659 results match your criteria studied pre-diabetics

Diabetes: Screening, Diagnosis, and Prevention of Type 2 Diabetes.

Ernestine Lee

FP Essent 2021 May;504:16-21

University of Texas at Austin Dell Medical School Department of Population Health, 1601 Trinity St. Bldg. B Stop Z0500, Austin, TX 78712.

From 2013-2016, 34.5% of US adults had prediabetes. The U. Read More

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Dysautonomia: A Forgotten Condition - Part 1.

Arq Bras Cardiol 2021 Apr;116(4):814-835

Serviço de Eletrofisiologia do Vitória Apart Hospital, Vitória, ES - Brasil.

Dysautonomia covers a range of clinical conditions with different characteristics and prognoses. They are classified as Reflex Syndromes, Postural Orthostatic Tachycardia Syndrome (POTS), Chronic Fatigue Syndrome, Neurogenic Orthostatic Hypotension (nOH) and Carotid Sinus Hypersensitivity Syndrome. Reflex (vasovagal) syndromes will not be discussed in this article. Read More

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Prediabetic Patient Outcomes 8 to 15 Years After Drug-Eluting Coronary Stenting.

Am J Cardiol 2021 Mar 20. Epub 2021 Mar 20.

Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Ohio.

Guidelines suggest differential management of diabetics and nondiabetics with coronary artery disease (CAD) referred for revascularization, but pre-diabetics, who now comprise up to 20% to 30% of CAD patients, have been excluded from the diabetic group. To address this, we studied long-term cardiac outcomes in 1,323 consecutively drug-eluting stent (DES)-stented patients from prespecified local zip codes, dividing patients into normal-glycemic patients, prediabetics and diabetics, based upon conventional definitions. Patient age was 63±11 years, 65. Read More

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Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise.

J Diabetes Res 2021 23;2021:5123241. Epub 2021 Feb 23.

MIMS Research Foundation, Mankavu P.O., Calicut, Kerala 673007, India.

Insulin resistance is a state of impaired responsiveness to insulin action. This condition not only results in deficient glucose uptake but increases the risk for cardiovascular diseases (CVD), stroke, and obesity. The present work investigates the molecular mechanisms of high carbohydrate and fat diet in inducing prediabetic hyperinsulinemia and effect of exercise on InsR signaling events, muscular AChE, and lactate dehydrogenase activity. Read More

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February 2021

Reversion from prediabetes to normoglycaemia after weight change in older persons: The KORA F4/FF4 study.

Nutr Metab Cardiovasc Dis 2021 02 12;31(2):429-438. Epub 2020 Sep 12.

German Center for Diabetes Research (DZD), München, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Background And Aims: In a non-interventional study of older persons, we assessed the impact of changes in BMI and waist circumference (WC) on reversion from glucose- and HbA1c-defined prediabetes to normoglycaemia (in short: reversion) and on persistence of normoglycaemia. Moreover, we studied whether reversion reduced cardiovascular risk.

Methods And Results: From the population-based KORA S4/F4/FF4 cohort study conducted in Southern Germany, we utilized data from the second and third visit to the study center (median follow-up 6. Read More

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February 2021

Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects.

Nutrients 2021 Feb 7;13(2). Epub 2021 Feb 7.

CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029 Madrid, Spain.

Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence of gene-diet interactions on plasma adiponectin levels is still little understood. We analyzed the association between plasma adiponectin levels and various metabolic traits in a high-cardiovascular risk Mediterranean population, as well as the genetic effect of four candidate single-nucleotide polymorphisms (SNPs) in the adiponectin gene () and their interactions with the Mediterranean dietary pattern. Read More

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February 2021

High protein diet leads to prediabetes remission and positive changes in incretins and cardiovascular risk factors.

Nutr Metab Cardiovasc Dis 2021 04 8;31(4):1227-1237. Epub 2020 Dec 8.

Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Background And Aims: High Protein diets may be associated with endocrine responses that favor improved metabolic outcomes. We studied the response to High Protein (HP) versus High Carbohydrate (HC) Diets in terms of incretin hormones GLP-1 and GIP, the hunger hormone ghrelin and BNP, which is associated with cardiac function. We hypothesized that HP diets induce more pronounced release of glucose lowering hormones, suppress hunger and improve cardiac function. Read More

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Evaluation of MASP1, CMPF and U.A serum levels in pre-diabetic subjects in comparison to Normal individuals for early diagnosis of subjects with pre-diabetes, a case-control study.

J Diabetes Metab Disord 2020 Dec 21;19(2):1593-1598. Epub 2020 Nov 21.

Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Background: The present study designed to evaluate the Serum levels of CMPF, MASP1 and UA in pre-diabetic subjects was compared to normal subjects

Methods: This research is a case-control study. We studied 44 pre-diabetics with 44 normal subjects and were evaluated serum concentration of CMPF, Masp1 and U.Ain both groups andfurthermore serum concentration FPG, BUN, Cr, Cho, TG, HDLc, LDLc, AST, ALT, ALP, HbA1c was examined and correlation between of CMPF, Masp1 and U. Read More

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December 2020

Bile acid, glucose, lipid profile, and liver enzyme changes in prediabetic patients 1 year after sleeve gastrectomy.

BMC Surg 2020 Dec 14;20(1):329. Epub 2020 Dec 14.

Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.

Background: Few articles have studied individuals with prediabetes after sleeve gastrectomy. Bile acid and lipid levels remain inconsistent in postbariatric patients. The purpose of this study was to explore bile acid, glucose, lipid, and liver enzyme changes in patients with different diabetes statuses who underwent sleeve gastrectomy. Read More

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December 2020

Clinical Characteristics and Outcomes of Patients With Diabetes Admitted for COVID-19 Treatment in Dubai: Single-Centre Cross-Sectional Study.

JMIR Public Health Surveill 2020 12 7;6(4):e22471. Epub 2020 Dec 7.

Department of Endocrinology, Mediclinic Parkview Hospital, Dubai, United Arab Emirates.

Background: Recent studies have shown that diabetes is a major risk factor that contributes to the severity of COVID-19 and resulting mortality. Poor glycemic control is also associated with poor patient outcomes (eg, hospitalization and death).

Objective: This study aimed to describe the clinical characteristics and outcomes of patients with diabetes who were admitted to our hospital for COVID-19 treatment. Read More

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December 2020

Vitamin E Levels in Ethnic Communities in Malaysia and Its Relation to Glucose Tolerance, Insulin Resistance and Advanced Glycation End Products: A Cross-Sectional Study.

Nutrients 2020 Nov 27;12(12). Epub 2020 Nov 27.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Petaling Jaya 47500, Selangor, Malaysia.

Malaysian national morbidity surveys on diabetic prevalence have shown ethnical variation among prediabetic and diabetic populations. In our attempt to understand this variation, we studied the α-tocopherol, insulin resistance, β-cell function and receptor of advanced glycation end-products (RAGE) levels, as risk factors of type 2 diabetes, among the different ethnicities. In total, 299 subjects of Malay, Chinese, Indian and aboriginal Orang Asli (OA) heritage were recruited from urban and rural areas of Malaysia by stratified random sampling. Read More

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November 2020

High resolution ultrasound imaging for repeated measure of wound tissue morphometry, biomechanics and hemodynamics under fetal, adult and diabetic conditions.

PLoS One 2020 23;15(11):e0241831. Epub 2020 Nov 23.

Department of Surgery, Davis Heart and Lung Research Institute, Center for Regenerative Medicine & Cell-Based Therapies, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America.

Non-invasive, repeated interrogation of the same wound is necessary to understand the tissue repair continuum. In this work, we sought to test the significance of non-invasive high-frequency high-resolution ultrasound technology for such interrogation. High-frequency high-resolution ultrasound imaging was employed to investigate wound healing under fetal and adult conditions. Read More

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January 2021

Insulin sensitivity predicts cognitive decline in individuals with prediabetes.

BMJ Open Diabetes Res Care 2020 11;8(2)

Department of Internal Medicine IV, University Hospital of Tübingen, Tübingen, Germany

Introduction: Epidemiological studies indicate an association between type 2 diabetes and cognitive dysfunction that appear to start already in the prediabetic state. Although cross-sectional studies have linked insulin resistance to impaired cognition, the potential predictive value of insulin resistance has not yet been sufficiently studied longitudinally without confounding by overt diabetes (and its pharmacological treatment).

Research Design And Methods: We investigated longitudinal data from participants of the 'Tübinger Evaluation of Risk Factors for Early Detection of Neurodegeneration' Study. Read More

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November 2020

Timing and Frequency of Daily Energy Intake in Adults with Prediabetes and Overweight or Obesity and Their Associations with Body Fat.

Nutrients 2020 Nov 13;12(11). Epub 2020 Nov 13.

Steno Diabetes Center Copenhagen, DK-2820 Gentofte, Denmark.

Knowledge on how energy intake and macronutrients are distributed during the day and the role of daily eating patterns in body composition among adults with overweight/obesity and prediabetes is lacking. Therefore, we evaluated the diurnal dietary intake and studied the associations of daily eating patterns with body fat percentage. A total of 119 adults with prediabetes were included (mean (SD) HbA 41 (2. Read More

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November 2020

Association of hyperglycaemia with periodontal status: Results of the Northern Finland Birth Cohort 1966 study.

J Clin Periodontol 2021 01 4;48(1):24-36. Epub 2020 Nov 4.

Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.

Aim: To investigate the association of hyperglycaemia and changes in glycaemic control with periodontal status in non-diabetic individuals.

Materials And Methods: A sub-population (n = 647) of the Northern Finland Birth Cohort 1966 was studied. We categorized long-term glucose balance based on fasting plasma glucose (FPG) at ages 31 and 46: FPG <5. Read More

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January 2021

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.

PLoS Genet 2020 09 14;16(9):e1009018. Epub 2020 Sep 14.

Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.

Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes and obesity and insulin resistance. To disentangle whether obesity causally drives prediabetes and insulin resistance already in non-diabetic individuals, we utilized the UK Biobank and METSIM cohort to perform a Mendelian randomization (MR) analyses in the non-diabetic individuals. Our results suggest that both prediabetes and systemic insulin resistance are caused by obesity (p = 1. Read More

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September 2020

The association of statins for secondary prevention with progression to diabetes in patients with prediabetic state after coronary artery bypass graft surgery: A retrospective cohort study.

J Diabetes Complications 2020 12 24;34(12):107713. Epub 2020 Aug 24.

Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Aim: Despite proven benefits of statins for secondary prevention of coronary artery diseases, their diabetogenic effect is still controversial. We aimed to examine the occurrence of type 2 diabetes mellitus (T2DM) in prediabetic patients after coronary artery bypass grafting (CABG).

Methods: The retrospective cohort population comprised of post-CABG patients who were prediabetic at the time of surgery and were taking statins. Read More

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December 2020

Examining the Relationship and Prognostic Implication of Diabetic Status and Extracellular Matrix Expansion by Cardiac Magnetic Resonance.

Circ Cardiovasc Imaging 2020 07 15;13(7):e011000. Epub 2020 Jul 15.

Department of Cardiology, Houston Methodist Hospital, TX (M.A.K., E.Y.Y., D.T.N., F.N., J.H., M.J., S.F.N., E.A.G., D.J.S.).

Background: Although not fully understood, diabetes mellitus is thought to be associated with cardiac fibrosis and stiffness due to alteration of myocardial extracellular matrix. Newer cardiac magnetic resonance techniques may be able to identify extracellular matrix expansion by measuring extracellular volume fraction (ECV). We used cardiac magnetic resonance to evaluate the association of alteration in the extracellular matrix with diabetic status and its implications on incident heart failure events and all-cause mortality. Read More

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Serum Heart Type Fatty Acid Binding Protein Levels in Prediabetes-An Invaluable Cardiovascular Biomarker.

J Assoc Physicians India 2020 Apr;68(4):42-46

Post Graduate Student, Medicine, PGIMER, Dr. RML Hospital.

Background: The pathophysiological effects of diabetes on the heart and the rest of the cardiovascular system begins much earlier in its precedent stage of prediabetes and one major underlying defect is insulin resistance. Heart-type fatty acid binding protein (H-FABP) is a recently studied molecule inherent to the cardiac myocytes found to rise in both coronary and non-coronary heart diseases. The utility of the molecule in prediabetes and its relationship with insulin resistance is being studied. Read More

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Circulating plasma proteins and new-onset diabetes in a population-based study: proteomic and genomic insights from the STANISLAS cohort.

Eur J Endocrinol 2020 Sep;183(3):285-295

Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France.

Objective: Determining the factors associated with new-onset pre-diabetes and type 2 diabetes mellitus (T2D) is important for improving the current prevention strategies and for a better understanding of the disease.

Design: To study the factors (clinical, circulating protein and genetic) associated with new onset pre-diabetes and T2D in an initially healthy (without diabetes) populational familial cohort with a long follow-up (STANISLAS cohort).

Methods: A total of 1506 participants attended both the visit 1 and visit 4, separated by ≈20 years. Read More

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September 2020

Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) Study: design of lifestyle intervention.

BMJ Open Diabetes Res Care 2020 06;8(1)

Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Introduction: Intensive lifestyle intervention (ILI) prevents progression from prediabetes to type 2 diabetes (T2D) but reversal of prediabetes is less well studied.

Research Design And Methods: The overall objectives of the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) Study (ClinicalTrials.gov ID: NCT02027571) are to determine the natural history and reversibility of prediabetes. Read More

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Cell-free long non-coding RNAs (LY86-AS1 & HCG27_201and GAS5) as biomarkers for pre-diabetes and type 2 DM in Egypt.

Biochem Biophys Rep 2020 Sep 2;23:100770. Epub 2020 Jun 2.

Medical Biochemistry & Molecular Biology, Menoufia University, Egypt.

Background: Increasing interest has been focused on lncRNAs as potential markers in the pathogenesis and progression of numerous diseases.

Aim: We aimed to investigate the expression pattern and role of cell-free lncRNAs (GAS5, HCG27_201 and LY86-AS1) in pre-diabetic, diabetic and T2DM groups.

Subjects & Methods: Quantification of the expression level of cell-free lncRNAs (GAS5, HCG27_201 and LY86-AS1) was performed by real-time PCR in 210 individuals classified in diabetic (T2DM), pre-diabetic and control groups. Read More

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September 2020

Supplemental selenium and coenzyme Q10 reduce glycation along with cardiovascular mortality in an elderly population with low selenium status - A four-year, prospective, randomised, double-blind placebo-controlled trial.

J Trace Elem Med Biol 2020 May 4;61:126541. Epub 2020 May 4.

Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.

Background: A low intake of selenium has been shown to increase the risk of cardiovascular mortality, and supplementation of selenium and coenzyme Q10 influences this. The mechanism behind is unclear although effects on inflammation, oxidative stress and microRNA expression have been reported. Fructosamine, a marker of long-term glycaemic control, is also a marker of increased risk of heart disease and death, even in non-diabetics. Read More

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Five-Year Glycemic Trajectories Among Healthy African-American and European-American Offspring of Parents With Type 2 Diabetes.

Am J Med Sci 2020 05 9;359(5):266-270. Epub 2020 Mar 9.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee; General Clinical Research Center, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address:

Background: Cross-sectional surveys report a higher prevalence of diagnosed type 2 diabetes mellitus (T2DM) in African Americans (AA) than European Americans (EA). We studied 5-year glycemic excursions among AA and EA in the Pathobiology of Prediabetes in A Biracial Cohort study, to assess ethnic disparities.

Materials And Methods: Pathobiology of Prediabetes in A Biracial Cohort followed normoglycemic offspring of parents with T2DM for 5 years, with serial assessments of oral glucose tolerance test , anthropometry, body fat, insulin sensitivity and beta-cell function. Read More

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Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life.

Diabetes Care 2020 07 28;43(7):1537-1545. Epub 2020 Apr 28.

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, U.K.

Objective: Type 2 diabetes develops for many years before diagnosis. We aimed to reveal early metabolic features characterizing liability to adult disease by examining genetic liability to adult type 2 diabetes in relation to metabolomic traits across early life.

Research Design And Methods: Up to 4,761 offspring from the Avon Longitudinal Study of Parents and Children were studied. Read More

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Whole Vegetable as a Functional Food Targeting Fat Accumulation and Insulin Resistance-a Preliminary Study in a Mouse Pre-Diabetic Model.

Nutrients 2020 Apr 10;12(4). Epub 2020 Apr 10.

Department of Nutrition and Food Sciences, University of Maryland, College Park, MD 20742, USA.

The shoot of is used in several cultures as a vegetable or herb. However, not much has been studied about the potential of this plant when consumed as a whole food/vegetable rather than an extract for dietary supplements. In a 12-week dietary intervention study, we tested the effect of vegetable on high fat diet induced obesity and insulin resistance in C57BL/6J mice. Read More

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Novel CB1 receptor antagonist BAR-1 modifies pancreatic islet function and clinical parameters in prediabetic and diabetic mice.

Nutr Diabetes 2020 03 4;10(1). Epub 2020 Mar 4.

Unidad de Biomedicina, FES Iztacala, Universidad Nacional Autónoma de México. Av. de Los Barrios 1, Los Reyes Iztacala, C.P., 54090, Tlalnepantla, Mexico.

Backgrouds: Cannabinoid receptor antagonists have been suggested as a novel treatment for obesity and diabetes. We have developed a synthetic cannabinoid receptor antagonist denominated BAR-1. As the function and integrity of a β-cell cellular structure are important keys for diabetes onset, we evaluated the effects of pharmacological administration of BAR-1 on prediabetic and diabetic rodents. Read More

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Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis.

Int J Behav Nutr Phys Act 2020 03 4;17(1):29. Epub 2020 Mar 4.

Engineering East, Swansea University, Fabian Way, Crymlyn Burrows, Skewen, Swansea, Wales, SA1 8EN.

Background: Physical activity, sedentary time and sleep have been shown to be associated with cardio-metabolic health. However, these associations are typically studied in isolation or without accounting for the effect of all movement behaviours and the constrained nature of data that comprise a finite whole such as a 24 h day. The aim of this study was to examine the associations between the composition of daily movement behaviours (including sleep, sedentary time (ST), light intensity physical activity (LIPA) and moderate-to-vigorous activity (MVPA)) and cardio-metabolic health, in a cross-sectional analysis of adults with pre-diabetes. Read More

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Fasting glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans.

Metabolism 2020 04 8;105:154175. Epub 2020 Feb 8.

Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address:

Purpose: Abnormal glucagon concentrations are a feature of prediabetes but it is uncertain if α-cell dysfunction contributes to a longitudinal decline in β-cell function. We therefore sought to determine if a decline in β-cell function is associated with a higher nadir glucagon in the postprandial period or with higher fasting glucagon.

Methods: This was a longitudinal study in which 73 non-diabetic subjects were studied on 2 occasions 6. Read More

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Aspalathin Protects Insulin-Producing β Cells against Glucotoxicity and Oxidative Stress-Induced Cell Death.

Mol Nutr Food Res 2020 04 12;64(8):e1901009. Epub 2020 Feb 12.

Cell Differentiation Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Jette, Brussels, Belgium.

Scope: Aspalathin, the main polyphenolic phytochemical of rooibos (Aspalathus linearis), has been attributed with health promoting properties, including a glucose lowering effect that can prove interesting for application as nutraceutical or therapeutic in (pre-)diabetics. Preservation of β cell mass in the pancreas is considered a key issue for diabetes prevention or treatment, therefore the aim is to investigate whether aspalathin also has β cell cytoprotective potential.

Methods And Results: Rat pancreatic islets and the β cell line Insulinoma 1E (INS1E) are studied in vitro after exposure to various cytotoxic agents, namely streptozotocin (STZ), hydrogen peroxide, or chronic high glucose. Read More

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