732 results match your criteria struma ovarii


Metastatic Malignant Struma Ovarii and Graves' Disease: A Rare Occurrence.

AACE Clin Case Rep 2021 Jul-Aug;7(4):243-246. Epub 2021 Jan 6.

Tan Tock Seng Hospital, Department of Endocrinology, Novena, Singapore.

Objective: Malignant struma ovarii (SO) is a rare condition. Although there have been a few reported cases of malignant SO with coexisting Graves' disease (GD), the exact incidence of metastasis in these cases is not known. We report a rare case of metastatic malignant SO coexisting with GD. Read More

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January 2021

Malignant struma ovarii: From case to analysis.

J Obstet Gynaecol Res 2021 Jul 4. Epub 2021 Jul 4.

Department of Gynecologic Oncology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

Aim: To evaluate the clinico-pathologic features, treatment options, prognostic factors, and survival outcomes of malignant struma ovarii based on a systematic literature review in association with our case study.

Methods: A systematic review of the medical literature was performed to identify articles about malignant struma ovarii from January 1983 until July 2020. We evaluated 178 cases. Read More

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Metastatic malignant struma ovarii: a case report and review of the literature on the management of malignant struma ovarii.

Acta Clin Belg 2021 Jun 30:1-5. Epub 2021 Jun 30.

Department of Endocrinology, AZ Maria Middelares, Ghent, Belgium.

Objectives: To present a case of metastatic struma ovarii, to review the literature on malignant struma ovarii and to discuss the management in locoregional and metastatic disease.

Methods: We present a case of an 82-year-old patient with a malignant struma ovarii and liver metastasis. The patient was treated with pelvic surgery, total thyroidectomy, radioactive iodine therapy and TSH suppression therapy with levothyroxine. Read More

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First case report of papillary thyroid carcinoma arising within a functional teratoma in Graves' disease patient.

Gynecol Endocrinol 2021 Jun 28:1-4. Epub 2021 Jun 28.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei City Hospital, Ren-Ai branch, Taipei, Taiwan.

Aim: Mature cystic teratoma is the most common kind of ovarian germ tumor. However, malignant transformation is uncommon, differentiated thyroid carcinoma is even rare. Hyperthyroidism due to coexistence of Graves' disease (GD) and struma ovarii has been reported. Read More

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Malignant struma ovarii with late recurrence harbouring high microsatellite instability.

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Monter Cancer Center, Medical Oncology and Hematology, Northwell Health, Lake Success, New York, USA

Struma ovarii (SO) is a rare ovarian teratoma containing abundant mature thyroid tissue. Malignant transformation is even less common and distant metastasis is documented in about 5%-10%. The time from diagnosis of primary SO to metastatic disease varies. Read More

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Follicular thyroid carcinoma arising in a struma ovarii and femoral metastasis.

Rev Esp Med Nucl Imagen Mol 2021 May 31. Epub 2021 May 31.

Servicio de Medicina Nuclear, Hospital Meixoeiro (Complejo Hospitalario Universitario de Vigo), Vigo, Pontevedra, España.

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Struma ovarii and peritoneal strumosis during pregnancy.

BMC Pregnancy Childbirth 2021 May 2;21(1):347. Epub 2021 May 2.

Department of Obstetrics and Gynecology, Peking University First Hospital, 100034, Beijing, P.R. China.

Background: Struma ovarii is a special type of ovarian dermoid cyst and accounts for approximately 2-3 % of all dermoid tumours. Benign struma ovarii may manifest as distant metastasis, called peritoneal strumosis, which makes it biologically similar to malignancy, and has been reported in limited cases but never discovered during pregnancy.

Case Presentation: We report a patient with a history of right struma ovarii cystectomy. Read More

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Resolution of hyperthyroidism and thyroid antibodies following struma ovarii resection: an uncommon entity.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Division of Endocrinology, Department of Medicine, The George Washington University, Washington, DC, USA

We report a case of 34-year-old clinically asymptomatic woman who had been followed for 6 years for hyperthyroidism with thyroid stimulating hormone <0.006 uIU/mL, free T4 1.98 ng/mL, free T3 5. Read More

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Clinical characteristics and survival outcomes of malignant struma ovarii confined to the ovary.

BMC Cancer 2021 Apr 9;21(1):383. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China.

Background: Malignant struma ovarii (MSO) is a unique type of ovarian malignancy that data on the survival outcome is limited and management strategy remains controversial due to its extreme rarity.

Methods: To investigate the clinical characteristics and treatment options in patients with MSO confined to the ovary, while also evaluating the recurrent-free survival (RFS) and overall survival (OS) rate in this population, a retrospective study was conducted. One hundred twenty-five cases of MSO confined to the ovary were enrolled and their clinical characteristics, treatment strategies, and results of follow-up were analyzed. Read More

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Recurrent Struma Ovarii Presented with High Levels of Thyroglobulin.

Case Rep Surg 2021 22;2021:8868095. Epub 2021 Mar 22.

417 NIMTS, Veteran Hospital, Athens, Greece.

Struma ovarii are rare ovarian tumors, of monodermal germ cell origin, containing predominantly thyroid tissue. They are typically benign unilateral pelvic masses. Among the rare cases of malignancy, the most common histological type is that of the papillary carcinoma. Read More

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The Clinical and Pathological Characteristics of Malignant Struma Ovarii: An Analysis of 144 Published Patients.

Front Oncol 2021 5;11:645156. Epub 2021 Mar 5.

Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China.

The objective of this study is to summarize the clinical and pathologic characteristics of malignant struma ovarii to facilitate the early diagnosis and treatment of this disease. All 144 patients were females from 27 countries. The mean age of the patients at diagnosis was 42. Read More

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Struma ovarii in bilateral ovarian teratoma-case report and literature review.

J Surg Case Rep 2021 Mar 8;2021(3):rjab028. Epub 2021 Mar 8.

Gynecology and Obstetrics, Centro Hospitalar Tondela-Viseu, 3504-509 Viseu, Portugal.

Struma ovarii is an uncommon ovarian tumour, defined by the finding of thyroid tissue in the ovary, and more frequently found in teratomas. Symptoms of struma ovarii are nonspecific. The definite diagnosis is made by histological examination. Read More

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An unusual case of struma ovarii.

Endocrinol Diabetes Metab Case Rep 2021 Mar 5;2021. Epub 2021 Mar 5.

Department of Internal Medicine IVUniversity Hospital of Munich, LMU Munich, Munich, Germany.

Summary: Struma ovarii is a teratoma of the ovaries predominantly composed of thyroid tissue. Hyperthyroidism associated with struma ovarii is rare, occurring in approximately 8% of cases. Due to the rarity of struma ovarii, available data are limited to case reports and small case series. Read More

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Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.

Arch Gynecol Obstet 2021 04 29;303(4):863-870. Epub 2021 Jan 29.

Department of Gynaecology Oncology, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK.

Purpose: Struma ovarii is rare, accounting for 0.3-1% of ovarian tumours. Malignant transformation may occur, most often into papillary thyroid carcinoma. Read More

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Follicular carcinoma arising from struma ovarii. A case report.

Pathologica 2020 Dec;112(4):224-228

University of Tunis El Manar, Tunis Faculty of Medicine, Tunisia.

Struma ovarii is a monodermal variant of ovarian teratoma. Thyroid-type carcinoma arising in struma ovarii is rare. The most common type is papillary carcinoma, followed by typical follicular carcinoma. Read More

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December 2020

Struma ovarii: two case reports of a rare teratoma of the ovary.

J Surg Case Rep 2020 Dec 7;2020(12):rjaa493. Epub 2020 Dec 7.

Department of Surgical Oncology, Mohammed VI University Hospital, Regional Oncology Center, Oujda, Morocco.

Struma ovarii is an extremely rare type of ovarian teratoma distinguished by the unusual presence of thyroid tissue. It is usually a benign condition; however, malignant transformation is sometimes detected. The diagnosis relies on histopathological examination and is infrequently made on routine investigations. Read More

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December 2020

Metabolic Response by 18F-FDG PET/CT in Metastatic Malignant Struma Ovarii Treated With Targeted Therapies.

Clin Nucl Med 2021 Jan;46(1):52-54

From the Departments of Nuclear Medicine and Endocrine Oncology.

Malignant struma ovarii (MSO) is a rare malignant ovarian tumor, histologically identical to differentiated thyroid cancers. Given the rarity of this disease, there are no treatment guidelines, and the place of imaging for response assessment remains controversial. We report a metabolic response assessed by F-FDG PET/CT in a 71-year-old woman with radioiodine-refractory metastatic MSO treated by targeted therapies (first line with lenvatinib and second line with pazopanib). Read More

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January 2021

FIGO Stage IV and Age Over 55 Years as Prognostic Predicators in Patients With Metastatic Malignant Struma Ovarii.

Front Oncol 2020 29;10:584917. Epub 2020 Sep 29.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Metastatic malignant struma ovarii (MSO) is an extremely rare disease that lacks treatment consensus and accurate prognosis. The objective of this study was to present the clinical, pathological, and treatment characteristics of metastatic MSO, while also investigate the overall survival (OS) rate and factors affecting prognosis in this population. A total of 79 cases of metastatic MSO were reviewed, including four cases of metastatic MSO from our hospital and 75 cases selected from the literature. Read More

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September 2020

Correction to: Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations.

Endocrine 2020 Dec;70(3):661

Pathology Unit, Department of Oncology, University of Turin, via Santena 7, 10126, Turin, Italy.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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December 2020

Methylation profiles of imprinted genes are distinct between mature ovarian teratoma, complete hydatidiform mole, and extragonadal mature teratoma.

Mod Pathol 2021 02 1;34(2):502-507. Epub 2020 Sep 1.

Department of Pathology, Aomori Prefectural Central Hospital, Aomori, Japan.

Mature ovarian teratoma is considered to be a parthenogenetic tumor that arises from a single oocyte/ovum. Conversely, complete hydatidiform mole (CHM) is androgenetic in origin: classic CHM arises from a single or two sperm. Since mature ovarian teratoma and CHM have only maternal and paternal genomes, respectively, their genome imprinting is theoretically reverse, but this has yet to be investigated. Read More

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February 2021

Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges.

Ann Diagn Pathol 2020 Oct 15;48:151584. Epub 2020 Aug 15.

Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

The presence of thyroid tissue outside of the thyroid gland may occur in various clinical settings and anatomic locations and includes both benign and malignant differential diagnoses. Some of these entities include thyroglossal duct cyst, lingual thyroid, parasitic nodule, thyroid tissue within a lymph node and struma ovarii. In routine daily practice, these entities do pose diagnostic challenges for the pathologists. Read More

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October 2020

Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations.

Endocrine 2021 01 2;71(1):216-224. Epub 2020 Aug 2.

Pathology Unit, Department of Oncology, University of Turin, via Santena 7, 10126, Turin, Italy.

Purpose: Struma ovarii (SO) is a highly specialized ovarian teratoma, consisting of thyroid tissue. Rarely, carcinomas histologically identical to their thyroid counterparts may occur, and are comprehensively defined as malignant struma ovarii (MSO). Their optimal management is controversial, and the molecular profile of the malignant counterpart in the ovary is incompletely known. Read More

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January 2021

Complete response of recurrent malignant struma ovarii followed by I therapy.

J Obstet Gynaecol 2021 Jan 9;41(1):152-154. Epub 2020 Jun 9.

Department of Gynaecology and Obstetrics, Perking University First Hospital, Beijing, China.

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January 2021

[Struma ovarii: A rare ovarian tumor to know].

Gynecol Obstet Fertil Senol 2020 11 26;48(11):837-839. Epub 2020 May 26.

Faculté de médecine Paris Descartes, université de Paris, Paris, France; AP-HP, Centre, hôpital Européen Georges-Pompidou, chirurgie cancérologique gynécologique et du sein, Paris, France; Inserm UMR-S 1147, université de Paris, centre universitaire des Saints-Pères, Paris, France.

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November 2020

Papillary Thyroid Carcinoma in Struma Ovarii.

Cureus 2020 Apr 7;12(4):e7582. Epub 2020 Apr 7.

Pathology, Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.

Struma ovarii is a variant of a germ cell tumor composed predominantly of thyroid tissue. It is most often unilateral. The incidence of malignancy arising in patients with struma ovarii is rare. Read More

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Multiple malignant transformations of an ovarian mature cystic teratoma.

Ecancermedicalscience 2020 4;14:1009. Epub 2020 Feb 4.

Department of Gynecologic Oncology, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10021, USA.

Background: Malignant transformation of mature cystic teratomas (MCTs) is a rare phenomenon. The most common histology of a malignant transformation is squamous cell carcinoma, and there are limited reports of multiple malignancies arising in a single MCT. Further data are necessary to guide management of these atypical cases. Read More

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February 2020

Pure T3 thyrotoxicosis from a Struma Ovarii characterised by a paradoxical rise in thyroxine on treatment.

Endocrinol Diabetes Metab Case Rep 2020 Mar 13;2020. Epub 2020 Mar 13.

Department of Endocrinology, Croydon University Hospital, London, UK.

Summary: A 33-year-old female presented with a right 11.6 cm ovarian cyst. Routine pre-operative thyroid function tests showed thyroid stimulating hormone (TSH) of less than 0. Read More

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Immunohistochemical Profile and 47-Gene Next-Generation Sequencing (NGS) Solid Tumor Panel Analysis of a Series of 13 Strumal Carcinoids.

Endocr Pathol 2020 Jun;31(2):101-107

Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr, 55, 45147, Essen, Germany.

Strumal carcinoid is an extraordinary rare tumor of the ovary consisting of thyroid tissue intermixed with neuroendocrine tumor component. The cellular origin of strumal carcinoids has been an area of debate. There is also little data on detailed immunohistochemical and molecular characteristics of these neoplasms. Read More

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Malignant struma ovarii with a robust response to radioactive iodine.

Endocrinol Diabetes Metab Case Rep 2020 Feb 14;2020. Epub 2020 Feb 14.

Cancer Genetics, Kolling Institute of Medical Research, Sydney, New South Wales, Australia.

Summary: Struma ovarii is a rare, usually benign ovarian tumour with malignancy occurring in <5% of cases. Metastases, particularly seeding to bone, are extremely rare. Presentation is variable but often features local pain and/or ascites and hyperthyroidism may occur. Read More

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February 2020