J Cosmet Dermatol 2021 May 6. Epub 2021 May 6.
Instituto de Assistência Médica ao Servidor Público Estadual, São Paulo, SP, Brazil.
Background: French maritime pine bark (Pinus pinaster) extract (PBE), the registered trade name of which is Pycnogenol , has been studied for its depigmenting action due to its antioxidant, anti-inflammatory, and anti-melanogenic activity. However, the mechanisms through which PBE are still not fully clear.
Objective: Evaluate the impact of PBE on four in-vitro parameters closely associated with cutaneous pigmentation, including melanin synthesis, tyrosinase activity, endothelin-1 (ED1) and production of peroxisome proliferator-activated receptor α, δ, and γ (PPAR α, δ, and γ), by studying the modulation of action of ultraviolet radiation A (UVA)/ultraviolet radiation B (UVB), infrared-A (IR-A), visible light (VL), and association of UVA/UVB, IR-A, and VL (ASS). Read More