511,198 results match your criteria studies demonstrated


AIRE-overexpressing BMDCs suppress T cells through ICOSL to prevent and attenuate autoimmune diabetes in NOD mice.

Int Immunopharmacol 2021 Jul 19;99:107979. Epub 2021 Jul 19.

Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. Electronic address:

The strong genetic association between autoimmune regulator (AIRE) and autoimmune diseases indicates its critical role in immune tolerance. AIRE deficiency is thought to promote the development of follicular helper T (T) cells, which are considered to be essential in B cell proliferation. Excessive T cell generation is a key step towards the development of autoimmune diseases, including type 1 diabetes. Read More

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Monomeric C-reactive protein promotes platelets to release mitochondrial DNA in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Mol Immunol 2021 Jul 19;137:228-237. Epub 2021 Jul 19.

Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, 300052, China. Electronic address:

Although high level of circulating C-reactive protein (pCRP) is considered as a biomarker for disease activity, the significance of CRP in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has not been clarified. We once reported in AAV, pentameric CRP (pCRP) could dissociate into monomeric CRP (mCRP) and activate platelets. Recent studies have demonstrated that the activated platelets can release mitochondrial DNA (mtDNA). Read More

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Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.

Ecotoxicol Environ Saf 2021 Jul 19;222:112529. Epub 2021 Jul 19.

Department of Pathophysiology, College of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, Sichuan Province, PR China. Electronic address:

Mercury is a naturally occurring element and highly toxic to humans even at a low dosage. Curcumin is a polyphenol found in turmeric (Curcuma longa), widely used as a treatment strategy to improve antioxidant and anti-inflammatory properties. The purpose of this study was to investigate the potential protective mechanisms of curcumin in spleen damage induced by HgCl. Read More

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Oxidative stress and endoplasmic reticulum stress contributed to hepatotoxicity of decabromodiphenyl ethane (DBDPE) in L-02 cells.

Chemosphere 2021 Jul 13;286(Pt 1):131550. Epub 2021 Jul 13.

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address:

Decabromodiphenyl ethane (DBDPE) is one of the most commonly used novel brominated flame retardants (NBFRs), and its mass production and widespread application have caused health threats to the human being. Existing studies have shown that DBDPE has hepatotoxicity. And we have found that DBDPE could change cytochrome P450 3A (CYP3A) expression levels in rat livers, whereas the mechanism is unclear. Read More

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Electrophysiological predictors of response to subcutaneous immunoglobulin therapy in chronic inflammatory demyelinating polyneuropathy.

Clin Neurophysiol 2021 Jun 12;132(9):2184-2190. Epub 2021 Jun 12.

Ellen & Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada. Electronic address:

Objective: To assess axonal function prior to subcutaneous immunoglobulin (SCIG) therapy or placebo in relation to relapse in chronic inflammatory demyelinating polyneuropathy (CIDP) to determine whether axonal damage can predict therapy response.

Methods: Relapse rates in patients from the Polyneuropathy and Treatment with Hizentra (PATH) study, where patients were treated with placebo or SCIG (IgPro20), were analyzed by baseline (post-intravenous immunoglobulin stabilization) axonal damage (≤1 mV peroneal compound muscle action potential) status.

Results: In patients with non-axonal damage, relapses were significantly higher with placebo (73. Read More

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The Effects of Chronic Lymphocytic Thyroiditis on Clinicopathological Factors In Papillary Thyroid Cancer.

Endocr Pract 2021 Jul 19. Epub 2021 Jul 19.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Introduction: This study evaluated the impact of chronic lymphocytic thyroiditis (CLT) on clinicopathological parameters, prognostic outcome and initial treatment responses in patients with papillary thyroid cancer (PTC).

Methods: A retrospective review was made of 1409 patients with PTC, comprising 443 pathology proven PTC patients with CLT and 447 PTC patients without CLT.

Results: The median follow-up time was 58 (8-380) months and the median age at the time of diagnosis was 43 years. Read More

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Envelope following response measurements in young veterans are consistent with noise-induced cochlear synaptopathy.

Hear Res 2021 Jul 10;408:108310. Epub 2021 Jul 10.

VA RR&D National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System, Portland, OR, USA. Electronic address:

Animal studies have demonstrated that noise exposure can lead to the loss of the synapses between the inner hair cells and their afferent auditory nerve fiber targets without impacting auditory thresholds. Although several non-invasive physiological measures appear to be sensitive to cochlear synaptopathy in animal models, including auditory brainstem response (ABR) wave I amplitude, the envelope following response (EFR), and the middle ear muscle reflex (MEMR), human studies of these measures in samples that are expected to vary in terms of the degree of noise-induced synaptopathy have resulted in mixed findings. One possible explanation for the differing results is that synaptopathy risk is lower for recreational noise exposure than for occupational or military noise exposure. Read More

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American Academy of Ophthalmology recommendations on screening for endogenous Candida endophthalmitis.

Ophthalmology 2021 Jul 19. Epub 2021 Jul 19.

Department of Ophthalmology, Mayo Clinic, Rochester, Minneapolis.

The American Academy of Ophthalmology evaluated the practice of routine screening for intraocular infection from Candida septicemia. In the United States, ophthalmologists are consulted in the hospital to screen for intraocular infection routinely for patients with Candida bloodstream infections. This practice was established in the era prior to the utilization of systemic antifungal medication and to the establishment of definitions of ocular disease with candidemia. Read More

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Targeted gene disruption in a marsupial, Monodelphis domestica, by CRISPR/Cas9 genome editing.

Curr Biol 2021 Jul 13. Epub 2021 Jul 13.

Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima Minami-machi, Chuou-ku, Kobe 650-0047, Japan; Mouse Genetics Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Marsupials represent one of three extant mammalian subclasses with very unique characteristics not shared by other mammals. Most notably, much of the development of neonates immaturely born after a relatively short gestation takes place in the external environment. Among marsupials, the gray short-tailed opossum (Monodelphis domestica; hereafter "the opossum") is one of very few established laboratory models. Read More

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Comparison of culture with antibiogram to NGS using bacterial isolates and formalin fixed paraffin embedded gastric biopsies.

Gastroenterology 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX. Electronic address:

Introduction: The decline in Helicobacter pylori cure rates emphasizes the need for readily available methods to determine antimicrobial susceptibility.

Aim: To compare targeted next generation sequencing (NGS) and culture-based H. pylori susceptibility testing using clinical isolates and paired formalin-fixed paraffin embedded gastric biopsies (FFPE). Read More

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The role of alcohol dehydrogenase 1C in regulating inflammatory responses in ulcerative colitis.

Biochem Pharmacol 2021 Jul 19:114691. Epub 2021 Jul 19.

Clinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang, China; Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou 310014, Zhejiang, China. Electronic address:

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease caused by an interaction of genetics, immune responses, and environmental factors. However, the precise pathogenesis of UC remains poorly understood. The aim of the present study was to explore the potential target genes implicated in UC and to elucidate its underlying pathogenic mechanism. Read More

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Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms.

Am J Hum Genet 2021 Jul 15. Epub 2021 Jul 15.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

Although expression quantitative trait loci (eQTLs) have been powerful in identifying susceptibility genes from genome-wide association study (GWAS) findings, most trait-associated loci are not explained by eQTLs alone. Alternative QTLs, including DNA methylation QTLs (meQTLs), are emerging, but cell-type-specific meQTLs using cells of disease origin have been lacking. Here, we established an meQTL dataset by using primary melanocytes from 106 individuals and identified 1,497,502 significant cis-meQTLs. Read More

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Individual variability in human urinary metabolites identifies age-related, body mass index-related, and sex-related biomarkers.

Mol Genet Genomic Med 2021 Jul 22:e1738. Epub 2021 Jul 22.

Materia Medica Development Group, Institute of Medicinal Chemistry, Lanzhou University School of Pharmacy, Lanzhou, China.

Background: Metabolites present in human urine can be influenced by individual physiological parameters (e.g., body mass index [BMI], age, and sex). Read More

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Trauma-focused treatments for depression. A systematic review and meta-analysis.

PLoS One 2021 22;16(7):e0254778. Epub 2021 Jul 22.

School of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia.

Background: Trauma-focused treatments (TFTs) have demonstrated efficacy at decreasing depressive symptoms in individuals with PTSD. This systematic review and meta-analysis evaluated the effectiveness of TFTs for individuals with depression as their primary concern.

Methods: A systematic search was conducted for RCTs published before October 2019 in Cochrane CENTRAL, Pubmed, EMBASE, PsycInfo, and additional sources. Read More

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New Catalytic Radical Process Involving 1,4-Hydrogen Atom Abstraction: Asymmetric Construction of Cyclobutanones.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.

While alkyl radicals have been well demonstrated to undergo both 1,5- and 1,6-hydrogen atom abstraction (HAA) reactions, 1,4-HAA is typically a challenging process both entropically and enthalpically. Consequently, chemical transformations based on 1,4-HAA have been scarcely developed. Guided by the general mechanistic principles of metalloradical catalysis (MRC), 1,4-HAA has been successfully incorporated as a key step, followed by 4-- radical substitution (RS), for the development of a new catalytic radical process that enables asymmetric 1,4-C-H alkylation of diazoketones for stereoselective construction of cyclobutanone structures. Read More

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Exploring amino acid functions in a deep mutational landscape.

Mol Syst Biol 2021 Jul;17(7):e10305

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.

Amino acids fulfil a diverse range of roles in proteins, each utilising its chemical properties in different ways in different contexts to create required functions. For example, cysteines form disulphide or hydrogen bonds in different circumstances and charged amino acids do not always make use of their charge. The repertoire of amino acid functions and the frequency at which they occur in proteins remains understudied. Read More

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Clinical and Histopathological Spectrum of Delayed Adverse Cutaneous Reactions Following COVID-19 Vaccination.

J Cutan Pathol 2021 Jul 22. Epub 2021 Jul 22.

The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York.

Background: As more people become vaccinated against the SARS-CoV-2 virus, reports of delayed cutaneous hypersensitivity reactions are beginning to emerge.

Methods: In this IRB-approved retrospective case series, biopsies of potential cutaneous adverse reactions from the Pfizer-BioNTech or Moderna mRNA vaccine were identified and reviewed. Clinical information was obtained through the requisition form, referring clinician, or medical chart review. Read More

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Enhanced ammonia detoxification to urea in hepatocytes transduced with human aquaporin-8 gene.

Biotechnol Bioeng 2021 Jul 22. Epub 2021 Jul 22.

Instituto de Fisiología Experimental (IFISE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.

Hepatic ammonia detoxification to urea is critical for prevention of hyperammonemia and neurological damage. Hepatocyte mitochondrial aquaporin-8 (AQP8) channels have been involved in ammonia-derived ureagenesis. Herein, we studied whether the adenoviral gene transfer of human AQP8 (hAQP8) to hepatocyte mitochondria enhances ammonia conversion to urea. Read More

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Habitat use and nursery evaluation for the longnose stingray Hypanus guttatus (Bloch & Schneider, 1801) using vertebral microchemistry.

J Fish Biol 2021 Jul 22. Epub 2021 Jul 22.

Laboratório de Dinâmica de Populações Marinhas (DIMAR), Departamento de Pesca e Aquicultura, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil.

Here, we use vertebral microchemistry to investigate the habitat use patterns of the longnose stingray Hypanus guttatus in the northern and northeastern regions of Brazil, and to evaluate the existence of potential nurseries of the species. Samples were collected in Maranhão, Rio Grande do Norte, and Pernambuco states between 2008 and 2019. Trace element concentrations of Ba:Ca, Mg:Ca, Mn:Ca, and Sr. Read More

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Variation in outcomes across surgeons meeting the Leapfrog volume standard for complex oncologic surgery.

Cancer 2021 Jul 22. Epub 2021 Jul 22.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: A large body of evidence supports regionalization of complex oncologic surgery to high-volume surgeons at high-volume hospitals. However, whether there is heterogeneity of outcomes among high-volume surgeons at high-volume hospitals remains unknown.

Methods: Patients who underwent esophagectomy, lung resection, pancreatectomy, or proctectomy for primary cancer were identified within the Medicare 100% Standard Analytic File (2013-2017). Read More

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Efficacy and safety of onabotulinumtoxinA in patients with overactive bladder: subgroup analyses by sex and by serum prostate-specific antigen levels in men from a randomized controlled trial.

Int Urol Nephrol 2021 Jul 22. Epub 2021 Jul 22.

Specialty Medical and Development, GlaxoSmithKline, Tokyo, Japan.

Purpose: We aimed to assess onabotulinumtoxinA treatment outcomes by sex in patients with overactive bladder (OAB) and then explore the impact of serum prostate-specific antigen (PSA) levels in men.

Methods: Patients inadequately managed with OAB medications were randomized to receive single-dose onabotulinumtoxinA (100 U) or placebo intravesical injection in a phase III trial in Japan. We performed subgroup analyses by sex and post-hoc subgroup analyses using male PSA categories. Read More

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Interventions to Improve Trainers' Learning and Behaviors for Educating Health care Professionals Using Train-the-Trainer Method: A Systematic Review and Meta-analysis.

J Contin Educ Health Prof 2021 Jul 20. Epub 2021 Jul 20.

Ms. Poitras: Professor, Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Saguenay, Canada. Ms. Bélanger: Candidate, Psychology Department Université du Québec à Trois-Rivières, Trois-Rivières, Canada. Ms. T Vaillancourt: Research coordinator, Department of Family and Emergency Medicine, Université de Sherbrooke, Saguenay, Canada. Ms. Kienlin: PhD Student, Faculty of Health Sciences, Department of Health and Caring Sciences, University of Tromsø and The South-Eastern Norway Regional Health Authority, Department of Medicine and Healthcare, Tromsø, Norway. Ms. Körner: Professor, Medical Psychology and Medical Sociology, University of Freiburg, Freiburg, Germany. Ms. Godbout: Coordinator, Quebec SPOR Unit, Université du Québec à Montréal, Montréal, Canada. Ms. Bernard-Hamel: Registered Nurse, CIUSSS de l'Estrie, Sherbrooke, Canada. Ms. O'Connor: PhD Student, Department of Pharmacy, Université Laval, Québec, Canada. Ms. Blanchette: PhD Student, School of Nursing, Université de Sherbrooke, Saguenay, Canada. Ms. Khadhraoui: Biostatistician, Quebec SPOR Unit, Université Laval, Québec, Canada. Ms. Sawadogo: Student, Quebec SPOR Unit, Université Laval. Ms. Massougbodji: PhD Student, Department of Social and Preventive Medicine, Université Laval, Québec, Canada. Mr. Zomahoun: Scientific Coordonnator, Department of Social and Preventive Medicine, Université Laval, Québec, Canada, Québec, Canada. Ms. Gallani: Professor, Nursing Faculty, Université Laval, Québec, Canada. Ms. Stacey: School of Nursing, University of Ottawa and Ottawa Hospital Research Institute. Dr. Légaré: Professor, Department of Family Medicine and Emergency Medicine, Université Laval, Québec, Canada.

Introduction: Train-the-trainer (TTT) programs are frequently used to facilitate knowledge dissemination. However, little is known about the effectiveness of these programs. Therefore, we sought to assess the impact of TTT programs on learning and behavior of trainers for educating health and social professionals (trainees). Read More

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Cognitive-behavioral and related therapies for obsessive-compulsive and related disorders.

Curr Opin Psychiatry 2021 Jul 20. Epub 2021 Jul 20.

Obsessive-Compulsive Disorder (OCD) Clinic Accelerator Program for Discovery in Brain Disorders Using Stem Cells (ADBS) Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.

Purpose Of Review: Cognitive behavioral therapy (CBT) with exposure and response prevention is the first-line treatment for obsessive-compulsive disorder (OCD) and related disorders such as body dysmorphic disorder (BDD). We review here recent developments in CBT and related therapies in treating OCD and related disorders.

Recent Findings: Superiority of CBT over medications in treating OCD is being questioned by some recent meta-analyses, nonetheless CBT continues to be the mainstay of treatment. Read More

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Prebiotic inulin as a treatment of obesity related nonalcoholic fatty liver disease through gut microbiota: a critical review.

Crit Rev Food Sci Nutr 2021 Jul 22:1-11. Epub 2021 Jul 22.

Key laboratory of Animal Disease-resistant Nutrition, Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Yaan, People's Republic of China.

The microbial-derived products, including short chain fatty acids, lipopolysaccharide and secondary bile acids, have been shown to participate in the regulation of hepatic lipid metabolism. Previous studies have demonstrated that prebiotics, such as oligosaccharide and inulin, have abilities to change the concentration of microbial-derived products through modulating the microbial community structure, thus controlling body weight and alleviating hepatic fat accumulation. However, recent evidence indicates that there are individual differences in host response upon inulin treatment due to the differences in host microbial composition before dietary intervention. Read More

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Stimulant Therapy Utilization for Neurocognitive Deficits in Mild Traumatic Brain Injury.

Sports Health 2021 Jul 22:19417381211031842. Epub 2021 Jul 22.

USF Morsani College of Medicine, Department of Family Medicine, Tampa, Florida.

Context: There are 3.8 million mild traumatic brain injuries (mTBIs) that occur each year in the United States. Many are left with prolonged life-altering neurocognitive deficits, including difficulties in attention, concentration, mental fatigue, and distractibility. Read More

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Diversity fatigue: A survey for measuring attitudes towards diversity enhancing efforts in academia.

Cultur Divers Ethnic Minor Psychol 2021 Jul 22. Epub 2021 Jul 22.

Office of Research.

Objectives: Academia is grappling with how to address persistent underrepresentation and reduce inequities. With so many diversity-enhancing initiatives underway, some within the academic community might experience "diversity fatigue," a construct we use to understand majority groups' feelings of weariness toward diversity efforts.

Method: For our testing purposes, we focused on ethnic and minority underrepresentation, and collected data in four studies from 473 White American students and faculty. Read More

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Fabrication of Two-Dimensional Functional Covalent Organic Frameworks the Thiol-Ene "Click" Reaction as Lubricant Additives for Antiwear and Friction Reduction.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, P. R. China.

To address the energy wastage problem caused by friction, novel lubricant additives other than the traditional and basic used additives with outstanding performance are urgently needed. A facile and efficient postsynthetic strategy for modification of two-dimensional (2D) covalent organic frameworks (COFs) was proposed to obtain dialkyl dithiophosphate (DDP)-functionalized COFs ([email protected]) as lubricant additives. The [email protected] was prepared by amine-aldehyde condensation reaction of the triazine compound and vinyl-functionalized monomers through a solvothermal process to form a vinyl-functionalized 2D COF (TD-COF), followed by covalent bonding of commercial lubricating molecules (DDP) the UV-induced thiol-ene "click" reaction. Read More

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Facile Synthesis of Electrically Conductive and Heatable Nanoparticle/Nanocarbon Hybrid Aerogels.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

Department of Materials, University of Manchester, Manchester M13 9PL, U.K.

Joule heating studies on nanoparticle/nanocarbon hybrid aerogels have been reported, but systematic investigations on hydrotalcite-derived catalysts supported onto reduced graphene oxide (rGO) aerogels are rare. In this study, hydrotalcite-derived Cu-AlO nanoparticles were incorporated into a porous and multifunctional rGO aerogel support for fabricating electrically conducting Cu-AlO/rGO hybrid aerogels, and their properties were investigated in detail. The hybridization of Cu-AlO with a 3D nanocarbon support network imparts additional functionalities to the widely used functional inorganic nanoparticles, such as direct electrical framework heating and easy regeneration and separation of spent nanoparticles, with well-spaced nanoparticle segregation. Read More

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Elevated levels of cortisol, brain-derived neurotropic factor and tissue plasminogen activator in male children with autism spectrum disorder.

Autism Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Child and Adolescent Psychiatry, Gaziosmanpasa University School of Medicine, Tokat, Turkey.

Several studies demonstrated biological effects of cortisol, brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) on human metabolism and central nervous system. Our study investigated the serum levels of tPA along with BDNF and cortisol in children with autism spectrum disorder (ASD). Thirty three male children with ASD ranging in age from 2 to 15 years were selected for the study group and 27 age-matched healthy male children were selected for the control group. Read More

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Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway.

Environ Toxicol 2021 Jul 22. Epub 2021 Jul 22.

Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.

Bladder cancer is the most common malignancy of the urinary tract and arising from the epithelial lining of the urinary bladder. Resistance to cytotoxic therapies is associated with overexpression of oncogenic proteins; including HER2, and Akt in chemotherapy resistance of bladder cancer. Various studies demonstrated that curcuminoids, the most important active phenolic compounds of turmeric (Curcuma longa), have anti-tumor activities in a wide range of human malignant cell lines. Read More

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