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Population-based mammography screening attendance in Sweden 2017-2018: A cross-sectional register study to assess the impact of sociodemographic factors.

Breast 2021 Jun 2;59:16-26. Epub 2021 Jun 2.

Department of Translational Medicine, Diagnostic Radiology, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden.

Sweden has a population-based mammography screening programme for women aged 40-74. The objective of this study was to examine the association between mammography screening attendance and sociodemographic factors in 15 of Sweden's 21 health care regions. Register-based information was collected on all mammography screening invitations and attendance during 2017 and 2018, and linked to individual-level sociodemographic data from Statistics Sweden. Read More

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Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.

ESMO Open 2021 Jun 9;6(4):100187. Epub 2021 Jun 9.

Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan; Outpatient Treatment Center, National Cancer Center Hospital, Tokyo, Japan. Electronic address:

Background: Precision and matched cancer medicine has the potential to complement the existing biomarker approaches in cancer treatment. However, despite their promising potential, certain negative results have highlighted their limitations in molecular biology-driven treatment strategies. This study aimed to evaluate the clinical benefits of precision therapies. Read More

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Carvacrol, citral and α-terpineol essential oil incorporated biodegradable films for functional active packaging of Pacific white shrimp.

Food Chem 2021 May 30;363:130252. Epub 2021 May 30.

Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand. Electronic address:

Biodegradable poly(butylene adipate terephthalate) and poly(lactic acid) (PBAT/PLA) blend films compounded with carvacrol, citral and α-terpineol essential oils (EOs) were produced for food packaging via blown-film extrusion. PBAT/PLA interacted with citral and α-terpineol via hydrogen bonding and carbonyl groups. Microstructures and barrier properties against water vapor and oxygen were modified depending on types and concentrations (3% and 6%) of EOs. Read More

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Computer modelling of heat strain responses of exercising personnel in tropical climate.

Comput Biol Med 2021 May 29;134:104530. Epub 2021 May 29.

Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117575, Singapore.

Physiologically based thermoregulatory models are useful for deriving predictions of heat strain for pragmatic applications such as planning of continuous exercise/work-rest protocols. The SCENARIO model is an example of a thermoregulatory model that predicts heat strain including body core temperature (Tc) from individual characteristics, physical activity, clothing properties and environmental conditions. This paper presents work to optimize and enhance the SCENARIO model for prediction of Tc during high intensity load carriage tasks under predominantly tropical climate conditions. Read More

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Are periodontal diseases associated with sleep duration or sleep quality? A systematic review.

Arch Oral Biol 2021 Jun 6;129:105184. Epub 2021 Jun 6.

Department of Periodontology, School of Dentistry, Federal University of Pelotas, Rua Gonçalves Chaves, 457, Pelotas, RS, 96015-560, Brazil. Electronic address:

Objectives: This study aimed to systematically review the associations between periodontal diseases/tooth loss and sleep duration/quality.

Material And Methods: PubMed, Scopus, and Embase databases were searched (up to May 2021) to identify studies that assessed the association between periodontal diseases or number of teeth with sleep quality and sleep duration. Two researchers independently selected the studies and extracted the data. Read More

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Emerging biomarkers of delayed graft function in kidney transplantation.

Transplant Rev (Orlando) 2021 May 26;35(4):100629. Epub 2021 May 26.

Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address:

Delayed Graft Function (DGF) is one of the most common early complications in kidney transplantation, associated with poor graft outcomes, prolonged post-operative hospitalization and higher rejection rates. Given the severe shortage of high-quality organs for transplantation, DGF incidence is expected to raise in the next years because of the use of nonstandard kidneys from Extended Criteria Donors (ECD) and from Donors after Circulatory Death (DCD). Alongside conventional methods for the evaluation of renal allograft [e. Read More

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Buprenorphine use and disparities in access among emergency department patients with opioid use disorder: A cross-sectional study.

J Subst Abuse Treat 2021 Apr 20;130:108405. Epub 2021 Apr 20.

Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ 08103, United States of America; Cooper University Hospital, Department of Emergency Medicine, Keleman 152, 1 Cooper Plaza, Camden, NJ 08103, United States of America. Electronic address:

Background: Buprenorphine, a partial mu-opioid agonist and kappa-opioid antagonist, is an approved treatment for opioid use disorder (OUD). Studies demonstrate that buprenorphine decreases cravings for other opioids, effectively ameliorates withdrawal symptoms, and decreases opioid overdose and mortality. However, buprenorphine remains under-utilized. Read More

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Temporal transition of racial/ethnic disparities in COVID-19 outcomes in 3108 counties of the United States: Three phases from January to December 2020.

Sci Total Environ 2021 Jun 1;791:148167. Epub 2021 Jun 1.

School of the Environment, Yale University, New Haven, CT, United States of America.

Early studies reported higher risk of COVID-19 outcomes for racial/ethnic minorities in the early phase of the pandemic in the United States. While the initial surge of COVID-19 was concentrated in some areas, COVID-19 became pervasive across the entire continent with high impacts in the northern region and central region in the end of 2020. With this geographical transition, we aim to investigate patterns of these racial/ethnic disparities over time. Read More

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Synthesis of a 2D copper(II)-carboxylate framework having ultrafast adsorption of organic dyes.

J Colloid Interface Sci 2021 May 31;602:43-54. Epub 2021 May 31.

Department of Chemistry, GC University Lahore, 54000, Pakistan. Electronic address:

Two-dimensional (2D) coordination polymers are very interesting materials for their attractive applications. A novel 2D metal-organic framework (MOF) was derived from copper(II) and amino benzoic acid under both room temperature and solvothermal reaction conditions using different solvents. From both of the synthesis methods, an identical MOF was crystalized with monoclinic crystal system having P2/c space group. Read More

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Health of African refugee children outside Africa: A scoping review.

J Pediatr Nurs 2021 Jun 9;61:199-206. Epub 2021 Jun 9.

Department of Educational Psychology, University of Alberta, Edmonton, Alberta T6G 2G5, Canada. Electronic address:

Problem: Africa is the largest source continent of refugee children. However, we found no published synthesis of the literature on the health of African refugee children outside Africa. Conducting a review of the literature on this particular population will help illuminate the particular contextual health issues faced by African child refugees who live outside Africa. Read More

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Occurrence and migration of phthalates in adhesive materials to fruits and vegetables.

J Hazard Mater 2021 Jun 2;418:126277. Epub 2021 Jun 2.

Beijing Advanced Innovation Centre for Food Nutrition and Human Health. Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, PR China. Electronic address:

Labels or tapes are widely used on fresh fruits and vegetables, which may contain phthalates (PAEs). There are few studies on the contamination pathway of PAEs from labels or tapes to food stuff. In this study, the concentrations of eleven PAEs in adhesive labels, tapes, labeled fruits and vegetables on the market were investigated. Read More

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Toxic mechanism on phenanthrene-induced cytotoxicity, oxidative stress and activity changes of superoxide dismutase and catalase in earthworm (Eisenia foetida): A combined molecular and cellular study.

J Hazard Mater 2021 Jun 9;418:126302. Epub 2021 Jun 9.

School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 72# Jimo Binhai Road, Qingdao, Shandong 266237, PR China. Electronic address:

Phenanthrene (PHE) is an important organic compound, which is widespread in the soil environment and exhibits potential threats to soil organisms. Toxic effects of PHE to earthworms have been extensively studied, but toxic mechanisms on PHE-induced cytotoxicity and oxidative stress at the molecular and cellular levels have not been reported yet. Therefore, we explored the cytotoxicity and oxidative stress caused by PHE in earthworm coelomocytes and the interaction mechanism between PHE and the major antioxidant enzymes SOD/CAT. Read More

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In vitro generation of oxidized standards for lipidomics. Application to major membrane lipid components.

J Chromatogr A 2021 May 19;1651:462254. Epub 2021 May 19.

Centre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Madrid. Spain. Electronic address:

Membrane lipids (sphingolipids, glycerophospholipids, cardiolipins, and cholesteryl esters) are critical in cellular functions. Alterations in the levels of oxidized counterparts of some of these lipids have been linked to the onset and development of many pathologies. Unfortunately, the scarce commercial availability of chemically defined oxidized lipids is a limitation for accurate quantitative analysis, characterization of oxidized composition, or testing their biological effects in lipidomic studies. Read More

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Improving Vaccination for Young Children (IVY): A Stepped-Wedge Cluster Randomized Trial.

Acad Pediatr 2021 Jun 9. Epub 2021 Jun 9.

Vanderbilt University Medical Center, Department of Pediatrics, 1211 Medical Center Dr, Nashville, TN 37232, Nashville, Tennessee, United States. Electronic address:

Background: High childhood vaccination rates are critical for public health. We hypothesized that implementation of a vaccine education and quality improvement (QI) program, Improving Vaccinations for Young Children (IVY), would improve childhood vaccine rates.

Methods: Eight pediatric practices (3 academic-based, 5 community-based) were randomized to implement IVY within a stepped-wedge cluster randomized trial (SWCRT) in middle Tennessee. Read More

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Glycoproteogenomics: Setting the Course for Next Generation Cancer Neoantigens Discovery for Cancer Vaccines.

Genomics Proteomics Bioinformatics 2021 Jun 9. Epub 2021 Jun 9.

Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Porto 4200-072, Portugal; Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto 4050-313, Portugal; Porto Comprehensive Cancer Center (P.ccc), Porto 4200-072, Portugal.

Molecular-assisted precision oncology gained tremendous ground with high throughput next-generation sequencing (NGS), supported by robust bioinformatics. The quest for genomics-based cancer medicine set the foundations for improved patient stratification, while unveiling a wide array of neoantigens for immunotherapy. Upfront pre-clinical and clinical studies have successfully used tumor-specific peptides in vaccines with minimal off-target effects. Read More

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Fibrosing interstitial lung disease in primary Sjogren syndrome.

Joint Bone Spine 2021 Jun 9:105237. Epub 2021 Jun 9.

Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy.

Objectives: Interstitial lung disease (ILD) represents the main pulmonary involvement in primary Sjogren syndrome (pSS). A proportion of patients with pSS develop a progressive fibrosing form of ILD, but no data are available about the prevalence of these patterns in pSS patients. Aim of this monocentric, cross-sectional study was to investigate the prevalence of fibrosing patterns in pSS patients with ILD. Read More

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Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jun 9. Epub 2021 Jun 9.

Department of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/University Hospital Virgen del Rocio, 41013 Seville, Spain. Electronic address:

Background: Long-term care facilities (LTCFs) are health care settings with high antimicrobial consumption and hence need to develop effective antimicrobial stewardship programs (ASPs).

Objective: To assess the effects of ASPs on care-related, clinical, and ecological outcomes in LTCFs.

Methods: Data sources were PubMed, EMBASE, CINAHL, and SCOPUS. Read More

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7-ketocholesterol: effects on viral infections and hypothetical contribution in COVID-19.

J Steroid Biochem Mol Biol 2021 Jun 9:105939. Epub 2021 Jun 9.

University Bourgogne Franche-Comté, Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270 / Inserm, 21000 Dijon, France. Electronic address:

7-ketocholesterol, which is one of the earliest cholesterol oxidization products identified, is essentially formed by the auto-oxidation of cholesterol. In the body, 7-ketocholesterol is both provided by food and produced endogenously. This pro-oxidant and pro-inflammatory molecule, which can activate apoptosis and autophagy at high concentrations, is an abundant component of oxidized Low Density Lipoproteins. Read More

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Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy.

Eur J Pharm Sci 2021 Jun 9:105907. Epub 2021 Jun 9.

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), H-1111, Budapest, Műegyetem rakpart 3, Hungary. Electronic address:

Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several studies, however, continuous manufacturing of tablets have not been realized yet. This research presents the first integrated continuous processing of milled drug-loaded electrospun materials to tablet form supplemented by process analytical tools for monitoring the active pharmaceutical ingredient (API) content. Read More

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A 48-Channel Receive Array Coil for Mesoscopic Diffusion-Weighted MRI of ex vivo Human Brain on the 3 T Connectome Scanner.

Neuroimage 2021 Jun 9:118256. Epub 2021 Jun 9.

Institute of Medical Physics and Radiation Protection (IMPS), TH-Mittelhessen University of Applied Sciences (THM), Giessen, Germany; Center for Mind, Brain and Behavior (CMBB), Marburg, Germany.

In vivo diffusion-weighted magnetic resonance imaging is limited in signal-to-noise-ratio (SNR) and acquisition time, which constrains spatial resolution to the macroscale regime. Ex vivo imaging, which allows for arbitrarily long scan times, is critical for exploring human brain structure in the mesoscale regime without loss of SNR. Standard head array coils designed for patients are sub-optimal for imaging ex vivo whole brain specimens. Read More

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High-resolution in vivo imaging of rhesus cerebral cortex with ultrafast portable photoacoustic microscopy.

Neuroimage 2021 Jun 9:118260. Epub 2021 Jun 9.

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China. Electronic address:

Revealing the structural and functional change of microvasculature is essential to match vascular response with neuronal activities in the investigation of neurovascular coupling. The increasing use of rhesus models in fundamental and clinical studies of neurovascular coupling presents an emerging need for a new imaging modality. Here we report a structural and functional cerebral vascular study of rhesus monkeys using an ultrafast, portable, and high resolution photoacoustic microscopic system with a long working distance and a special scanning mechanism to eliminate the relative displacement between the imaging interface and samples. Read More

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Anti-seizure activity of African medicinal plants: the identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model.

J Ethnopharmacol 2021 Jun 9:114282. Epub 2021 Jun 9.

Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa, 0001. Electronic address:

Ethnopharmacological Relevance: Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available antiepileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Read More

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Exploring the alternative: fish, flies and worms as preclinical models for ALS.

Neurosci Lett 2021 Jun 9:136041. Epub 2021 Jun 9.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium. Electronic address:

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterized by the loss of upper and lower motor neurons. In general, patients succumb to respiratory insufficiency due to respiratory muscle weakness. Despite many promising therapeutic strategies primarily identified in rodent models, patient trials remain rather unsuccessful. Read More

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Attention modulates repetition effects in a context of low periodicity.

Brain Res 2021 Jun 9:147559. Epub 2021 Jun 9.

Centre National de la Recherche Scientifique (CNRS), Integrative Neuroscience and Cognition Center (INCC), Unité Mixte de Recherche, 8002, 75006 Paris, France; Université de Paris, 75006 Paris, France; Fondation Ophtalmologique Rothschild, Paris, France. Electronic address:

Stimulus repetition can result in a reduction in neural responses (i.e., repetition suppression) in neuroimaging studies. Read More

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Beneficial effect of the methanolic leaf extract of Allium hookeri on stimulating glutathione biosynthesis and preventing impaired glucose metabolism in type 2 diabetes.

Arch Biochem Biophys 2021 Jun 9:108961. Epub 2021 Jun 9.

Chemical Biology Lab, Institute of Advanced Study in Science and Technology (IASST) Paschim Boragaon, Guwahati, 35, India; Assam Down Town University, Panikhaiti, Assam, 781068, India. Electronic address:

Oxidative stress resulting from the depletion of glutathione (GSH) level plays a vital role in generating various degenerative diseases, including type 2 diabetes (T2D). We tested the hypothesis that depleted glutathione levels can be enhanced and the impaired glucose metabolism can be prevented by supplementing Allium hookeri, a herb rich in organosulfur compounds, in a High Fat (HF) diet-induced T2D Male Sprague Dawley rat model. The experimental rats were divided into three groups (n = 6), namely normal diet, high-fat diet, and high-fat diet treated with A. Read More

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Characterization of the immune cell infiltration landscape in bladder cancer to aid immunotherapy.

Arch Biochem Biophys 2021 Jun 9;708:108950. Epub 2021 Jun 9.

Diabetes Center, Zhejiang Provincial Key Laboratory of Pathophysiology, Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo, China. Electronic address:

The tumor microenvironment (TME) is composed mainly of tumor cells, tumorinfiltrating immune cells, and matrix components. Recent clinical studies have indicated that tumor immune cell infiltration (ICI) is related to the sensitivity of immunotherapy and the prognosis of patients with bladder cancer (BC). Nevertheless, up to now, the landscape of immune infiltration in BC has not been clearly defined. Read More

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Follicular thyroid cancer in a patient with Pendred syndrome.

Ann Endocrinol (Paris) 2021 Jun 9. Epub 2021 Jun 9.

Department of Nursing, The Jacob of Paradies University, Gorzów Wielkopolski, Poland.

We present the clinical and molecular studies of a family with Pendred syndrome, in which one affected individual developed follicular thyroid cancer. Two siblings with classic Pendred syndrome triad were operated on because of enormous multinodular goiter. Histopathology showed a follicular thyroid cancer in the male and a multinodular goiter in the female. Read More

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Analysis and comparison of autologous platelet-rich plasma preparation systems used in the treatment of enthesopathies: A preliminary study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Trauma and Hand Surgery, Wroclaw Medical University, Poland.

Background: Autologous platelet-rich plasma (PRP) injection is an alternative but widely accepted method for the treatment of degenerative changes in tendon attachments known as enthesopathies. The PRP is considered a safe source for high concentrations of the growth factors involved in the healing process. Despite initial promising outcomes, many recent studies report conflicting results for this treatment. Read More

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Combination of copigmentation and encapsulation strategies for the synergistic stabilization of anthocyanins.

Compr Rev Food Sci Food Saf 2021 Jun 12. Epub 2021 Jun 12.

Department of Food Science, Cornell University, Stocking Hall, Ithaca, New York, USA.

Copigmentation and encapsulation are the two most commonly used techniques for anthocyanin stabilization. However, each of these techniques by itself suffers from many challenges associated with the simultaneous achievement of color intensification and high stability of anthocyanins. Integrating copigmentation and encapsulation may overcome the limitation of usage of a single technique. Read More

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The association of triglyceride and glucose index, and triglyceride to high-density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross-sectional population study.

J Clin Hypertens (Greenwich) 2021 Jun 12. Epub 2021 Jun 12.

Tianjin Chest Hospital, Tianjin, China.

Insulin resistance (IR) plays an important role in the development of hypertension. Triglyceride and glucose index (TyG index), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c) as effective IR surrogate indexes have been verified in numerous studies. Therefore, the authors conducted a large cross-sectional study to explore the association of TyG index and TG/HDL-c with prehypertension and hypertension in the same normoglycemic subjects from Tianjin, China. Read More

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