491,730 results match your criteria studies revealed

Lithium dilution cardiac output measurements in isoflurane-anaesthetised goats: Jugular versus cephalic lithium chloride administration.

Res Vet Sci 2021 Oct 20;141:95-102. Epub 2021 Oct 20.

University College Dublin, UCD Veterinary Hospital, Belfield, Dublin 4 D04W6F6, Ireland.

The administration of lithium chloride (LiCl) for cardiac output (CO) measurement via a peripheral instead of a central vein has been described previously as a valid alternative route in pigs and dogs. The aim of the study was to compare CO measurements after administration of LiCl using two peripheral veins, cephalic or jugular, in goats. Ten adult, female, experimental goats undergoing bilateral stifle arthrotomy were recruited for the study. Read More

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October 2021

Novel Imaging Biomarker Prediction of Parenchymal Hemorrhage after Mechanical Thrombectomy in Patients with Large Ischemic Core.

J Stroke Cerebrovasc Dis 2021 Oct 24;31(1):106125. Epub 2021 Oct 24.

Department of Neurology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang 310014, China. Electronic address:

Background: Recently studies have shown that select acute ischemic stroke (AIS) patients with large ischemic core could be deemed as reasonable candidates to receive mechanical thrombectomy (MT) with low risk of developing parenchymal hemorrhage (PH) or symptomatic intracerebral hemorrhage (sICH); however, the selection criterion remains lacking. Our study aims to investigate the relationship between a novel imaging biomarker of largest core mass volume (LCMV) and development of PH in stroke patients with large ischemic core who have undergone MT.

Methods: A total of 26 AIS patients with large ischemic core (defined as ischemic core volume ≧ 50 ml) were enrolled in the study. Read More

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October 2021

Requirements for Additional Strength Biowaivers for Modified Release Solid Oral Dosage Forms in International Pharmaceutical Regulators Programme Participating Regulators and Organisations: Differences and Commonalities.

J Pharm Pharm Sci 2021 ;24:548-562

U.S. Department of Health and Human Services, Food and Drug Administration (USFDA), Center for Drug Evaluation and Research, Office of Generic Drugs, Silver Spring, Maryland, USA.

This article describes an overview of waivers of in vivo bioequivalence studies for additional strengths in the context of the registration of modified release generic products and is a follow-up to the recent publication for the immediate release solid oral dosage forms. The current paper is based on a survey among the participating members of the Bioequivalence Working Group for Generics (BEWGG) of the International Pharmaceutical Regulators Program (IPRP) regarding this topic. Most jurisdictions consider the extrapolation of bioequivalence results obtained with one (most sensitive) strength of a product series as less straightforward for modified release products than for immediate release products. Read More

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January 2021

Factors that influence parents' and informal caregivers' views and practices regarding routine childhood vaccination: a qualitative evidence synthesis.

Cochrane Database Syst Rev 2021 Oct 27;10:CD013265. Epub 2021 Oct 27.

Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.

Background: Childhood vaccination is one of the most effective ways to prevent serious illnesses and deaths in children. However, worldwide, many children do not receive all recommended vaccinations, for several potential reasons. Vaccines might be unavailable, or parents may experience difficulties in accessing vaccination services; for instance, because of poor quality health services, distance from a health facility, or lack of money. Read More

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October 2021


Arq Gastroenterol 2021 Jul-Sep;58(3):329-336

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: There is limited research examining reasons causing refractory chronic constipation (RCC) in children. The effects of lead (Pb) and cadmium (Cd) exposures on this condition have been even less clear. However, some related factors may contribute to evaluation of blood lead levels (BLLs) and blood cadmium levels (BCLs). Read More

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December 2020

Enzymatic activity of bone markers on Lithobates catesbeianus (Shaw, 1802) growth during the ossification process.

Braz J Biol 2021 25;84:e251970. Epub 2021 Oct 25.

Universidade Estadual Paulista "Júlio de Mesquita Filho" - UNESP, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Tecnologia, Jaboticabal, SP, Brasil.

In order to better understand the ossification processes in anurans our study was carried out on tadpoles and adults of Lithobates catesbeianus. In this sense, we characterized the kinetic properties of alkaline phosphatase with p-nitrophenylphosphatase (pNPP) and pyrophosphate (PPi) and evaluated the activities of tartrate-resistant acid phosphatase and acid phosphatase. The enzyme extracts were obtained from tadpoles and adult femurs, which were divided into epiphysis and diaphysis. Read More

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October 2021

Investigation of attributes of bourbon oil and cobalt nitrate constituted electrospun nanoscaffolds for blood compatibility and in vitro bone formation.

An Acad Bras Cienc 2021 22;93(4):e20201140. Epub 2021 Oct 22.

Universiti Teknologi Malaysia, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, 81310, Skudai, Malaysia.

This work aims to fabricate scaffold using polyurethane (PU) integrated with bourbon oil (BB) and cobalt nitrate (CoNO3) using the electrospinning technique. Morphological investigation signified a fall in fibre diameter for the PU/BB and PU/BB/CoNO3 nanocomposite than the PU. Spectral analysis indicated that BB and CoNO3 were added within the PU matrix. Read More

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October 2021

The Brazilian octocoral Phyllogorgia dilatata as a source of cytotoxic compounds.

An Acad Bras Cienc 2021 22;93(4):e20200686. Epub 2021 Oct 22.

Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Instituto de Química, Outeiro de São João Batista, s/n, 24020-141 Niterói, RJ, Brazil.

The extensive marine biodiversity has proved to be a promising source of substances with biomedical potential. In this study, the cytotoxicity of the Brazilian octocoral Phyllogorgia dilatata (Gorgoniidae) was evaluated against two tumor cell lines and three bacterial strains. The methanol/dichloromethane crude extract presented no antibacterial activity up to the highest concentration tested (512 µg/mL), however it revealed a noteworthy antiproliferative effect against HCT-116 (80%) and MCF-7 (54%) cell lines at 50 μg/mL. Read More

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October 2021

The early development and physiology of Xenopus laevis tadpole lateral line system.

J Neurophysiol 2021 Oct 27. Epub 2021 Oct 27.

School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom.

Xenopus laevis has a lateral line mechanosensory system throughout its full life cycle and a previous study on pre-feeding stage tadpoles revealed that it may play a role in motor responses to both water suction and water jets. Here, we investigated the physiology of the anterior lateral line system in newly hatched tadpoles and the motor outputs induced by its activation in response to brief suction stimuli. High-speed videoing showed tadpoles tended to turn and swim away when strong suction was applied close to the head. Read More

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October 2021

Genomic Analysis of a Hospital-Associated Outbreak of : Implications on Transmission.

J Clin Microbiol 2021 Oct 27:JCM0154721. Epub 2021 Oct 27.

Division of Infectious Diseases, Duke University School of Medicine, Durham, NC.

Whole genome sequencing (WGS) has recently been used to investigate acquisition of (MABC). Investigators have reached conflicting conclusions about the meaning of genetic distances for interpretation of person-to-person transmission. Existing genomic studies were limited by a lack of WGS from environmental MABC isolates. Read More

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October 2021

β-Arrestins as Important Regulators of Glucose and Energy Homeostasis.

Annu Rev Physiol 2021 Oct 27. Epub 2021 Oct 27.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, US Department of Health and Human Services, Bethesda, Maryland, USA; email:

β-Arrestin-1 and -2 (also known as arrestin-2 and -3, respectively) are ubiquitously expressed cytoplasmic proteins that dampen signaling through G protein-coupled receptors. However, β-arrestins can also act as signaling molecules in their own right. To investigate the potential metabolic roles of the two β-arrestins in modulating glucose and energy homeostasis, recent studies analyzed mutant mice that lacked or overexpressed β-arrestin-1 and/or -2 in distinct, metabolically important cell types. Read More

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October 2021

Studies of Catalyst-Controlled Regioselective Acetalization and Its Application to Single-Pot Synthesis of Differentially Protected Saccharides.

J Am Chem Soc 2021 Oct 27. Epub 2021 Oct 27.

Chemistry Department, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.

This article describes studies on the regioselective acetal protection of monosaccharide-based diols using chiral phosphoric acids (CPAs) and their immobilized polymeric variants, ()-Ad-TRIP-PS and ()-SPINOL-PS, as the catalysts. These catalyst-controlled regioselective acetalizations were found to proceed with high regioselectivities (up to >25:1 rr) on various d-glucose-, d-galactose-, d-mannose-, and l-fucose-derived 1,2-diols and could be carried out in a regiodivergent fashion depending on the choice of chiral catalyst. The polymeric catalysts were conveniently recycled and reused multiple times for gram-scale functionalizations with catalytic loadings as low as 0. Read More

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October 2021

Association of Alopecia Areata and the Risk of Dementia: A Nationwide Cohort Study.

J Clin Psychiatry 2021 Oct 26;82(6). Epub 2021 Oct 26.

School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Alopecia areata (AA) is associated with multiple comorbidities and shares a similar inflammatory signature with dementia. The great negative psychosocial impact of AA may result in poor social engagement, a typical risk factor for dementia. However, little is known about the association between AA and dementia. Read More

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October 2021

Innate immune remodeling by short-term intensive fasting.

Aging Cell 2021 Oct 27:e13507. Epub 2021 Oct 27.

Research Center for Blood Engineering and Manufacturing, Cyrus Tang Medical Institute, National Clinical Research Center for Hematologic Diseases, Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.

Previous studies have shown that long-term light or moderate fasting such as intermittent fasting can improve health and prolong lifespan. However, in humans short-term intensive fasting, a complete water-only fasting has little been studied. Here, we used multi-omics tools to evaluate the impact of short-term intensive fasting on immune function by comparison of the CD45 leukocytes from the fasting subjects before and after 72-h fasting. Read More

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October 2021

O-GlcNAc Transferase (OGT) Protects Cerebral Neurons from Death During Ischemia/Reperfusion (I/R) Injury by Modulating Drp1 in Mice.

Neuromolecular Med 2021 Oct 27. Epub 2021 Oct 27.

Department of Neurology, Hebei General Hospital, No.348 Heping West Road, Shijiazhuang, 050051, Hebei, P. R. China.

Previous studies have demonstrated that increased O-linked N-acetylglucosamine (O-GlcNAc) level could promote cell survival following environmental stresses. This study aimed to explore the role of O-GlcNAc transferase (OGT) during cerebral ischemia/reperfusion (I/R) injury. The mouse model with cerebral I/R injury was induced by middle cerebral artery occlusion/reperfusion (MCAO/R). Read More

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October 2021

Eugenol-Mediated Inhibition of Biofilm Formed by S. aureus: a Potent Organism for Pediatric Digestive System Diseases.

Appl Biochem Biotechnol 2021 Oct 27. Epub 2021 Oct 27.

Department of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, 215000, Jiangsu Province, China.

Ocimum tenuiflorum (KT) is a common ethnobotanical plant of Southeast Asia. The ethnic communities of these regions use the various parts of the plants, especially the leaves, for the treatment of various ailments like cold and flu, chronic infections, and surface ailments. The leaves of these plants are consumed to act as immune boosters in the body. Read More

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October 2021

SNARE Proteins Mediate α-Synuclein Secretion via Multiple Vesicular Pathways.

Mol Neurobiol 2021 Oct 27. Epub 2021 Oct 27.

Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.

The cell-to-cell transmission of pathological α-synuclein (α-syn) has been proposed to be a critical event in the development of synucleinopathies. Recent studies have begun to reveal the underlying molecular mechanism of α-syn propagation. As one of the central steps, α-syn secretion is reported to be Ca-dependent and mediated by unconventional exocytosis. Read More

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October 2021

Autogenic Training for Reducing Chronic Pain: a Systematic Review and Meta-analysis of Randomized Controlled Trials.

Int J Behav Med 2021 Oct 27. Epub 2021 Oct 27.

Institute of Psychosocial Medicine, Psychotherapy and Psychooncology, Jena University Hospital, Stoystr. 3, 07743, Jena, Germany.

Background: Autogenic training (AT) is frequently used as therapeutic approach in multimodal pain therapy. The aim of this systematic review and meta-analysis is to investigate the efficacy of AT in individuals suffering from chronic pain in comparison to passive and active control groups.

Methods: A comprehensive literature search in Medline, Web of Science, PsycInfo, and PubPsych and manual searches (last search April 7, 2021) were conducted to locate randomized controlled trials (RCTs). Read More

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October 2021

Model-Based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population.

Cardiovasc Drugs Ther 2021 Oct 27. Epub 2021 Oct 27.

Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.

Purpose: Increased bleeding risk was found associated with concurrent prescription of rivaroxaban and amiodarone. We previously recommended dose adjustment for rivaroxaban utilizing a physiologically based pharmacokinetic (PBPK) modeling approach. Our subsequent in vitro studies discovered the pivotal involvement of human renal organic anion transporter 3 (hOAT3) in the renal secretion of rivaroxaban and the inhibitory potency of amiodarone. Read More

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October 2021

Pediatric Medullary Stroke, Severe Dysphagia, and Multimodal Intervention.

Dysphagia 2021 Oct 27. Epub 2021 Oct 27.

Children's Healthcare of Atlanta, 1405 Clifton Road NE, Atlanta, GA, 30322, USA.

Lateral medullary syndrome/Wallenberg syndrome is a stroke in the lateral medulla with symptoms often including dysphagia and dysphonia. In adults, this stroke is the most common brainstem stroke, but it is rare in the pediatric population. Insults to the medulla can involve the "swallowing centers," the nucleus ambiguus and nucleus tractus solitarius, and the cranial nerves involved in swallowing, namely IX (glossopharyngeal) and X (vagus). Read More

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October 2021

Effects of branched-chain amino acid-rich supplementation on EWGSOP2 criteria for sarcopenia in older adults: a systematic review and meta-analysis.

Eur J Nutr 2021 Oct 27. Epub 2021 Oct 27.

Center of Evidence-Based Medicine, Department of Education, Taipei Medical University Hospital, 252 Wu-Xing Street, Taipei, Taiwan, ROC.

Purpose: According to criteria recommended by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), we analyzed the effects of branched-chain amino acid (BCAA)-rich supplements on muscle strength, muscle mass, and physical performance in older people.

Methods: We searched PubMed, Embase, Cochrane Library, and CINAHL from inception until March 2021. Randomized controlled trials that examined the effect of BCAA-rich supplements on older people were included. Read More

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October 2021

Ion Transporter Gene Families as Physiological Targets of Natural Selection During Salinity Transitions in a Copepod.

Carol Eunmi Lee

Physiology (Bethesda) 2021 Nov;36(6):335-349

Department of Integrative Biology, University of Wisconsin, Madison, Wisconsin.

Salinity is a key factor that structures biodiversity on the planet. With anthropogenic change, such as climate change and species invasions, many populations are facing rapid and dramatic changes in salinity throughout the globe. Studies on the copepod species complex have implicated ion transporter gene families as major loci contributing to salinity adaptation during freshwater invasions. Read More

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November 2021

Dopaminergic Input from the Posterior Hypothalamus to the Raphe Pallidus Area Inhibits Brown Adipose Tissue Thermogenesis.

Am J Physiol Regul Integr Comp Physiol 2021 Oct 27. Epub 2021 Oct 27.

Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, United States.

Systemic administration of dopamine (DA) receptor agonists leads to falls in body temperature. However, the central thermoregulatory pathways modulated by DA have not been fully elucidated. Here we identified a source and site of action contributing to DA's hypothermic action by inhibition of brown adipose tissue (BAT) thermogenesis. Read More

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October 2021

Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury.

Physiol Genomics 2021 Oct 27. Epub 2021 Oct 27.

Department of Pediatrics and Adolescent Medicine, University Hospital of Erlangen, Erlangen, Germany.

Preterm neonates are at a high risk for nephron loss under adverse clinical conditions. Renal damage potentially collides with postnatal nephrogenesis. Recent animal studies suggest that nephron loss within this vulnerable phase leads to renal damage later in life. Read More

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October 2021

Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein Microarray.

Microbiol Spectr 2021 Oct 27:e0141621. Epub 2021 Oct 27.

Antigen Discovery Incorporated (ADI), Irvine, California, USA.

The rapid worldwide spread of SARS-CoV-2 has accelerated research and development for controlling the COVID-19 pandemic. A multi-coronavirus protein microarray was created containing full-length proteins, overlapping protein fragments of various lengths, and peptide libraries from SARS-CoV-2 and four other human coronaviruses. Sera from confirmed COVID-19 patients as well as unexposed individuals were applied to multicoronavirus arrays to identify specific antibody reactivity. Read More

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October 2021

Screening of differentially expressed proteins in placentas from patients with late-onset preeclampsia.

Proteomics Clin Appl 2021 Oct 27:e2100053. Epub 2021 Oct 27.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Purpose: Preeclampsia (PE) is a severe disease that endangers the safety of mothers and fetuses worldwide. In the absence of specific treatments, more studies on novel predictive and diagnostic biomarkers for PE are required.

Experimental Design: Data-independent acquisition proteomics, with five biological replicates, was used to investigate the protein expression profiles of placental tissues from patients with PE and normal pregnant women. Read More

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October 2021

Olfactory-related Quality of Life Adjustments in Smell Loss during the Coronavirus-19 Pandemic.

Am J Rhinol Allergy 2021 Oct 27:19458924211053118. Epub 2021 Oct 27.

27271Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.

Background: Previous studies provided the first evidence that the importance of olfaction decreases with the duration of olfactory dysfunction (OD).

Objective: To evaluate differences in olfactory-related quality of life (QoL) between patients with new-onset and persistent smell loss (>4 weeks) during the coronavirus-19 (COVID-19) pandemic and patients with persistent postinfectious OD (PIOD) that were recruited before the pandemic.

Methods: This was a retrospective study that included 149 patients with self-reported OD. Read More

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October 2021

Tin(II) Ureide Complexes: Synthesis, Structural Chemistry, and Evaluation as SnO Precursors.

Inorg Chem 2021 Oct 27. Epub 2021 Oct 27.

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

In an attempt to tailor precursors for application in the deposition of phase pure SnO, we have evaluated a series of tin (-) ureide complexes. The complexes were successfully synthesized by employing ,'-trialkyl-functionalized ureide ligands, in which features such as stability, volatility, and decomposition could be modified with variation of the substituents on the ureide ligand in an attempt to find the complex with the ideal electronic, steric, or coordinative properties, which determine the fate of the final products. The tin(II) ureide complexes - were synthesized by direct reaction [Sn{NMe}] with aryl and alkyl isocyanates in a 1:2 molar ratio. Read More

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October 2021

Fibroblast growth factor 19 as a countermeasure to muscle and locomotion dysfunctions in experimental cerebral palsy.

J Cachexia Sarcopenia Muscle 2021 Oct 26. Epub 2021 Oct 26.

Studies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Background: Cerebral palsy (CP) associates cerebral function damages with strong locomotor defects and premature sarcopenia. We previously showed that fibroblast growth factor 19 (FGF19) exerts hypertrophic effects on skeletal muscle and improves muscle mass and strength in mouse models with muscle atrophy. Facing the lack of therapeutics to treat locomotor dysfunctions in CP, we investigated whether FGF19 treatment could have beneficial effects in an experimental rat model of CP. Read More

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October 2021

Dysregulated circular RNAs as novel biomarkers in esophageal squamous cell carcinoma: a meta-analysis.

Cancer Med 2021 Oct 26. Epub 2021 Oct 26.

Department of Nuclear Medicine, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Introduction: Circular RNAs (circRNAs) play critical roles in tumorigenesis, but their clinical efficacy in esophageal squamous cell carcinoma (ESCC) still retains controversial. This meta-analysis aims at evaluating the associations between circRNA expressions and clinicopathologic features as well as the diagnostic and prognostic values of circRNAs in ESCC.

Materials & Methods: PubMed, EMBASE, and other online databases were systematically searched to collect studies on circRNAs and clinicopathological features, diagnostic, and/or prognostic assessments of ESCC. Read More

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October 2021