosis due to various craniofacial deformities and prior traumatic injuries. Read More

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Assessment of the Banff Working Group Classification of Definitive BK Polyomavirus Nephropathy.

Transpl Int 2021 Aug 2. Epub 2021 Aug 2.

Department of Medicine, Division of Nephrology, Eastern Virginia Medical School, Norfolk, VA, USA.

Polyomavirus nephropathy (PyVAN) continues to be a burden in renal transplantation leading to allograft insufficiency or graft failure. Presumptive diagnosis of PyVAN is made based on the presence of BK polyomavirus in patients' plasma; however, kidney biopsy remains the gold standard to establish a definitive diagnosis. The Banff Working Group on PyVAN proposed a novel classification of definitive PyVAN based on polyomavirus replication/load level and the extent of interstitial fibrosis. Read More

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Neuropathological findings from COVID-19 patients with neurological symptoms argue against a direct brain invasion of SARS-CoV-2: a critical systematic review.

Eur J Neurol 2021 Aug 2. Epub 2021 Aug 2.

IRCCS Mondino Foundation, Pavia, Italy.

Background: Neuropathological studies can elucidate the mechanisms of nervous system damage associated with SARS-CoV-2 infection. Despite literature on this topic is rapidly expanding, correlations between neurological symptoms and brain pathology findings in COVID-19 patients remain largely unknown.

Methods: We performed a systematic literature review on neuropathological studies in COVID-19, including 438 patients from 45 papers published by April 22, 2021. Read More

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Comparison of the ED50 propofol requirements during the insertion of laryngeal mask airway Ambu AuraFlex with Ambu AuraOnce in children undergoing strabismus surgery.

J Clin Pharm Ther 2021 Aug 2. Epub 2021 Aug 2.

Department of Anesthesiology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

What Is Known And Objective: Optimal airway management is crucial in strabismus surgery due to the inaccessibility of the airway throughout the procedure. Laryngeal mask airway offers advantages over tracheal intubation in ophthalmic surgery as it does not increase the intraocular pressure. The purpose of this study was to determine the median effective dose of propofol required, when combined with 0. Read More

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Macronutrient composition of olive baboon (Papio anubis) milk: A comparison to rhesus macaque (Macaca mulatta) milk.

Am J Primatol 2021 Aug 2:e23315. Epub 2021 Aug 2.

Center for Species Survival, Smithsonian National Zoological Park & Conservation Biology Institute, Washington, District of Columbia, USA.

This study was designed to (1) characterize the macronutrient composition of olive baboon (Papio anubis) milk, (2) compare baboon milk composition to that of rhesus macaques (Macaca mulatta), and (3) evaluate the association between the proportion of milk energy derived from protein and relative growth rate within anthropoid primates. A single milk sample was collected from each of eight lactating olive baboons ranging between 47- and 129-days postparturition and six rhesus macaques from 15- to 92-days living at the same institution under identical management conditions. Macronutrient composition (water, fat, protein sugar, and ash) was determined using standard techniques developed at the Nutrition Laboratory at the Smithsonian National Zoological Park. Read More

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Adipocytes are larger in lymphedematous extremities than in controls.

J Plast Surg Hand Surg 2021 Aug 2:1-8. Epub 2021 Aug 2.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Lymphedema is caused by dysfunctional lymph vessels or as a complication of cancer treatment leading to edema and adipose tissue deposition. One hypothesis is that adipocyte hypertrophy contributes to the volume increase in lymphedema. The aim of the study was to compare adipocyte size in arm and leg lymphedema and controls. Read More

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Multicenter Outcomes After Revision Hip Arthroscopy: Comparative Analysis of 2-Year Outcomes After Labral Repair Versus Labral Reconstruction.

Am J Sports Med 2021 Aug 2:3635465211030511. Epub 2021 Aug 2.

Section of Young Adult Hip Surgery, Division of Sports Medicine, Department of Orthopaedic Surgery, Hip Preservation Center, Rush University Medical Center, Chicago, Illinois, USA.

Background: There is a paucity of literature evaluating patient outcomes in patients undergoing revision labral repair and labral reconstruction.

Purpose: To compare outcomes in patients undergoing revision hip arthroscopy for treatment of labral tears by labral repair or labral reconstruction.

Study Design: Cohort study; Level of evidence, 3. Read More

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Management of Patellar Instability: A Network Meta-analysis of Randomized Control Trials.

Am J Sports Med 2021 Aug 2:3635465211020000. Epub 2021 Aug 2.

NYU Langone Health, New York, New York, USA.

Background: Multiple surgical options exist for the treatment of patellar instability; however, the most common procedures involve either a reconstruction of the medial patellofemoral ligament (MPFL) or a repair/plication of the MPFL and medial soft tissues.

Purpose: To perform a network meta-analysis of the randomized controlled trials (RCTs) in the literature to compare MPFL reconstruction, MPFL repair, and nonoperative management for patellar instability.

Study Design: Systematic review and network meta-analysis; Level of evidence, 1. Read More

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A Vaccine to Prevent Egg Layer Peritonitis in Chickens.

Avian Dis 2021 Mar;65(1):198-204

Epitopix, LLC, Willmar, MN 56201.

A series of studies was undertaken in specific-pathogen-free white leghorn chickens for the development of a chicken model of avian pathogenic (APEC) peritonitis. Once established, this model was then used to measure the effectiveness of a siderophore receptor and porin proteins (SRP) APEC vaccine. Initially, five pilot studies were performed to compare the serotype, challenge route, and dose of inoculum that resulted in pathologies characteristic of the peritonitis observed in commercial layer facilities, such as widespread organ infection, atrophy, discoloration, corrugation of yolk sacs, and the presence of caseous exudate. Read More

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Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment (JCP-21-Apr-212-R1).

J Clin Pharmacol 2021 Aug 2. Epub 2021 Aug 2.

Tufts University School of Medicine, Boston, MA, United States.

Brexpiprazole is an oral antipsychotic agent indicated for use in patients with schizophrenia, or as adjunctive treatment for major depressive disorder (MDD). As obesity (BMI ≥35 kg/m ) has the potential to affect drug pharmacokinetics and is a common comorbidity of both schizophrenia and MDD, it is important to understand changes in brexpiprazole disposition in this population. This study utilizes a whole-body physiologically-based pharmacokinetic (PBPK) model to compare the pharmacokinetics of brexpiprazole in obese and normal-weight (BMI 18-25 kg/m ) individuals known to be CYP2D6 extensive (EM) and poor metabolizers (PMs). Read More

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Timing of pancreatic enzyme replacement therapy (PERT) in cystic fibrosis.

Cochrane Database Syst Rev 2021 Aug 2;8:CD013488. Epub 2021 Aug 2.

Division of Child Health, Obstetrics & Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.

Background: Cystic fibrosis (CF) is an autosomal recessive, life-limiting, multisystem disease affecting over 70,000 individuals worldwide. Between 80% and 90% of people with CF suffer with pancreatic exocrine insufficiency, which if left untreated, leads to a poor nutritional status. Pancreatic enzyme replacement therapy (PERT) has been shown to be effective in improving nutritional status and subsequently associated with improved lung function. Read More

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Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method.

Tissue Eng Regen Med 2021 Aug 2. Epub 2021 Aug 2.

Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.

Background: An in vitro study on rapid culturing method of human gingival fibroblast cells (HGFCs) was established to investigate the potential use of the leukocyte-platelet rich fibrin (L-PRF) in tissue engineering technology, different medical fields, including periodontology and implantology.

Methods: Eight biopsies were obtained from eight different donors and a modified culturing technique was developed to obtain HGFCs. The modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay was used to compare the cell viability when the modified culturing method was used in comparison to the standard method. Read More

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Analysis of Clinical and Radiological Findings in Oncology Patients Undergoing Thoracic Tomography for Suspected Pulmonary Embolism.

Cardiovasc Toxicol 2021 Aug 2. Epub 2021 Aug 2.

Department of Radiology, Mersin University Medical Faculty, Mersin, Turkey.

In the present study, we aimed to compare clinical and radiological findings between patients with and without pulmonary embolism (PE) and determine possible risk factors for PE development among patients with cancer. This was a retrospective study that examined the clinical features and tomographic findings of patients with cancer who underwent thoracic tomography for suspected PE. A total of 487 cases were included in the study. Read More

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Robotic versus laparoscopic right hemicolectomy: a case-matched study.

J Robot Surg 2021 Aug 2. Epub 2021 Aug 2.

Department of Colorectal Surgery, University Hospital Limerick, St Nessan's Road, Dooradoyle Co, Limerick, Ireland.

The current gold standard surgical treatment for right colonic malignancy is the laparoscopic right hemicolectomy (LRH). However, laparoscopic surgery has limitations which can be overcome by robotic surgery. The benefits of robotics for rectal cancer are widely accepted but its use for right hemicolectomy remains controversial. Read More

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Measuring health-related quality of life and well-being: a head-to-head psychometric comparison of the EQ-5D-5L, ReQoL-UI and ICECAP-A.

Eur J Health Econ 2021 Aug 2. Epub 2021 Aug 2.

Centre for Health Systems and Policy Research, Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.

Objective: This study aimed to assess the psychometric properties of three generic preference-based measures and compare their performance in a sample of Hong Kong general population.

Methods: Data used for this analysis were obtained from a cross-sectional telephone-based survey in July 2020. Participants were asked to complete several measures, including The EuroQol five-dimensional five levels (EQ-5D-5L), Recovering Quality of Life-Utility Index (ReQoL-UI) and ICEpop CAPability measure for adults (ICECAP-A). Read More

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Immune checkpoint inhibitor treatment induces colitis with heavy infiltration of CD8 + T cells and an infiltration pattern that resembles ulcerative colitis.

Virchows Arch 2021 Aug 2. Epub 2021 Aug 2.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

Colitis is a common, but poorly understood, adverse event of immune checkpoint inhibitors that are standard-of-care for an expanding range of cancer types. This explorative study aimed to describe the immune infiltrates in the colon from individuals developing checkpoint inhibitor colitis and compare them to well-known immunophenotypes of acute graft-versus-host disease, ulcerative colitis, and Crohn's disease. Colon biopsies (n = 20 per group) of patients with checkpoint inhibitor colitis, acute graft-versus-host disease, ulcerative colitis and Crohn's disease, all colitis treatment-naïve, and of individuals with a normal colon were analyzed using immunohistochemistry: CD8 for cytotoxic T cells, CD4 for T helper cells, and CD68 to identify cells of macrophage lineage. Read More

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Effectiveness of experimental and commercial pertussis vaccines in the elimination of Bordetella pertussis isolates with different genetic profiles in murine model.

Med Microbiol Immunol 2021 Aug 2. Epub 2021 Aug 2.

Department of Vaccines and Sera Evaluation, National Institute of Public Health, National Institute of Hygiene, Warsaw, Poland.

The aim of this study was to compare the elimination of Bordetella pertussis clinical isolates, representing different genotypes in relation to alleles encoding virulence factors (MLST-multi-locus antigen sequence typing), MLVA type (multi-locus variable-number tandem repeat analysis) and PFGE group (pulsed-field gel electrophoresis) from the lungs of naive mice or mice were immunised with the commercial whole-cell pertussis vaccine, the acellular pertussis vaccine and the experimental whole-cell pertussis vaccine. Molecular data indicate that the resurgence of pertussis in populations with high vaccine coverage is associated with genomic adaptation of B. pertussis, to vaccine selection pressure. Read More

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Association of Expanded Prenatal Care Coverage for Immigrant Women With Postpartum Contraception and Short Interpregnancy Interval Births.

JAMA Netw Open 2021 Aug 2;4(8):e2118912. Epub 2021 Aug 2.

Center for Health Systems Effectiveness, Oregon Health & Science University, Portland.

Importance: Access to prenatal and postpartum care is restricted among women with low income who are recent or undocumented immigrants enrolled in Emergency Medicaid.

Objective: To examine the association of extending prenatal care coverage to Emergency Medicaid enrollees with postpartum contraception and short interpregnancy interval births.

Design, Setting, And Participants: This cohort study used a difference-in-differences design to compare the staggered rollout of prenatal care in Oregon with South Carolina, a state that does not cover prenatal or postpartum care. Read More

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Evaluation of the Repeatability of the LacryDiag Ocular Surface Analyzer for Assessment of the Meibomian Glands and Tear Film.

Transl Vis Sci Technol 2021 Aug;10(9)

Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Purpose: This study aimed to determine the intra- and interobserver repeatability of the new LacryDiag Ocular Surface Analyzer and compare it to a similar all-in-one device, the OCULUS Keratograph 5M.

Methods: Thirty healthy subjects aged 18 years and above were recruited for this study. All patients were free of any existing ocular pathology. Read More

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Percutaneous Coronary Intervention Versus Medical Therapy in the Treatment of Stable Coronary Artery Disease: An Updated Meta-Analysis of Contemporary Randomized Controlled Trials.

J Invasive Cardiol 2021 Aug;33(8):E647-E657

Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.

Background: The net clinical benefit of percutaneous coronary intervention (PCI) compared with medical therapy (MT) alone for the treatment of stable coronary artery disease (CAD) remains uncertain. We conducted an updated meta-analysis of randomized controlled trials (RCTs) to compare PCI with MT for the treatment of patients with stable CAD.

Methods: RCTs of PCI vs MT in patients with stable CAD were identified from MEDLINE, the Cochrane Library, and manual search of bibliographies to March 2020. Read More

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