70,321 results match your criteria structure suggests


Binding Analysis of Functionalized Multimode Optical-Fiber Sandwich-like Structure with Organic Polymer and Its Sensing Application for Humidity and Breath Monitoring.

Biosensors (Basel) 2021 Sep 8;11(9). Epub 2021 Sep 8.

Departamento de Alimentos, Centro Interdisciplinario del Noreste (CINUG), Universidad de Guanajuato, Tierra Blanca, Guanajuato 37975, Mexico.

In recent years, the chemical modification of optical fibers (OFs) has facilitated the manufacture of sensors because OFs can identify several analytes present in aqueous solutions or gas phases. Nevertheless, it is imperative better to understand the chemical interactions in this molecular system to generate low-cost and efficient sensors. This work presents a theoretical and experimental study of organic polymeric functionalized OF structures and proposes a cost-effective alternative to monitor breathing and humidity. Read More

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September 2021

A taxonomy and framework for identifying and developing actionable statements in guidelines suggests avoiding informal recommendations.

J Clin Epidemiol 2021 Sep 22. Epub 2021 Sep 22.

Public Health Agency of Canada, Canada.

Objectives: To propose a taxonomy and framework that identifies and presents actionable statements in guidelines.

Study Design And Setting: We took an iterative approach reviewing case studies of guidelines produced by the World Health Organization and the American Society of Hematology to develop an initial conceptual framework. We then tested it using randomly selected recommendations from published guidelines addressing COVID-19 from different organizations, evaluated its results, and refined it before retesting. Read More

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September 2021

Facial structure and perception of sexual orientation: Research with face models based on photographs of real people.

Int J Psychol 2021 Sep 25. Epub 2021 Sep 25.

Department of Basic and Clinical Psychology and Psychobiology, University Jaume I, Castellón, Spain.

Some evidence suggests that lay persons are able to perceive sexual orientation from face stimuli above the chance level. A morphometric study of 390 heterosexual and homosexual Canadian people of both sexes reported that facial structure differed depending on the sexual orientation. Gay and heterosexual men differed on three metrics as the most robust multivariate predictors, and lesbian and heterosexual women differed on four metrics. Read More

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September 2021

Molecular Dynamics Simulations and Experimental Results Provide Insight into Clinical Performance Differences between Sandimmune® and Neoral® Lipid-Based Formulations.

Pharm Res 2021 Sep 24. Epub 2021 Sep 24.

Monash Institute of Pharmaceutical Sciences, Melbourne, Australia.

Objective: Molecular dynamics (MD) simulations provide an in silico method to study the structure of lipid-based formulations (LBFs) and the incorporation of poorly water-soluble drugs within such formulations. In order to validate the ability of MD to effectively model the properties of LBFs, this work investigates the well-known cyclosporine A formulations, Sandimmune® and Neoral®. Sandimmune® exhibits poor dispersibility and its absorption from the gastrointestinal tract is enhanced when administered after food, whereas Neoral® disperses comparatively well and shows no food effect. Read More

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September 2021

Sedimentary supply of humic-like fluorescent dissolved organic matter and its implication for chemoautotrophic microbial activity in the Izu-Ogasawara Trench.

Sci Rep 2021 Sep 24;11(1):19006. Epub 2021 Sep 24.

Physical and Chemical Oceanography Research Group, Global Ocean Observation Research Center, Research Institute for Global Change, Japan Agency for Marine-Earth Science and Technology, Yokosuka, Japan.

Microbial community structure in the hadal water is reported to be different from that in the upper abyssal water. However, the mechanism governing the difference has not been fully understood. In this study, we investigate the vertical distributions of humic-like fluorescent dissolved organic matter (FDOM), chemoautotrophic production, apparent oxygen utilization (AOU), and N* in the Izu-Ogasawara Trench. Read More

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September 2021

Transcriptional and cellular signatures of cortical morphometric remodelling in chronic pain.

Pain 2021 Sep 23. Epub 2021 Sep 23.

Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School Wolfson CARD, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE1 1UL.

Abstract: Chronic pain is a highly debilitating and difficult to treat condition, which affects the structure of the brain. While the development of chronic pain is moderately heritable, how disease-related alterations at the microscopic genetic architecture drive macroscopic brain abnormalities is currently largely unknown. Here, we examined alterations in morphometric similarity (MS) and applied an integrative imaging transcriptomics approach to identify transcriptional and cellular correlates of these MS changes, in three independent small cohorts of patients with distinct chronic pain syndromes (knee osteoarthritis, low back pain and fibromyalgia) and age and sex-matched pain-free controls. Read More

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September 2021

Computational study on novel natural inhibitors targeting c-MET.

Medicine (Baltimore) 2021 Sep;100(38):e27171

Department of Oncology, First People's Hospital of Xinxiang, Xinxiang, China.

Abstract: This study was designed to select ideal lead compounds and preclinical drug candidates http://dict.youdao.com/w/eng/preclinical_drug_candidate/javascript:void (0); with inhibitory effect on c-MET from the drug library (ZINC database). Read More

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September 2021

Flanker: a tool for comparative genomics of gene flanking regions.

Microb Genom 2021 Sep;7(9)

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Analysing the flanking sequences surrounding genes of interest is often highly relevant to understanding the role of mobile genetic elements (MGEs) in horizontal gene transfer, particular for antimicrobial-resistance genes. Here, we present Flanker, a Python package that performs alignment-free clustering of gene flanking sequences in a consistent format, allowing investigation of MGEs without prior knowledge of their structure. These clusters, known as 'flank patterns' (FPs), are based on Mash distances, allowing for easy comparison of similarity across sequences. Read More

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September 2021

Network structure of swollen iodine-doped poly(vinyl alcohol) amorphous domain as characterized by low field NMR.

Soft Matter 2021 Sep 24. Epub 2021 Sep 24.

National Synchrotron Radiation Laboratory, Anhui Provincial Engineering Laboratory of Advanced Functional Polymer Film, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei 230026, China.

The network structure in the amorphous domain of swollen iodine-doped poly(vinyl alcohol) (PVA) was systematically investigated by low-field (LF) NMR techniques to reveal the PVA-iodine complex formation mechanism. Three PVA-iodine complexes were obtained under different iodine concentrations () of KI/I solution: (i) < 0.1 M: PVA-I/I complex only exists in the non-crystalline region, (ii) 0. Read More

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September 2021

Genomic Analyses Revealed the Genetic Difference and Potential Selection Genes of Growth Traits in Two Duroc Lines.

Front Vet Sci 2021 7;8:725367. Epub 2021 Sep 7.

College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.

Duroc pigs are famous for their high growth rate, feed conversion efficiency, and lean meat percentage. Given that they have been subjected to artificial selection and breeding in multiple countries, various lines with obvious differences in production performance have formed. In this study, we genotyped 3,770 American Duroc (AD) pigs and 2,098 Canadian Duroc (CD) pigs using the GeneSeek Porcine SNP50 Beadchip to dissect the genetic differences and potential selection genes of growth traits in these two Duroc pig lines. Read More

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September 2021

Systematic Analysis of the Impact of R-Methylation on RBPs-RNA Interactions: A Proteomic Approach.

Front Mol Biosci 2021 7;8:688973. Epub 2021 Sep 7.

Laboratory of Nuclear Proteomics to Study Gene Expression Regulation in Cancer, European Institute of Oncology (IEO) IRCSS, Department of Experimental Oncology (DEO), Milan, Italy.

RNA binding proteins (RBPs) bind RNAs through specific RNA-binding domains, generating multi-molecular complexes known as ribonucleoproteins (RNPs). Various post-translational modifications (PTMs) have been described to regulate RBP structure, subcellular localization, and interactions with other proteins or RNAs. Recent proteome-wide experiments showed that RBPs are the most representative group within the class of arginine (R)-methylated proteins. Read More

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September 2021

Species diversity and community structure of crustacean zooplankton in the highland small waterbodies in Northwest Yunnan, China.

PeerJ 2021 2;9:e12103. Epub 2021 Sep 2.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.

Small waterbodies are a unique aquatic ecosystem with an increasing recognition for their important role in maintaining regional biodiversity and delivering ecosystem services. However, small waterbodies in Northwest Yunnan, one of the most concerned global biodiversity hot-spots, remain largely unknown. Here, we investigated the community structure of crustacean zooplankton and their relationships with limnological, morphometric and spatial variables in the highland small waterbodies in Northwest Yunnan in both the dry (October 2015) and rainy (June 2016) seasons. Read More

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September 2021

Weak spatial-genetic structure in a native invasive, the southern pine beetle (), across the eastern United States.

PeerJ 2021 2;9:e11947. Epub 2021 Sep 2.

Northern Research Station, USDA Forest Service, Hamden, CT, United States of America.

The southern pine beetle, is a native pest of pine trees that has recently expanded its range into the northeastern United States. Understanding its colonization, dispersal, and connectivity will be critical for mitigating negative economic and ecological impacts in the newly invaded areas. Characterization of spatial-genetic structure can contribute to this; however, previous studies have reached different conclusions about regional population genetic structure, with one study reporting a weak east-west pattern, and the most recent reporting an absence of structure. Read More

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September 2021

Species co-occurrence and management intensity modulate habitat preferences of forest birds.

BMC Biol 2021 Sep 23;19(1):210. Epub 2021 Sep 23.

Chair of Wildlife Ecology and Management, University of Freiburg, Tennenbacher Str. 4, 79106, Freiburg, Germany.

Background: Species co-occurrences can have profound effects on the habitat use of species, and therefore habitat structure alone cannot fully explain observed abundances. To account for this aspect of community organization, we developed multi-species abundance models, incorporating the local effect of co-occurring and potentially associated species, alongside with environmental predictors, linked mainly to forest management intensity. We coupled it with a landscape-scale analysis to further examine the role of management intensity in modifying the habitat preferences in connection with the landscape context. Read More

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September 2021

Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression.

Transl Oncol 2021 Sep 21;14(12):101219. Epub 2021 Sep 21.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China. Electronic address:

Background: It has been known for decades that circRNAs are deregulated in cancer. Here, we characterized the role and underlying mechanism of circ_0088212 in osteosarcoma.

Methods: The expression levels of circ_0088212, miR-520 h, and APOA1 were determined by RT-qPCR. Read More

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September 2021

The relationship between plasma free fatty acids, cognitive function and structural integrity of the brain in middle-aged healthy humans.

Aging (Albany NY) 2021 Sep 23;13(undefined). Epub 2021 Sep 23.

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria.

Background: The cerebral composition of ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) is believed to influence cognitive function and structural damage of the aging brain. However, existing data is inconsistent.

Materials And Methods: This retrospective study explored the association between free plasma PUFA concentrations, cognitive function and brain structure atrophy in a well-characterized community-dwelling cohort of elderly individuals without stroke and dementia. Read More

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September 2021

Integrative Chemical Biology Approaches to Deciphering the Histone Code: A Problem-Driven Journey.

Acc Chem Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 999077 China.

ConspectusThe hereditary blueprint of a eukaryotic cell is encoded in its genomic DNA that is tightly compacted into chromatin together with histone proteins. The basic repeating units of chromatin fibers are nucleosomes, in which approximately 1.7 turns of DNA wrap around a proteinaceous octamer consisting of two copies of histones H2A, H2B, H3, and H4. Read More

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September 2021

Influence of European Beech (Fagales: Fagaceae) Rot Hole Habitat Characteristics on Invertebrate Community Structure and Diversity.

J Insect Sci 2021 Sep;21(5)

School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.

Hollows of veteran trees (i.e., rot holes) provide habitat for many rare and threatened saproxylic invertebrates. Read More

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September 2021

Early Response to Dehydration Six-Like Transporter Family: Early Origin in Streptophytes and Evolution in Land Plants.

Front Plant Sci 2021 6;12:681929. Epub 2021 Sep 6.

Laboratoire Ecologie et Biologie des Interactions, UMR Centre National de la Recherche Scientifique 7267, Université de Poitiers, Poitiers, France.

Carbon management by plants involves the activity of many sugar transporters, which play roles in sugar subcellular partitioning and reallocation at the whole organism scale. Among these transporters, the early response to dehydration six-like (ESL) monosaccharide transporters (MSTs) are still poorly characterized although they represent one of the largest sugar transporter subfamilies. In this study, we used an evolutionary genomic approach to infer the evolutionary history of this multigenic family. Read More

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September 2021

Structural basis of gating modulation of Kv4 channel complexes.

Nature 2021 Sep 22. Epub 2021 Sep 22.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Modulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the physiological function of channels in the brain and heart. Native Kv4 tetrameric channels form macromolecular ternary complexes with two auxiliary β-subunits-intracellular Kv channel-interacting proteins (KChIPs) and transmembrane dipeptidyl peptidase-related proteins (DPPs)-to evoke rapidly activating and inactivating A-type currents, which prevent the backpropagation of action potentials. However, the modulatory mechanisms of Kv4 channel complexes remain largely unknown. Read More

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September 2021

Structure and stability of the designer protein WRAP-T and its permutants.

Sci Rep 2021 Sep 22;11(1):18867. Epub 2021 Sep 22.

Laboratory of Biomolecular Modelling and Design, Department of Chemistry, KU Leuven, 3001, Leuven, Belgium.

[Formula: see text]-Propeller proteins are common natural disc-like pseudo-symmetric proteins that contain multiple repeats ('blades') each consisting of a 4-stranded anti-parallel [Formula: see text]-sheet. So far, 4- to 12-bladed [Formula: see text]-propellers have been discovered in nature showing large functional and sequential variation. Using computational design approaches, we created perfectly symmetric [Formula: see text]-propellers out of natural pseudo-symmetric templates. Read More

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September 2021

One year incubation of pyrite at the deep seafloor and its microbiological and biogeochemical characterizations.

Appl Environ Microbiol 2021 Sep 22:AEM0097721. Epub 2021 Sep 22.

Institute for Extra-cutting-edge Science and Technology Avant-garde Research (X-star), Japan Agency for Marine-Earth Science & Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan.

In this study, we performed a year-long incubation experiment of a common ferrous sulfide (Fe-S) mineral, pyrite, at the oxidative deep seafloor in the hydrothermal vent field in the Izu-Bonin arc, Japan, and characterized its microbiological and biogeochemical properties to understand the microbial alteration processes of the pyrite, focusing on the Fe(II) oxidation. The microbial community analysis of the incubated pyrite showed that the domain heavily dominated over compared with that of the ambient seawater, and and distinctively co-dominated at the class level. The mineralogical characterization by surface-sensitive Fe X-ray absorption near-edge structure (XANES) analysis revealed that specific Fe(III) hydroxides (schwertmannite and ferrihydrite) were locally formed at the pyrite surface as the pyrite alteration products. Read More

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September 2021

Structural and electronic analysis of the octarepeat region of prion protein with four Cu by polarizable MD and QM/MM simulations.

Phys Chem Chem Phys 2021 Sep 22. Epub 2021 Sep 22.

Department of Chemistry, University of North Texas, Denton, Texas, 76201, USA.

Prions have been linked to neurodegenerative diseases that affect various species of mammals including humans. The prion protein, located mainly in neurons, is believed to play the role of metal ion transporter. High levels of copper ions have been related to structural changes. Read More

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September 2021

Dengue virus serotype 1 conformational dynamics confers virus strain-dependent patterns of neutralization by polyclonal sera.

J Virol 2021 Sep 22:JVI0095621. Epub 2021 Sep 22.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Dengue virus co-circulates globally as four serotypes (DENV1-4) that vary up to 40% at the amino acid level. Viral strains within a serotype further cluster into multiple genotypes. Eliciting a protective tetravalent neutralizing antibody response is a major goal of vaccine design, and efforts to characterize epitopes targeted by polyclonal mixtures of antibodies are ongoing. Read More

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September 2021

pH-Dependent complexation and polyelectrolyte chain conformation of polyzwitterion-polycation coacervates in salted water.

Soft Matter 2021 Sep 22. Epub 2021 Sep 22.

Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI 48202, USA.

The phase behavior and chain conformational structure of biphasic polyzwitterion-polyelectrolyte coacervates in salted aqueous solution are investigated with a model weak cationic polyelectrolyte, poly(2-vinylpyridine) (P2VP), whose charge fraction can be effectively tuned by pH. It is observed that increasing the pH leads to the increase of the yielding volume fraction and the water content of dense coacervates formed between net neutral polybetaine and cationic P2VP in contrast to the decrease of critical salt concentration for the onset of coacervation, where the P2VP charge fraction is reduced correspondingly. Surprisingly, a single-molecule fluorescence spectroscopic study suggests that P2VP chains upon coacervation seem to adopt a swollen or an even more expanded conformational structure at higher pH. Read More

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September 2021

Skin adhesion to the percutaneous component of direct bone anchored systems: systematic review on preclinical approaches and biomaterials.

Biomater Sci 2021 Sep 22. Epub 2021 Sep 22.

IRCCS - Istituto Ortopedico Rizzoli, Complex Structure of Surgical Sciences and Technologies, Via di Barbiano 1/10, 40136, Bologna, Italy.

Nowadays, direct bone anchored systems are an increasingly adopted approach in the therapeutic landscape for amputee patients. However, the percutaneous nature of these devices poses a major challenge to obtain a stable and lasting proper adhesion between the implant surface and the skin. A systematic review was carried out in three databases (PubMed, Scopus, Web of Science) to provide an overview of the innovative strategies tested with preclinical models ( and ) in the last ten years to improve the skin adhesion of direct bone anchored systems. Read More

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September 2021

Meta-analysis of transanal versus laparoscopic total mesorectal excision for rectal cancer: a 'New Health Technology' assessment in South Korea.

Ann Surg Treat Res 2021 Sep 31;101(3):167-180. Epub 2021 Aug 31.

TaTME Assessment Committee, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea.

Purpose: Under the South Korea's unique health insurance structure, any new surgical technology must be evaluated first by the government in order to consider whether that particular technology can be applied to patients for further clinical trials as categorized as 'New Health Technology,' then potentially covered by the insurance sometime later. The aim of this meta-analysis was to assess the safety and efficacy of transanal total mesorectal excision (TaTME) for rectal cancer, activated by the National Evidence-based Healthcare Collaborating Agency (NECA) TaTME committee.

Methods: We systematically searched Ovid-MEDLINE, Ovid-Embase, Cochrane, and Korean databases (from their inception until August 31, 2019) for studies published that compare TaTME with laparoscopic total mesorectal excision (LaTME). Read More

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September 2021

Bank Systemic Risk around COVID-19: A Cross-Country Analysis.

J Bank Financ 2021 Aug 20:106299. Epub 2021 Aug 20.

School of Finance, Nankai University, 38 Tongyan Road, Jinnan District, Tianjin, 300350, PR China.

Using 1,584 listed banks from 64 countries during the COVID-19 pandemic, we conduct the first broad-based international study of the effect of the pandemic on bank systemic risk. We find the pandemic has increased systemic risk across countries. The effect operates through government policy response and bank default risk channels. Read More

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A direct aircraft observation of helical rolls in the tropical cyclone boundary layer.

Sci Rep 2021 Sep 21;11(1):18771. Epub 2021 Sep 21.

Nanjing University/School of Atmospheric Sciences, Nanjing, China.

Helical rolls are known to play a significant role in modulating both the mean and turbulence structure of the atmospheric boundary layer in tropical cyclones. However, in-situ measurements of these rolls have been limited due to safety restrictions. This study presents analyses of data collected by an aircraft operated by the Hong Kong Observatory in Typhoon Kalmaegi (1415) and Typhoon Nida (1604). Read More

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September 2021

Epistasis shapes the fitness landscape of an allosteric specificity switch.

Nat Commun 2021 Sep 21;12(1):5562. Epub 2021 Sep 21.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.

Epistasis is a major determinant in the emergence of novel protein function. In allosteric proteins, direct interactions between inducer-binding mutations propagate through the allosteric network, manifesting as epistasis at the level of biological function. Elucidating this relationship between local interactions and their global effects is essential to understanding evolution of allosteric proteins. Read More

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September 2021