278,327 results match your criteria studies selected

Genome-wide survey of the F-box/Kelch (FBK) members and molecular identification of a novel FBK gene TaAFR in wheat.

PLoS One 2021 22;16(7):e0250479. Epub 2021 Jul 22.

College of Life Sciences/Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Hebei Agricultural University, Baoding, Hebei, China.

F-box proteins play critical roles in plant responses to biotic/abiotic stresses. In the present study, a total of 68 wheat F-box/Kelch (TaFBK) genes, unevenly distributed across 21 chromosomes and encoding 74 proteins, were identified in EnsemblPlants. Protein sequences were compared with those of Arabidopsis and three cereal species by phylogenetic and domain analyses, where the wheat sequences were resolved into 6 clades. Read More

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Synthetic pulmonary perfusion images from 4DCT for functional avoidance using deep learning.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Radiation Oncology, Beaumont Health System, Royal Oak, Michigan, UNITED STATES.

Purpose: To develop and evaluate the performance of a deep learning model to generate synthetic pulmonary perfusion images from clinical 4DCT images for patients undergoing radiotherapy for lung cancer.

Methods: A clinical data set of 58 pre- and post-radiotherapy 99mTc-labelled MAA-SPECT perfusion studies (32 patients) each with contemporaneous 4DCT studies was collected. Using the inhale and exhale phases of the 4DCT, a 3D-Residual Network was trained to create synthetic perfusion images utilizing the MAA-SPECT as ground truth. Read More

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3D Modeling in Training, Simulation, and Surgical Planning in Open Vascular and Endovascular Neurosurgery: A Systematic Review of the Literature.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois.

Background: The expanding use of three-dimensional (3D) printing in open vascular and endovascular neurosurgery presents a promising new tool in resident learning as well as operative planning. Recent studies have investigated the accuracy, efficacy, and practicality of 3D printed models of patient-specific pathology.

Objective: To review the current literature exploring 3D modeling in neurovascular and endovascular surgery for training, simulation, and surgical preparation. Read More

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Glenohumeral osteoarthritis with intact rotator cuff treated with reverse shoulder arthroplasty: a systematic review.

J Shoulder Elbow Surg 2021 Jul 19. Epub 2021 Jul 19.

Division of Upper Extremity Surgery, Department of Orthopaedic Surgery, Director of Upper Extremity Surgery Research, Emory University 59 Executive Park South, Atlanta, GA 30329, USA.

Background: While reverse shoulder arthroplasty has shown satisfactory outcomes in rotator cuff deficient shoulders, its performance in shoulders with an intact rotator cuff has not been fully elucidated. Shoulder osteoarthritis can present with alterations in glenoid morphology which have contributed to inconsistent outcomes in anatomic shoulder replacement. A predominance of these arthroplasty complications is due to the glenoid component. Read More

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Formulation development, in vitro and in vivo evaluation of topical hydrogel formulation of econazole nitrate-loaded β-cyclodextrin nanosponges.

J Pharm Sci 2021 Jul 19. Epub 2021 Jul 19.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. Electronic address:

Econazole nitrate, an antifungal drug used in the handling of skin ailments, is commercially not efficient as these ailments typically require a more elevated concentration of the drug to offer an effective pharmacological retort. Like so, it is proposed to assess the effectiveness of the topical hydrogel of econazole-loaded nanosponge in the management of skin ailment(s). Econazole nitrate-laden β-cyclodextrin nanosponges were developed by employing the melt method using β-cyclodextrin as the organic polymer and N,N-carbonyldiimidazole as the crosslinker. Read More

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Genetically predicted insulin-like growth factor-I in relation to muscle mass and strength.

Clin Endocrinol (Oxf) 2021 Jul 22. Epub 2021 Jul 22.

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Objective: Insulin-like growth factor I (IGF-I) has been associated with muscle status in animal- and population-based studies. We conducted a Mendelian randomisation study to assess the causality of the associations of IGF-I with muscle strength and mass.

Design And Patients: Genetic variants associated with serum IGF-I at genome-wide significance in the UK Biobank study (358,072 individuals of European descent) were selected as instrumental variables. Read More

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What are the effects of teaching Evidence-Based Health Care (EBHC) at different levels of health professions education? An updated overview of systematic reviews.

PLoS One 2021 22;16(7):e0254191. Epub 2021 Jul 22.

Centre for Evidence-based Health Care, Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Cape Town, South Africa.

Background: Evidence-based healthcare (EBHC) knowledge and skills are recognised as core competencies of healthcare professionals worldwide, and teaching EBHC has been widely recommended as an integral part of their training. The objective of this overview of systematic reviews (SR) was to update evidence and assess the effects of various approaches for teaching evidence-based health care (EBHC) at undergraduate (UG) and postgraduate (PG) medical education (ME) level on changes in knowledge, skills, attitudes and behaviour.

Methods And Findings: This is an update of an overview that was published in 2014. Read More

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Electronic patient-reported outcome measures using mobile health technology in rheumatology: A scoping review.

PLoS One 2021 22;16(7):e0253615. Epub 2021 Jul 22.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Objective: This scoping review aims to characterize the current literature on electronic patient-reported outcome measures (ePROMs) in rheumatology and assess the feasibility and utility of ePROMs and mobile health technology in the management of rheumatic disease.

Introduction: Patient-reported outcome measures (PROMs) are commonly used in rheumatology as they are important markers of disease activity and overall function, encourage shared decision-making, and are associated with high rates of patient satisfaction. With the widespread use of mobile devices, there is increasing interest in the use of mobile health technology to collect electronic PROMs (ePROM). Read More

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Food and alcohol disturbance among US college students: a mixed methods scoping review.

J Am Coll Health 2021 Jul 22:1-17. Epub 2021 Jul 22.

Department of Psychology, Smith College, Northampton, Massachusetts, USA.

Objective: Conduct a scoping review of food and alcohol disturbance (FAD) in US college students to overview the literature within this population and identify research opportunities.

Methods: Studies ( = 39) were selected using systematic searches of databases and references. Search terms included: drunkorexia, "food and alcohol disturbance," and "compensatory behavior" AND alcohol AND eating. Read More

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Investigating Endocrine Disrupting Properties of Chemicals in Fish and Amphibians: Opportunities to Apply the 3Rs.

Integr Environ Assess Manag 2021 Jul 22. Epub 2021 Jul 22.

Shell Health, Shell International B.V., Carel van Bylandtlaan 16, 2596 HR, The Hague, The Netherlands.

Many regulations are beginning to explicitly require investigation of a chemical's endocrine disrupting properties as a part of the safety assessment process, for substances already on or about to be placed on the market. Different jurisdictions are applying distinct approaches. However, all share a common theme requiring testing for endocrine activity and adverse effects, typically involving in vitro and in vivo assays on selected endocrine pathways. Read More

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Long-term increases in pathogen seroprevalence in polar bears (Ursus maritimus) influenced by climate change.

Glob Chang Biol 2021 Jul 22. Epub 2021 Jul 22.

Wildlife Research Division, Science and Technology Branch, Environment and Climate Change Canada, Edmonton, AB, Canada.

The influence of climate change on wildlife disease dynamics is a burgeoning conservation and human health issue, but few long-term studies empirically link climate to pathogen prevalence. Polar bears (Ursus maritimus) are vulnerable to the negative impacts of sea ice loss as a result of accelerated Arctic warming. While studies have associated changes in polar bear body condition, reproductive output, survival, and abundance to reductions in sea ice, no long-term studies have documented the impact of climate change on pathogen exposure. Read More

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The role of Acanthamoeba spp. in biofilm communities: a systematic review.

Parasitol Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, UNIFESP, Rua Pedro de Toledo, 669 - Vila Clementino, São Paulo, SP, 04039-032, Brazil.

Acanthamoeba spp. have always caused disease in immunosuppressed patients, but since 1986, they have become a worldwide public health issue by causing infection in healthy contact lens wearers. Amoebae of the Acanthamoeba genus are broadly distributed in nature, living either freely or as parasites, and are frequently associated with biofilms throughout the environment. Read More

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Self-report instruments for assessing adherence to warfarin therapy: a systematic review.

Eur J Clin Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.

Background: The assessment of adherence to warfarin therapy is useful in clinical practice due to its wide variability in dose-response and risks of complications. The aim of this study was to investigate validated instruments used to assess adherence to warfarin therapy.

Methods: Information was collected from the MEDLINE (PubMed), LILACS, EMBASE, and Cochrane Library databases. Read More

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Systematic Review of Self-Monitoring of Blood Glucose in Patients with Type 2 Diabetes.

Nurs Res 2021 Jul 20. Epub 2021 Jul 20.

University of Derby Online Learning, Derby, UK University of Derby College of Health, Psychology and Social Care, Derby, UK University of Derby Centre for Human Sciences Research, Derby, UK.

Background: The benefit of self-monitoring of blood glucose in reducing HbA1c in non-insulin-treated participants remains unclear. HbA1c may be improved in this population with self-monitoring.

Objective: To conduct a meta-analysis of the effect in non-insulin-treated participants with type 2 diabetes of self-monitoring of blood glucose versus usual care, structured versus unstructured self-monitoring of blood glucose on glycemic control, and use of self-monitoring of blood glucose readings used to adjust therapy versus usual care. Read More

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Primary prevention of prescription opioid diversion: a systematic review of medication disposal interventions.

Am J Drug Alcohol Abuse 2021 Jul 22:1-11. Epub 2021 Jul 22.

Surgical Outcomes and Quality Improvement Center (SOQIC), Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

: In the U.S., 50-75% of nonmedical users of prescription opioids obtain their pills through diversion by friends or relatives. Read More

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Transition Metal Ion FRET in the Gas Phase: A 10-40 Å Range Molecular Ruler for Mass-Selected Biomolecular Ions.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry and Applied Biosciences, ETH Zürich Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.

Structural studies of mass-selected biomolecules in the gas phase can reveal their intrinsic properties and provide useful benchmarks for biomolecular modeling. Here, we report the first evidence of transition metal ion FRET (tmFRET) in the gas phase and its application to measure short (10-40 Å) biomolecular backbone distances. The measured FRET efficiencies in rhodamine dye (donor) labeled helical peptides complexed with Cu ions (acceptor) decreased with increasing donor - acceptor distances, confirming the occurrence of tmFRET. Read More

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Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder.

Autism Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Child and Adolescent Psychiatry, Gaziosmanpasa University School of Medicine, Tokat, Turkey.

Several studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15 years were selected for the study group and 27 age-matched healthy male children were selected for the control group. Read More

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Phonological variations in typically-developing Italian-speaking children aged 3;0-4;11.

Clin Linguist Phon 2021 Jul 22:1-19. Epub 2021 Jul 22.

Health Sciences School, Division of Human Communication Sciences, The University of Sheffield, Sheffield, UK.

Normative data on phonological acquisition of a language are a prerequisite for evaluating children's speech sound competences. To date, these data are not sufficiently available for Italian. This study, therefore, aimed to describe the phonological development of 183 typically developing monolingual Italian-speaking children aged 3;0-4;11 (four 6-months age bands). Read More

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[Atherosclerosis of the intracranial arteries and of the extracranial carotid artery.]

Ther Umsch 2021 Aug;78(6):277-289

Department für Neurologie, Inselspital, Universitätsspital und Universität Bern.

Atherosclerosis of the intracranial arteries and of the extracranial carotid artery. Intracranial atherosclerotic stenoses are the most common cause of ischemic stroke worldwide. Nowadays, three therapeutic approaches are available for consideration for patients with intracranial atherosclerotic stenoses: A conservative therapy (best medical treatment, management of vascular risk factors and healthy lifestyle), endovascular and surgical therapy. Read More

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The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.

Int J Rheum Dis 2021 Jul 21. Epub 2021 Jul 21.

Department of Bone and Joint Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Aim: Previous studies have provided evidence linking the DPEP1 gene to the risk of osteoarthritis (OA) in Europeans. In this study, we aimed to examine the relationship between DPEP1 gene and the susceptibility and clinical severity of OA in a Chinese Han population.

Methods: This study comprised two independent samples. Read More

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Influence of patellar denervation on anterior knee pain and knee function following total knee replacement: A systematic review and meta-analysis.

ANZ J Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Orthopaedics, The People's Hospital, Guang'an, China.

Background: Previous studies have reached mixed results regarding the effects of patellar denervation with electrocautery (PD) on total knee replacement (TKR). This systematic review and meta-analysis aimed to summarize all available literatures to investigate the influence of PD on postoperative anterior knee pain (AKP) and knee function after TKR.

Methods: Electronic databases, including PubMed, Cochrane Library and Embase, were searched from their inception to March 2021. Read More

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Omega-3 phospholipids and obesity-associated NAFLD: Potential mechanisms and therapeutic perspectives.

Eur J Clin Invest 2021 Jul 22:e13650. Epub 2021 Jul 22.

Laboratory of Adipose Tissue Biology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

Prevalence of non-alcoholic fatty liver disease (NAFLD) increases in line with obesity and type 2 diabetes, and there is no approved drug therapy. Polyunsaturated fatty acids of n-3 series (omega-3) are known for their hypolipidemic and anti-inflammatory effects. Existing clinical trials suggest varying effectiveness of triacylglycerol- or ethyl ester-bound omega-3 in the treatment of NAFLD, without affecting advanced stages such as non-alcoholic steatohepatitis. Read More

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Interferential Electrical Stimulation Efficacy in the Management of Lower Urinary Tract Dysfunction in Children: A Review of the Literature.

Urol J 2021 Jul 22. Epub 2021 Jul 22.

Pediatric Urology and Regenerative Medicine Research Center, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Lower urinary tract dysfunction (LUTD) is the most common problem of the referral children to the pediatric urology clinics. If this condition does not treat early in life, it will be a lifelong problem. During recent decades, electrical stimulation therapy has been expanded and extensively used for the treatment of LUTD in both adults and children. Read More

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Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet.

Am J Clin Nutr 2021 Jul 22. Epub 2021 Jul 22.

Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.

Background: The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease.

Objectives: We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevención con Dieta Mediterránea) trial with Mediterranean diet (MedDiet). Read More

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Do You Prefer Safety to Social Participation? Finnish Population-Based Preference Weights for the Adult Social Care Outcomes Toolkit (ASCOT) for Service Users.

MDM Policy Pract 2021 Jul-Dec;6(2):23814683211027902. Epub 2021 Jul 9.

Personal Social Services Research Unit, University of Kent, Kent, UK.

The Adult Social Care Outcomes Toolkit (ASCOT) was developed in England to measure people's social care-related quality of life (SCRQoL). The aim of this article is to estimate preference weights for the Finnish ASCOT for service users (ASCOT). In addition, we tested for learning and fatigue effects in the choice experiment used to elicit the preference weights. Read More

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Preparing and assessing the physiochemical properties of curcumin niosomes and evaluating their cytotoxicity in 3T3 and MCF-7 cell lines.

Avicenna J Phytomed 2021 Jul-Aug;11(4):417-427

Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Objective: Application of vesicular drug delivery systems has made major progress in pharmaceutical science and technology. Niosomal drug delivery is potentially efficient to improve the pharmacokinetic and pharmacological properties of many compounds. Curcumin (CUR) has several documented anticancer activities; however, it has a low bioavailability that necessitates the development of efficient delivery systems. Read More

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A systematic review of clinical trials on Ginkgo () effectiveness on sexual function and its safety.

Avicenna J Phytomed 2021 Jul-Aug;11(4):324-331

Clinical Instructor Mpilo School of Midwifery Zimbabwe. Zimbabwe Confederation of Midwives, Bulawayo, Zimbabwe.

Objective: During recent years, evidence-based practice as a way to support higher standards of care was emphasized by health care policymakers. Sexual dysfunction (SD) is a common problem that affects the quality of life in individuals. Today, the use of extract (GBE) for treating SD has been considered, so this study was performed to evaluate the current evidence for the efficacy and safety of ginkgo in treating SD. Read More

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November 2020

Team-based learning versus Traditional lecture-based learning: An investigation of students' perceptions and academic achievements.

Pak J Med Sci 2021 Jul-Aug;37(4):1080-1085

Muhammad Qasim Javed, Assistant Professor, Department of Conservative Dental Sciences, College of Dentistry, Qassim University, Saudi Arabia.

Objectives: Evaluation of TBL from students' perspective has been done extensively, but limited studies have analyzed the effect of TBL on students' academic performance. Objectives of the present study were to assess students' perceptions about team-based learning versus traditional lectures and then to compare with students' grades in both TBL and lecture-based assessments.

Methods: Cross-sectional descriptive study which included 147 dentistry students was conducted between March and June, 2020 at Qassim University, Saudi Arabia. Read More

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December 2020

Probiotic and Antifungal Attributes of MYSN105, Isolated From an Indian Traditional Fermented Food Pozha.

Front Microbiol 2021 5;12:696267. Epub 2021 Jul 5.

Departmen of Studies in Microbiology, University of Mysore, Mysuru, India.

The use of probiotics and antifungal capabilities of the lactic acid bacteria (LAB) isolated from different niches is a strategy to prepare functional cultures and biopreservatives for food/feed industries. In the present study, LAB strains isolated from an Indian traditional fermented food, Pozha, were evaluated for their probiotic properties and biocontrol potential. A total of 20 LAB isolates were selected from Pozha samples collected aseptically and screened for their antagonistic activity against . Read More

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An Improved Transformation System for Using Green Fluorescent Protein.

Front Microbiol 2021 5;12:682754. Epub 2021 Jul 5.

Department of Botany and Plant Pathology, Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, United States.

is a destructive pathogen causing root rot and dieback diseases on hundreds of economically and ecologically important plant species. Effective transformation systems enable modifications of candidate genes to understand the pathogenesis of . A previous study reported a polyethylene glycol and calcium dichloride (PEG/CaCl)-mediated protoplast transformation method of . Read More

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