263,033 results match your criteria studies confirmed


Target therapies plus somatostatin analogues in NETs: a network meta-analysis.

Endocr Relat Cancer 2021 May 1. Epub 2021 May 1.

F de Braud, Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori Milano, Milan, Italy.

Although combination therapy is not recommended in patients with gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs), this strategy is widely used in clinical practice. This network meta-analysis of randomized trials evaluates targeted therapies and somatostatin analogues in GEP advanced NETs, either alone or in combination, comparing the efficacy of different single or combined treatment strategies in terms of progression-free survival (PFS). Interventions were grouped as analogues, everolimus, everolimus plus SSAs, sunitinib and placebo. Read More

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Structural and functional magnetic resonance imaging in isolated REM sleep behavior disorder: A systematic review of studies using neuroimaging software.

Sleep Med Rev 2021 Apr 22;59:101495. Epub 2021 Apr 22.

Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED:CB06/05/0018-ISCIII), Barcelona, Spain; Sleep Disorders Center, Neurology Service, Hospital Clínic, Barcelona, Catalonia, Spain.

Isolated rapid eye movement sleep behavior disorder (iRBD) is a harbinger for developing clinical synucleinopathies. Magnetic resonance imaging (MRI) has been suggested as a tool for understanding the brain bases of iRBD and its evolution. This review systematically analyzed original full text articles on structural and functional MRI in patients with video-polysomnography-confirmed iRBD according to systematic procedures suggested by Reviews and Meta-analyses (PRISMA). Read More

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BRCC3 promotes activation of the NLRP6 inflammasome following Cerebral Ischemia/Reperfusion (I/R) Injury in Rats.

Neurosci Lett 2021 May 9:135954. Epub 2021 May 9.

Department of Pathology, Chongqing Medical University, Chongqing, CQ, 400016, China. Electronic address:

NOD-like receptor family pyrin domain containing 6 (NLRP6), a novel member of the NLR family, has been confirmed to have an inflammasome-dependent proinflammatory effect in cerebral ischemia/reperfusion injury. NLRP6 assembles a multimeric inflammasome complex comprising the adaptor ASC and the effector pro-caspase-1 to mediate the activation of caspase-1. The molecular mechanism regulating activation of the NLRP6 inflammasome remains unclear. Read More

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Associations between interpersonal dependency and severity of prolonged grief disorder symptoms in bereaved surviving family members.

Compr Psychiatry 2021 Apr 30;108:152242. Epub 2021 Apr 30.

Cornell Center for Research on End-of-Live Care, 321 Lasdon House, 420 East 70(th) Street, Weill Cornell Medicine, NY, New York 10021, United States of America; Department of Medicine, Division of Geriatrics and Palliative Medicine, Baker Pavilion 14(th) Floor, East 68(th) Street, Weill Cornell Medicine, NY, New York 10021, United States of America. Electronic address:

Background: Several studies have shown that interpersonal dependency is a risk factor for prolonged grief disorder (PGD), a disorder that has been recently approved by the American Psychiatric Association Assembly for inclusion in the Diagnostic and Statistical Manual of Mental Disorders-5-Text Revision (DSM-5-TR). Nevertheless, it remains unclear whether this relationship is independent of depression, which may also be related to both loss and interpersonal dependency. Furthermore, anaclitic dependency (maladaptive and immature) compared to relatedness (more adaptive and mature) dependency, and the relationships between these types of dependency and PGD, have not been examined. Read More

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Acyclovir-Loaded Nanoemulsions: Preparation, Characterization and Irritancy Studies for Ophthalmic Delivery.

Curr Eye Res 2021 May 12. Epub 2021 May 12.

Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: The main goal of the present work was to develop and evaluate nanoemulsions (NEs) containing acyclovir (ACV) for ophthalmic drug delivery.

Method: Firstly, component screening was performed by determining ACV solubility in various oils, surfactants, and co-surfactants. Different NE formulations were developed based on pseudo-ternary phase diagrams, and physicochemical assets were evaluated. Read More

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The Mechanism of Macular Sparing.

Annu Rev Vis Sci 2021 May 12. Epub 2021 May 12.

Department of Ophthalmology, Program in Neuroscience, University of California, San Francisco, California 94143, USA; email:

Patients with homonymous hemianopia sometimes show preservation of the central visual fields, ranging up to 10°. This phenomenon, known as macular sparing, has sparked perpetual controversy. Two main theories have been offered to explain it. Read More

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Training and usage of detection dogs to better understand bumble bee nesting habitat: Challenges and opportunities.

PLoS One 2021 12;16(5):e0249248. Epub 2021 May 12.

Faculty of Environmental and Urban Change, York University, Toronto, Ontario, Canada.

Bumble bees are among the most imperiled pollinators. However, habitat use, especially nest site selection, remains relatively unknown. Methods to locate nests are invaluable to better understand habitat requirements and monitor wild populations. Read More

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Coronary artery calcification and epicardial adipose tissue as independent predictors of mortality in COVID-19.

Int J Cardiovasc Imaging 2021 May 12. Epub 2021 May 12.

Cardiology Division, Montefiore Medical Center, 111 E 210th, Bronx, NY, 10467, USA.

Recent epidemiological studies have demonstrated that common cardiovascular risk factors are strongly associated with adverse outcomes in COVID-19. Coronary artery calcium (CAC) and epicardial fat (EAT) have shown to outperform traditional risk factors in predicting cardiovascular events in the general population. We aim to determine if CAC and EAT determined by Computed Tomographic (CT) scanning can predict all-cause mortality in patients admitted with COVID-19 disease. Read More

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Utility of Volumetric Metabolic Parameters on Preoperative FDG PET/CT for Predicting Tumor Lymphovascular Invasion in Non-Small Cell Lung Cancer.

AJR Am J Roentgenol 2021 May 12. Epub 2021 May 12.

Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, Hubei Province, China.

Lymphovascular invasion (LVI) is an adverse prognostic indicator in non-small cell lung cancer (NSCLC) and serves as an indication for postoperative adjuvant chemotherapy recommendation after resection. To assess the utility of clinicopathologic factors and volumetric metabolic parameters from preoperative FDG PET/CT in predicting primary tumor LVI in NSCLC. This retrospective study included 161 patients (mean age, 61. Read More

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Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling.

Environ Toxicol 2021 May 12. Epub 2021 May 12.

Department of Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, China.

Lead (Pb) poses a potential environmental risk factor for cognitive dysfunction during early life and childhood. Resveratrol is considered a promising antioxidant with respect to the prevention of cognitive deficits and act as a potent SIRT1 agonist. Here in, this study aims to investigate the profile of neurogenesis markers following Pb exposure and to determine the regulatory role of resveratrol in this process. Read More

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Pathologic Spectrum and Molecular Landscape of Myeloid Disorders Harboring SF3B1 Mutations.

Am J Clin Pathol 2021 May 12. Epub 2021 May 12.

Division of Hematopathology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Objectives: SF3B1 mutations are the most common mutations in myelodysplastic syndromes (MDS). The International Working Group for the Prognosis of MDS (IWG-PM) recently proposed SF3B1-mutant MDS (SF3B1-mut-MDS) as a distinct disease subtype. We evaluated the spectrum and molecular landscape of SF3B1-mutated myeloid disorders and assessed the prognostication in MDS harboring SF3B1 mutations (MDS-SF3B1). Read More

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Structural and proton conductivity studies of fibrous π-TiO(PO)·2HO: application in chitosan-based composite membranes.

Dalton Trans 2021 May 11. Epub 2021 May 11.

Department of Physical and Analytical Chemistry, University of Oviedo - CINN (CSIC), 33006, Oviedo, Spain.

Although the fibrous polymorphic modification of titanium phosphate, π-Ti2O(PO4)2·2H2O (π-TiP) has been known for decades, its crystal structure has remained unsolved. Herewith, we report the crystal structure of π-TiP at room temperature, as determined from synchrotron radiation powder X-ray diffraction, and corroborated by 31P solid state NMR and accurate density functional theory calculations. In contrast to the previously reported ρ-TiP polymorph, the as-synthesized hydrated phase crystallizes in the monoclinic system (P21/c, a = 5. Read More

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Baicalin ameliorates -induced inflammatory injury in the chicken lung through regulating the intestinal microbiota and phenylalanine metabolism.

Food Funct 2021 May;12(9):4092-4104

College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin 150030, Xiangfang District, P. R. China. and Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, 600 Changjiang Road, Harbin 150030, Xiangfang District, P. R. China.

Baicalin shows excellent protective effects against Mycoplasma gallisepticum (MG) induced inflammatory injury as discussed in our previous studies. However, the physiological effects of baicalin are notable in contrast to its low bioavailability, and the critical mechanism for the protective effects of baicalin against MG infection is still unclear. The main objective of this study was to investigate whether baicalin alleviates MG-induced lung inflammatory injury through regulating gut microbiota. Read More

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Consumer preferences for low-salt foods - a Danish case study based on a comprehensive supermarket intervention.

Public Health Nutr 2021 May 12:1-26. Epub 2021 May 12.

Department of Food and Resource Economics, University of Copenhagen, Rolighedsvej 25, 1958 Frederiksberg C, Denmark.

Objective: The objective is to analyze Danish consumers' attitudes to buying food with reduced salt content.

Design: The study is based on a comprehensive store intervention that included 114 stores belonging to the same supermarket chain. Three different salt claims were tested for eight weeks on six test products within the categories bread, cornflakes and frozen pizzas. Read More

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Multifunctional Modified Polylactic Acid Nanofibrous Scaffold Incorporating Sodium Alginate Microspheres Decorated with Strontium and Black Phosphorus for Bone Tissue Engineering.

J Biomater Sci Polym Ed 2021 May 12:1-16. Epub 2021 May 12.

Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Material Science, Fujian Normal University, Fuzhou, Fujian 350007, China.

Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies. However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization. Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study. Read More

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Deciphering Potential Roles of Earthworms in Mitigation of Antibiotic Resistance in the Soils from Diverse Ecosystems.

Environ Sci Technol 2021 May 12. Epub 2021 May 12.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Earthworms are capable of redistributing bacteria and antibiotic resistance genes (ARGs) through soil profiles. However, our understanding of the earthworm gut microbiome and its interaction with the antibiotic resistome is still lacking. Here, we characterized the earthworm gut and soil microbiome and antibiotic resistome in natural and agricultural ecosystems at a national scale, and microcosm studies and field experiments were also employed to test the potential role of earthworms in dynamics of soil ARGs. Read More

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An iron oxide nanoworm hybrid on an interdigitated microelectrode silica surface to detect abdominal aortic aneurysms.

Mikrochim Acta 2021 May 11;188(6):185. Epub 2021 May 11.

Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory for Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin, 130031, China.

An abdominal aortic aneurysm (AAA) is abnormal swelling in the abdominal aorta and a prevalent life-threatening disease. This research introduces a new interdigitated microelectrode (IDME)-sensing surface modified by iron oxide nanoworms (IONWs) for detecting the AAA biomarker insulin-like growth factor-1 (IGF1). A sandwich pattern was formulated with the IGF1 aptamer and IGFBP1 (IGF binding protein-1) on the IONW-constructed IDME hybrid to identify IGF1. Read More

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Vietnam's Success Story Against COVID-19.

Public Health Pract (Oxf) 2021 May 7:100132. Epub 2021 May 7.

Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Vietnam's close proximity to China where the COVID-19 outbreak started made it one of the countries expected to have widespread transmission of the virus. However, the country opposed this expectation and attained low spread of COVID-19 infection due to its proactive approaches in containing the disease. As of 11 March 2021, Vietnam has a total of 2,529 confirmed cases, equivalent to 26 cases per one million population-compared to the global rate of 15,223 cases. Read More

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Seroprevalence of SARS-CoV-2 in Utsunomiya City, Greater Tokyo, after the first pandemic in 2020.

J Gen Fam Med 2021 May 16;22(3):160-162. Epub 2020 Dec 16.

Department of Global Health Promotion Tokyo Medical and Dental University Tokyo Japan.

Background: A seroepidemiological study was conducted on a random sample of households in Utsunomiya City, Tochigi Prefecture, Greater Tokyo, Japan, to assess the seroprevalence of SARS-CoV-2.

Methods: The level of IgG antibodies in the blood of the recruited subjects was assessed using chemiluminescence immunoassay analysis. In addition, the population-based prevalence of SARS-CoV-2 was estimated. Read More

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Two Atypical Cases of Hantavirus Infection: Experience from a Tertiary Care Unit in Sri Lanka.

Case Rep Infect Dis 2021 21;2021:5555613. Epub 2021 Apr 21.

National Hospital-Kandy, Kandy, Sri Lanka.

Hantaviruses are a large family of enveloped viruses with two medically important families Cricetidae and Muridae which are known to cause rodent-borne diseases worldwide. Some strains cause clinical syndromes with multiorgan involvement in humans such as hantavirus haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which is also known as hantavirus pulmonary syndrome. Clinical differentiation of this infection from other endemic infections in Sri Lanka such as leptospirosis and rickettsial infections is extremely difficult due to overlapping clinical and epidemiologic features such as exposure to rodents and farming. Read More

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Auto-brewery syndrome caused by oral fungi and periodontal disease bacteria.

Acute Med Surg 2021 Jan-Dec;8(1):e652. Epub 2021 May 3.

Department of Central Clinical Laboratory Iwate Medical University Hospital Morioka Japan.

Background: Auto-brewery syndrome (ABS) is often caused by fungi in the intestinal tract. We describe a rare case of alcohol production by and periodontal disease bacteria in the oral cavity.

Case Presentation: A man aged in his 60s had a car accident, and alcohol was detected on his breath. Read More

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Diagnosis of skin and soft tissue infections using near-infrared spectroscopy.

Acute Med Surg 2021 Jan-Dec;8(1):e642. Epub 2021 May 3.

Department of Emergency and Critical Care Medicine Kitasato University School of Medicine Sagamihara Japan.

Aim: Skin and soft tissue infections are classified into cellulitis and necrotizing fasciitis, which are difficult to distinguish. Necrotizing fasciitis has a poor prognosis and requires immediate intensive care. The diagnostic gold standard is to incise the lesion to determine whether necrosis has reached the fascia. Read More

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Comparative gut content analysis of invasive mosquitofish from Italy and Spain.

Ecol Evol 2021 May 15;11(9):4379-4398. Epub 2021 Mar 15.

Department of Biological Sciences Centre for Ecology, Evolution and Behaviour Royal Holloway University of London Egham UK.

Eastern mosquitofish () are among the most widely introduced freshwater species globally. To gain a better understanding of feeding patterns in non-native populations, and which local factors may influence them at the population level, we carried out gut content analysis on 163 specimens from nine invasive populations in Italy and Spain. Based on previous studies, we predicted that (a) mosquitofish are omnivores with a preference for detritus and cladocerans; (b) they display size- and population-specific differences in gut morphologies and diet, with larger fish feeding more intensively over a wider range of prey items; and (c) some of the variation would be associated with differences in local environmental and climatic factors. Read More

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Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224-3p/PLK1 signaling.

J Cancer 2021 12;12(11):3354-3366. Epub 2021 Apr 12.

Department of Rehabilitation, Children's Hospital of Nanjing Medical University, Jiangsu, China.

Previous studies have demonstrated that circular RNAs (circRNAs) play vital roles in pathological process of various diseases, including tumors. This study aimed at exploring the role and mechanism of circRNA RNA ZNF609 (circ-ZNF609) in the occurrence and development of glioma. Real-time quantitative PCR (qRT-PCR) was applied to measure the expression of circ-ZNF609, miRNA-1224-3p (miR-1224-3p) and Polo-like kinase 1 (PLK1) in glioma tissues and cell lines. Read More

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Dyslipidemia, Not Inflammatory Markers or Adipokines, Contributes Significantly to a Higher SYNTAX Score in Stable Coronary Artery Disease (from the Taichung CAD Study).

Acta Cardiol Sin 2021 May;37(3):232-238

Cardiovascular Center, Taichung Veterans General Hospital, Taichung.

Background: The SYNTAX score is an index of coronary severity used to determine the revascularization strategy of a patient. Our previous study confirmed that the SYNTAX score is helpful in predicting major adverse cardiac events in patients with stable coronary artery disease (CAD). However, few studies have comprehensively investigated the predictors for SYNTAX scores in patients with stable CAD, including conventional risk factors, lipid parameters, inflammatory markers and adipokines. Read More

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Functional characterization and related evolutionary implications of invertebrate gonadotropin-releasing hormone/corazonin in a well-established model species.

Sci Rep 2021 May 11;11(1):10028. Epub 2021 May 11.

NAP Adaptive Neuroethology, Balaton Limnological Research Institute, Eötvös Loránd Research Network (ELKH), Klebelsberg Kuno u. 3., Tihany, 8237, Hungary.

In vertebrates, gonadotropin-releasing hormone (GnRH) peptide is the central mediator of reproduction. Homologous peptides have previously also been identified in molluscan species. However, emerging evidence suggests that these molecules might serve diverse regulatory functions and proposes to consider them as corazonin (CRZ). Read More

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The feasibility of Gazefinder under 12 months of age infants.

Sci Rep 2021 May 11;11(1):10009. Epub 2021 May 11.

Department of Pediatrics, Shimane University Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Eye-tracking to evaluate gaze patterns has developed as an assessment tool for children with autism spectrum disorder (ASD). Gazefinder is one of Eye-tracking devices and few studies have investigated whether it can measure the gaze data of infants under 12 months of age. We conducted a prospective cross-sectional study from April 2019 to March 2020 in a periodic health checkup in Ohchi County, Shimane, Japan. Read More

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First comprehensive quantification of annual land use/cover from 1990 to 2020 across mainland Vietnam.

Sci Rep 2021 May 11;11(1):9979. Epub 2021 May 11.

Faculty of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8572, Japan.

Extensive studies have highlighted a need for frequently consistent land cover information for interdisciplinary studies. This paper proposes a comprehensive framework for the automatic production of the first Vietnam-wide annual land use/land cover (LULC) data sets (VLUCDs) from 1990 to 2020, using available remotely sensed and inventory data. Classification accuracies ranged from 85. Read More

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Glutamate signaling via the AMPAR subunit GluR4 regulates oligodendrocyte progenitor cell migration in the developing spinal cord.

J Neurosci 2021 May 7. Epub 2021 May 7.

Department of Biology, University of Virginia, Charlottesville, VA 22904, USA

Oligodendrocyte progenitor cells (OPC) are specified from discrete precursor populations during gliogenesis and migrate extensively from their origins, ultimately distributing throughout the brain and spinal cord during early development. Subsequently, a subset of OPCs differentiates into mature oligodendrocytes, which myelinate axons. This process is necessary for efficient neuronal signaling and organism survival. Read More

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Adherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study.

Infect Dis Now 2021 Jun 30;51(4):334-339. Epub 2020 Dec 30.

Hospices Civils de Lyon, Groupement Hospitalier Nord, Hôpital de la Croix-Rousse, Service Pharmacie, 103, Grande Rue de la Croix-Rousse, 69004 Lyon, France; Université Claude Bernard Lyon 1, Lyon, France; University Lyon, Université Claude Bernard Lyon 1, UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France.

Objectives: The management of bone and joint infections (BJI) is complex and requires prolonged antimicrobial therapy. Few data exist on adherence to anti-infectious treatment other than HIV, and none on BJI, even though compliance is considered as a major determinant of clinical outcome. This work aimed at evaluating adherence to oral antimicrobial treatment in patients with BJI. Read More

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