162,497 results match your criteria study 3-5

A direct contact bioassay using sulfur-oxidizing bacteria (SOB) for toxicity assessment of contaminated field soils.

Chemosphere 2021 Jul 20;286(Pt 1):131599. Epub 2021 Jul 20.

Department of Biological Environment, Kangwon National University, 192-1 Hyoja-dong, Gangwon-do, Chuncheon-si, 200-701, Republic of Korea. Electronic address:

In this study, 11 low/uncontaminated (including Lufa 2.2) and 9 contaminated field soils with varying geophysical and physicochemical characteristics were evaluated for toxicities based on oxygen consumption of sulfur-oxidizing bacteria (SOB). Oxygen consumption of the low/uncontaminated soils ranged between 7. Read More

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Highly efficient removal of DEET by UV-LED irradiation in the presence of iron-containing coagulant.

Chemosphere 2021 Jul 20;286(Pt 1):131613. Epub 2021 Jul 20.

School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China.

N,N-Diethyl-3-methyl benzoyl amide (DEET) has been detected as an emerging pollutant in various water bodies because of its widespread use as an insect repellent. In this study, the combination of UV-LED and iron-containing coagulant (FeCl) was used for the elimination of DEET in water. It was found that UV-LED/FeCl (98 %) system presented a favorable removal of DEET compared with UV/FeCl (59 %) and UV-LED/Fe(SO) (81 %) processes at initial pH 3. Read More

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Mechanical and microstructural properties of recycling granite residual soil reinforced with glass fiber and liquid-modified polyvinyl alcohol polymer.

Chemosphere 2021 Jul 22;286(Pt 1):131652. Epub 2021 Jul 22.

School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou, 510006, China.

Glass fiber and liquid-modified polyvinyl alcohol polymer (SH Polymer) are used to reinforce granite residual soil. In this paper, scanning electron microscopy (SEM) tests and drop-weight tests were used to study the microscopic interaction mechanism and impact resistance of granite residual soil specimens reinforced by glass fiber and SH Polymer. Combined with the equivalent confining pressure theory, Mohr-Coulomb intensity lines were used to quantitatively analyze the reinforcement effect of glass fiber. Read More

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Resting-state EEG theta activity reflects degree of genetic determination of the major epilepsy syndromes.

Clin Neurophysiol 2021 Jul 3;132(9):2232-2239. Epub 2021 Jul 3.

University of Debrecen, Faculty of Medicine, Department of Neurology, Hungary.

Objective: To explore relationship between EEG theta activity and clinical data that imply the degree of genetic determination of epilepsy.

Methods: Clinical data of interest were epilepsy diagnosis and positive / negative family history of epilepsy. Study groups were: idiopathic generalized epilepsy (IGE), focal epilepsy (FE); FE of unknown etiology (FEUNK), FE of postnatal-acquired etiology (FEPA); all patients with positive / negative family history of epilepsy (FAPALL, FANALL, respectively), disregarding of the syndrome; FAP patients with 1st degree affected relative (FAP1) and those with 2nd degree epileptic relative only (FAP2). Read More

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Insulin signaling, androgen receptor and PSMA immunohistochemical analysis by semi-automated tissue microarray in prostate cancer with diabetes (DIAMOND study).

Transl Res 2021 Jul 24. Epub 2021 Jul 24.

Urology Section, Department of Surgery, University of Catania, Catania, Italy. Electronic address:

In the last years, many studies have highlighted the hypothesis that diabetes and hyperglycemia could be relevant for prostate cancer (PC) development and progression. We aimed to identify the prognostic value of tissue expression of androgen receptor (AR), Prostate-Specific Membrane Antigen (PSMA), Ki-67, insulin receptors (IR)  α and β, insulin growth factor-1 (IGF-1) receptor, in patients with PC and to evaluate their association with diabetes. We retrospectively collected data from 360 patients who underwent radical prostatectomy for PC or surgery for benign prostatic hyperplasia (BPH), between 2010 and 2020. Read More

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Can stable isotopes quantify soil carbon build-up from organic fertilizers?

Isotopes Environ Health Stud 2021 Jul 27:1-22. Epub 2021 Jul 27.

CIRAD, Internal Research Unit (UPR) Recycling and Risk, Station de La Bretagne, Réunion, France.

The application of organic fertilizers (OF) can supply carbon (C) to the soil in crop fields. OF-derived C (OF-C) is often estimated using the differential method that can be biased due to indirect effects of OF on soil C. This study tested three methods to quantify OF-C: (i) the widespread differential method, (ii) the synchronic isotope method comparing plots with and without OF and (iii) the asynchronic isotope method mimicking a trial without a control plot. Read More

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Urodynamic effects of prostatic urethral lift procedure for male voiding LUTS.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Radboudumc, 6034, Urology, Nijmegen, Gelderland, Netherlands;

Aims: Primary objective is to investigate whether prostatic urethral lift (PUL) results in an improvement of urodynamic parameters that define bladder outlet obstruction (urethral resistance algorithm [URA], Schäfer grade, PdetQmax, PdetOpen).

Methods: 20 patients (main inclusion criteria: ≥ 50 years of age, BPO, IPSS ≥ 13, prostate volume ≤ 60 mL, no middle prostate lobe) were enrolled in the study and a PUL was performed. Patients underwent urodynamic investigation and filled out the IPSS and QoL before and after PUL. Read More

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GSK-3β inhibitor TDZD-8 prevents reduction of aquaporin-1 expression via activating autophagy under renal ischemia reperfusion injury.

FASEB J 2021 08;35(8):e21809

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Renal ischemia/reperfusion (I/R) injury is a main cause of acute kidney injury (AKI). Aquaporin (AQP)-1 water channel in the kidney is critical for the maintenance of water homeostasis and the urinary concentrating ability. Increasing evidence supports an important role of autophagy in the pathogenesis of AKI induced by renal I/R. Read More

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Children's education and level of health care utilization among parents: a pooled cross-sectional study from national population-based survey in India.

Geroscience 2021 Jul 27. Epub 2021 Jul 27.

Harvard Center for Population and Development Studies, 9 Bow Street, Harvard T. H. Chan School of Public Health, Cambridge, MA, USA.

The study of upward spill over on parents of their offspring's education is vital for understanding the family dynamics and role of adult children in the decisions of parents. Such association has widespread implication and application on ageing policies. We use pooled data from population-based cross-sectional health consumption surveys conducted by the National Sample Survey Organization in 2014 and 2018 (rounds 71 and 75, respectively) in this study. Read More

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Oral acetaminophen as an adjunct to continuous epidural infusion and patient-controlled epidural analgesia in laboring parturients: a randomized controlled trial.

J Anesth 2021 Jul 27. Epub 2021 Jul 27.

Department of Obstetrics and Gynaecology, Government Medical College and Hospital, Chandigarh, India.

Background: Intravenous acetaminophen is safe and effective as an adjunct to labor analgesia with combined spinal-epidural (CSE) analgesia and patient-controlled epidural analgesia (PCEA). Oral acetaminophen is a much cheaper and safe option but has not been studied as an adjunct to labor analgesia till date. The aim of the present study is to evaluate the effect of oral acetaminophen as an adjunct in patients receiving local anesthetic-opioid combination using CSE analgesia. Read More

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Weight Loss Prior to Pregnancy and Early Gestational Glycemia: Prepare, a Randomized Clinical Trial.

J Clin Endocrinol Metab 2021 Jul 27. Epub 2021 Jul 27.

Kaiser Permanente, Center for Health Research, 3800 N. Interstate Ave, Portland, OR.

Purpose: To determine whether pre-pregnancy weight loss improved the early metabolic environment as measured by early gestational diabetes diagnosis.

Methods: This was a secondary analysis of a pragmatic randomized clinical trial conducted between May 2015 and October 2019 in an integrated health system that encouraged first trimester gestational diabetes screening for high-risk women, including those with obesity. Women aged 18-40 years with BMI ≥27 kg/m 2 who were planning pregnancy were randomized to a behavioral weight loss intervention or usual care. Read More

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Cost-effectiveness of Dapagliflozin for the Treatment of Heart Failure With Reduced Ejection Fraction.

JAMA Netw Open 2021 Jul 1;4(7):e2114501. Epub 2021 Jul 1.

Harvard Medical School, Boston, Massachusetts.

Importance: Heart failure with reduced ejection fraction produces substantial morbidity, mortality, and health care costs. Dapagliflozin is the first sodium-glucose cotransporter 2 inhibitor approved for the treatment of heart failure with reduced ejection fraction.

Objective: To examine the cost-effectiveness of adding dapagliflozin to guideline-directed medical therapy for heart failure with reduced ejection fraction in patients with or without diabetes. Read More

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Immigration Background and the Widowhood Effect on Mortality.

J Gerontol B Psychol Sci Soc Sci 2021 Jul 27. Epub 2021 Jul 27.

Max Planck Institute for Demographic Research, Rostock, Germany.

Objectives: Widowhood is a stressful life event with one of the most profound negative effects on health and longevity. Immigrant populations are growing and aging throughout Western nations, and marginalization and cultural differences may make some immigrants especially vulnerable to the stressors of widowhood. However, studies have yet to systematically explore whether the widowhood effect differs between immigrant and native-born individuals. Read More

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Microwave-assisted synthesis of hybrid PABA-1,3,5-triazine derivatives as an antimalarial agent.

J Biochem Mol Toxicol 2021 Jul 27:e22860. Epub 2021 Jul 27.

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India.

The present manuscript deals with the development of novel p-aminobenzoic acid (PABA) associated 1,3,5-triazine derivatives as antimalarial agents. The molecules were developed via microwave-assisted synthesis and structures of compounds were ascertained via numerous analytical and spectroscopic techniques. The synthesized compounds were also subjected to ADMET analysis. Read More

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The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury.

Shock 2021 Jul 26. Epub 2021 Jul 26.

Institute of Disaster Medicine, Tianjin University, Tianjin, China Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin, China Department of Intensive Care Medicine, Taida hospital of Tianjin University, Tianjin, China Department of Intensive Care Medicine, Shijiazhuang Circulating Chemical Industry Park Hospital, Hebei, China Department of Emergency Medicine, General Hospital of Tianjin Medical University, Tianjin, China Department of Nephrology, Characteristic Medical Center of Chinese People's Armed Police Forces, Tianjin, China Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.

Background: Crush syndrome (CS) is the most common cause of deaths following earthquakes and other disasters. The pathogenesis of CS has yet to be fully elucidated. Thus, clinical choice of ideal drug treatments for CS remains deficient. Read More

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Long-term outcomes of CT-guided percutaneous cryoablation of T1a and T1b renal cell carcinoma.

Diagn Interv Radiol 2021 Jul;27(4):524-528

Department of Clinical Radiology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.

Purpose: We aimed to evaluate the long-term outcomes of computed tomography-guided percutaneous cryoablation (PCA) for biopsy-confirmed renal cell carcinoma (RCC).

Methods: This was a single-center, retrospective study investigating all patients treated with PCA between January 2010 and February 2019 for RCC tumors. Primary outcome measures included overall survival (OS), disease-free survival (DFS), progression-free survival (PFS) and cancer-specific survival (CSS). Read More

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Severity and duration of allergic conjunctivitis: are they associated with severity and duration of allergic rhinitis and asthma?

Eur Ann Allergy Clin Immunol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pneumology and Allergy, Hospital Clínic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERES, Barcelona, Spain.

Summary: The association of allergic conjunctivitis (AC) with rhinitis and/or asthma is poorly understood. The objective of this study was to apply the Consensus Document for Allergic Conjunctivitis (DECA) criteria for the classification of AC to a population of patients with AC to assess the association between the severity and duration of AC and rhinitis and/or asthma. Patients with ocular symptoms of AC who participated in the 'Alergológica 2015' study were included. Read More

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Effects of fruit tree canopy shading on grain filling of intercropping winter wheat.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2458-2468

Institute of Horticultural Crops, Xinjiang Academy of Agricultural Sciences/Scientific Observation and Experimental Station of Pomology (Xinjiang), Ministry of Agriculture and Rural Affairs, Urumqi 830091, China.

Fruit tree-wheat intercropping system is the main agricultural production pattern in sou-thern Xinjiang. In this study, almond ()-winter wheat (Xindong 20 (, var. Xindong 20) intercropping system was used as the research object. Read More

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Thirty-day hospital readmission rate, reasons, and risk factors after acute inpatient cancer rehabilitation.

Cancer Med 2021 Jul 27. Epub 2021 Jul 27.

Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Objectives: To evaluate the 30-day hospital readmission rate, reasons, and risk factors for patients with cancer who were discharged to home setting after acute inpatient rehabilitation.

Design, Setting, And Participants: This was a secondary retrospective analysis of participants in a completed prospective survey study that assessed the continuity of care and functional safety concerns upon discharge and 30 days after discharge in adults. Patients were enrolled from September 5, 2018, to February 7, 2020, at a large academic quaternary cancer center with National Cancer Institute Comprehensive Cancer Center designation. Read More

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Outcomes for emergency department patients with suspected and confirmed COVID-19: An analysis of the Australian experience in 2020 (COVED-5).

Emerg Med Australas 2021 Jul 27. Epub 2021 Jul 27.

Emergency and Trauma Centre, Alfred Health, Melbourne, Australia.

Objective: The aim of this study was to describe the characteristics and outcomes of patients presenting to Australian emergency departments (EDs) with suspected and confirmed COVID-19 during 2020, and to determine the predictors of in-hospital death for SARS-CoV-2 positive patients.

Methods: This analysis from the COVED Project presents data from twelve sites across four Australian states for the period from 1 April to 30 November 2020. All adult patients who met local criteria for suspected COVID-19 and underwent testing for SARS-CoV-2 in the ED were eligible for inclusion. Read More

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Influence of protein extraction and texturization on odor-active compounds of pea proteins.

J Sci Food Agric 2021 Jul 27. Epub 2021 Jul 27.

Department of Food Material Science, Institute of Food Science and Biotechnology, University of Hohenheim, Garbenstrasse 21/25, 70599, Stuttgart, Germany.

Background: The applicability of plant proteins as food ingredients might be limited due to the presence of foreign or off-flavors, which may evolve during extraction and subsequent processing. In this study, the influence of dry (TVP) and wet (WTP) texturization on characteristic volatile compounds of two different pea protein isolates was assessed by gas chromatography-mass spectrometry-olfactometry (GC-MS-O) after direct immersion stir bar sorptive extraction (DI-SBSE).

Results: An entirety of 24 odor-active compounds was found with a prevalence of carbonyl compounds from fat oxidation. Read More

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Analysis of profibrogenic microRNAs (miRNAs) expression in urine and serum of chronic kidney disease (CKD) stage 1-4 patients and their relationship with proteinuria and kidney function.

Int Urol Nephrol 2021 Jul 27. Epub 2021 Jul 27.

Department of Nephrology, Hypertension and Internal Medicine, University Hospital in Bydgoszcz Nicolaus Copernicus University, Toruń, Poland.

Purpose: Besides conventional kidney diseases diagnostics, micro RNAs (miRNAs) assessment in urine and serum is considered to be a promising non-invasive method of diagnostics of renal parenchymal diseases and valuable therapeutic target also. The purpose of the study was to investigate the role of several miRNAs as a markers of kidney damage.

Methods: Assessment of 45 chronic kidney disease (CKD) patients stage 1-4 and 17 healthy control. Read More

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Assessment of single slope solar still using block and disc magnets via productivity, economic, and enviro-economic perspectives: a comparative study.

Environ Sci Pollut Res Int 2021 Jul 26. Epub 2021 Jul 26.

Department of Mechanical Engineering, Hindusthan College of Engineering and Technology, Coimbatore, 641032, India.

In this research, the productivity, economic, and enviro-economic analysis of single slope solar stills using block magnets (BMSS) and disc magnets (DMSS) were performed under the climatic conditions of Coimbatore city (latitude, 11° 01' 68″ N, and longitude, 76° 95' 58″ E), in India, 2019. The results observed in BMSS and DMSS were compared with conventional solar still (CSS) under the same climatic conditions. The usage of block and disc magnets in basin of solar still was improved the daily productivity significantly. Read More

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Learning process of laparoscopic liver resection and postoperative outcomes: chronological analysis of single-center 15-years' experience.

Surg Endosc 2021 Jul 26. Epub 2021 Jul 26.

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Limited studies have reported the actual learning process of laparoscopic liver resection (LLR). This study aimed to chronologically evaluate our 15 years' experience of LLR.

Methods: All consecutive LLRs between 2006 to 2020 were retrospectively analyzed. Read More

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Poverty, social exclusion, and mental health: the role of the family context in children aged 7-11 years INMA mother-and-child cohort study.

Eur Child Adolesc Psychiatry 2021 Jul 26. Epub 2021 Jul 26.

Joint Research Unit in Epidemiology, Environment and Health FISABIO-University of Valencia - Universitat Jaume I, Valencia, Spain.

Mental health problems are common in childhood and tend to be more frequent in populations at risk of poverty or social exclusion (AROPE). The family environment can play a role in reducing the impact of economic hardship on these problems. The aim of this study was to assess the effect of multidimensional poverty on the mental health of children aged 7-11 years and the role of the family environment in two areas of Spain. Read More

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All-cause mortality of patients with idiopathic pulmonary fibrosis: a nationwide population-based cohort study in Korea.

Sci Rep 2021 Jul 26;11(1):15145. Epub 2021 Jul 26.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.

Most epidemiologic studies of patients with idiopathic pulmonary fibrosis (IPF) have been conducted in North America and Europe. Moreover, there are limited data concerning the cause of death and cause-specific mortality rate of IPF patients in population-based studies. We analyzed information from the Korean National Health Insurance Service database from 2006 to 2016. Read More

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Place Matters: Closing the Gap on Rural Primary Care Quality Improvement Capacity-the Healthy Hearts Northwest Study.

J Am Board Fam Med 2021 Jul-Aug;34(4):753-761

From the Oregon Rural Practice-based Research Network, Oregon Health & Science University, Portland (LJF, KR, CD); Oregon Health & Science University/Portland State University School of Public Health (KR); Qualis Health/Comagine Health, Seattle, WA (TK); Kaiser Permanente Washington Health Research Institute, MacColl Center for Health Care Innovation, Seattle, WA (MLP).

Context: To compare rural independent and health system primary care practices with urban practices to external practice facilitation support in terms of recruitment, readiness, engagement, retention, and change in quality improvement (QI) capacity and quality metric performance.

Methods: The setting consisted of 135 small or medium-sized primary care practices participating in the Healthy Hearts Northwest quality improvement initiative. The practices were stratified by geography, rural or urban, and by ownership (independent [physician-owned] or system-owned [health/hospital system]). Read More

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January 2021

Evaluating a Web-Based Adult ADHD Toolkit for Primary Care Clinicians.

J Am Board Fam Med 2021 Jul-Aug;34(4):741-752

From the American Academy of Family Physicians National Research Network, American Academy of Family Physicians, Leawood, KS (NYL, CBL, EC, MKF, EAR).

Introduction: Approximately 5% of the US adult population has Attention Deficient Hyperactivity Disorder (ADHD) that can negatively impact quality of life. Health care professionals report a need to increase their knowledge of and confidence in treating adult ADHD. The American Academy of Family Physicians National Research Network (AAFP NRN) collaborated with a panel of experts to create a web-based AAFP Adult ADHD Toolkit composed of resources to aid in the diagnosis, management, and treatment of adults with ADHD. Read More

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November 2020

Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice.

J Pharmacol Exp Ther 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Pharmaceutical Sciences, Kinki University, Japan

In receptor-type transcription factors-mediated cytochrome P450 (P450)s induction, few studies have attempted to clarify the roles of protein kinase N (PKN) in the transcriptional regulation of P450s. This study aimed to examine the involvement of PKN in the transcriptional regulation of P450s by receptor-type transcription factors, including the aryl hydrocarbon receptor, constitutive androstane receptor (CAR), and pregnane X receptor. The mRNA and protein levels, and metabolic activity, of P450s in the livers of wild-type (WT) and double-mutant (D) mice harboring both PKN1 kinase-negative knock-in and PKN3 knockout mutations [ ; ] were determined following treatment with activators for receptor-type transcription factors. Read More

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Pyeloplasty in children with low differential renal function: Functional recoverability.

J Pediatr Urol 2021 Jul 7. Epub 2021 Jul 7.

Urology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Introduction And Objective: Ureteropelvic junction obstruction (UPJO) is a common pathology in pediatric urology practice. Indications for intervention are well established while the ideal management of children with UPJO in poorly functioning kidneys is still debatable. We aimed in this study to evaluate the outcome of pyeloplasty in patients with UPJO and low DRF ≤20%. Read More

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