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BMJ Open 2021 Apr 9;11(4):e041861. Epub 2021 Apr 9.

Centre for Children's Burns and Trauma Research, Child Health Research Centre, The University of Queensland, Saint Lucia, Queensland, Australia.

Introduction: Using patient-reported outcome measures (PROMs) with children have been described as 'giving a voice to the child'. Few studies have examined the routine use of these measures as potentially therapeutic interventions. This study aims to investigate: (1) the of feedback using graphical displays of information from electronic PROMs (ePROMs) that target health-related quality of life, to improve health outcomes, referrals and treatment satisfaction and (2) the of ePROMs and graphical displays by assessing acceptability, sustainability, cost, fidelity and context of the intervention and study processes. Read More

BMJ Open 2021 Apr 9;11(4):e041619. Epub 2021 Apr 9.

Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians University Munich, Munich, Germany.

Objectives: To comprehensively map the existing evidence assessing the impact of travel-related control measures for containment of the SARS-CoV-2/COVID-19 pandemic.

Design: Rapid evidence map.

Data Sources: MEDLINE, Embase and Web of Science, and COVID-19 specific databases offered by the US Centers for Disease Control and Prevention and the WHO. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):311-317

Department of Kidney Diseaseand Blood Purification, the Second Hospital of Tianjin Medical University, Tianjin 300211, China. Corresponding author: Wang Lihua, Email:

Objective: To systematically evaluate the predictive value of neutrophil-lymphocyte ratio (NLR) in acute kidney injury (AKI).

Methods: All studies about the predictive effect of NLR on AKI were searched in the National Medical Library of the United States PubMed Database, the Embase database in the Netherlands, the Chinese Biology Medicine disc (CBMdisc) and the Chinese Evidence Based Medicine Cochrane Centre Database (CEBM/CCD). The data updated by October 2020, and regardless of language, region or whether blind method was used. Read More

Prosthet Orthot Int 2021 Feb;45(1):12-19

1School of Architecture, Design and Planning, The University of Sydney, Sydney, NSW, Australia 2EPIC Lab, The Children's Hospital at Westmead, Sydney, NSW, Australia 3University of Sydney School of Health Sciences & Children's Hospital at Westmead, Westmead, Sydney, NSW, 2145, Australia.

Background: The evaluation of ankle-foot orthoses is primarily focused on biomechanical performance, with comparatively less studies pertaining to users' quality of life and experiential factors.

Objectives: To investigate how child users regard acquisition and use of ankle-foot orthoses through the perspectives of child users, parents/carers and practitioners.

Study Design: Inductive content analysis of secondary data. Read More

World J Plast Surg 2021 Jan;10(1):60-65

Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Previous studies in pediatric populations have demonstrated that vitamin D deficiency is common in patients with large burns. The aim of the current comparative study was to investigate the serum level of vitamin D in patients with large burns [>20% total body surface area (TBSA)] after 6 months of therapy.

Methods: This case control study was conducted during 6-month period from 2017 to 2018 in Amiralmomenin Hospital, Shiraz, Iran. Read More

Prostaglandins Leukot Essent Fatty Acids 2021 Mar 31;168:102268. Epub 2021 Mar 31.

Department of Kinesiology, University of Guelph-Humber, Toronto, ON, M9W 5L7, Canada; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G2W1, Canada. Electronic address:

Measuring fatty acid (FA) levels in blood as a risk factor for chronic disease has been studied extensively. Previous research has used either plasma or serum samples to examine these associations. However, whether results from plasma and serum samples can be compared remains unclear, as differences in methodology related to the separation of plasma and serum from whole blood may impact FA levels. Read More

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2481-2492

Department of Burn Plastic Surgery, The Fourth People's Hospital of Jinan, Jinan, Shandong Province, P.R. China.

Objective: Burns are one of the most commonly occurring soft tissue injuries worldwide. It has been reported that burns are associated with a higher prevalence of complications, mortality, and hospitalization-related outcomes in patients with coexisting diabetes mellitus. Moreover, the morbidity and mortality related outcomes associated with diabetes in patients with burns. Read More

J Anim Ecol 2021 Apr 6. Epub 2021 Apr 6.

Department of Zoology, University of Oxford, Oxford, UK.

Approximately 25% of mammals are currently threatened with extinction, a risk that is amplified under climate change. Species persistence under climate change is determined by the combined effects of climatic factors on multiple demographic rates (survival, development and reproduction), and hence, population dynamics. Thus, to quantify which species and regions on Earth are most vulnerable to climate-driven extinction, a global understanding of how different demographic rates respond to climate is urgently needed. Read More

Saudi J Anaesth 2021 Jan-Mar;15(1):33-39. Epub 2021 Jan 5.

Department of Anesthesiology and Critical Care, AIIMS, Rishikesh, India.

Despite our growing knowledge about the COVID pandemic, not much concern has been focused upon the effective pain management in pediatric patients suffering from this SARS CoV2 virus. Symptoms with pain like myalgia (10%-40%), sore throat (5%-30%), headache (14%-40%) and abdominal pain (10%) are common in children suffering from COVID. (3-5) We conducted a systematic review regarding analgesia for COVID positive pediatric patients. Read More

Burns 2021 Feb 20. Epub 2021 Feb 20.

Department of Burns and Plastic Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, Jiangsu Province, China. Electronic address:

Background: Extensive burn injury results in a complex immune response that is associated with mortality and prognosis. Studies on acquired immune and the development of sepsis in burn patients have been reported. However, one of the main cells in innate immune, neutrophil dysfunction in the burn shock stage has not been thoroughly characterized. Read More

Front Nutr 2021 18;8:623336. Epub 2021 Mar 18.

Department of Food, Nutrition, Dietetics and Health, Kansas State University, Manhattan, KS, United States.

Educating and training a multisectoral food systems workforce is a critical part of developing sustainable, resilient, and healthy food and water systems. This paper shares perspectives from a working group of educators, learners, and food systems subject matter experts that collaborated over the course of a year to develop, pilot test, and evaluate two interactive webinar series with a multi-site cohort of dietetics interns and graduate students. The three-part webinar series format included a training webinar, a practice activity, and a synthesis webinar. Read More

Front Oncol 2021 17;11:662318. Epub 2021 Mar 17.

Department of Oncology, Xijing Hospital, Air Force Medical University of PLA, Xian, China.

Background: Previous studies, both and , have established that apatinib has anti-tumor properties. However, insufficient empirical evidence of the efficacy and safety of apatinib has been published for bone and soft tissue sarcoma, the reported results differing widely. Here, we conducted a meta-analysis to assess the efficacy and toxicity of apatinib for the treatment of bone and soft tissue sarcoma. Read More

Front Oncol 2021 17;11:643613. Epub 2021 Mar 17.

Department of Burns and Plastic Surgery, People's Liberation Army (PLA) 960 Hospital, Jinan, China.

Alkylating agents are critical therapeutic options for melanoma, while dacarbazine (DTIC)-based chemotherapy showed poor sensitivity in clinical trials. Long non-coding RNAs (lncRNAs) were highlighted in the progression of malignant tumors in recent years, whereas little was known about their involvement in melanoma. The functional role and molecular mechanism of lncRNA POU3F3 were evaluated on DTIC-resistant melanoma cells. Read More

J Health Pollut 2021 Mar 2;11(29):210306. Epub 2021 Mar 2.

Centre for Environmental Health, Public Health Foundation of India, Institutional Area Gurugram, Delhi, India.

Background: India is the fifth biggest producer of e-waste in the world, discarding 1.7 million tons in 2014. E-waste gets recycled mainly in the informal sector which means activities are largely unaccounted for. Read More

Front Immunol 2021 16;12:644982. Epub 2021 Mar 16.

Medical Center of Hematology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for many hematological disorders and autoimmune diseases, but acute graft-versus-host disease (aGVHD) has remained a major obstacle that limits allo-HSCT and exhibits a daunting mortality rate. The gastrointestinal system is among the most common sites affected by aGVHD. Experimental advances in the field of intestinal microbiota research enhanced our understanding - not only of the quantity and diversity of intestinal microbiota - but also their association with homeostasis of the immune system and disease pathogenesis, including that of aGVHD. Read More

Indian J Plast Surg 2021 Jan 4;54(1):94-96. Epub 2021 Mar 4.

Department of Medicine, St. Philomena's Hospital, Viveknagar, Bangalore, Karnataka, India.

Chemical burns account for a small percentage of burns but contribute to significant number of burn-related mortalities. The major challenge posed by chemical burns is difficulty in correct depth estimation, as the damage continues to progress until they are effectively neutralized. Besides the most common etiology of chemical burns by alkalis and acids, there are many other unique causes of chemical burns. Read More

J Alzheimers Dis 2021 Mar 28. Epub 2021 Mar 28.

Kuakini Medical Center, Honolulu, HI, USA.

Background: Few studies have compared factors related to cognitive function among people with similar genetic backgrounds but different lifestyles.

Objective: We aimed to identify factors related to lower cognitive scores among older Japanese men in two genetically similar cohorts exposed to different lifestyle factors.

Methods: This cross-sectional study of community-dwelling Japanese men aged 71-81 years included 2,628 men enrolled in the Kuakini Honolulu-Asia Aging Study based in Hawaii and 349 men in the Shiga Epidemiological Study of Subclinical Atherosclerosis based in Japan. Read More

Burns 2021 Feb 27. Epub 2021 Feb 27.

US Army Institute of Surgical Research, Joint Base San Antonio, Fort Sam Houston, TX, USA. Electronic address:

Laryngeal inhalation injury carries a significant increase in mortality rate and often indicates immediate airway evaluation. This may be difficult in the setting of clinical deterioration necessitating immediate intubation, which itself can synergistically cause mucosal damage. Prior studies do not encompass predictive factors or long-term outcomes for the laryngotracheal complex. Read More

Burns 2021 Feb 23. Epub 2021 Feb 23.

The Department of Burn, The First Affiliated Hospital of Nanchang University, No. 17 Yong Wai Street, Nanchang 330006, Jiangxi, PR China. Electronic address:

Introduction: Although skin grafts are widely used in reconstruction of large skin defect and complex wounds, many factors lead to suboptimal graft take. Negative-pressure wound therapy (NPWT) reportedly increases the graft take rates when added to skin grafting, but a summary analysis of the data of randomized controlled trials has yet to be performed. We conducted this systematic review and meta-analysis of randomized controlled trials to compare the effectiveness and safety of NPWT and non-NPWT for patients with skin grafts. Read More

Nanomaterials (Basel) 2021 Mar 12;11(3). Epub 2021 Mar 12.

Department of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, 68 Bolshevistskaya str., 430005 Saransk, Russia.

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5-25%) corresponded to 5-6 nm and 10-18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings "BC-ZnO NPs-BDP" was investigated in rats using a burn wound model. Read More

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, MI 49503, USA.

Uterine fibroid tissues are often compared to their matched myometrium in an effort to understand their pathophysiology, but it is not clear whether the myometria of uterine fibroid patients represent truly non-disease control tissues. We analyzed the transcriptomes of myometrial samples from non-fibroid patients (M) and compared them with fibroid (F) and matched myometrial (MF) samples to determine whether there is a phenotypic difference between fibroid and non-fibroid myometria. Multidimensional scaling plots revealed that M samples clustered separately from both MF and F samples. Read More

Cancers (Basel) 2021 Mar 24;13(7). Epub 2021 Mar 24.

Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX 78229, USA.

RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell gene that controls the balance between self-renewal and differentiation. Read More

Int J Environ Res Public Health 2021 03 2;18(5). Epub 2021 Mar 2.

Department of General Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008558, Japan.

The coronavirus disease 2019 (COVID-19) global pandemic has drastically changed how we live and work. Amid the prolonged pandemic, burnout of the frontline healthcare professionals has become a significant concern. We conducted a cross-sectional survey study to provide data about the relationship between the COVID-19 pandemic and the prevalence of burnout in healthcare professionals in Japan. Read More

PLoS One 2021 1;16(4):e0248505. Epub 2021 Apr 1.

Department of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, China.

Background: In recent years, autologous fat grafting (AFG), also known as fat transfer or lipofilling, has been widely performed for periorbital rejuvenation and defect correction, although the evidence regarding its efficacy and safety is still lacking. Besides, with respect to the periorbital region, it is invariably the earliest appearance area of the facial aging phenomenon. Therefore, a systematic review and meta-analysis is needed to evaluate the efficacy and safety of this technique. Read More

Asian Pac Isl Nurs J 2021 ;5(4):236-247

John A. Burns School of Medicine, University of Hawai'i, Hawai'i, United States.

Chronic conditions such as diabetes (DM) and cardiovascular disease are associated with disability and poor quality of life. Asians are 30% more likely than non-Hispanic Whites to develop type 2 DM. The important roles of wearable technological applications or devices in maintaining individuals' motivation to attain their physical activity (PA) goal have been reported. Read More

Clin Cosmet Investig Dermatol 2021 23;14:261-284. Epub 2021 Mar 23.

Institute of Pharmacy, Shaheed Mohtarma Benazir Bhutto (SMBB) Medical University, Larkana, Pakistan.

Introduction: Vitiligo is disfiguring and devastating condition that can humans feel stigmatic and devalued. Melasma is a general condition of hyperpigmentation particularly involving the face. The pigmentation disorders of vitiligo (hypopigmentation or de-pigmentation) and melasma (Hypermelanosis) are common among the world's population (around 1% for vitiligo). Read More

J Immunol 2021 Apr 31;206(8):1817-1831. Epub 2021 Mar 31.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129

merozoite surface protein (MSP)2 is a target of parasite-neutralizing Abs. Inclusion of recombinant MSP2 (rMSP2) as a component of a multivalent malaria vaccine is of interest, but presents challenges. Previously, we used the highly immunogenic MSP8 as a carrier to enhance production and/or immunogenicity of malaria vaccine targets. Read More

J Eat Disord 2021 Mar 31;9(1):41. Epub 2021 Mar 31.

Physical Education and Sports Science, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore, 637616, Singapore.

Background: A sustained mismatch between energy intake and exercise energy expenditure (EEE) can lead to Low Energy Availability (LEA), health and performance impairments characteristic of Relative Energy Deficiency in Sport (RED-S). Questionnaires can conveniently identify symptoms and/or LEA/ RED-S risk factors. This study aimed to systematically identify, and critique questionnaires used or developed to measure LEA/ RED-S risk in athletic populations. Read More

Burns 2021 Feb 25. Epub 2021 Feb 25.

Shriners Hospital for Children-Boston, 51 Blossom Street, Suite 930, Boston, MA, 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA, 02114, USA; Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

The purpose of this systematic literature review is to critically evaluate split-thickness skin graft (STSG) donor-site morbidities. The search of peer-reviewed articles in three databases from January 2009 to July 2019 identified 4271 English-language publications reporting STSG donor-site clinical outcomes, complications, or quality of life. Of these studies, 77 met inclusion criteria for analysis. Read More

Arch Rehabil Res Clin Transl 2021 Mar 16;3(1):100095. Epub 2020 Dec 16.

Texas Woman's University Libraries, Texas Woman's University, Denton, Texas.

Objective: To conduct a scoping review of mobile health (mHealth) application (app) interventions to support needs of adults living with the effects of stroke reported in the literature.

Data Sources: PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Scopus were systematically searched for peer-reviewed publications. Articles were published between January 2007 and September 2020 and met predefined inclusion and exclusion criteria. Read More