89 results match your criteria structures ness

Protein and Imaging Biomarkers in the Eye for Early Detection of Alzheimer's Disease.

J Alzheimers Dis Rep 2021 May 3;5(1):375-387. Epub 2021 May 3.

Boston University School of Medicine, Department of Ophthalmology, Boston, MA, USA.

Alzheimer's disease (AD) is one of the most common causes of dementia worldwide. Although no formal curative therapy exists for the treatment of AD, considerable research has been performed to identify biomarkers for early detection of this disease, and thus improved subsequent management. Given that the eye can be examined and imaged non-invasively with relative ease, it has emerged as an exciting area of research for evidence of biomarkers and to aid in the early diagnosis of AD. Read More

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Novel method for quantifying cells on carriers and its demonstration during SARS-2 vaccine development.

Biotechnol Bioeng 2021 Jun 10. Epub 2021 Jun 10.

Department of Biotechnology, Israel Institute for Biological Research, Ness Ziona, Israel.

The most effective way to prevent and control infectious disease outbreak is through vaccines. The increasing use of vaccines has elevated the need to establish new manufacturing strategies. One of the major approaches is cell-based production, which creates a need for high cell density to enable higher cell production levels. Read More

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Luminescent Phage-Based Detection of : From Engineering to Diagnostics.

Pharmaceuticals (Basel) 2021 Apr 9;14(4). Epub 2021 Apr 9.

Research Department, BiomX Ltd., Ness Ziona 7414002, Israel.

Bacteriophages ("phages") infect and multiply within specific bacterial strains, causing lysis of their target. Due to the specific nature of these interactions, phages allow a high-precision approach for therapy which can also be exploited for the detection of phage-sensitive pathogens associated with chronic diseases due to gut microbiome imbalance. As rapid phage-mediated detection assays becoming standard-of-care diagnostic tools, they will advance the more widespread application of phage therapy in a precision approach. Read More

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Type 1 Pilus - A Multifunctional Tool for Optimized Host Interaction.

Front Microbiol 2021 9;12:615924. Epub 2021 Feb 9.

FG Protein Biochemistry & Cellular Microbiology, Department of Applied Sciences and Mechatronics, Munich University of Applied Sciences, Munich, Germany.

represents a major Gram-positive human pathogen causing bacterial pneumonia, otitis media, meningitis, and other invasive diseases. Several pneumococcal isolates show increasing resistance rates against antibacterial agents. A variety of virulence factors promote pneumococcal pathogenicity with varying importance in different stages of host infection. Read More

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February 2021

The coronavirus disease 2019 main protease inhibitor from (Burm. f) Ness.

J Adv Pharm Technol Res 2020 Oct-Dec;11(4):157-162. Epub 2020 Oct 10.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.

The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention. (Burm. f) Ness (AP) is naturally used to treat various diseases, including infectious diseases. Read More

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October 2020

Feeding relations: applying Luhmann's operational theory to the food system.

Agric Human Values 2021 Jan 3:1-12. Epub 2021 Jan 3.

Department of International Political Economy, University of Puget Sound, 1500 N. Warner Street, Tacoma, WA 98416 USA.

Current, prevalent models of the food system, including complex-adaptive systems theories and commodity-as-relation thinking, have usefully analyzed the food system in terms of its elements and relationships, confronting persistent questions about a system's identity and leverage points for change. Here, inspired by Heldke's (Monist 101:247-260, 2018) analysis, we argue for another approach to the "system-ness" of food that carries those key questions forward. Drawing on Niklas Luhmann's systems theory, we propose a model of the food system defined by the relational process of feeding itself; that is, the food system is made of feeding and only feeding, and system structures are produced by the coupling of that process to its various contexts. Read More

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January 2021

Quantum simulation investigation of work-function variation in nanowire tunnel FETs.

Nanotechnology 2021 Apr;32(15):150001

School of Electronic Engineering, Xi'an University of Posts and Telecommunications, Xi'an 710121, Shaanxi, People's Republic of China.

The variability induced by the work-function variation (WFV) in p-type ultra-scaled nanowire tunnel FET (TFET) has been studied by using the Non-Equilibrium Green's Function module implemented in University of Glasgow quantum transport simulator called NESS. To provide a thorough insight into the influence of WFV, we have simulated 250 atomistically different nanowire TFETs and the obtained results are compared to nanowire MOSFETs first. Our statistical simulations reveal that the threshold voltage (V ) variations of MOSFETs and TFETs are comparable, whereas the on-current (I ) and off-current (I ) variations of TFETs are smaller and higher, respectively in comparison to the MOSFET. Read More

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Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Sci Rep 2020 11 30;10(1):20808. Epub 2020 Nov 30.

The Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, 69978, Tel Aviv, Israel.

The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C-like protease, 3CLpro) is a potential target for drug design. Crystal and co-crystal structures of the SARS-CoV-2 Mpro have been solved, enabling the rational design of inhibitory compounds. Read More

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November 2020

Nonequilibrium continuous phase transition in colloidal gelation with short-range attraction.

Nat Commun 2020 07 16;11(1):3558. Epub 2020 Jul 16.

Institute of Physics, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, The Netherlands.

The dynamical arrest of attractive colloidal particles into out-of-equilibrium structures, known as gelation, is central to biophysics, materials science, nanotechnology, and food and cosmetic applications, but a complete understanding is lacking. In particular, for intermediate particle density and attraction, the structure formation process remains unclear. Here, we show that the gelation of short-range attractive particles is governed by a nonequilibrium percolation process. Read More

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Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.

Mol Biol Cell 2020 08 10;31(17):1879-1891. Epub 2020 Jun 10.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorigenesis is unclear. Glu571 of CRM1 is located in its nuclear export signal (NES)-binding groove, suggesting that binding of select NESs may be altered. We generated HEK 293 cells with either monoallelic CRM1WT/E571K or biallelic CRM1E571K/E571K using CRISPR/Cas9. Read More

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The Cauxin-femme binary: Femme performativity as a response to violence in Guyana.

Preity R Kumar

J Lesbian Stud 2021 18;25(2):89-106. Epub 2019 Nov 18.

Department of Women's, Gender and Sexuality Studies, The College of New Jersey, NJ, USA.

The Caribbean region has a long history of violence and conflict due to colonization and contemporary neocolonial policies and structures. The region's political, economic, and social climate is overshadowed by activism that centers legal repeal of homophobic laws left intact by colonial powers. These movements have created a polarization between the mainstream groups seeking legal changes, and those who are denied and erased from these discourses. Read More

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[Infections of the eye - what should internal specialists know?]

Dtsch Med Wochenschr 2019 10 8;144(20):1405-1410. Epub 2019 Oct 8.

Klinik für Augenheilkunde, Universitätsklinikum Freiburg.

Infections can affect all structures of the eye. This article focuses on corneal and uveal infections, and on endophthalmitis. The typical pathogens, the signs and symptoms and the therapy are presented. Read More

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October 2019

On-Demand Radial Electrodeposition of Alginate Tubular Structures.

ACS Biomater Sci Eng 2019 Jul 12;5(7):3184-3189. Epub 2019 Jun 12.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, New York 12180, United States.

We present an electrodeposition technique for fabricating tubular alginate structures. In this technique, two electrodes (anode and cathode) are suspended in a solution of alginate and insoluble calcium carbonate particles, and the application of an electrical potential produces a localized pH change at the anode surface causing suspended divalent cations to become soluble and cross-link the alginate. We robustly characterize how the fabrication parameters influence the rate of radial deposition on the anode, including deposition time, applied voltage, alginate concentration, type of divalent cation and concentration, and anode diameter. Read More

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Strategies for interfacing with the trigeminal nerves in rodents for bioelectric medicine.

J Neurosci Methods 2019 08 20;324:108321. Epub 2019 Jun 20.

Department of Biomedical Engineering, University of Wisconsin-Madison, United States; Department of Neurological Surgery, University of Wisconsin-Madison, United States. Electronic address:

Background: Bioelectric medicine seeks to modulate neural activity via targeted electrical stimulation to treat disease. Recent clinical evidence supports trigeminal nerve stimulation as a bioelectric treatment for several neurological disorders; however, the mechanisms of trigeminal nerve stimulation and potential side effects remain largely unknown. The goal of this study is to optimize the methodology and reproducibility of neural interface implantation for mechanistic studies in rodents. Read More

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Are We Opening the Door to a New Era of Medicinal Chemistry or Being Collapsed to a Chemical Singularity?

J Med Chem 2019 11 26;62(22):10026-10043. Epub 2019 Jun 26.

Insilico Medicine Hong Kong Limited (previously Insilico Medicine, Inc.) , Unit 307A, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park , Pak Shek Kok , Hong Kong.

The paradigm of "drug-like-ness" dramatically altered the behavior of the medicinal chemistry community for a long time. In recent years, scientists have empirically found a significant increase in key properties of drugs that have moved structures closer to the periphery or the outside of the rule-of-five "cage". Herein, we show that for the past decade, the number of molecules claimed in patent records by major pharmaceutical companies has dramatically decreased, which may lead to a "chemical singularity". Read More

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November 2019

A novel strategy for rapid screening of the complex triterpene saponin mixture present in the methanolic extract of blackberry leaves (Rubus cv. Loch Ness) by UHPLC/QTOF-MS.

J Pharm Biomed Anal 2019 Feb 7;164:47-56. Epub 2018 Oct 7.

Centre for Metabolomics and Bioanalysis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain. Electronic address:

Triterpene saponins are important chemical constituents in blackberry leaves and have significant antimicrobial activity, among other healthful properties. In this study, a new UHPLC-MS method was optimized with outstanding efficiency for a non-targeted metabolic approach and comprehensive analysis of bioactive compounds in blackberry leaves (Rubus cv. Loch Ness). Read More

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February 2019

Neolignans isolated from twigs of Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity.

J Venom Anim Toxins Incl Trop Dis 2018 27;24:27. Epub 2018 Sep 27.

1Center of Natural Sciences and Humanities, Federal University of ABC (UFBC), Avenida dos Estados 5001, Santo Andre, SP 09210-580 Brazil.

Background: The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). Given these aspects, the search for new compounds based on floristic biodiversity is crucial. In the present work, we report the isolation, characterization and antileishmanial activity of six related neolignans () of bioactive extract from (Lauraceae) twigs. Read More

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September 2018

Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina.

Biomed Opt Express 2018 Jul 28;9(7):3464-3480. Epub 2018 Jun 28.

Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA 02118, USA.

Elastic light scattering spectroscopy (ELSS) has been proven a powerful method in measuring tissue structures with exquisite nanoscale sensitivity. However, ELSS contrast in the living human retina has been relatively underexplored, primarily due to the lack of imaging tools with a large spectral bandwidth. Here, we report a simple all fiber-based setup to implement dual-channel visible and near infrared (NIR) optical coherence tomography (vnOCT) for human retinal imaging, bridging over a 300nm spectral gap. Read More

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A Bayesian Active Learning Experimental Design for Inferring Signaling Networks.

J Comput Biol 2018 07 21;25(7):709-725. Epub 2018 Jun 21.

4 College of Science, College of Computer and Information Science, Northeastern University , Boston, Massachusetts.

Machine learning methods for learning network structure are applied to quantitative proteomics experiments and reverse-engineer intracellular signal transduction networks. They provide insight into the rewiring of signaling within the context of a disease or a phenotype. To learn the causal patterns of influence between proteins in the network, the methods require experiments that include targeted interventions that fix the activity of specific proteins. Read More

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A Systems Approach to Evaluate One Health Initiatives.

Front Vet Sci 2018 9;5:23. Epub 2018 Mar 9.

Royal Veterinary College, London, United Kingdom.

Challenges calling for integrated approaches to health, such as the One Health (OH) approach, typically arise from the intertwined spheres of humans, animals, and ecosystems constituting their environment. Initiatives addressing such wicked problems commonly consist of complex structures and dynamics. As a result of the EU COST Action (TD 1404) "Network for Evaluation of One Health" (NEOH), we propose an evaluation framework anchored in systems theory to address the intrinsic complexity of OH initiatives and regard them as subsystems of the context within which they operate. Read More

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Lesions of the central amygdala and ventromedial medulla reduce bladder hypersensitivity produced by acute but not chronic foot shock.

Brain Res 2017 Nov 1;1675:1-7. Epub 2017 Sep 1.

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address:

Both acute and chronic stress has been shown to exacerbate symptoms of chronic visceral pain conditions such as interstitial cystitis. Studies using animal models support these findings in that both acute and chronic exposure to foot shock-induced stress (FS) augment nociceptive reflex responses to urinary bladder distension (UBD). Only a few studies have examined the neural substrates mediating these phenomena and it is not clear whether acute and chronic stress engage the same or different substrates to produce bladder hypersensitivity. Read More

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November 2017

Oscillatory rheology of dense, athermal suspensions of nearly hard spheres below the jamming point.

Soft Matter 2017 May 28;13(19):3664-3674. Epub 2017 Apr 28.

Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK.

The viscosity of a dense suspension has contributions from hydrodynamics and particle interactions, both of which depend upon the flow-induced arrangement of particles into fragile structures. Here, we study the response of nearly hard sphere suspensions to oscillatory shear using simulations and experiments in the athermal, non-inertial limit. Three distinct regimes are observed as a function of the strain amplitude γ. Read More

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Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.

Elife 2017 03 10;6. Epub 2017 Mar 10.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.

Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015). Read More

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Pseudodirect to Direct Compositional Crossover in Wurtzite GaP/InGaP Core-Shell Nanowires.

Nano Lett 2016 12 1;16(12):7930-7936. Epub 2016 Dec 1.

Department of Applied Physics, Eindhoven University of Technology , 5600 MB Eindhoven, The Netherlands.

Thanks to their uniqueness, nanowires allow the realization of novel semiconductor crystal structures with yet unexplored properties, which can be key to overcome current technological limits. Here we develop the growth of wurtzite GaP/InGaP core-shell nanowires with tunable indium concentration and optical emission in the visible region from 590 nm (2.1 eV) to 760 nm (1. Read More

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December 2016

Chemoselective N-Difluoromethylation of Functionalized Tertiary Amines.

J Org Chem 2016 10 19;81(19):9180-9187. Epub 2016 Sep 19.

The Department of Organic Chemistry, Israel Institute for Biological Research , Ness-Ziona 74100, Israel.

A practical, convenient, and general method for the difluoromethylation of tertiary amines, using diethyl bromodifluoromethylphosphonate and fluoride, is described. This commercially available phosphonate smoothly reacts with a fluoride ion to liberate a difluorocarbene intermediate that in the presence of a proton source and a tertiary amine generates the corresponding α-difluoromethylammonium compound in good to excellent yields. Despite the involvement of a difluorocarbene intermediate, this difluoromethylation occurs almost exclusively on the nitrogen atom with diverse molecular structures, including drugs, surfactants, chiral phase transfer catalysts, polymers, ionic liquids, and other fine chemicals. Read More

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October 2016

Structure-Function Correlation of Aminated Poly(α)glutamate as siRNA Nanocarriers.

Biomacromolecules 2016 09 2;17(9):2787-800. Epub 2016 Aug 2.

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Room 607, Tel Aviv University , Tel Aviv 69978, Israel.

It has been two decades since cationic polymers were introduced to the world of oligonucleotides delivery. However, the optimal physicochemical properties to make them a successful delivery vehicle are yet unknown. An ideal system became particularly interesting and necessary with the introduction of RNA interference as a promising therapeutic approach. Read More

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September 2016

Bladder Distension Increases Blood Flow in Pain Related Brain Structures in Subjects with Interstitial Cystitis.

J Urol 2016 Sep 24;196(3):902-10. Epub 2016 Mar 24.

Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Purpose: In healthy control subjects certain brain regions of interest demonstrate increased regional cerebral blood flow in response to painful stimuli. We examined the effect of bladder distension on arterial spin label functional magnetic resonance imaging measures of regional cerebral blood flow in regions of interest in subjects with interstitial cystitis.

Materials And Methods: A total of 11 female subjects with interstitial cystitis and 11 healthy controls underwent 3 brain perfusion scan studies using arterial spin label functional magnetic resonance imaging, including 1) with a full bladder, 2) with an empty bladder and 3) while experiencing heat pain. Read More

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September 2016

Network nestedness as generalized core-periphery structures.

Sang Hoon Lee

Phys Rev E 2016 Feb 19;93(2):022306. Epub 2016 Feb 19.

School of Physics, Korea Institute for Advanced Study, Seoul 02455, Korea.

The concept of nestedness, in particular for ecological and economical networks, has been introduced as a structural characteristic of real interacting systems. We suggest that the nestedness is in fact another way to express a mesoscale network property called the core-periphery structure. With real ecological mutualistic networks and synthetic model networks, we reveal the strong correlation between the nestedness and core-periphery-ness (likeness to the core-periphery structure), by defining the network-level measures for nestedness and core-periphery-ness in the case of weighted and bipartite networks. Read More

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February 2016

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.

J Am Chem Soc 2016 Mar 21;138(12):3966-9. Epub 2016 Mar 21.

Department of Biology, University of Copenhagen , 2200 Copenhagen, Denmark.

The formation of reactive oxygen species (ROS) is linked to the pathogenesis of neurodegenerative diseases. Here we have investigated the effect of soluble and aggregated amyloid-β (Aβ) and α-synuclein (αS), associated with Alzheimer's and Parkinson's diseases, respectively, on the Cu(2+)-catalyzed formation of ROS in vitro in the presence of a biological reductant. We find that the levels of ROS, and the rate by which ROS is generated, are significantly reduced when Cu(2+) is bound to Aβ or αS, particularly when they are in their oligomeric or fibrillar forms. Read More

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