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Expression of the fructose transporter GLUT5 in patients with fructose malabsorption.

Z Gastroenterol 2021 Jun 15;59(6):531-539. Epub 2021 Jun 15.

Specialist Practice for Internal Medicine, Oldenburg, Oldenburg Germany.

Background:  Patients with abdominal symptoms are frequently diagnosed with fructose malabsorption (FM). Fructose is absorbed by monosaccharide transporters located in the brush border of the human small intestine. The aim of this study was to investigate the histoanatomical distribution of the main fructose transporter GLUT5. Read More

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White Matter Hyperintensities after Five-Year Follow-Up and a Cross-Sectional FA Decrease in Bipolar I and Major Depressive Patients.

Neuropsychobiology 2021 Jun 15:1-12. Epub 2021 Jun 15.

Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Introduction: An increase in brain white matter hyperintensities (WMHs) and a decrease in white matter fractional anisotrophy (FA) have been detected in bipolar I (BPI), II (BPII), and major depressive disorder (MDD) patients. Their relationship, and differences in diagnostic groups are obscure. Longitudinal studies are rare. Read More

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Effects of dynamic adsorption on bubble formation and coalescence in partitioned-EDGE devices.

J Colloid Interface Sci 2021 Jun 4;602:316-324. Epub 2021 Jun 4.

Wageningen University, Food Process Engineering Group, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands. Electronic address:

Hypothesis: Dynamic adsorption effects can play a crucial role in bubble formation and stabilization. We hypothesize that microfluidic tools provide direct insights to these effects, and that the final bubble size depends on the intersection of time scales for bubble formation versus adsorption of proteins.

Experiments: We use a microfluidic device to study Laplace pressure-driven formation of bubbles that are stabilized by whey proteins. Read More

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Nitrogen fertilizer affects rhizosphere Cd re-mobilization by mediating gene AmALM2 and AmALMT7 expression in edible amaranth roots.

J Hazard Mater 2021 Jun 6;418:126310. Epub 2021 Jun 6.

Key Laboratory of Environmental Pollution and Health of Guangdong Province, School of Environment, Jinan University, Guangzhou 510632, China. Electronic address:

In-situ stabilization of Cd-contaminated farmland is a commonly used remediation technology. Yet, rhizosphere metabolites (e.g. Read More

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Anti-flagellin IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound murine models in a non-type-specific mode.

Mol Immunol 2021 Jun 12;136:118-127. Epub 2021 Jun 12.

Medicinal Plants Research Center, Shahed University, Tehran, Iran.

Pseudomonas aeruginosa (PA) is one of the most dominant causes of nosocomial infections in burn patients. Increasing emergence of antibiotic-resistant strains highlights the need for novel antimicrobial agents. Flagellin, the main component protein of flagellum, is determined as the major antigen interacting with anti-P. Read More

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Delivery of a spheroids-incorporated human dermal fibroblast sheet increases angiogenesis and M2 polarization for wound healing.

Biomaterials 2021 Jun 7;275:120954. Epub 2021 Jun 7.

School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi, 16419, Republic of Korea. Electronic address:

Low cell engraftment is a major problem in tissue engineering. Although various methods related with cell sheets have been attempted to resolve the issue, low cell viability due to oxygen and nutrient depletion remains an obstacle toward advanced therapeutic applications. Cell therapy using fibroblasts is thought of as a good alternative due to the short doubling times of fibroblasts together with their immunomodulatory properties. Read More

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Comparison of the sorption capacity of basic, acid, direct and reactive dyes by compost in batch conditions.

J Environ Manage 2021 Jun 12;294:113005. Epub 2021 Jun 12.

Department of Soil Science and Agricultural Chemistry, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain. Electronic address:

Research on biosorption of organic dyes is an important subject for the development of clean technologies for the treatment of textile wastewater. In this work, the process of sorption of four textile dyes of different natures, namely Basic Violet 10 (BV10), Acid Red 27 (AR27), Direct Blue 151 (DB151) and Reactive Violet 4 (RV4) onto two composts, pine bark compost and municipal solid waste compost, has been studied. For this, sorption kinetics and equilibrium sorption at different solution pH values (3. Read More

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Indicator of redox in soil (IRIS) films as a water management tool for rice farmers.

J Environ Manage 2021 Jun 12;294:112920. Epub 2021 Jun 12.

Department of Plant and Soil Sciences, 531 S. College Avenue, Townsend Hall Rm 152, University of Delaware, Newark, DE, 19716, USA. Electronic address:

Rice is a crucial part of the world's food supply but is also susceptible to uptake of contaminants including arsenic (As) and cadmium (Cd) depending on the soil redox potential. Careful control of soil redox state by implementing alternate wetting and drying (AWD) water management can decrease mobility of soil As and Cd, but can be difficult to manage. Indicators of reduction in soil (IRIS) tubes and films have been studied by pedologists for wetland delineation; here, we explore the use of the IRIS film technology as passive samplers of soil redox potential in rice paddies. Read More

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Influence of packing material on the biofiltration of butyric acid: A comparative study from a physico-chemical, olfactometric and microbiological perspective.

J Environ Manage 2021 Jun 12;294:113044. Epub 2021 Jun 12.

Department of Inorganic Chemistry and Chemical Engineering, Area of Chemical Engineering, Universidad de Córdoba, Campus Universitario de Rabanales, Carretera N-IV, Km 396, Edificio Marie Curie, 14071, Córdoba, Spain. Electronic address:

The influence of bed material on the odor removal performance of a biofilter was studied. A compost-wood biofilter and a wood biofilter were treated with a gaseous stream contaminated with butyric acid and comparatively evaluated at pilot scale using olfactometric, physico-chemical and microbiological approaches. The variables analyzed in both biofilters were correlated with specific families of their microbiota composition. Read More

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Stroke Mechanism in COVID-19 Infection: A Prospective Case-Control Study.

J Stroke Cerebrovasc Dis 2021 Jun 1;30(8):105919. Epub 2021 Jun 1.

Department of Neurology, Hacettepe University Hospitals Turkey.

Background: The characteristics and pathophysiological mechanisms involved in acute ischemic stroke in patients with COVID-19 infection have not been fully clarified. We prospectively studied the phenotypic and etiological features of acute stroke occurring in COVID-19 infection.

Patients & Methods: Within nine months starting from April-2020, the presence of COVID-19 infection was determined by thoracic CT and SARS-CoV-2 PCR in all acute stroke cases managed in a single tertiary center. Read More

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The effect of femtosecond laser irradiation on the growth kinetics of Staphylococcus aureus: An in vitro study.

J Photochem Photobiol B 2021 Jun 4;221:112240. Epub 2021 Jun 4.

Laser Institute for Research and Applications LIRA, Beni-Suef University, Beni-Suef 62511, Egypt. Electronic address:

We investigated the effect of femtosecond laser irradiation on the growth kinetics of Staphylococcus aureus. In order to improve laser-based antimicrobial therapy and develop a clinically viable modality, various laser parameters such as laser light wavelength, laser power, exposure time, and energy density were studied. The INSPIRE HF100 laser system (Spectra Physics) provided the femtosecond laser light, which was pumped by a mode-locked femtosecond Ti: sapphire laser MAI TAI HP (Spectra Physics). Read More

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Transcatheter aortic valve replacement in bicuspid valves: The synergistic effects of eccentric and incomplete stent deployment.

J Mech Behav Biomed Mater 2021 Jun 7;121:104621. Epub 2021 Jun 7.

Department of Mechanical and Materials Engineering, University of Denver, Denver, CO, USA. Electronic address:

Bicuspid aortic valve is a congenital cardiac anomaly and common etiology of aortic stenosis. Given the positive outcomes of transcatheter aortic valve replacement (TAVR) in low-risk patients, TAVR will become more prevalent in the future in the treatment of severe bicuspid valve stenosis. However, asymmetrical bicuspid valve anatomy and calcification can prevent the circular and complete expansion of transcatheter aortic valves (TAVs). Read More

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Microbial degradation of azo dyes by textile effluent adapted, Enterobacter hormaechei under microaerophilic condition.

Microbiol Res 2021 Jun 9;250:126805. Epub 2021 Jun 9.

Geobiotechnology Laboratory, National College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirapalli, Tamil Nadu, 620001, India; PG and Research Department of Botany, National College (Autonomous), Tiruchirapalli, Tamil Nadu, 620001, India.

Landmark and sustainable eco-friendly dye treatment processes are highly desirous to ameliorate their effect on the environment. The present study investigated the azo dye degradation efficiency of adapted Enterobacter hormaechei SKB 16 from textile effluent polluted soil in optimized culture conditions. The adapted bacteria strain was identified by standard microbiological and molecular techniques. Read More

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Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.

Transl Oncol 2021 Jun 12;14(9):101148. Epub 2021 Jun 12.

Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 Huaihai West Road, Shanghai 200030, PR China. Electronic address:

Although immunotherapy (anti-PD-1/PD-L1 antibodies) has been approved for clinical treatment of lung cancer, only a small proportion of patients respond to monotherapy. Hence, understanding the regulatory mechanism of PD-L1 is particularly important to identify optimal combinations. In this study, we found that inhibition of CDK5 induced by shRNA or CDK5 inhibitor leads to reduced expression of PD-L1 protein in human lung adenocarcinoma cells, while the mRNA level is not substantially altered. Read More

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Effects of semantic variables on word production in aphasia.

Cortex 2021 Apr 20;141:363-402. Epub 2021 Apr 20.

Department of Cognitive Science, Macquarie University, NSW, Australia.

Words differ in the complexity of their semantic representations and their relationships to other words and these differences can be operationalised as a variety of semantic variables. The research presented here investigates how word production in aphasia is influenced by six feature-based semantic variables (number of near semantic neighbours, semantic similarity, number of semantic features, typicality, intercorrelational density, and distinctiveness). Previous research has reported inconsistent findings for some of the semantic variables, while others have not been previously studied in aphasia. Read More

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Micronutrient deficiencies in critical illness.

Clin Nutr 2021 May 11;40(6):3780-3786. Epub 2021 May 11.

Department of Intensive Care Medicine, Gelderse Vallei Hospital, Willy Brandtlaan 10, 6716 RP, Ede, the Netherlands; Division of Human Nutrition and Health, Wageningen University & Research, HELIX (Building 124), Stippeneng 4, 6708 WE, Wageningen, the Netherlands. Electronic address:

Background & Aims: Low micronutrient levels in critical illness have been reported in multiple studies. Because of the antioxidant properties of various micronutrients, micronutrient deficiency may augment oxidative stress in critical illness. However, it remains unclear whether micronutrient concentrations in ICU patients are different from those in healthy age-matched controls. Read More

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Trimethylacetic anhydride-based derivatization facilitates quantification of histone marks at the MS1 level.

Mol Cell Proteomics 2021 Jun 12:100114. Epub 2021 Jun 12.

Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic; Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Electronic address:

Histone post-translational modifications (hPTMs) are epigenetic marks that strongly affect numerous processes, including cell cycling and protein interactions. They have been studied by both antibody- and mass spectrometry-based methods for years, but the analyses are still challenging, mainly due to the diversity of histones and their modifications arising from high contents of reactive amine groups in their amino acid sequences. Here, we introduce use of trimethylacetic anhydride (TMA) as a new reagent for efficient histone derivatization, which is a requirement for bottom-up proteomic hPTM analysis. Read More

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Combining gene expression signature with clinical features for survival stratification of gastric cancer.

Genomics 2021 Jun 12;113(4):2683-2694. Epub 2021 Jun 12.

Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, P.R. China; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, P.R. China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang 310003, P.R. China; Department of Molecular Genetics, University of Toronto, Toronto, ONM5S 1A8, Canada. Electronic address:

The AJCC staging system is considered as the golden standard in clinical practice. However, it remains some pitfalls in assessing the prognosis of gastric cancer (GC) patients with similar clinicopathological characteristics. We aim to develop a new clinic and genetic risk score (CGRS) to improve the prognosis prediction of GC patients. Read More

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Degradation of amoxicillin with sono, photo, and sonophotocatalytic oxidation under low-frequency ultrasound and visible light.

Environ Res 2021 Jun 12;200:111515. Epub 2021 Jun 12.

Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, 400 076, India. Electronic address:

The presence of pharmaceutically active compounds in aquatic bodies is a global concern, and suitable treatment technologies are required. In this study, the efficacy of photocatalytic, sonocatalytic, and sonophotocatalytic oxidation processes for the degradation of amoxicillin (AMX) was investigated using visible light with N doped TiO (N-TiO) nanoparticles as the catalyst and low-frequency ultrasound in a novel multifrequency reactor. The influence of different operational parameters on the extent of AMX degradation was studied. Read More

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Intraspecific variations of the cytoplasmic male sterility genes and in Brassica maurorum and Moricandia arvensis, and the specificity of the mRNA processing.

Genome 2021 Jun 15. Epub 2021 Jun 15.

Dept. Biotech., Fac. Eng., Kyoto Sangyo Univ., Motoyama, Kamigamo, Kyoto, Kyoto, Japan, 603-8555;

The mitochondrial gene co-transcribed with and causes cytoplasmic male sterility in crops, is widely distributed across wild species and genera of . However, intraspecific variations in the presence of have not yet been studied, and the mechanisms for the wide distribution of the gene remain unclear. We analyzed the presence and sequence variations of in two wild species, and . Read More

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Landfast ice: a major driver of reproductive success in a polar seabird.

Biol Lett 2021 Jun 16;17(6):20210097. Epub 2021 Jun 16.

Centre d'Études Biologiques de Chizé (CEBC), CNRS UMR 7372, 79360 Villiers en Bois, France.

In a fast-changing world, polar ecosystems are threatened by climate variability. Understanding the roles of fine-scale processes, and linear and nonlinear effects of climate factors on the demography of polar species is crucial for anticipating the future state of these fragile ecosystems. While the effects of sea ice on polar marine top predators are increasingly being studied, little is known about the impacts of landfast ice (LFI) on this species community. Read More

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Proximal femoral derotation osteotomy in children with CP : long term outcome and the role of age at time of surgery.

Acta Orthop Belg 2021 Mar;87(1):167-173

The femoral derotation osteotomy (FDO) is seen as the golden standard treatment in children with cerebral palsy and internal rotated gait. This study provides quantitative evidence in support of the beneficial effect of FDO after long term follow up. Retrospective clinical and kinematic evaluation of 31 CP patients (55 operated limbs) pre-, 1 and 3 years postoperatively after proximal FDO was conducted for a minimal follow-up of 3 years. Read More

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Functional and radiological outcome after forearm plating in children and adolescent fracture.

Acta Orthop Belg 2021 Mar;87(1):143-149

The literature on forearm overgrowth after plating in traumatic conditions is relatively poor though this technique can be useful when intra-medullary nailing is not sufficient in pediatric cases. The goal of this study was to assess a potential overgrowth after plating and identify impact on function. We conducted a retrospective study of all pediatric patients who underwent open surgery of the radius and/or ulna diaphysis with internal fixation by plating, in our institution, between October 2013 and July 2019. Read More

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Functional outcome of ligament reconstruction with tendon interposition after failed first carpometacarpal joint prosthesis.

Acta Orthop Belg 2021 Mar;87(1):137-142

The purpose is to determine if ligament reconstruction with tendon interposition (LRTI) is a recommendable salvage option for failed total joint prosthesis of the first carpometacarpal joint. Twenty-two patients in our database met the in- clusion criteria for this retrospective study, with at least 6 months follow-up. Fourteen participated and were invited for a clinical examination and asked to fill out two questionnaires. Read More

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The role of homeobox gene-encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model.

J Pineal Res 2021 Jun 15:e12753. Epub 2021 Jun 15.

Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Homeobox genes encode transcription factors controlling development; however, a number of homeobox genes are expressed postnatally specifically in melatonin-producing pinealocytes of the pineal gland and photoreceptors of the retina along with transcripts devoted to melatonin synthesis and phototransduction. Homeobox genes regulate melatonin synthesis in pinealocytes, but some homeobox genes also seem to be involved in regulation of retinal phototransduction. Due to the lack of photoreceptor models, we here introduce rat pinealocyte culture as an in vitro model for studying retinal phototransduction. Read More

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Osmolyte enhanced aqueous two-phase system for virus purification.

Biotechnol Bioeng 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemical Engineering, Michigan Technological University, Houghton, Michigan, USA.

Due to the high variation in viral surface properties, a platform method for virus purification is still lacking. A potential alternative to the high-cost conventional methods is aqueous two-phase systems (ATPSs). However, optimizing virus purification in ATPS requires a large experimental design space, and the optimized systems are generally found to operate at high ATPS component concentrations. Read More

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Long-term Kidney Function and Survival in Recipients of Allografts from Living Kidney Donors with Hypertension: A National Cohort Study.

Transpl Int 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore.

Allografts from living kidney donors with hypertension may carry subclinical kidney disease from the donor to recipient and thus lead to adverse recipient outcomes. We examined eGFR trajectories and all-cause allograft failure in recipients from donors with vs. without hypertension, using mixed-linear and Cox regression models stratified by donor age. Read More

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Multiple in vivo Effects of Cadmium on Photosynthetic Electron Transport in Pea Plants.

Photochem Photobiol 2021 Jun 15. Epub 2021 Jun 15.

Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.

The inhibitory effects of cadmium (CdSO ) on the primary photosynthetic processes were studied in vivo in Pisum sativum by using Multi-function Plant Efficiency Analyser (M-PEA-2). Photosynthetic parameters related to photosystem (PS) II, PS I and intersystem electron carriers were calculated from the light-induced kinetics of prompt chlorophyll a fluorescence (OJIP transient), delayed chlorophyll a fluorescence (DF), and 820 nm modulated reflection (MR). Low-dose exposure to cadmium (20 μM CdSO for 48 h) reduced probability of electron transfer from plastoquinones to the terminal electron acceptors of PSI (δ ) accompanied by a decrease in the rate of P and PC reduction (V ) and the magnitude of the I step on the DF kinetics. Read More

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Bacillus velezensis strain MBY2, a potential agent for the management of crown gall disease.

PLoS One 2021 15;16(6):e0252823. Epub 2021 Jun 15.

Laboratory of Protection and Improvement of Genetic Resources of Olive, Olive Tree Institute, Tunis, Tunisia.

The reduction of the use chemical pesticides in agriculture is gaining importance as an objective of decision-makers in both politics and economics. Consequently, the development of technically efficient and economically affordable alternatives as, e.g. Read More

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The discrepancy between admission and discharge diagnoses: Underlying factors and potential clinical outcomes in a low socioeconomic country.

PLoS One 2021 15;16(6):e0253316. Epub 2021 Jun 15.

Department of Medicine, Section of Internal Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Objective: The discrepancy between admission and discharge diagnosis can lead to possible adverse patient outcomes. There are gaps in integrated studies, and less is understood about its characteristics and effects. Therefore, this study was conducted to determine the frequency, characteristics, and outcomes of diagnostic discrepancies at admission and discharge. Read More

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