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Retrospective evaluation of gastrointestinal foreign bodies and presurgical predictors for enterectomy versus enterotomy in dogs (2013-2016): 82 cases.

J Vet Emerg Crit Care (San Antonio) 2021 Sep 23. Epub 2021 Sep 23.

Department of Clinical Studies, Matthew J. Ryan Veterinary Teaching Hospital, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objective: To evaluate preoperative diagnostics in dogs with gastrointestinal foreign body (GIFB) obstruction and to identify clinical variables associated with the performance of simple enterotomy (EO) versus enterectomy (EC).

Design: Retrospective case control study from October 2013 to January 2016.

Setting: Veterinary Teaching Hospital. Read More

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September 2021

Reciprocal associations between affectual, associational, and normative solidarity with parents during children's early to established adulthood.

Fam Process 2021 Sep 23. Epub 2021 Sep 23.

Department of Human Development and Family Science, Department of Sociology, and Aging Studies Institute, Syracuse University, Syracuse, New York, USA.

Intergenerational solidarity has become increasingly important to understand, as close family members mobilize the provision of social support across generations and contribute to family wellbeing. However, less is known about continuity and change in normative (eldercare norms), affectual, and associational solidarity with mothers and fathers as children emerge into full or established adulthood. Therefore, we focused on reciprocal associations between three dimensions of intergenerational solidarity (normative, affectual, and associational) as reported by young-adult children from their early twenties to late thirties. Read More

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September 2021

Rehabilitation of Patients with Osseointegrated Prosthesis after Transfemoral Amputation - Literature-based Recommendation for Postoperative Rehabilitative Procedure.

Z Orthop Unfall 2021 Sep 23. Epub 2021 Sep 23.

Bundeswehr Centre of Sports Medicine, Warendorf, Germany.

Background: Osseointegrative implantation after amputation of the lower extremity is a special treatment option. Physiotherapeutic treatment is important for the functional outcome. This study systematically evaluated existing follow-up treatment protocols to establish a literature-based recommendation for postoperative rehabilitation procedures. Read More

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September 2021

Single-cell Polyfunctional Proteomics of CD4 Cells from Patients with AML Predicts Responses to Anti-PD-1-based therapy.

Blood Adv 2021 Sep 23. Epub 2021 Sep 23.

MD Anderson Cancer Center, Houston, Texas, United States.

Acute myeloid leukemia (AML) remains a difficult disease to treat disease. In a phase 2 clinical trial in patients with relapsed/refractory AML, combining the hypomethylating agent, azacitidine, with the PD-1 checkpoint inhibitor, nivolumab, demonstrated encouraging response rates (33%), median event-free and overall survival, compared with a historical cohort of contemporary patients treated with azacitidine-based therapies, with an acceptable safety profile. Biomarkers of response are yet to be determined. Read More

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September 2021

Machine learning-based scoring models to predict hematopoietic stem cell mobilization in allogeneic donors.

Blood Adv 2021 Sep 23. Epub 2021 Sep 23.

Washington University School of Medicine, St. Louis, Missouri, United States.

Mobilized peripheral blood has become the primary source of hematopoietic stem cells for both autologous and allogeneic stem cell transplantation. Granulocyte Colony-Stimulating Factor (G-CSF) is currently the standard agent used in the allogeneic setting. Despite the high mobilization efficacy in most donors, G-CSF requires 4-5 days of daily administration, and a small percentage of the donors fail to mobilize an optimal number of stem cells necessary for a safe allogeneic stem cell transplant. Read More

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September 2021

A novel 3D culture model recapitulates primary FL B cell features and promotes their survival.

Blood Adv 2021 Sep 23. Epub 2021 Sep 23.

INSERM U1053, Bordeaux, France.

Non-Hodgkin B-cell lymphomas (B-NHL) mainly develop within lymph nodes (LN) as densely packed aggregates of tumor cells and their surrounding microenvironment, creating a tumor niche specific to each lymphoma subtypes. In vitro preclinical models mimicking biomechanical forces, cellular microenvironment, and 3D organization of B-cell lymphomas remain scarce, while all these parameters constitute key determinants of lymphomagenesis and drug resistance. Using a microfluidic method based on cell encapsulation inside permeable, elastic, and hollow alginate microspheres, we developed a new tunable 3D-model incorporating lymphoma B cells, extracellular matrix (ECM), and/or tonsil stromal cells (TSC). Read More

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September 2021

Quantitative proteomics of plasma and liver reveals the mechanism of turmeric in preventing hyperlipidemia in mice.

Food Funct 2021 Sep 23. Epub 2021 Sep 23.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.

Hyperlipidemia is manifested by abnormal levels of circulating lipids and may lead to various cardiovascular diseases. Studies have demonstrated that turmeric supplemented in food can effectively prevent hyperlipidemia. The aim of this study is to elucidate the underlying mechanism. Read More

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September 2021

Intravenous Cetirizine vs Intravenous Diphenhydramine for the Prevention of Hypersensitivity Infusion Reactions: Results of an Exploratory Phase 2 Study.

J Infus Nurs 2021 Sep 22. Epub 2021 Sep 22.

St. Joseph Health Cancer Center, Santa Rosa, California (Dr Holmes); Oncology Consultants PA, Department of Research, Houston, Texas (Dr Peguero); Baylor Scott & White Medical Center, Temple, Texas (Dr Garland); and TerSera Therapeutics, Deerfield, Illinois (Ms North and Drs Young, Brent, and Joseph-Ridge). Jarrod P. Holmes, MD, FACP, is a hematologist/oncologist and associate medical director of oncology for Northern California, Providence Medical Group, in Santa Rosa, California. Julio A. Peguero, MD, is board certified in internal medicine and medical oncology and the director of research at Oncology Consultants in Houston, Texas. R. Campbell Garland, DO, is a hematologist/oncologist at Baylor Scott & White Medical Center based in Central Texas. Janine North, BS, is executive director of clinical development at TerSera Therapeutics, in Deerfield, Illinois. Stacia Young, PharmD, BCOP, MBA, is director of oncology medical science liaisons at TerSera Therapeutics. Lonnie D. Brent, PharmD, is vice president of medical affairs at TerSera Therapeutics. Nancy Joseph-Ridge, MD, is executive vice president of research and development and chief medical officer at TerSera Therapeutics.

Pretreatment with antihistamines for the prevention of hypersensitivity infusion reactions is recommended for certain biologics and chemotherapies. Cetirizine is the first injectable second-generation antihistamine recently approved for acute urticaria. A randomized, exploratory phase 2 study evaluated intravenous (IV) cetirizine 10 mg versus IV diphenhydramine 50 mg as pretreatment in patients receiving an anti-CD20 agent or paclitaxel. Read More

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September 2021

Humanization of care for adult ICU patients: a scoping review protocol.

JBI Evid Synth 2021 Sep 22. Epub 2021 Sep 22.

School of Nursing Sciences, Faculty of Nursing, Université Laval, Quebec, Canada Quebec Heart and Lung Research Centre- Université Laval, Quebec, Canada CHU de Québec- Université Laval, Quebec, Canada.

Objective: The objective of this review is to review and map data from studies on the humanization of care in intensive care units based on a conceptual framework.

Introduction: The critical context of adult patients in intensive care units directs the focus on clinical medical interventions, drawing attention away from the humanization of care. Rethinking intensive care is imperative and the humanization of care is an absolute priority. Read More

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September 2021

Comparative Analyses of the Transport Proteins Encoded within the Genomes of nine Bifidobacterium Species.

Microb Physiol 2021 Sep 23:1-15. Epub 2021 Sep 23.

Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California, USA.

The human microbiome influences human health in both negative and positive ways. Studies on the transportomes of these organisms yield information that may be utilized for various purposes, including the identification of novel drug targets and the manufacture of improved probiotic strains. Moreover, these genomic analyses help to improve our understanding of the physiology and metabolic capabilities of these organisms. Read More

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September 2021

An evaluation of allogeneic freeze-dried concentrated growth factors biocompatibilityand.

Biomed Mater 2021 Sep 23. Epub 2021 Sep 23.

Department of Stomatology, the First Dongguan Affiliated Hospital of Guangdong Medical University, Scientific Research Platform, the Second Clinical Medical College, Guangdong Medical University, Dongguan , 523710, CHINA.

This study evaluated the biocompatibility of allogeneic freeze-dried concentrated growth factors (AFD-CGFs) in vitro and in vivo. For the in vitro experiments, bone marrow stem cells (BMSCs) were cultured in 10% fresh allogeneic concentrated growth factors (CGFs). AFD-CGF solution was used as the experimental group, and Dulbecco's modified Eagle medium (DMEM) was used as control. Read More

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September 2021

Impact of Nonadherence to NCCN Adjuvant Radiotherapy Initiation Guidelines in Head and Neck Squamous Cell Carcinoma in an Underserved Urban Population.

J Natl Compr Canc Netw 2021 Sep 22:1-7. Epub 2021 Sep 22.

6Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center, Bronx, New York.

Background: Nonadherence to NCCN Guidelines during time from surgery to postoperative radiotherapy (S-PORT) can alter survival outcomes in head and neck squamous cell carcinomna (HNSCC). There is a need to validate this impact in an underserved urban population and to understand risk factors and reasons for delay. We sought to investigate the impact of delayed PORT with outcomes of overall survival (OS) in HNSCC, to analyze predictive factors of delayed PORT, and to identify reasons for delay. Read More

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September 2021

Agricultural ammonia emissions and its impact on PM concentrations in the Beijing-Tianjin-Hebei region from 2000 to 2018.

Environ Pollut 2021 Sep 11;291:118162. Epub 2021 Sep 11.

College of Environmental & Energy Engineering, Key Laboratory of Beijing on Regional Air Pollution Control, Beijing University of Technology, Beijing, 100124, China. Electronic address:

Ammonia (NH) discharged from agricultural activities to the atmosphere plays a crucial role in the formation of secondary inorganic aerosols. This study analyzed the temporal-spatial development of agricultural NH emissions from 2000 to 2018 in the Beijing-Tianjin-Hebei (BTH) region and assessed the effects of reducing PM by removing agricultural NH using an air quality model. The results showed that the interannual agricultural NH emissions in the BTH region exhibited a stairs trend from 2000 to 2018, with an average of 971. Read More

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September 2021

Exploring core competencies of clinical nurse preceptors: A nominal group technique study.

Nurse Educ Pract 2021 Sep 11;56:103200. Epub 2021 Sep 11.

School of Nursing & Nursing Department, Chang Gung University of Science and Technology & Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan. Electronic address:

Aim: The aim of this study was to explore core competencies of nurse preceptors based on the perspectives of postgraduate-year nurses, nurse preceptors and head nurses.

Background: Perspectives of core competencies of nurse preceptors are varied among postgraduate-year nurses, nurse preceptors and head nurses, which makes it difficult to establish preceptor training programs and develop evaluation instruments.

Design: A nominal group technique study. Read More

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September 2021

Automatic segmentation of blood cells from microscopic slides: A comparative analysis.

Tissue Cell 2021 Sep 17;73:101653. Epub 2021 Sep 17.

Department of Electrical & Computer Engineering, North South University, Bashundhara, Dhaka, 1229, Bangladesh. Electronic address:

With the recent developments in deep learning, automatic cell segmentation from images of microscopic examination slides seems to be a solved problem as recent methods have achieved comparable results on existing benchmark datasets. However, most of the existing cell segmentation benchmark datasets either contain a single cell type, few instances of the cells, not publicly available. Therefore, it is unclear whether the performance improvements can generalize on more diverse datasets. Read More

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September 2021

Efficacy of freeze-chilled storage combined with tea polyphenol for controlling melanosis, quality deterioration, and spoilage bacterial growth of Pacific white shrimp (Litopenaeus vannamei).

Food Chem 2021 Aug 23;370:130924. Epub 2021 Aug 23.

Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address:

This study aimed to investigate melanosis, quality attributes, and bacterial growth of freeze-chilled Pacific white shrimp (Litopenaeus vannamei) during 6 days of chilled storage, as well as the preservative effects of tea polyphenol on shrimp. The results showed that freeze-chilled storage retarded the growth of bacteria and the accumulation of putrescine in shrimp. The growth of spoilage bacteria Photobacterium and Shewanella were inhibited. Read More

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Long term Be deposition in Romania.

J Environ Radioact 2021 Sep 20;240:106738. Epub 2021 Sep 20.

Faculty of Physics, University of Bucharest, Strada, Atomiștilor 405, Magurele, 077125, Romania; Extreme Light Infrastructure - Nuclear Physics, IFIN-HH, 30 Atomistilor Str, Bucharest-Magurele, Romania. Electronic address:

This study is based on monthly Be deposition data at 29 of the stations of Romania's National Environmental Radioactivity Surveillance Network (NERSN), with different geographical and climatological conditions, extending over periods up to 17 years (1979-1995). The Be activity in each monthly sample from each station was determined using high-resolution gamma-ray spectrometry performed at the Environmental Radioactivity Laboratory, Bucharest-Afumati. The annual dynamics of atmospheric deposition of Be at each NERSN station showed a strong seasonal trend, very similar to the precipitation regime, with the highest values being observed in spring/summer and the lowest in winter. Read More

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September 2021

Detection of ataxia in low disability MS patients by hybrid convolutional neural networks based on images of plantar pressure distribution.

Mult Scler Relat Disord 2021 Sep 15;56:103261. Epub 2021 Sep 15.

Department of Neurology, Faculty of Medical, Fırat University, Elazığ, Turkey.

Background: This study aimed to detect ataxia in patients with multiple sclerosis (PwMS) with a deep learning-based approach based on images showing plantar pressure distribution of the patients. The secondary aim of the study was to investigate an alternative and objective method in the early diagnosis of ataxia in these patients.

Methods: A total of 105 images showing plantar pressure distribution of 43 ataxic PwMS and 62 healthy individuals were analyzed. Read More

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September 2021

"Theyabduct usand rapeus": Adolescents' participatory visual reflections of their vulnerability to sexual violence in South African townships.

Soc Sci Med 2021 Sep 15;287:114401. Epub 2021 Sep 15.

Centre for Community-Based Research, Human Sciences Research Council and School of Law, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

The abduction and sexual violation of adolescents, especially in township contexts, has increasingly made headlines in South Africa. These incidents are evocative of jackrolling, a phenomenon that plagued townships during the apartheid upheavals in the late 1980s. The abduction of adolescents on their school journeys has been reported in several South African townships. Read More

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September 2021

Effects of simulated environmental discharges of the salmon lice pesticides deltamethrin and azamethiphos on the swimming behaviour and survival of adult Northern shrimp (Pandalus borealis).

Aquat Toxicol 2021 Sep 17;240:105966. Epub 2021 Sep 17.

NORCE Norwegian Research Centre, Mekjarvik 12, 4072, Randaberg, Norway. Electronic address:

Swimming behaviour was investigated in adult egg-carrying northern shrimp (Pandalus borealis) exposed to dilute concentrations of the pesticides Alpha Max® (active ingredient deltamethrin) and Salmosan® (active ingredient azamethiphos) used to control parasitic copepods in salmon aquaculture. These treatments are applied topically within fish nets or well boats. Following a short treatment period, the pesticides are directly discharged to sea, exposing non-target organisms such as P. Read More

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September 2021

Suppression of reflected signals from substrate as clutters for cell measurements using acoustic impedance microscopy.

Ultrasonics 2021 Sep 15;118:106580. Epub 2021 Sep 15.

Honda Electronics Co., Ltd, Toyahashi, Aichi 441-3193, Japan.

Recently, a method for estimating three-dimensional acoustic impedance profiles in cultured cells and human dermal organs was proposed by interpreting the reflected ultrasonic signal based on a 1-D transmission line model for acoustic impedance microscopy (AIM). However, AIM has a disadvantage that reflected signals from cells overlap with that from a reference substrate. Additionally, the amplitudes of the reflected signals from the specimens are significantly weaker than that from the substrate. Read More

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September 2021

Construction of a prognostic signature in Ewing's sarcoma: Based on metabolism-related genes.

Transl Oncol 2021 Sep 20;14(12):101225. Epub 2021 Sep 20.

Department of Orthopaedics, the First Hospital of Jilin University, Street Xinmin 71, Changchun, China. Electronic address:

Objective: By combining the expression profiles of metabolism-related genes (MRGS) with clinical information, the expression quantities of MRGS and the influence on development and prognosis were systematically analyzed, so as to provide a theoretical basis for the clinical study on the prognosis of Ewing's sarcoma.

Methods: MRGs expression profiles of 64 patients with Ewing's sarcoma were obtained from GEO dataset. Univariate Cox regression analysis was used to identify metabolization-related differentially expressed genes (DEGs) related with prognosis in Ewing's sarcoma patients. Read More

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September 2021

Effectiveness of 4-1BB-costimulated HER2-targeted chimeric antigen receptor T cell therapy for synovial sarcoma.

Transl Oncol 2021 Sep 20;14(12):101227. Epub 2021 Sep 20.

Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata City, Niigata 951-8510, Japan. Electronic address:

Background: Synovial sarcoma is a rare malignant soft-tissue tumor that is prevalent in adolescents and young adults, and poor prognosis has been reported in patients with metastatic lesions. Chimeric antigen receptor (CAR) T-cell therapy is an emerging novel therapy for solid tumors; however, its application in synovial sarcoma has not yet been explored.

Methods: A novel human epidermal growth factor receptor 2 (HER2)-targeted CAR containing scFv-FRP5, CD8α hinge and transmembrane domains as well as 4-1BB costimulatory and CD3ζ signaling domains was developed. Read More

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September 2021

Relationship between carbohydrate-to-fat intake ratio and the development of chronic kidney disease: A community-based prospective cohort study.

Clin Nutr 2021 Sep 9;40(10):5346-5354. Epub 2021 Sep 9.

Division of Nephrology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea; Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea. Electronic address:

Background & Aims: It is well-known that high protein intake is associated with renal hyperfiltration and faster renal function decline, but the association of other macronutrients, carbohydrate and fat, with development of chronic kidney disease (CKD) is still inconclusive. Therefore, we aimed to examine the relationship between fat-to-carbohydrate intake ratio (F/C ratio) and incident CKD.

Methods: We included 9226 subjects from the Korean Genome and Epidemiology Study. Read More

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September 2021

Economic comparison of an ear tag automated activity monitor for estrus detection with timed-AI in Holstein heifers.

Theriogenology 2021 Sep 16;175:155-162. Epub 2021 Sep 16.

Department of Agricultural Food and Nutritional Sciences, University of Alberta, Edmonton, T6G 2P5, Canada. Electronic address:

The objective of this study was to compare the economic performance of an ear tag automated activity monitor system (AAM) versus a timed-AI (TAI) protocol in Holstein heifers. In total, 340 heifers were enrolled onto the study at 13.5 mo of age and randomly assigned to receive either an AAM (n = 170) or TAI (n = 170) protocol before breeding eligibility (D 0). Read More

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September 2021

QSPR modeling of absorption maxima of dyes used in dye sensitized solar cells (DSSCs).

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 20;265:120387. Epub 2021 Sep 20.

Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, 188 Raja S C Mullick Road, Kolkata 700032, India. Electronic address:

Dye-sensitized solar cells (DSSCs) have recently received a significant attention as possible sources of renewable energy. As a result, a significant effort is being made to develop organic dyes for highly power conversion efficient DSSCs, in order to overcome the disadvantages of previous solar cell systems, such as cost reduction, weight reduction, and production methods that minimize environmental pollution. As shown by multiple recent research publications, computational techniques such as quantitative structure-property relationship (QSPR) modeling may aid in the development of suitable dyes for DSSCs satisfying many fundamental desired characteristics. Read More

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September 2021

Quantification and mapping of fish waste in retail trade and restaurant sector: Experience in Emilia-Romagna, Italy.

Waste Manag 2021 Sep 20;135:256-266. Epub 2021 Sep 20.

University of Bologna, CIRSA - Interdepartmental Research Centre for Environmental Sciences, Via Sant'Alberto 163, 48123 Ravenna, Italy; University of Bologna, Department of Physics and Astronomy, Via Irnerio, 46, 40126 Bologna, Italy.

The circular economy approach imposes the complete recovery of components, materials and energy from waste. Many active compounds with biomedical and nutraceutical applications can be extracted by Fish Waste (FW), but few are the operating industrial plants. Quantification and mapping of the potential FW availability along the entire fish value-chain is crucial in fostering its actual valorisation. Read More

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September 2021

Lifetime cumulative adversity and physical health deterioration in old age: Evidence from a fourteen-year longitudinal study.

Soc Sci Med 2021 Sep 16;289:114407. Epub 2021 Sep 16.

Paul Baerwald School of Social Work, The Hebrew University of Jerusalem, Mount Scopus, 91905, Jerusalem, Israel.

Background: Although several studies have demonstrated the associations between lifetime cumulative adversity and late-life physical health, many of them were conducted at a single time point and examined events that occurred in childhood only. Less is known about the effect of lifelong adversity on the aging process over time. This study aimed to investigate the impact of cumulative adversity on the accelerated deterioration in health over time - mobility limitation and self-rated state of health in old age. Read More

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September 2021

Rocktape provides no benefit over sham taping in people with knee osteoarthritis who are completing an exercise program: a randomised trial.

Physiotherapy 2021 May 17;113:29-36. Epub 2021 May 17.

Physiotherapy Department, The Alfred Hospital, PO Box 315, Prahran, VIC, 3181, Australia; Allied Health, La Trobe University, Plenty Rd & Kingsbury Dr, Bundoora, VIC, 3086, Australia. Electronic address:

Objectives: To investigate if Rocktape combined with exercise is more effective than exercise and sham taping in patients with knee osteoarthritis.

Design: Single institution, prospective, participant and assessor blinded, randomised study.

Setting: Outpatient physiotherapy department of a tertiary hospital. Read More

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Allopurinol adherence, persistence and patterns of use in individuals with diabetes and gout: A retrospective, population-based cohort analysis.

Semin Arthritis Rheum 2021 Sep 16;51(6):1162-1169. Epub 2021 Sep 16.

Department of Medicine, University of Toronto, Toronto, ON, Canada; ICES, ON, Canada; Women's College Hospital, Women's College Research Institute, Toronto, ON, Canada.

Objective: There has been growing interest in the potential role for allopurinol to reduce cardiovascular events in people with diabetes. While adherence to allopurinol is poor in those with gout, our aim was to characterize persistence, patterns of use, and predictors of allopurinol use in a population-based cohort of individuals with diabetes and gout.

Methods: Individuals with diabetes older than 66 (thus eligible for prescription medication coverage) and newly prescribed allopurinol were followed for up to three years in a retrospective cohort study. Read More

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September 2021