J Neural Eng 2021 May 13. Epub 2021 May 13.
Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, 842 W Taylor St, 2039 ERF, MC 251, USA, Chicago, Illinois, 60607, UNITED STATES.
Objective: Our laboratory has proposed chemical stimulation of retinal neurons using exogenous glutamate as a biomimetic strategy for treating vision loss caused by photoreceptor degenerative diseases. Although our previous in-vitro studies using pneumatic actuation indicate that chemical retinal stimulation is achievable, an actuation technology that is amenable to microfabrication, as needed for an in-vivo implantable device, has yet to be realized. In this study, we sought to evaluate electroosmotic flow (EOF) as a mechanism for delivering small quantities of glutamate to the retina. Read More