332,424 results match your criteria studies required

Grab it or not? Measuring avoidance of spiders with touchscreen-based hand movements.

J Behav Ther Exp Psychiatry 2021 Jun 16;73:101670. Epub 2021 Jun 16.

Centre for Cognitive Neuroscience and Dept. of Psychology, University of Salzburg, Salzburg, Austria.

Background And Objectives: Previous studies have shown that humans, particularly those with high levels of spider fear, show automatic avoidance of spiders. However, most tasks used in these studies employ symbolic approach-avoidance movements instead of naturalistic movements.

Methods: The current study employed a touchscreen-based approach-avoidance task in which 86 female participants made hand and arm movements that mimic the real-life touching, grasping, and moving of spiders. Read More

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Steroid hormones in the aquatic environment.

Sci Total Environ 2021 Jun 16;792:148306. Epub 2021 Jun 16.

Division of Environmental Science, Department of Life Sciences, Brunel University London, Uxbridge, Middlesex UB8 3PH, United Kingdom. Electronic address:

Steroid hormones are extremely important natural hormones in all vertebrates. They control a wide range of physiological processes, including osmoregulation, sexual maturity, reproduction and stress responses. In addition, many synthetic steroid hormones are in widespread and general use, both as human and veterinary pharmaceuticals. Read More

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Emerging lessons from the commissioning and delivery of a gambling treatment service.

J Woodall C Freeman

Public Health 2021 Jun 19;196:69-73. Epub 2021 Jun 19.

School of Health and Community Studies, Leeds Beckett University, UK.

Objectives: Gambling is a public health concern, given the multiplicity of harms for individuals, families and communities. This article reports on the commissioning and delivery of a problem gambling treatment service in a metropolitan area in England, where the concentration of problem gambling is often higher than the national average.

Study Design: This is a cross-sectional study, using purposively sampled 'experts' and stakeholders involved in the conception and set-up of the service. Read More

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Green light antinociceptive and reversal of thermal and mechanical hypersensitivity effects rely on endogenous opioid system stimulation.

J Pain 2021 Jun 19. Epub 2021 Jun 19.

Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America; Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America; Neuroscience Graduate Interdisciplinary Program, College of Medicine, The University of Arizona, Tucson, Arizona, 85742, USA.. Electronic address:

Benefits of phototherapy were characterized in multiple diseases including depression, circadian rhythm disruptions, and neurodegeneration. Studies on migraine and fibromyalgia patients revealed that green light-emitting diodes (GLED) exposure provides a pragmatic and safe therapy to manage chronic pain. In rodents, GLED reversed hypersensitivity related to neuropathic pain. Read More

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A systematic review with meta-analysis on the antihypertensive efficacy of Nigerian medicinal plants.

J Ethnopharmacol 2021 Jun 19:114342. Epub 2021 Jun 19.

Centre for Biotechnology Research, Bayero University, Kano, Nigeria.

Ethnopharmacological Relevance: Despite the promising effects of herbal preparations in lowering blood pressure (BP), hypertension remains a major clinical challenge in Nigeria. The BP-lowering effects of medicinal plants are due to the presence of bioactive compounds.

Aim Of The Study: This meta-analysis presents a precise estimate of the therapeutic benefits of medicinal plants utilized in Nigeria for the management of hypertension in animals and humans. Read More

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Strength and endurance deficits in adults with moderate-to-severe hip osteoarthritis, compared to healthy, older adults.

Disabil Rehabil 2021 Jun 22:1-8. Epub 2021 Jun 22.

Orthopaedic Research Institute, Bournemouth University, Bournemouth, UK.

Purpose: This study compares lower limb muscle strength and endurance in adults with hip osteoarthritis, to an age-matched control group.

Methods: Thirteen adults with moderate-to-severe hip osteoarthritis (as graded by the Oxford Hip Score) and fifteen older adults participated. Maximal voluntary isometric contraction of the knee extensors, knee flexors and hip abductors and isotonic endurance of the knee extensors were measured using a dynamometer. Read More

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The timeframe for safe resumption of high-level mobility following traumatic brain injury is currently unknown: a systematic review.

Disabil Rehabil 2021 Jun 22:1-11. Epub 2021 Jun 22.

Department of Physiotherapy, Epworth HealthCare, Melbourne, Australia.

Purpose: To examine the safety of high-level mobility (HLM) prescription in the early sub-acute phase of recovery following moderate-to-extremely severe traumatic brain injury (TBI) with specific focus on provocation of concussion-like symptoms.

Design: Systematic review. PROSPERO ID: CRD42017069369. Read More

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Prostate cancer in transgender women: what does a urologist need to know?

BJU Int 2021 Jun 22. Epub 2021 Jun 22.

Imperial Urology, Division of Surgery, Cancer and Cardiovascular Medicine, Imperial College Healthcare NHS Trust, UK.

Introduction: The transgender population share many of the same healthcare needs as their cisgender counterparts, but may have additional specialist needs, including and/or related to gender affirming hormone therapy (GAHT) and gender affirming surgery (GAS). With the rise in global population of transgender and gender non-conforming individuals to 25 million, certain areas of healthcare such as gender-at-birth cancers have been identified where more guidance is required for healthcare professionals. One such example is prostate cancer in transgender women. Read More

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Challenges Facing Pathologists Evaluating PD-L1 in Head & Neck Squamous Cell Carcinoma.

J Oral Pathol Med 2021 Jun 22. Epub 2021 Jun 22.

Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.

Programmed death-ligand 1 (PD-L1) expression with combined positive score (CPS) ≥1 is required for administration of checkpoint inhibitor therapy in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). The 22C3 pharmDx Dako immunohistochemical assay is the one approved as companion diagnostic for pembrolizumab, but many laboratories work on other platforms and/or with other clones, and studies exploring the potential interchangeability of assays have appeared. After review of the literature, it emerges that the concordance among assays ranges from fair to moderate, with a tendence of assay SP263 to yield a higher quota of positivity and of assay SP142 to stain better immune cells. Read More

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Index-Based Dietary Patterns and Inflammatory Bowel Disease: A Systematic Review of Observational Studies.

Adv Nutr 2021 Jun 22. Epub 2021 Jun 22.

Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Diet is one of the most critical factors for inflammatory bowel disease (IBD). A whole dietary pattern should be considered when doing nutrient-based research to preserve the potential for synergism between nutrients. Dietary indices are important tools to evaluate diet quality, and we investigated the associations of it with IBD. Read More

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Volar plate fixation vs. non-operative management for distal radius fractures in older adults: a meta-analysis.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):3955-3966

Department of Orthopedics, Zaozhuang Hospital of Traditional Chinese Medicine, Zaozhuang, Shandong Province, P.R. China.

Objective: The aim of the study was to perform a systematic literature search and conduct a meta-analysis of studies comparing clinical and functional outcomes of open reduction with internal fixation (ORIF) using a volar plate and closed reduction with casting for distal radius fracture in older adults (≥60 years of age).

Materials And Methods: A comprehensive electronic search was done for PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials), and Google scholar databases. Only randomized controlled trials (RCTs) comparing the two treatment modalities for functional and clinical outcomes were eligible to be included. Read More

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Prevalence and Incidence of Chronic Fibrosing Interstitial Lung Diseases with a Progressive Phenotype in the United States Estimated in a Large Claims Database Analysis.

Adv Ther 2021 Jun 17. Epub 2021 Jun 17.

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.

Introduction: Many fibrosing interstitial lung diseases (ILDs) develop a chronic progressive phenotype. While idiopathic pulmonary fibrosis, which is always progressive, is well characterized with established treatment options, the epidemiology of other chronic fibrosing ILDs with a progressive phenotype has not been widely investigated. Treatment options are limited, with a high unmet need. Read More

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Exercise programme to improve quality of life for patients with end-stage kidney disease receiving haemodialysis: the PEDAL RCT.

Health Technol Assess 2021 Jun;25(40):1-52

School of Health Sciences, Queen Margaret University, Edinburgh, UK.

Background: Whether or not clinically implementable exercise interventions in haemodialysis patients improve quality of life remains unknown.

Objectives: The PEDAL (PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease) trial evaluated the clinical effectiveness and cost-effectiveness of a 6-month intradialytic exercise programme on quality of life compared with usual care for haemodialysis patients.

Design: We conducted a prospective, multicentre randomised controlled trial of haemodialysis patients from five haemodialysis centres in the UK and randomly assigned them (1 : 1) using a web-based system to (1) intradialytic exercise training plus usual-care maintenance haemodialysis or (2) usual-care maintenance haemodialysis. Read More

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Maxillary Sinus Floor Infiltration: Results From a Series of 118 Maxillary Sinus Cancers.

Laryngoscope 2021 Jun 22. Epub 2021 Jun 22.

Head and Neck Surgery and Forensic Dissection Research Center (HNS&FDRc), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Objectives/hypothesis: Maxillary cancers are rare and aggressive tumors, which can spread beyond the sinus bony walls. Preoperative assessment of infiltration of maxillary sinus floor (MSF) is paramount for surgical planning, as palatomaxillary demolition significantly impacts patients' quality of life. This study investigates the challenges involved in the preoperative and intraoperative evaluation of MSF infiltration and analyzes its prognostic relevance. Read More

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Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.

JCI Insight 2021 Jun 22;6(12). Epub 2021 Jun 22.

Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, China.

PDCD10, also known as CCM3, is a gene found to be associated with the human disease cerebral cavernous malformations (CCMs). PDCD10 forms a complex with GCKIII kinases including STK24, STK25, and MST4. Studies in C. Read More

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Antenatal Exposure to UV-B Radiation and Preeclampsia: A Retrospective Cohort Study.

J Am Heart Assoc 2021 Jun 22:e020246. Epub 2021 Jun 22.

Institute of Health and Wellbeing University of Glasgow United Kingdom.

Background Risk of preeclampsia varies by month of delivery. We tested whether this seasonal patterning may be mediated through maternal vitamin D concentration using antenatal exposure to UV-B radiation as an instrumental variable. Methods and Results Scottish maternity records were linked to antenatal UV-B exposure derived from satellites between 2000 and 2010. Read More

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Clinical and Molecular Effects of GnRH Agonist and Antagonist on The Cumulus Cells in The Fertilization Cycle.

Int J Fertil Steril 2021 Jul 22;15(3):202-209. Epub 2021 Jun 22.

Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran. Email:

Background: Gonadotropin-releasing hormone (GnRH) analogues have been extensively utilized in the ovarian stimulation cycle for suppression of endogenous rapid enhancement of luteinizing hormone (LH surge). Exclusive properties and functional mechanisms of GnRH analogues in fertilization (IVF) cycles are clearly described. This study was performed to evaluate clinical and molecular impacts of the GnRH agonist and antagonist protocols in IVF cycles. Read More

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Is metoclopramide beneficial for the postpyloric placement of nasoenteric tubes? A systematic review and meta-analysis of randomized controlled trials.

Nutr Clin Pract 2021 Jun 22. Epub 2021 Jun 22.

Department of Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Background: Metoclopramide is frequently prescribed as an adjuvant for the postpyloric placement of nasoenteric tubes (NETs). However, a recent meta-analysis showed that metoclopramide was not beneficial in adults. Thus, this study aimed to reevaluate the effect of metoclopramide on the postpyloric placement of NETs. Read More

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Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives.

Biomed Rep 2021 Aug 8;15(2):66. Epub 2021 Jun 8.

Second Department of Propaedeutic Surgery, Laiko General Hospital, Athens 11527, Greece.

The induction of wound healing by insulin-like growth factor-I (IGF-I) has been demonstrated in several animal studies; however, there are disproportionately fewer studies assessing its value in humans. The aim of the present review is to provide a comprehensive summary of all the available evidence pertaining to the effects of IGF-I administration on the process of wound anaplasias, both in human tissues and in cells . A systematic search of Medline, Scopus and Google Scholar was performed for relevant studies published until May 2020. Read More

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Cardiorespiratory fitness and physical performance after childhood hematopoietic stem cell transplantation: a systematic review and meta-analysis.

Bone Marrow Transplant 2021 Jun 21. Epub 2021 Jun 21.

Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capital Region, Denmark.

The effects of childhood hematopoietic stem cell transplantation (HSCT) on key organs can impair cardiorespiratory fitness, muscle strength, and physical performance. We aimed to provide an overview of childhood HSCT survivors' status on these parameters compared with healthy controls and discuss current insights into clinical risk factors. We performed a systematic search in six scientific databases, including studies published before April 2019 and performed a meta-analysis on cardiorespiratory fitness. Read More

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3D monitoring of the surface slippage effect on micro-particle sedimentation by digital holographic microscopy.

Sci Rep 2021 Jun 21;11(1):12916. Epub 2021 Jun 21.

Department of Physics, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran.

In several phenomena in biology and industry, it is required to understand the comprehensive behavior of sedimenting micro-particles in fluids. Here, we use the numerical refocusing feature of digital holographic microscopy (DHM) to investigate the slippage effect on micro-particle sedimentation near a flat wall. DHM provides quantitative phase contrast and three-dimensional (3D) imaging in arbitrary time scales, which suggests it as an elegant approach to investigate various phenomena, including dynamic behavior of colloids. Read More

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Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis.

Sci Rep 2021 Jun 21;11(1):13007. Epub 2021 Jun 21.

Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.

Infectious keratitis (IK) is the 5th leading cause of blindness globally. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though adjuvant treatment or surgeries are often required in refractory cases of IK. This systematic review aimed to examine the effectiveness and safety of adjuvant amniotic membrane transplantation (AMT) for treating IK. Read More

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FURIN and placental syncytialisation: a cautionary tale.

Cell Death Dis 2021 Jun 21;12(7):635. Epub 2021 Jun 21.

School of Biomedical Sciences and Pharmacy, Priority Research Centre for Reproductive Science, Pregnancy and Reproduction Program, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.

FURIN is a pro-protein convertase previously shown to be important for placental syncytialisation (Zhou et al. [1]), a process of cell fusion whereby placental cytotrophoblast cells fuse to form a multinucleated syncytium. This finding has been broadly accepted however, we have evidence suggesting the contrary. Read More

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Effectiveness and Predictors of Discontinuation of Aripiprazole Long-acting Injection: A 12-Month Naturalistic Cohort Study.

J Clin Psychopharmacol 2021 Jun 22. Epub 2021 Jun 22.

From the Sussex Partnership NHS Foundation Trust, Sussex Education Centre, Brighton, UK Center for Research in Neuropsychology and Cognitive-Behavioral Intervention, Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal Department of Medical Education, Brighton and Sussex Medical School, Brighton, UK.

Purpose/background: This study aimed to explore the discontinuation rate of aripiprazole long-acting injection (LAI) in a naturalistic clinical setting.

Methods/procedures: A retrospective cohort study of 1 year duration was conducted on the first 200 patients registered to receive aripiprazole LAI in Sussex, UK. Rate of discontinuation and the association of robustly recorded clinical variables with discontinuation or a new acute care episode were explored. Read More

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Earlier initiation of palliative care in the disease trajectory of people living with dementia: a scoping review protocol.

BMJ Open 2021 06 21;11(6):e044502. Epub 2021 Jun 21.

Atlantic Fellow for Equity in Brain Health, Global Brain Health Institute (GBHI), University of California, San Francisco, California, USA.

Introduction: While the need for palliative care for people living with dementia has widely been recognised, they continue to be a disadvantaged group when it comes to timely initiation, and controversies remain regarding appropriate timing, or what elements constitute high quality palliative care early in the disease trajectory. To date, no literature review has summarised this debate or offered insights. The aim of this scoping review is to provide a general overview of research regarding palliative care in mild or moderate dementia, to identify existing controversies, and to examine what are key components of palliative care in dementia, specifically when initiated earlier in the disease trajectory. Read More

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Spontaneous resolution of a Chiari malformation with syringomyelia.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Department of Neurosurgery, University Hospital of North Staffordshire NHS Trust, Stoke-on-Trent, UK.

The Chiari I malformation (CM-I) is characterised by overcrowding of the posterior fossa and descent of the cerebellar tonsils and is associated with syringomyelia. With the increasing availability of magnetic resonance imaging, CM-I is placing a growing burden on neurosurgical services. However, its natural history remains poorly understood, and the timing and nature of surgical intervention is controversial. Read More

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Single-center experience of 105-minimalistc transfemoral transcatheter aortic valve replacement and its outcome.

Indian Heart J 2021 May-Jun;73(3):301-306. Epub 2021 Feb 3.

Cardiology, Eternal Hospital, Jaipur, India.

Introduction: Transcatheter aortic valve replacement (TAVR) increases worldwide, and indications expand from high-risk aortic stenosis patients to low-risk aortic stenosis. Studies have shown that minimalistic TAVR done under conscious sedation is safe and effective. We report single-operator, the single-center outcome of 105 minimalist transfemoral, conscious sedation TAVR patients, analyzed retrospectively. Read More

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February 2021

Histological, Histochemical, and Ultrastructural Approach to the Ductus Deferens in Male Nile Monitor Lizard ().

Microsc Microanal 2021 Jun 22:1-6. Epub 2021 Jun 22.

Department of Theriogenology, Faculty of Veterinary Medicine, South Valley University, Qena83523, Egypt.

The ductus deferens is a fundamental part of the male genital tract and the continuation of the epididymal duct. As a male secondary sex organ, the ductus deferens plays a crucial role in the nourishment, storage, and maturation of spermatozoa. Some studies have provided information about the ductus deferens structure in reptiles; however, the full description of the ductus deferens remains to be clarified. Read More

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Peer-to-peer health promotion interventions among African American men: a scoping review protocol.

Syst Rev 2021 Jun 22;10(1):184. Epub 2021 Jun 22.

Department of Psychology, University of South Carolina, 1512 Pendleton Avenue, Barnwell College, Mailbox 38, Columbia, South Carolina, 29208, USA.

Background: Health promotion efforts among African American men have been met with significant challenges and have produced limited results. Interventions that do not align with the values, perspectives, and preferences of African American men often produce less effective results. Research among African American men has provided compelling evidence that these men prefer informal networks of health support. Read More

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A rare ovarian hilus cell tumour accompanying bilateral serous cystadenomas: report of a case.

J Ovarian Res 2021 Jun 21;14(1):81. Epub 2021 Jun 21.

Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan.

Background: Hilus cell tumours is considered an uncommon branch of androgen producing neoplasms that accounts for < 5% of all ovarian tumours. They are mostly benign and have characteristic gross and microscopic features. Here we present the first case of a hilus cell tumour in association with bilateral serous cystadenomas. Read More

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