156,291 results match your criteria studied populations

Bacillus velezensis strain MBY2, a potential agent for the management of crown gall disease.

PLoS One 2021 15;16(6):e0252823. Epub 2021 Jun 15.

Laboratory of Protection and Improvement of Genetic Resources of Olive, Olive Tree Institute, Tunis, Tunisia.

The reduction of the use chemical pesticides in agriculture is gaining importance as an objective of decision-makers in both politics and economics. Consequently, the development of technically efficient and economically affordable alternatives as, e.g. Read More

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BIO-LGCA: A cellular automaton modelling class for analysing collective cell migration.

PLoS Comput Biol 2021 Jun 15;17(6):e1009066. Epub 2021 Jun 15.

Centre for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.

Collective dynamics in multicellular systems such as biological organs and tissues plays a key role in biological development, regeneration, and pathological conditions. Collective tissue dynamics-understood as population behaviour arising from the interplay of the constituting discrete cells-can be studied with on- and off-lattice agent-based models. However, classical on-lattice agent-based models, also known as cellular automata, fail to replicate key aspects of collective migration, which is a central instance of collective behaviour in multicellular systems. Read More

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Non-Official Language Concordance in Urban Canadian Medical Practice: Implications for Care during the COVID-19 Pandemic.

Healthc Policy 2021 May;16(4):84-96

Professor, Department of Economics, Lakehead University, Thunder Bay, ON.

Language barriers can reduce access to medical and virtual care. Although the topic of healthcare professionals and linguistic minorities has been studied in Canada, it has mainly been done for official languages (i.e. Read More

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Adaptation of Drosophila subobscura chromosomal inversions to climatic variables: the Balkan natural population of Avala.

Genetica 2021 Jun 15;149(3):155-169. Epub 2021 Jun 15.

Departament de Genètica, Microbiologia i Estadística, Secció de Genètica Biomèdica, Evolutiva i Desenvolupament - IRBio (Institut de Recerca per la Biodiversitat), Universitat de Barcelona, Barcelona, Spain.

The adaptive value of chromosomal inversions continues raising relevant questions in evolutionary biology. In many species of the Drosophila genus, different inversions have been recognized to be related to thermal adaptation, but it is necessary to determine to which specific climatic variables the inversions are adaptive. With this aim, the behavior of thermal adapted inversions of Drosophila subobscura regarding climatic variables was studied in the natural population of Avala (Serbia) during the 2014-2017 period. Read More

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A deep convolutional visual encoding model of neuronal responses in the LGN.

Brain Inform 2021 Jun 15;8(1):11. Epub 2021 Jun 15.

Computer and Systems Engineering Department, Faculty of Engineering, Ain Shams University, 1 El-Sarayat St., Abbassia, Cairo, Egypt.

The Lateral Geniculate Nucleus (LGN) represents one of the major processing sites along the visual pathway. Despite its crucial role in processing visual information and its utility as one target for recently developed visual prostheses, it is much less studied compared to the retina and the visual cortex. In this paper, we introduce a deep learning encoder to predict LGN neuronal firing in response to different visual stimulation patterns. Read More

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Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations.

Microb Genom 2021 Jun;7(6)

Institute of Hygiene, University of Münster, Münster, Germany.

The bacterial genotoxin colibactin interferes with the eukaryotic cell cycle by causing dsDNA breaks. It has been linked to bacterially induced colorectal cancer in humans. Colibactin is encoded by a 54 kb genomic region in . Read More

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Colonic Transit Time and Fecal Impaction in Children and Adolescents with Cystic Fibrosis-Associated Constipation.

J Pediatr Gastroenterol Nutr 2021 Jun 11. Epub 2021 Jun 11.

Discipline of Pediatric Gastroenterology, Pediatric Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil, Rua dos Otonis, 839, São Paulo - SP, Brazil, CEP 04025-002 Discipline of Pediatric Specialties, Division of Pediatric Pneumology, Pediatric Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil, Rua Borges Lagoa, 760, São Paulo, SP, Brazil, CEP 04038-002.

Background: Constipation is prevalent in pediatric cystic fibrosis patients and colonic motility has not been studied in this population. In this study, we aimed to evaluate the total and segmental colonic transit time in children and adolescents with cystic fibrosis based on the presence of constipation and radiological fecal impaction.

Methods: In this case series, all patients aged 3 to 20 years of a cystic fibrosis reference center were invited to participate. Read More

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Stock structure analysis of the endemic fish, Barbodes carnaticus (Jerdon 1849), for conservation in a biodiversity hotspot.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

ICAR-Central Institute of Fisheries Education, Mumbai, India.

The population structure of Barbodes carnaticus species was studied using conventional (based on body morphometrics and meristic) and image-based analysis (truss network system) methods. The study was carried out with four stocks, namely Karnataka (KA) and Tamil Nadu (TN) stocks from the River Cauvery, Kerala (KE) stock from the River Chalakudy and farm-reared stock (CI) from Central Institute of Freshwater Aquaculture, Bangalore. A total of 27 morphometric, 9 meristic and 30 truss measurements were used in the study for the stock structure. Read More

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Mathematical modeling of COVID-19 in India and its states with optimal control.

Model Earth Syst Environ 2021 Jun 10:1-16. Epub 2021 Jun 10.

Division of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, India.

A pandemic is an epidemic spread over a huge geographical area. COVID-19 is such pandemic documented after 1918 flu pandemic. In this work, we frame a mathematical epidemic model taking inspiration from the classic SIR model and develop a compartmental model with ten compartments to study the coronavirus dynamics in India and three of its most affected states, namely, Maharashtra, Karnataka, and Tamil Nadu, with inclusion of factors related to face mask efficacy, contact tracing, and testing along with quarantine and isolation. Read More

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Crossing Social Boundaries in an Immigration Context: Exogamy and Gendered Employment Patterns in Unions in Germany.

Gender Issues 2021 Jun 10:1-35. Epub 2021 Jun 10.

Institute for Sociology and Demography, University of Rostock, Rostock, Germany.

We study gendered employment patterns in unions by focusing on the role of exogamy for non-migrants in Germany. Classical assimilation theory has studied such mixed migrant-non-migrant unions mainly with a focus on the members of ethnic minorities. However, this perspective neglects the question of the social consequences of exogamy for the members of the majority group. Read More

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Reconstituting T cell receptor selection in-silico.

Genes Immun 2021 Jun 14. Epub 2021 Jun 14.

Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA.

Each T cell receptor (TCR) gene is created without regard for which substances (antigens) the receptor can recognize. T cell selection culls developing T cells when their TCRs (i) fail to recognize major histocompatibility complexes (MHCs) that act as antigen presenting platforms or (ii) recognize with high affinity self-antigens derived from healthy cells and tissue. While T cell selection has been thoroughly studied, little is known about which TCRs are retained or removed by this process. Read More

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Substrate-Specific Respiration of Isolated Skeletal Muscle Mitochondria after 1 h of Moderate Cycling in Sedentary Adults.

Med Sci Sports Exerc 2021 Jul;53(7):1375-1384

School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR.

Introduction: Skeletal muscle mitochondria have dynamic shifts in oxidative metabolism to meet energy demands of aerobic exercise. Specific complexes oxidize lipid and nonlipid substrates. It is unclear if aerobic exercise stimulates intrinsic oxidative metabolism of mitochondria or varies between substrates. Read More

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Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales.

Am J Cardiol 2021 Jun 11. Epub 2021 Jun 11.

Keele Cardiovascular Research Group, School of Medicine, Keele University, Stoke-on-Trent, United Kingdom; Department of cardiology, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom; Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

We investigated the incidence, management, and outcomes of acute myocardial infarction (AMI) patients according to cardiac arrest location. Patients admitted with a diagnosis of AMI between January 1, 2010 to March 31, 2017 from the Myocardial Ischaemia National Audit Project (MINAP) were studied. We used logistic regression models to evaluate predictors of the clinical outcomes and treatment strategy. Read More

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Interpreting deep learning models for epileptic seizure detection on EEG signals.

Artif Intell Med 2021 Jul 1;117:102084. Epub 2021 May 1.

Embedded Systems Laboratory (ESL), EPFL, Lausanne, Switzerland.

While Deep Learning (DL) is often considered the state-of-the art for Artificial Intel-ligence-based medical decision support, it remains sparsely implemented in clinical practice and poorly trusted by clinicians due to insufficient interpretability of neural network models. We have approached this issue in the context of online detection of epileptic seizures by developing a DL model from EEG signals, and associating certain properties of the model behavior with the expert medical knowledge. This has conditioned the preparation of the input signals, the network architecture, and the post-processing of the output in line with the domain knowledge. Read More

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Substance Use Trajectories: Nonmedical Use (NMU) of Prescription Stimulants via Non-Oral Routes of Administration Among Adults Recruited from Reddit.

CNS Spectr 2021 Apr;26(2):166-167

Syracuse University, Syracuse, NY, USA.

NMU of prescription stimulant medications (RxStim) intended for treatment of attention deficit/hyperactivity disorder (ADHD) is a growing public health concern, particularly when used via non-oral routes of administration. However, the role of non-oral routes of administration for RxStim NMU in the larger substance abuse pathway is less well studied. The purpose of this study was to characterize RxStim NMU and investigate substance use trajectories among adults who reported non-oral RxStim NMU recruited from Reddit. Read More

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Dental markers of biocultural sex differences in an early modern population from Gothenburg, Sweden: caries and other oral pathologies.

BMC Oral Health 2021 Jun 14;21(1):304. Epub 2021 Jun 14.

Department of Cariology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: With the aim to study dental pathological lesions in an early Swedish modern population, with special reference to sex variances of dental caries, the prevalence and distribution of dental caries and tooth wear were determined in complete and partial human dentitions from an early modern-time city graveyard (1500-1620) excavated in Gamlestaden, Gothenburg, Sweden.

Methods: Partial and complete dentitions were examined through visual inspection and using a dental probe. Pathologies were studied, evaluated and presented by teeth and alveoli. Read More

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Antibiotic prescriptions and risk factors for antimicrobial resistance in patients hospitalized with urinary tract infection: a matched case-control study using the French health insurance database (SNDS).

BMC Infect Dis 2021 Jun 14;21(1):571. Epub 2021 Jun 14.

Epidemiology and Modeling of bacterial Evasion to Antibacterials Unit (EMEA), Institut Pasteur, 25-28, Rue du Dr. Roux, 75724, Paris Cedex 15, France.

Background: Antibiotic resistance is increasing among urinary pathogens, resulting in worse clinical and economic outcomes. We analysed factors associated with antibiotic-resistant bacteria (ARB) in patients hospitalized for urinary tract infection, using the comprehensive French national claims database.

Methods: Hospitalized urinary tract infections were identified from 2015 to 2017. Read More

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The bacterial community composition and its environmental drivers in the rivers around eutrophic Chaohu Lake, China.

BMC Microbiol 2021 Jun 14;21(1):179. Epub 2021 Jun 14.

Taihu Laboratory for Lake Ecosystem Research, State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, 210008, Nanjing, China.

Background: Bacterial community play a key role in environmental and ecological processes in river ecosystems. Rivers are used as receiving body for treated and untreated urban wastewaters that brings high loads of sewage and excrement bacteria. However, little is known about the bacterial community structure and functional files in the rivers around the eutrophic Chaohu Lake, the fifth largest freshwater lake in China, has been subjected to severe eutrophication and cyanobacterial blooms over the past few decades. Read More

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Sequence subtyping of from Bonelli's eagle () during four years (2014-2017) reveals that MLS type is associated with lesions.

Avian Pathol 2021 Jun 15:1-58. Epub 2021 Jun 15.

Departament of Animal Health, Faculty of Veterinary Medicine, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain.

Avian trichomonosis is a parasitic disease that affects wild birds, The objective of this work was to determine the importance of avian trichomonosis in Bonelli's eagles to improve conservation measures in this population. One hundred and eighty-eight birds were studied: 181 chicks,, two juveniles, one subadult and four adults. The birds were externally examined and gross lesions at the oropharynx registered. Read More

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Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study.

Diabetes Metab J 2021 Jun 15. Epub 2021 Jun 15.

Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period in subjects with suspected MetS. Read More

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SAXS studies of the thermally-induced fusion of diblock copolymer spheres: formation of hybrid nanoparticles of intermediate size and shape.

Chem Sci 2020 Mar 27;11(17):4312-4321. Epub 2020 Mar 27.

Department of Chemistry, University of Sheffield Dainton Building, Brook Hill Sheffield South Yorkshire S3 7HF UK

Dilute dispersions of poly(lauryl methacrylate)-poly(benzyl methacrylate) (PLMA-PBzMA) diblock copolymer spheres (a.k.a. Read More

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Sarcopenic obesity as a determinant of cardiovascular disease risk in older people-a systematic review.

Postgrad Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Geriatric Medicine, Rotherham General Hospital, Moorgate Road, Rotherham S60 2UD, UK.

Background: Ageing is associated with body composition changes that include a reduction of muscle mass or sarcopenia and an increase in visceral obesity. Thus, ageing involves a muscle-fat imbalance with a shift towards more fat and less muscle. Therefore, sarcopenic obesity, defined as a combination of sarcopenia and obesity, is a global health phenomenon due to the increased ageing of the population combined with the increased epidemic of obesity. Read More

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Patients with schizophrenia have decreased COVID-19 prevalence among hospitalized patients with psychiatric and neurological diseases: a retrospective analysis in Mexican population.

Int J Clin Pract 2021 Jun 14:e14528. Epub 2021 Jun 14.

Laboratorio de Neuropsiquiatría, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Mexico.

Background: Increased COVID-19 incidence and mortality in hospitalized patients with psychiatric and neurologic disorders have been reported.

Methods: The clinical records of 198 patients with psychiatric and neurological disorders hospitalized in the Dr. Rafael Serrano Psychiatric Hospital in Puebla during the peak of the first wave of the COVID-19 pandemic in Mexico were analyzed for psychiatric or neurologic diagnosis, gender, age, medical diagnosis, and COVID-19 prevalence. Read More

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Parasite species variation and impact of spatial displacement of the population on cutaneous leishmaniasis in Rio de Janeiro, Brazil.

Trans R Soc Trop Med Hyg 2021 Jun 14. Epub 2021 Jun 14.

Departamento de Epidemiologia e Métodos Quantitativos em Saúde, Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz, Rua Leopoldo Bulhões, 1480, Manguinhos, Rio de Janeiro, CEP: 21041-210, RJ, Brazil.

Background: Cutaneous leishmaniasis results from complex interactions between human beings, vectors and the environment. Parasitic species differ in epidemiological and geographical contexts.

Methods: We studied a retrospective cohort of 696 patients with cutaneous leishmaniasis treated at a reference centre in the state of Rio de Janeiro, Brazil, between 2000 and 2015. Read More

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Egyptian patients'/guardians' experiences and perception about clinical informed consent and its purpose: Cross sectional study.

PLoS One 2021 14;16(6):e0252996. Epub 2021 Jun 14.

Free-Lancer, Khartoum, Sudan.

Background: Informed consent (IC) is a healthcare standard emphasizing the meaning of human dignity as clarified in the Universal Declaration of Human Rights. Data about IC practices in Egypt is insufficient. This study aimed to assess the Egyptian patients'/guardians' experiences about IC and their expectations about its practices' purposes in general and according to the type of the healthcare facility. Read More

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Ameliorative Role of Nutraceuticals on Neurodegenerative Diseases Using the as a Discovery Model to Define Bioefficacy.

J Am Coll Nutr 2021 Jun 14:1-29. Epub 2021 Jun 14.

School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India.

Neurodegeneration is the destruction of neurons, and once the neurons degenerate they can't revive. This is one of the most concerned health conditions among aged population, more than ∼70% of the elderly people are suffering from neurodegeneration. Among all of the neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's disease (PD) and Poly-glutamine disease (Poly-Q) are the major one and affecting most of the people around the world and posing excessive burden on the society. Read More

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Pioneer plant species and fungal root endophytes in metal-polluted tailings deposited near human populations and agricultural areas in Northern Mexico.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

Departamento El Hombre y su Ambiente, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.

As a consequence of industrial mining activity, high volumes of tailings are scattered around Mexico. Frequently, tailings contain heavy metals (HM) which entail threats against all organisms. The aim of this research was to identify plants and root fungal endophytes in polymetallic polluted tailings with the potential to be used in strategies of bioremediation. Read More

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Survival after radical cystectomy during holiday periods.

Scand J Urol 2021 Jun 14:1-5. Epub 2021 Jun 14.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Objective: For patients undergoing radical cystectomy for bladder cancer, a procedure requiring complex urinary tract reconstruction prone to major postoperative complications, the timing and quality of the surgery have been associated with outcomes.

Patients And Methods: This study investigated if radical cystectomy for bladder cancer performed during holiday periods had worse disease-specific (DSS) and overall survival (OS), higher 90-day mortality and risk of readmissions. All patients operated on with radical cystectomy for primary bladder cancer during 1997-2014 with holiday periods as exposure (with one narrow (7 weeks) and one wider (14 weeks) definition) in the Swedish population-based bladder cancer research-database (BladderBaSe) were studied. Read More

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Impacts of Cognitive Behavioral Therapy for Insomnia and Pain on Sleep in Women with Gynecologic Malignancies: A Randomized Controlled Trial.

Behav Sleep Med 2021 Jun 14:1-17. Epub 2021 Jun 14.

Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida.

Insomnia is an adverse cancer outcome impacting mood, pain, quality of life, and mortality in cancer patients. Cognitive Behavioral Therapy (CBT) is an evidence-based treatment for diverse psychophysiological disorders, including pain and insomnia. Primarily studied in breast cancer, there is limited research on CBT within gynecology oncology. Read More

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High antibody levels against human herpesvirus-6A interact with lifestyle factors in multiple sclerosis development.

Mult Scler 2021 Jun 14:13524585211022011. Epub 2021 Jun 14.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background: Infection with human herpesvirus 6A (HHV-6A) has been suggested to increase multiple sclerosis (MS) risk. However, potential interactions between HHV-6A and environmental/lifestyle risk factors for MS have not previously been studied.

Methods: We used two Swedish population-based case-control studies comprising 5993 cases and 5995 controls. Read More

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