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Historical review of malaria control and elimination in the border areas of China: A case study of Yunnan Province.

Adv Parasitol 2022 23;116:33-67. Epub 2022 Mar 23.

Yunnan Institute of Parasitic Diseases, Yunnan Provincial Centre of Malaria Research, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Institute of Parasitic Diseases Innovative Team of Key Techniques for Vector Borne Disease Control and Prevention, Training Base of International Scientific Exchange and Education in Tropical Diseases for South and Southeast Asia, Puer, Yunnan, PR China.

To understand how malaria could be eliminated in the original hyperendmic area for malaria along international borders in Yunnan Province, malaria situation and control were described on the basis of seven phases. At last the experiences and lessons of the program that reduced border malaria from hyperendmicity to malaria-free status were summarized. Malaria control and elimination area were particularly difficult in the Yunnan border. Read More

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Research and development of traditional medicines in low- and middle-income countries: A case study of artemisinin discovery in China.

Adv Parasitol 2022 17;116:187-209. Epub 2022 Feb 17.

Department of Global Health, Peking University School of Public Health, Beijing, PR China; Institute for Global Health, Peking University, Beijing, PR China. Electronic address:

Though traditional medicines have been developed through practice for thousands of years, limited research has discussed the research and development (R&D) pattern of traditional medicines. China's discovery of artemisinin accumulated valuable experiences to explore traditional medicine under low-resource settings. With limited R&D resources, China mobilized all domestic research units at different levels and departments to develop artemisinin collaboratively. Read More

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February 2022

Progression-Free Survival at 24 Months as A Landmark After Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B-cell Lymphoma.

Transplant Cell Ther 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) who achieve progression-free survival (PFS) at 24 months (PFS24) following immunochemotherapy (IC) have excellent overall survival (OS) comparable to that of the age- and sex-matched general population. However, a similar landmark has not been established for patients with relapsed or refractory (RR) DLBCL following frontline IC who are subsequently treated with salvage therapy followed by autologous stem cell transplant (ASCT).

Objective: To evaluate the role of PFS24 as a landmark after ASCT in patients with RR DLBCL. Read More

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Dental and maxillofacial manifestations of Steinert's myotonic dystrophy: a retrospective case series and therapeutic investigation.

J Stomatol Oral Maxillofac Surg 2022 Jun 22. Epub 2022 Jun 22.

Department and Maxillo-Facial Surgery, CHU Salengro, Rue Emile Laisne, 59037 Lille, France.

This retrospective study was performed to analyse the facial features and occlusal anomalies in 18 patients with Steinert's myotonic dystrophy (MD1). Medical and surgical management issues noted in this study may contribute to clinical decision-making. This series included 18 patients with MD1 who presented for maxillofacial consultations. Read More

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Clinical impact and prognosis of cryoglobulinemia and cryofibrinogenemia in systemic sclerosis.

Autoimmun Rev 2022 Jun 22:103133. Epub 2022 Jun 22.

Centre Hospitalier Universitaire, Medecine Interne, Toulouse, France; Centre Hospitalier Universitaire, Laboratoire d'Immunologie, Toulouse, France; Clinique Saint-Exupery, Medecine Interne, Toulouse, France; Centre Hospitalier Universitaire, Néphrologie, Toulouse, France; Centre Hospitalier Universitaire, Cardiologie, Toulouse, France; Clinique Ambroise-Paré, Medecine Interne, Toulouse, France; Centre Hospitalier Universitaire, Pneumologie, Toulouse, France; Hopital Joseph Ducuing, Medecine Interne, Toulouse, France; Centre D'investigation Clinique (CIC), 1436 PEPSS Team, Toulouse, France.

Introduction: An association of systemic sclerosis (SSc) with cryoglobulin and/or cryofibrinogenemia has been described. However, clinical, biological, morphological and prognostic implications are unknown. The objective of this study was to describe the phenotype and evaluate the prognosis of cryoglobulinemia and/or cryofibrinogenemia in the progression of SSc. Read More

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Safety and immunogenicity of mRNA vaccines against SARS-CoV-2 in patients with lung cancer receiving immune checkpoint inhibitors: A multicenter observational study in Japan.

J Thorac Oncol 2022 Jun 4. Epub 2022 Jun 4.

Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachihirokoji, Kamigyoku, Kyoto, 602-8566, Japan.

Introduction: Cancer patients have been prioritized for vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there are limited data regarding the safety, efficacy, and risk of developing immune-related adverse events (irAEs) associated with mRNA vaccines in patients with lung cancer, especially those being actively treated with immune checkpoint inhibitors (ICIs).

Methods: This multicenter prospective cohort study was conducted at nine hospitals in Japan. Read More

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SARS-Cov-2 infection in severe asthma patients treated with biologics.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

1st Department of Pulmonary Medicine and Intensive Care Unit, National and Kapodistrian University of Athens, Medical School, 115 27 Athens, Greece.

Background: At the beginning of the pandemic, there have been considerable concerns regarding COVID-19 severity and outcomes in severe asthma patients treated with biologics.

Objective: To prospectively observe a cohort of severe asthmatics treated with biologics for the risk of SARS-CoV-2 infection and disease severity during COVID-19 pandemic.

Methods: Physicians from centers treating severe asthma patients all over Greece provided demographic and medical data regarding their patients treated with biologics. Read More

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Effectiveness of Maintenance and Reliever Therapy using inhaled corticosteroid-formoterol in asthmatics.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.

Background: Real-world evidence on the effectiveness of Maintenance and Reliever Therapy (MART) using inhaled corticosteroids plus long-acting beta 2-agonist (ICS-LABA) is sparse.

Objective: This study aimed to evaluate the clinical effectiveness of MART (ICS-formoterol) by comparing its effectiveness to that of ICS-LABA plus as-needed short-acting beta 2-agonist (SABA) in adult asthmatics.

Methods: We retrospectively retrieved data from the medical records of the Ajou University Medical Cente r, Korea, to compare clinical outcomes between patients treated with MART (the MART group) and those treated with ICS-LABA plus SABA (the non-MART group). Read More

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Adherence and Persistence to Single-Inhaler Versus Multiple-Inhaler Triple Therapy for Asthma Management.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

GlaxoSmithKline, Research Triangle Park, NC, USA.

Background: Treatment guidelines recommend triple therapy for patients with asthma who remain uncontrolled on inhaled corticosteroid/long-acting β-agonist therapy. Previously, triple therapy was only available via multiple inhalers. Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) is approved as maintenance treatment for asthma; however, real-world information on adherence and persistence is limited. Read More

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Tracking the Impact of Weather on Equine Activity While Pastured.

J Equine Vet Sci 2022 Jun 22:104052. Epub 2022 Jun 22.

Department of Animal Science, Michigan State University, East Lansing, MI, 48824, USA. Electronic address:

Keeping horses outdoors on pasture full-time with free access to shelter holds numerous advantages over housing in stalls, promoting both better mental and physical health. One reason for these benefits is the potential for increased physical activity in horses outdoors on pasture versus those confined to stalls. However, it is not guaranteed the horse will take advantage of this opportunity for greater movement. Read More

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Comparison of Golgi-Cox and intracellular loading of Lucifer yellow for dendritic spine density and morphology analysis in the mouse brain.

Neuroscience 2022 Jun 22. Epub 2022 Jun 22.

Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, United States. Electronic address:

Dendritic spines are small protrusions on dendrites that serve as the postsynaptic site of the majority of excitatory synapses. These structures are important for normal synaptic transmission, and alterations in their density and morphology have been documented in various disease states. Over 130 years ago, Ramón y Cajal used Golgi-stained tissue sections to study dendritic morphology. Read More

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Reducing taperin expression restores hearing in Grxcr2 mutant mice.

Neuroscience 2022 Jun 22. Epub 2022 Jun 22.

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, United States. Electronic address:

Recessive mutations in GRXCR2 cause deafness in both humans and mice. In Grxcr2 null hair cells, the sensory receptors for sound in the inner ear, stereocilia are disorganized. Reducing the expression of taperin, a protein that interacts with GRXCR2 at the base of stereocilia, corrects the morphological defects of stereocilia and restores hearing in Grxcr2 null mice. Read More

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Full-endoscopic Lumbar Interbody Fusion Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion with Tubular Retractor System: A Retrospective Controlled Study.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Orthopedic Surgery, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.

Objectives: To compare the safety and clinical efficacy of full-endoscopic lumbar interbody fusion (FE-LIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).

Methods: A total of 70 patients with single-level lumbar degenerative diseases underwent FE-LIF or MIS-TLIF with a tubular retractor system from August 2018 to August 2020. Postoperatively, the efficacy and safety were compared using several clinical and radiological indices. Read More

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Transfusion Guidelines in Brain Tumor Surgery: A Systematic Review and Critical Summary of Currently Available Evidence.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, TX, USA.

Objective: Red blood cell (RBC) transfusion is commonly indicated in brain tumor surgery due to risk of blood loss. Current transfusion guidelines are based on evidence derived from critically ill patients and may not be optimal for brain tumor surgeries. Our study is the first to synthesize available evidence to suggest RBC transfusion thresholds in brain tumor patients undergoing surgery. Read More

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Postoperative Complication Rates after One-Level Cervical Spine Surgery in Patients with Parkinson's Disease: A Database Study.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, California; Department of Orthopedic Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.

Objective: Parkinson's Disease (PD) is a risk factor for worse surgical outcomes. The degree to which Parkinson's affects outcomes in cervical spine surgery is not well understood. Therefore, we characterize rates of postoperative complications among patients with PD who undergo cervical spine surgery. Read More

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Corydecumine G Inhibits Microglia Activation via MAPK Pathway in a Rat Model of Neuropathic Pain.

J Chem Neuroanat 2022 Jun 22:102124. Epub 2022 Jun 22.

State Key Laboratory of Natural Medicines and Department of TCM pharmacology, School of Traditional Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China, 211198. Electronic address:

Background And Purpose: Microglial activation plays an important role in the onset and progression of neuropathic pain by producing a variety of pro-inflammatory cytokines that interact with neurons to enhance neuronal hyperexcitability. Corydalis decumbens (Thunb.) pers. Read More

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Plasticity changes in dorsolateral prefrontal cortex associated with procedural sequence learning are hemisphere-specific.

Neuroimage 2022 Jun 22:119406. Epub 2022 Jun 22.

School of Psychology, Shanghai University of Sport, Shanghai, China. Electronic address:

Corticocortical neuroplastic changes from higher-order cortices to primary motor cortex (M1) have been described for procedural sequence learning. The dorsolateral prefrontal cortex (DLPFC) plays critical roles in cognition, including in motor learning and memory. However, neuroplastic changes in the DLPFC and their influence on M1 and on motor learning are not well understood. Read More

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Regional hypothalamic, amygdala, and midbrain periaqueductal gray matter recruitment during acute pain in awake humans: a 7-tesla functional magnetic resonance imaging study.

Neuroimage 2022 Jun 22:119408. Epub 2022 Jun 22.

School of Medical Sciences (Neuroscience), Brain and Mind Centre, University of Sydney, Australia, 2006. Electronic address:

Over the past two decades, magnetic resonance imaging (MRI) studies have explored brain activation patterns during acute noxious stimuli. Whilst these human investigations have detailed changes in primarily cortical regions, they have generally not explored discrete changes within small brain areas that are critical in driving behavioural, autonomic, and endocrine responses to pain, such as within subregions of the hypothalamus, amygdala, and midbrain periaqueductal gray matter (PAG). Ultra-high field (7-Tesla) MRI provides enough signal-to-noise at high spatial resolutions to investigate activation patterns within these small brain regions during acute noxious stimulation in awake humans. Read More

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What makes somatosensory short-term memory maintenance effective? An EEG study comparing contralateral delay activity between sighted participants and participants who are blind.

Neuroimage 2022 Jun 22:119407. Epub 2022 Jun 22.

Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany.

Somatosensory short-term memory is essential for object recognition, sensorimotor learning, and, especially, Braille reading for people who are blind. This study examined how visual sensory deprivation and a compensatory focus on somatosensory information influences memory processes in this domain. We measured slow cortical negativity developing during short-term tactile memory maintenance (tactile contralateral delay activity, tCDA) in frontal and somatosensory areas while a sample of 24 sighted participants and 22 participants who are blind completed a tactile change-detection task where varying loads of Braille pin patterns served as stimuli. Read More

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Hypoxia alters posterior cingulate cortex metabolism during a memory task: a H fMRS study.

Neuroimage 2022 Jun 22:119397. Epub 2022 Jun 22.

School of Human and Behavioural Sciences, Bangor University, Bangor, UK; The Bangor Imaging Unit, Bangor University, Bangor, United Kingdom; Institute for Applied Human Physiology, Bangor University, Bangor, United Kingdom. Electronic address:

Environmental hypoxia (fraction of inspired oxygen (FO) ∼ 0.120) is known to trigger a global increase in cerebral blood flow (CBF). However, regionally, a heterogeneous response is reported, particularly within the posterior cingulate cortex (PCC) where decreased CBF is found after two hours of hypoxic exposure. Read More

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Feasibility and clinical utility of a workflow interfacing radiation oncology lung stereotactic body radiotherapy treatment planning and diagnostic radiology.

Pract Radiat Oncol 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah. Electronic address:

Stereotactic body radiotherapy (SBRT) is commonly used to treat early stage non-small cell lung cancer (NSCLC). SBRT beam arrangements include multiple entry/exit pathways resulting in irregular low dose distributions within normal lung parenchyma. An improved understanding of post-treatment radiographic changes may improve the ability to predict clinical complications including radiation pneumonitis as well as assist in early detection of local failures. Read More

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Combined effect of lower muscle quality and quantity on incident falls and fall-related fractures in community-dwelling older adults: A 3-year follow-up study.

Bone 2022 Jun 22:116474. Epub 2022 Jun 22.

National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi 474-8511, Japan. Electronic address:

Objective: Falls and fractures are serious geriatric adverse events worldwide, and skeletal muscle is considered to be a key factor in these incidents. The objective of this study was to investigate the combined effect of lower muscle quality and quantity on the incidence of falls and fall-related fractures in a 3-year follow-up period among community-dwelling older adults.

Methods: We recruited community-dwelling adults aged 65 years and older who were living independently in 2018. Read More

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Comparison of two non-union models with damaged periosteum in mice: Segmental defect and pin-clip fixation versus transverse fracture and K-wire stabilization.

Bone 2022 Jun 22:116475. Epub 2022 Jun 22.

Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany.

Despite growing knowledge about the mechanisms of fracture healing, non-union formation still represents a major complication in trauma and orthopedic surgery. Non-union models in mice gain increasing interest, because they allow investigating the molecular and cellular mechanisms of failed fracture healing. These models often use segmental defects to achieve non-union formation. Read More

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Impact of operability and total metastatic ablation on outcomes after stereotactic ablative radiotherapy (SABR) for oligometastases.

Int J Radiat Oncol Biol Phys 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.

Purpose: Medical operability is prognostic for survival after SABR in primary malignancies. This study investigates the prognostic significance of medical operability and total versus subtotal ablation of all oligometastatic disease sites.

Material/methods: Consecutive patients with 1-5 sites of active extracranial oligometastases had medical operability status and presence of subtotal versus total metastatic ablation recorded prospectively on an institutional database. Read More

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Frequency of unscheduled visits to the Obstetrical Triage Assessment unit by pregnant adolescents in an urban Canadian Center compared to a matched cohort of pregnant women.

J Obstet Gynaecol Can 2022 Jun 22. Epub 2022 Jun 22.

Division of Pediatric and Adolescent Gynecology, Department of Surgery, Children's Hospital of Eastern Ontario; University of Ottawa, Department of Obstetrics and Gynecology, Ottawa, Canada; Clinical Research Unit, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Canada.

Objectives: People from marginalized and vulnerable populations present more frequently for unscheduled, emergency obstetrical services at labour and delivery triage units. Based on our clinical experience, pregnant adolescents visit the obstetrical triage assessment units (OTAU) more often than adults do. This study was designed to assess this phenomenon by quantifying and describing the frequency of unscheduled visits to the OTAU by pregnant adolescents (age <20 y) compared with a matched cohort of adult pregnant patients (age ≥20 y). Read More

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Tamoxifen in mastalgia: A meta-analysis.

J Obstet Gynaecol Can 2022 Jun 22. Epub 2022 Jun 22.

Junior medical officer, AIIMS Bhubaneswar.

Objectives: Tamoxifen is prescribed for chronic mastalgia at a dosage of one 10- or 20-mg tablet for 3-6 months. A topical preparation of this drug has recently been approved. The aim of this study was to meta-analyze the effectiveness of tamoxifen and its different regimens for the treatment of mastalgia. Read More

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Drivers of Inpatient Hospitalization Costs, Joint-Specific Patient-Reported Outcomes, and Health-Related Quality of Life in Shoulder Arthroplasty for Cuff Tear Arthropathy.

J Shoulder Elbow Surg 2022 Jun 22. Epub 2022 Jun 22.

Department of Orthopaedics and Sports Medicine, University of Washington Medical Center, Seattle, WA, USA. Electronic address:

Background: Cuff tear arthropathy (CTA) can be successfully treated with various types of shoulder arthroplasty. While reverse total shoulder arthroplasty (RSA) is commonly used to treat CTA, CTA hemiarthroplasty (CTA-H, hemiarthroplasty with an extended humeral articular surface) can also be effective in patients with preserved glenohumeral elevation and an intact coracoacromial arch. As the value of arthroplasty is being increasingly scrutinized, cost containment has become a priority. Read More

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Conflicts of Interest among Patients: Do They Exist and Can They Bias Patient-Reported Outcome Measures? A Survey of Shoulder and Elbow Patients.

J Shoulder Elbow Surg 2022 Jun 22. Epub 2022 Jun 22.

Hannover Medical School Trauma Department Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Background: Potential conflicts of interest (COI) are common among physicians and may bias physician-reported outcome assessment in orthopedic research. It is unclear whether patients have COI and if this COI could affect patient-reported outcome measures (PROMs). The purposes of this study were to investigate (1) existence of COIs among patients and (2) their potential to bias PROMs with a pseudonymized survey among consecutive shoulder and elbow patients. Read More

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Primary Contributors to Dietary Acid Load in Patients with Urolithiasis.

J Ren Nutr 2022 Jun 22. Epub 2022 Jun 22.

Senior Scientist, University of Wisconsin School of Medicine and Public Health, Department of Urology; and Clinical Nutritionist, UW Health University Hospital and Clinics, 1685 Highland Avenue, 3258 MFCB, Madison, WI 53705-2281.

Objective: In susceptible individuals, high dietary acid load may contribute to the formation of certain types of kidney stones via lowering urine pH and citrate excretion. The objective of this study was to determine the contribution of dietary acid from food groups in people with urolithiasis.

Design: & Methods: Patients with calcium urolithiasis (n=83) who completed food records were used for this retrospective analysis. Read More

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Symptom control and survival for people severely ill with COVID: a multicentre cohort study (CovPall-Symptom).

J Pain Symptom Manage 2022 Jun 22. Epub 2022 Jun 22.

International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, UK.

Context: Evidence of symptom control outcomes in severe COVID is scant.

Objective: To determine changes in symptoms among people severely ill or dying with COVID supported by palliative care, and associations with treatments and survival.

Methods: Multicentre cohort study of people with COVID across England and Wales supported by palliative care services, during the pandemic in 2020 and 2021. Read More

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