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Assessment of Anti-inflammatory-like, Antioxidant activities and Molecular docking of three Alkynyl-substituted 3-ylidenedihydrobenzo[d] isothiazole 1,1-dioxide derivatives.

Chem Biol Interact 2021 May 8:109513. Epub 2021 May 8.

Center for Oxygen, Research and Development (CORD) and Center for Interdisciplinary Research on Medicine (CIRM) Institute of Chemistry University of Liège, Sart-Tilman (B.6a), 4000 Liège, Belgium.

The presence of enyne and benzoisothiazole functions in the molecular architecture of compounds 1, 2 and 3 were expected to provide biochemical activities. In the present work, we first examined the molecular surface contact of three alkynyl-substituted 3-ylidenedihydrobenzo[d] isothiazole 1,1-dioxides. The analysis of the Hirshfeld surfaces reveals that only compound 3 exhibited a well-defined red spots, indicating intermolecular interactions identified as S-O···H, C-H···O and C-O···H contacts. Read More

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Differentiation and proliferation of spermatogonial stem cells using a three-dimensional decellularized testicular scaffold: a new method to study the testicular microenvironment in vitro.

Int Urol Nephrol 2021 May 11. Epub 2021 May 11.

Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Gharib's Street, Keshavarz Boulevard, 1419433151, Tehran, Iran.

Purpose: Successful in vitro transplantation of spermatogonial stem cells (SSCs) demands effective culture systems for SSCs proliferation and differentiation. Natural extracellular matrix (ECM) creates a microenvironment suitable for culture of stem cells. In the present study, we intended to assess the capability of the porous scaffold consisting of hyaluronic acid (HA), chitosan, and decellularized testicular matrix (DTM) as a proper niche for SSCs seeding. Read More

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Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent.

Sci Rep 2021 May 10;11(1):9914. Epub 2021 May 10.

Department of Pharmaceutics, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Postal Code 45142, Saudi Arabia.

The purpose of this study was to develop a novel nano antibacterial formulation of dextran sulfate sodium polymer. The dextran sulfate sodium (DSS) nanoparticles were formulated with gelation technique. The nanoparticles exhibited significant physicochemical and effective antibacterial properties, with zeta potential of - 35. Read More

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Nudging Healthy Choices in Food Search Through Visual Attractiveness.

Front Artif Intell 2021 22;4:621743. Epub 2021 Apr 22.

Department of Information Science and Media Studies, University of Bergen, Bergen, Norway.

Recipe websites are becoming increasingly popular to support people in their home cooking. However, most of these websites prioritize popular recipes, which tend to be unhealthy. Drawing upon research on visual biases and nudges, this paper investigates whether healthy food choices can be supported in food search by depicting attractive images alongside recipes, as well as by re-ranking search results on health. Read More

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Enhancing the cardiovascular protective effects of a healthy dietary pattern with wolfberry (Lycium barbarum): A randomized controlled trial.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore, Singapore.

Background: The consumption of wolfberry (Lycium barbarum), a rich source of carotenoids and bioactive polysaccharides, may serve as a potential dietary strategy for cardiovascular disease (CVD) risk management although limited studies examined its effects as whole fruits.

Objectives: To investigate the impact of wolfberry consumption as part of a healthy dietary pattern on vascular health-related outcomes and classical CVD risk factors in middle-aged and older adults in Singapore.

Methods: This is a 16-week, parallel design, randomized controlled trial. Read More

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Association between Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism with the risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of 53 Studies.

Gene 2021 May 5:145696. Epub 2021 May 5.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Background And Aims: Hemorrhagic stroke (HS) results in significant mortality and disability worldwide. Angiotensin Convertase Enzyme (ACE) is responsible for blood pressure regulation and vascular homeostasis. Our objective was to conduct a comprehensive meta-analysis for ascertaining the association of ACE I/D polymorphism with HS since a number of studies depicted inconclusive evidence. Read More

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Fluid dynamics analyses of the intrahepatic portal vein tributaries using 7-T MRI.

HPB (Oxford) 2021 Apr 16. Epub 2021 Apr 16.

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Assessing portal vein (PV) hemodynamics is an essential part of liver disease management/liver surgery, yet the optimal methods of assessing intrahepatic PV flow have not yet been established. This study investigated the usefulness of 7-Tesla MRI with hemodynamic analysis for detecting small flow changes within narrow intrahepatic PV branches.

Methods: Flow data in the main PV was obtained by two methods, two-dimensional cine phase contrast-MRI (2D cine PC-MRI) and three-dimensional non-cine phase contrast-MRI (3D PC-MRI). Read More

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Immunomodulatory effects of standardized extract of val. on cytokines, antibody and delayed-type hypersensitivity response in Wistar rats.

Res Pharm Sci 2021 Feb 30;16(1):16-25. Epub 2020 Dec 30.

Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia.

Background And Purpose: Recently, we have highlighted the immunomodulatory activity of Val. on phagocytosis ability. The current study was conducted to determine the immunomodulatory effects of the standardized extract of rhizomes by and studies. Read More

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February 2021

Intestinal parasites among intellectually disabled individuals in Iran: a systematic review and meta-analysis.

Gut Pathog 2021 May 1;13(1):28. Epub 2021 May 1.

Toxoplasmosis Research Center, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Poor self-care skills and personal hygiene resulted from limitations in learning and understanding, put intellectually disabled individuals at greater risk for intestinal parasitic infections (IPIs). Despite several regional reports in Iran, the overall burden on IPIs among intellectually disabled individuals is poorly understood. Hence, the present study aimed to estimate the pooled prevalence of IPIs among intellectually disabled individuals in Iran. Read More

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Effect of backwashing biologically activated carbon on coagulability of organics in surface water.

Sci Total Environ 2021 Apr 18;785:147165. Epub 2021 Apr 18.

School of Engineering, Design and Built Environment, Western Sydney University, NSW 2751, Australia.

This study shows if biologically activated carbon (BAC) is backwashed at the correct frequency, a number of benefits can be derived in addition to aiding the subsequent coagulation process. Previous studies have shown that the BAC improves the removal of dissolved organic carbon (DOC) by subsequent coagulation by decreasing non-coagulable dissolved organic carbon (NC-DOC). However, the actual mechanism of such observation or optimising strategies of NC-DOC removal is unknown. Read More

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An integrated augmented reality surgical navigation platform using multi-modality imaging for guidance.

PLoS One 2021 30;16(4):e0250558. Epub 2021 Apr 30.

TECHNA Institute, University Health Network, Toronto, ON, Canada.

An integrated augmented reality (AR) surgical navigation system that potentially improves intra-operative visualization of concealed anatomical structures. Integration of real-time tracking technology with a laser pico-projector allows the surgical surface to be augmented by projecting virtual images of lesions and critical structures created by multimodality imaging. We aim to quantitatively and qualitatively evaluate the performance of a prototype interactive AR surgical navigation system through a series of pre-clinical studies. Read More

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Multidimensional trophic niche revealed by complementary approaches: gut content, digestive enzymes, fatty acids and stable isotopes in Collembola.

J Anim Ecol 2021 Apr 29. Epub 2021 Apr 29.

Biology Centre of the Czech Academy of Sciences, Institute of Soil Biology, Na Sádkách 7, 37005, České Budějovice, Czech Republic.

Trophic niche differentiation may explain coexistence and shape functional roles of species. In complex natural food webs, however, trophic niche parameters depicted by single and isolated methods may simplify the multidimensional nature of consumer trophic niches, which includes feeding processes such as food choice, ingestion, digestion, assimilation and retention. Here we explore the correlation and complementarity of trophic niche parameters tackled by four complementary methodological approaches, i. Read More

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Expressional and Prognostic Value of S100A16 in Pancreatic Cancer Integrated Bioinformatics Analyses.

Front Cell Dev Biol 2021 12;9:645641. Epub 2021 Apr 12.

Department of Hepatopancreatobiliary Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.

Studies have shown that the calcium-binding protein family S100 may play a role in the development of pancreatic cancer (PC), but the role of S100A16 in PC is still unknown. In this study, Oncomine was first used to detect the expression level and prognosis of S100A16 in PC and other tumors. The results showed that S100A16 was highly expressed in PC tissues compared with a normal pancreas, and the increased expression level may be related to poor prognosis in PC patients. Read More

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Molecular characterization of and gene in .

Saudi J Biol Sci 2021 Apr 23;28(4):2301-2315. Epub 2021 Jan 23.

Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.

(peanut) is a potential source of bioactive compounds including flavonols and proanthocyanidins, which have gained particular interest of metabolic engineering owing to their significance in the growth, development and defense responses in plants. To gain insight of proanthocyanidins and flavonols production in , and enzymes responsible for their production, have been structurally, transcriptionally and functionally characterized. Structural and functional analysis of putative protein sequence of indicated two functional motifs 2OG-FeII_Oxy and DIOX_N while six functional motifs belonging to the families of NAD-dependent dehydratase, 3, and NmrA-like family were observed in case of Promoter sequence analysis unraveled several promoter elements related to the development regulation, environmental stress responses and hormonal signaling. Read More

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Multifunctional natural polymer-based metallic implant surface modifications.

Biointerphases 2021 Apr 27;16(2):020803. Epub 2021 Apr 27.

Department of Engineering Sciences, METU, Ankara 06800, Turkey.

High energy traumas could cause critical damage to bone, which will require permanent implants to recover while functionally integrating with the host bone. Critical sized bone defects necessitate the use of bioactive metallic implants. Because of bioinertness, various methods involving surface modifications such as surface treatments, the development of novel alloys, bioceramic/bioglass coatings, and biofunctional molecule grafting have been utilized to effectively integrate metallic implants with a living bone. Read More

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Carbon Nanotube Exposure Triggers a Cerebral Peptidomic Response: Barrier Compromise, Neuroinflammation and a Hyperexcited State.

Toxicol Sci 2021 Apr 21. Epub 2021 Apr 21.

Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, 23298.

The unique physicochemical properties of carbon nanomaterials and their ever-growing utilization generate a serious concern for occupational risk. Pulmonary exposure to these nanoparticles induces local and systemic inflammation, cardiovascular dysfunction, and even cognitive deficits. While multiple routes of extrapulmonary toxicity have been proposed, the mechanism for and manner of neurologic effects remain minimally understood. Read More

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Whitewashing Nature: Sanitized Depictions of Biology in Children's Books and Parent-Child Conversation.

Child Dev 2021 Apr 23. Epub 2021 Apr 23.

Occidental College.

The biological world includes many negatively valenced activities, like predation, parasitism, and disease. Do children's books cover these activities? And how do parents discuss them with their children? In a content analysis of children's nature books (Study 1), we found that negatively valenced concepts were rarely depicted across genres and reading levels. When parents encountered negative information in books (Studies 2-3), they did not omit it but rather elaborated on it, adding their own comments and questions, and their children (ages 3-11) were more likely to remember the negative information but less likely to generalize that information beyond the animal in the book. Read More

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Brain-localized and Intravenous Microinjections in the Larval Zebrafish to Assess Innate Immune Response.

Bio Protoc 2021 Apr 5;11(7):e3978. Epub 2021 Apr 5.

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Creating a robust and controlled infection model is imperative for studying the innate immune response. Leveraging the particular strengths of the zebrafish model system, such as optical transparency, development, and large clutch size, allows for the development of methods that yield consistent and reproducible results. We created a robust model for activation of innate immunity by microinjecting bacterial particles or live bacteria into larval zebrafish, unlike previous studies which largely restricted such manipulations to embryonic stages of zebrafish. Read More

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Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA.

Sci Rep 2021 Apr 22;11(1):8706. Epub 2021 Apr 22.

Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA.

The ventral tegmental area (VTA) is the origin of dopaminergic neurons and the dopamine (DA) reward pathway. This pathway has been widely studied in addiction and drug reinforcement studies and is believed to be the central processing component of the reward circuit. In this study, we used a well-established rat model to expose mother dams to alcohol, nicotine-alcohol, and saline perinatally. Read More

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Enantioselective Total Synthesis of Cerorubenic Acid-III via Type II [5+2] Cycloaddition Reaction.

J Org Chem 2021 Apr 22. Epub 2021 Apr 22.

Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Shenzhen Grubbs Institute, Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.

The first enantioselective total synthesis of cerorubenic acid-III is described in detail. Different strategies and attempts, based on a type II [5+2] cycloaddition reaction, leading to the bicyclo[4.4. Read More

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A comparison of the performance on extrinsic and intrinsic cartographic visualizations through correctness, response time and cognitive processing.

PLoS One 2021 21;16(4):e0250164. Epub 2021 Apr 21.

Department of Information and Library Studies, Faculty of Arts, Masaryk University, Brno, Czech Republic.

The aim of this study was to compare the performance of two bivariate visualizations by measuring response correctness (error rate) and response time, and to identify the differences in cognitive processes involved in map-reading tasks by using eye-tracking methods. The present study is based on our previous research and the hypothesis that the use of different visualization methods may lead to significant cognitive-processing differences. We applied extrinsic and intrinsic visualizations in the study. Read More

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Survival Analysis of Patients With COVID-19 in India by Demographic Factors: Quantitative Study.

JMIR Form Res 2021 May 6;5(5):e23251. Epub 2021 May 6.

Department of Mathematical Demography and Statistics, International Institute for Population Sciences, Mumbai, India.

Background: Studies of the transmission dynamics of COVID-19 have depicted the rate, patterns, and predictions of cases of this pandemic disease. To combat transmission of the disease in India, the government declared a lockdown on March 25, 2020. Even after this strict lockdown was enacted nationwide, the number of COVID-19 cases increased and surpassed 450,000. Read More

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Periodic discharges with high frequency oscillations recorded from a cerebellar gangliocytoma in an epileptic infant.

Surg Neurol Int 2021 17;12:98. Epub 2021 Mar 17.

Department of Neurosurgery Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Subcortical epilepsies associated with developmental tumors in the cerebellum are rarely experienced. As supportive evidence of the intrinsic epileptogenicity of cerebellar tumors, previous electroencephalogram (EEG) studies with intratumoral depth electrodes demonstrated epileptiform or ictal discharges. Recent studies have demonstrated that high frequency oscillations (HFOs) can be regarded as a new biomarker of epileptogenesis and ictogenesis; however, there are few evidence about HFOs in cases of epilepsy associated with cerebellar tumors. Read More

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The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness.

Free Radic Biol Med 2021 Apr 18;169:224-237. Epub 2021 Apr 18.

Department of Molecular, Cell and Systems Biology, College of Natural and Agricultural Sciences, University of California Riverside, Riverside, 92521, CA, USA; Stem Cell Center, College of Natural and Agricultural Sciences, University of California Riverside, Riverside, 92521, CA, USA. Electronic address:

Previous views of reactive oxygen species (ROS) depicted them as harmful byproducts of metabolism as uncontrolled levels of ROS can lead to DNA damage and cell death. However, recent studies have shed light into the key role of ROS in the self-renewal or differentiation of the stem cell. The interplay between ROS levels, metabolism, and the downstream redox signaling pathways influence stem cell fate. Read More

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Karyomorphological and SEM studies in newly discovered populations of a critically endangered medicinal plant - Lilium polyphyllum D. Don ex Royle from a high altitude protected area of north-western Himalaya.

Microsc Res Tech 2021 Apr 20. Epub 2021 Apr 20.

Botanical Survey of India, Northern Regional Centre, Dehradun, Uttarakhand, India.

In this study, new populations of a critically endangered Himalayan herb, Lilium polyphyllum D. Don ex Royle have been reported from Chamba, Himachal Pradesh, India for the first time. Karyotypic, palynological, and spermological studies under the light microscope (LM) and scanning electron microscope (SEM) have been carried out on specimens from these populations with an aim to add more knowledge to the current database of the species. Read More

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Postural correlates of painful stimuli exposure: impact of mental simulation processes and pain-level of the stimuli.

Exp Brain Res 2021 Apr 19. Epub 2021 Apr 19.

UR-UPJV 4559, Laboratoire de Neurosciences Fonctionnelles et Pathologies, Centre Universitaire de Recherche en Sante, Amiens, France.

Previous studies have reported (i) freezing-like posturographic correlates in response to painful as compared to non-painful scenes vision (Lelard et al., Front Hum Neurosci 7:4, 2013) and (ii) an increase of this response during the mental simulation as compared to the passive viewing of the painful scenes (Lelard et al., Front Psychol 8:2012, 2017). Read More

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Correlation of older age with severity of lymphedema in breast cancer survivors: A systematic review.

Breast Dis 2021 Apr 7. Epub 2021 Apr 7.

Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA.

Background: Breast cancer is the most frequent cause of secondary lymphedema. Besides being progressive and chronic, lymphedema is usually hard to treat. That's why the clinicians are more focused on the prevention of its development and progression. Read More

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Biochemical and histopathological effects in muscular tissue of carp fish (Labeo rohita, Hamilton 1822) following exposure to untreated and treated sewage water.

Environ Sci Pollut Res Int 2021 Apr 17. Epub 2021 Apr 17.

Department of Zoology, Punjab Agricultural University, Ludhiana, Punjab, 141004, India.

Present work describes a laboratory study aiming at assessing the impact of sewage treatment plant (STP) effluents on fish health by means of biochemical and histopathological biomarkers in muscular tissue of fish. Labeo rohita (7.62 ±0. Read More

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Arbuscular mycorrhizal fungi improve growth, essential oil, secondary metabolism, and yield of tobacco (Nicotiana tabacum L.) under drought stress conditions.

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Drought is a major environmental threat limiting worldwide crop production. Drought stress affects the tobacco quality and yield; therefore, the current research studies were undertaken to investigate the effectiveness of arbuscular mycorrhizal fungi (AMF) under drought stress on morphological and biochemical attributes of tobacco (Nicotiana tabacum L. variety Yunyan 87). Read More

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Prevalence and factors associated with depression, anxiety and stress among healthcare workers of Trinidad and Tobago during COVID-19 pandemic: a cross-sectional study.

BMJ Open 2021 04 13;11(4):e044397. Epub 2021 Apr 13.

School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies at Saint Augustine, Port of Spain, Trinidad and Tobago.

Objectives: To determine the prevalence and factors associated with depression, anxiety and stress among healthcare workers (HCWs) during COVID-19 pandemic.

Design: Cross-sectional online survey.

Setting: HCWs from four major hospitals within the Regional Health Authorities of Trinidad and Tobago. Read More

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