84,291 results match your criteria structure organization

The regulating effect of trace elements Si, Zn and Sr on mineralization of gelatin-hydroxyapatite electrospun fiber.

Colloids Surf B Biointerfaces 2021 May 10;204:111822. Epub 2021 May 10.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, PR China. Electronic address:

Biomineralization approaches have been increasingly adopted to synthesizing advanced materials with superior properties. Nevertheless, the potential influence of inorganic trace elements on the mineralization process of collagen has been rarely reported, despite of the significant progress achieved on exploiting the critical roles of organic polymers in regulating the collagen mineralization. To this aim, the potential roles of Si, Zn and Sr in regulating the mineralization of gelatin-hydroxyapatite (HA) composite fibers have been examined in this study. Read More

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Effects of mixing, sheeting, and cooking on the starch, protein, and water structures of durum wheat semolina and chickpea flour pasta.

Food Chem 2021 Apr 30;360:129993. Epub 2021 Apr 30.

Departamento de Ingenieria de Procesos e Hidraulica, Universidad Autonoma Metropolitana-Iztapalapa, Apartado Postal 55-534, Iztapalapa 09340, Mexico.

The influence of the pasta preparation stages on starch, proteins, and water structures of semolina and chickpea pasta was studied. The hydrated starch structures (995/1022 FTIR ratio) increased in semolina and reduced in chickpea pasta. The processing stages in semolina pasta led to a significant increase of β-sheet structures (~50% to ~68%). Read More

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Comparative mitogenomes of three species in Moenkhausia: Rare irregular gene rearrangement within Characidae.

Int J Biol Macromol 2021 May 10. Epub 2021 May 10.

College of Biology and the Environment, Nanjing Forestry University, Nanjing 210037, People's Republic of China. Electronic address:

Generally, a teleostean group possesses only one type or a set of similar mitochondrial gene arrangements. However, a new type of gene arrangement has been identified in the mitochondrial genomes (mitogenomes) of Moenkhausia. Here, three newly sequenced complete mitogenomes of tetras (Characidae: Moenkhausia) are presented (M. Read More

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Transforming Disruption into Innovation: A Partnership Between the COVID-19 Medical Student Response Team and the University of British Columbia.

Acad Med 2021 May 11. Epub 2021 May 11.

V.W.L. Tsang is a fourth-year medical student, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0001-9401-008X. A. Yu is a fourth-year medical student, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-6384-6826. M.J. Haines is a fourth-year medical student, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-7680-5521. Z. Sagorin is a fourth-year medical student, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0003-4080-8859. D. Mitchell was a fourth-year medical student, at the time of writing, and is now a first-year resident, Department of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-3730-9947. G. Ching is a fourth-year medical student, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-8682-9172. C.L. Holmes is clinical professor, Division of Critical Care, Department of Medicine, and associate dean, Undergraduate Medical Education, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: http://orcid.org/0000-0001-5857-2704. M. Kestler is clinical assistant professor, Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-3466-4265.

The COVID-19 pandemic caused substantial disruptions in medical education. The University of British Columbia (UBC) MD Undergraduate Program (MDUP) is the sixth largest medical school in North America. MDUP students and faculty developed a joint response to these disruptions to address the curriculum and public health challenges that the pandemic posed. Read More

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Construction of an optically controllable CRISPR-Cas9 system using a DNA origami nanostructure.

Chem Commun (Camb) 2021 May 13. Epub 2021 May 13.

Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. and Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan and Organization for Research and Development of Innovative Science and Technology, Kansai University, Suita, Osaka 564-8680, Japan.

We demonstrated the photo-controlled sequence-selective dsDNA cleavage using a DNA origami structure with Cas9 nuclease. The activity of Cas9 incorporated inside the ring-shaped DNA origami was completely suppressed. After photoirradiation, Cas9 was released, and its activity for selective dsDNA cleavage was restored. Read More

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Visitor restrictions during the COVID-19 pandemic: An ethical case study.

Nurs Ethics 2021 May 13:9697330211005078. Epub 2021 May 13.

University College Cork, Ireland.

To prevent and reduce the transmission of the coronavirus to vulnerable populations, the World Health Organization recommended the restriction of visitors to nursing homes. It was recognised that such restrictions could have profound impact on residents and their families. Nonetheless, these measures were strictly imposed over a prolonged period in many countries; impeding families from remaining involved in their relatives' care and diluting the meaningful connections for residents with society. Read More

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Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis.

J Ind Microbiol Biotechnol 2021 Mar 24. Epub 2021 Mar 24.

Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA.

The ammosamides (AMMs) are a family of pyrroloquinoline alkaloids that exhibits a wide variety of bioactivities. A biosynthetic gene cluster (BGC) that is highly homologous in both gene content and genetic organization to the amm BGC was identified by mining the Streptomyces uncialis DCA2648 genome, leading to the discovery of a sub-family of new AMM congeners, named ammosesters (AMEs). The AMEs feature a C-4a methyl ester, differing from the C-4a amide functional group characteristic to AMMs, and exhibit modest cytotoxicity against a broad spectrum of human cancer cell lines, expanding the structure-activity relationship for the pyrroloquinoline family of natural products. Read More

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Ancient genomes provide insights into family structure and the heredity of social status in the early Bronze Age of southeastern Europe.

Sci Rep 2021 May 12;11(1):10072. Epub 2021 May 12.

Palaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg-University Mainz, 55099, Mainz, Germany.

Twenty-four palaeogenomes from Mokrin, a major Early Bronze Age necropolis in southeastern Europe, were sequenced to analyse kinship between individuals and to better understand prehistoric social organization. 15 investigated individuals were involved in genetic relationships of varying degrees. The Mokrin sample resembles a genetically unstructured population, suggesting that the community's social hierarchies were not accompanied by strict marriage barriers. Read More

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Water-oriented magnetic anisotropy transition.

Nat Commun 2021 May 12;12(1):2738. Epub 2021 May 12.

Institute for Materials Chemistry and Engineering & Integrated Research Consortium on Chemical Sciences (IRCCS), Kyushu University, Fukuoka, 819-0395, Japan.

Water reorientation is essential in a wide range of chemical and biological processes. However, the effects of such reorientation through rotation around the metal-oxygen bond on the chemical and physical properties of the resulting complex are usually ignored. Most studies focus on the donor property of water as a recognized σ donor-type ligand rather than a participant in the π interaction. Read More

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Formal thought disorder in patients with first-episode schizophrenia: Results of a one-year follow-up study.

Psychiatry Res 2021 Apr 29;301:113972. Epub 2021 Apr 29.

Department of Psychiatry, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Formal thought disorder (FTD) refers to abnormal speech patterns that can be characterized by deficiencies in thought organization and direction. The present study aimed to assess the factor structure of FTD and to examine its relationship with cognition and clinical features at first admission in patients with first-episode schizophrenia. We also examined the course of FTD during the twelve months after first admission. Read More

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Emotional Reactions to Cybersecurity Breach Situations: Scenario-Based Survey Study.

J Med Internet Res 2021 May 12;23(5):e24879. Epub 2021 May 12.

Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.

Background: With the ever-expanding interconnectedness of the internet and especially with the recent development of the Internet of Things, people are increasingly at risk for cybersecurity breaches that can have far-reaching consequences for their personal and professional lives, with psychological and mental health ramifications.

Objective: We aimed to identify the dimensional structure of emotion processes triggered by one of the most emblematic scenarios of cybersecurity breach, the hacking of one's smart security camera, and explore which personality characteristics systematically relate to these emotion dimensions.

Methods: A total of 902 participants from the United Kingdom and the Netherlands reported their emotion processes triggered by a cybersecurity breach scenario. Read More

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Co-creating an assistive technology peer-support community: learnings from AT Chat.

Disabil Rehabil Assist Technol 2021 May 12:1-7. Epub 2021 May 12.

Independent Living Assessment Incorporated, Perth, Australia.

Purpose: Inclusion is a core philosophy for health practitioners and human service users, and co-production is a way to achieve inclusion. Australia's assistive technology (AT) community seeks to include and amplify the voices of service and product users at multiple levels. Implementation of genuine partnerships for inclusion is however challenging. Read More

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Self-Organizing Microdroplet Protocells Displaying Light-Driven Oscillatory and Morphological Evolution.

Small 2021 May 12:e2101162. Epub 2021 May 12.

Department of Earth and Planetary Sciences and Origins of Life Initiative, Harvard University, Cambridge, MA, 02138, USA.

The development of synthetic systems that enable the sustained active self-assembly of molecular blocks to mimic the complexity and dynamic behavior of living systems is of great interest in elucidating the origins of life, understanding the basic principles behind biological organization, and designing active materials. However, it remains a challenge to construct microsystems with dynamic behaviors and functions that are connected to molecular self-assembly processes driven by external energy. Here, an active self-assembly of microdroplet protocells with dynamic structure and high structural complexity through living radical polymerization under constant energy flux is reported. Read More

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Diversity and circulation of Jingmen tick virus in ticks and mammals.

Virus Evol 2020 Jul 27;6(2):veaa051. Epub 2020 Jul 27.

Department of Zoonosis, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

Since its initial identification in ticks in 2010, Jingmen tick virus (JMTV) has been described in cattle, rodents, and primates. To better understand the diversity, evolution, and transmission of JMTV, we sampled 215 ticks, 104 cattle bloods, 216 bats, and 119 rodents in Wenzhou city, Zhejiang Province, China as well as 240 bats from Guizhou and Henan Provinces. JMTV was identified in 107 ticks (from two species), 54 bats (eleven species), 8 rodents (three species), and 10 cattle, with prevalence levels of 49. Read More

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Super-resolution visualization and modeling of human chromosomal regions reveals cohesin-dependent loop structures.

Genome Biol 2021 May 11;22(1):150. Epub 2021 May 11.

Institut Pasteur, Imaging and Modeling Unit, UMR 3691, CNRS, Paris, France.

Background: The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques to score DNA-DNA contacts, such as Hi-C, reveal the partitioning of chromosomes into epigenetically defined active and repressed compartments and smaller "topologically associated" domains. These domains are often associated with chromatin loops, which largely disappear upon removal of cohesin. Read More

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Structural performance of a climbing cactus: making the most of softness.

J R Soc Interface 2021 May 12;18(178):20210040. Epub 2021 May 12.

AMAP, Univ Montpellier, CIRAD, CNRS, INRAE, IRD, Montpellier, France.

Climbing plants must reach supports and navigate gaps to colonize trees. This requires a structural organization ensuring the rigidity of so-called 'searcher' stems. Cacti have succulent stems adapted for water storage in dry habitats. Read More

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Locomotor illusions are generated by perceptual body-environment organization.

PLoS One 2021 11;16(5):e0251562. Epub 2021 May 11.

University of Bern, Department of Psychology, Bern, Switzerland.

While one is walking, the stimulation by one's body forms a structure with the stimulation by the environment. This locomotor array of stimulation corresponds to the human-environment relation that one's body forms with the environment it is moving through. Thus, the perceptual experience of walking may arise from such a locomotor array of stimulation. Read More

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Altered nuclear architecture in blood cells from Huntington's disease patients.

Neurol Sci 2021 May 11. Epub 2021 May 11.

CompuMAINE Lab, Department of Chemical and Biomedical Engineering, University of Maine, Orono, ME, 04469, USA.

Background: Cell nuclear architecture has been explored in cancer and laminopathies but not in neurodegenerative disorders. Huntington's disease (HD) is a neurodegenerative disorder that leads to neuronal death. Chromosome-wide changes in gene expression have been reported in HD, not only in the brain but also in peripheral blood cells, but whether this translates into nuclear and chromosome architecture alterations has not yet been studied. Read More

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From telson to attack in mantis shrimp: bridging biomechanics and behavior in crustacean contests.

Integr Comp Biol 2021 May 10. Epub 2021 May 10.

Scripps Institution of Oceanography, Marine Biology Research Division, University of California, San Diego, La Jolla, CA 92093.

In the spirit of this symposium on the physical mechanisms of behavior, we review mantis shrimp ritualized fighting, from the telson to the attack, as an inspiring example of how the integration of biomechanics and behavioral research can yield a penetrating narrative for how animals accomplish important activities, including agonistic actions. Resolving conflicts with conspecifics over valuable resources is an essential task for animals, and this takes an unusual form in mantis shrimp due to their powerful raptorial appendages. Decades of field and laboratory research have provided key insights into the natural agonistic interactions of diverse mantis shrimp species, including how they use their raptorial weapons against one another in telson sparring matches over cavities. Read More

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Bone Mineral Density Measurements and Association With Brain Structure and Cognitive Function: The Framingham Offspring Cohort.

Alzheimer Dis Assoc Disord 2021 May 11. Epub 2021 May 11.

The Framingham Heart Study, Framingham Department of Neurology, Boston University School of Medicine Department of Biostatistics, Boston University School of Public Health, Boston, MA Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases Department of Population Health Sciences, University of Texas Health Science Center, San Antonio, TX Department of Neurology, University of California, Davis Division of Geriatrics, David Geffen School of Medicine at the University of California, Los Angeles, CA.

Background: Bone mineral density (BMD) is a potential surrogate marker of lifetime estrogen exposure previously linked to increased risk of Alzheimer dementia among elderly women. We examine the association between BMD in the "young old" with imaging biomarkers of brain aging and cognitive performance.

Methods: Offspring participants (N=1905, mean age 66) of a population-based cohort who had BMD, brain imaging and detailed cognitive assessment were included in the study. Read More

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Mapping Clinical Barriers and Evidence-Based Implementation Strategies in Low-to-Middle Income Countries (LMICs).

Worldviews Evid Based Nurs 2021 May 10. Epub 2021 May 10.

JBI, The University of Adelaide, Adelaide, SA, Australia.

Background: Low-to-middle income countries (LMICs) experience a high burden of disease from both non-communicable and communicable diseases. Addressing these public health concerns requires effective implementation strategies and localization of translation of knowledge into practice.

Aim: To identify and categorize barriers and strategies to evidence implementation in LMICs from published evidence implementation studies. Read More

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Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin.

Commun Biol 2021 May 10;4(1):538. Epub 2021 May 10.

Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan.

Shiga toxin (Stx) is a major virulence factor of enterohemorrhagic Escherichia coli, which causes fatal systemic complications. Here, we identified a tetravalent peptide that inhibited Stx by targeting its receptor-binding, B-subunit pentamer through a multivalent interaction. A monomeric peptide with the same motif, however, did not bind to the B-subunit pentamer. Read More

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A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.

Nat Commun 2021 May 10;12(1):2610. Epub 2021 May 10.

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC, Amsterdam, The Netherlands.

Angiogenic sprouting relies on collective migration and coordinated rearrangements of endothelial leader and follower cells. VE-cadherin-based adherens junctions have emerged as key cell-cell contacts that transmit forces between cells and trigger signals during collective cell migration in angiogenesis. However, the underlying molecular mechanisms that govern these processes and their functional importance for vascular development still remain unknown. Read More

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Dual-axis Volta phase plate cryo-electron tomography of Ebola virus-like particles reveals actin-VP40 interactions.

J Struct Biol 2021 May 7:107742. Epub 2021 May 7.

Schaller Research Groups, Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany; Research Group "Membrane Biology of Viral Infection", Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany. Electronic address:

Cryo-electron tomography (cryo-ET) is a pivotal imaging technique for studying the structure of pleomorphic enveloped viruses and their interactions with the host at native conditions. Owing to the limited tilting range of samples with a slab geometry, electron tomograms suffer from so-called missing wedge information in Fourier space. In dual-axis cryo-ET, two tomograms reconstructed from orthogonally oriented tilt series are combined into a tomogram with improved resolution as the missing wedge information is reduced to a pyramid. Read More

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Determining Excited-State Structures and Photophysical Properties in Phenylphosphine Rhenium(I) Diimine Biscarbonyl Complexes Using Time-Resolved Infrared and X-ray Absorption Spectroscopies.

Inorg Chem 2021 May 10. Epub 2021 May 10.

Department of Chemistry, Faculty of Science, Kyushu University, Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

We have explored the structural factors on the photophysical properties in two rhenium(I) diimine complexes in acetonitrile solution, ,-[Re(dmb)(CO)(PPhEt)] (Et(2,2)) and ,-[Re(dmb)(CO)(PPh)] ((3,3)) (dmb = 4,4'-dimethyl-2,2'-bipyridine, Ph = phenyl, Et = ethyl) using the combination method of time-resolved infrared spectroscopy, time-resolved extended X-ray absorption fine structure, and quantum chemical calculations. The difference between these complexes is the number of phenyl groups in the phosphine ligand, and this only indirectly affects the central Re(I). Despite this minor difference, the complexes exhibit large differences in emission wavelength and excited-state lifetime. Read More

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Structural characterisation of the Chaetomium thermophilum Chl1 helicase.

PLoS One 2021 10;16(5):e0251261. Epub 2021 May 10.

Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute, London, United Kingdom.

Chl1 is a member of the XPD family of 5'-3' DNA helicases, which perform a variety of roles in genome maintenance and transmission. They possess a variety of unique structural features, including the presence of a highly variable, partially-ordered insertion in the helicase domain 1. Chl1 has been shown to be required for chromosome segregation in yeast due to its role in the formation of persistent chromosome cohesion during S-phase. Read More

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Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations.

J Biomol Struct Dyn 2021 May 10:1-12. Epub 2021 May 10.

Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey.

Phenylketonuria is an autosomal recessive disorder caused by mutations in the phenylalanine hydroxylase gene. In phenylketonuria causes various symptoms including severe mental retardation. PAH gene of a classical Phenylketonuria patient was sequenced, and two novel heterozygous mutations, p. Read More

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Theoretical study of the vibrational properties of L-alanine and its zwitterionic form in the gas phase and in solution.

J Biomol Struct Dyn 2021 May 10:1-9. Epub 2021 May 10.

Laboratoire de Structure Elaboration et Application aux Matériaux Moléculaires SEA2M, Université Abdelhamid Ibn Badis-Mostaganem, Mostaganem, Algeria.

Theoretical calculations have been performed to study the structures of L-alanine and its zwitterionic form in the gas phase and in solution. The energies and the vibrational frequencies of the L-alanine in both neutral and zwitterionic form have been calculated using HF, MP2, CCSD and density functional theory (DFT) B3LYP hybrid exchange correlation functional with different basis sets. The conductor-like solvation model of the polarizable continuum model (CPCM) has been used to compute energies, geometric structures and harmonic frequencies in solution for the L-alanine and its zwitterionic form. Read More

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The Challenge of Integrating eHealth Into Health Care: Systematic Literature Review of the Donabedian Model of Structure, Process, and Outcome.

J Med Internet Res 2021 May 10;23(5):e27180. Epub 2021 May 10.

National eHealth Living Lab, Leiden University Medical Centre, Leiden, Netherlands.

Background: Health care organizations are increasingly working with eHealth. However, the integration of eHealth into regular health care is challenging. It requires organizations to change the way they work and their structure and care processes to be adapted to ensure that eHealth supports the attainment of the desired outcomes. Read More

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The Role of Cell Adhesion and Cytoskeleton Dynamics in the Pathogenesis of the Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders.

Front Cell Dev Biol 2021 21;9:649082. Epub 2021 Apr 21.

Division of Biomedical Sciences, Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, United Kingdom.

The Ehlers-Danlos syndromes (EDS) are a group of 13 disorders, clinically defined through features of joint hypermobility, skin hyperextensibility, and tissue fragility. Most subtypes are caused by mutations in genes affecting the structure or processing of the extracellular matrix (ECM) protein collagen. The Hypermobility Spectrum Disorders (HSDs) are clinically indistinguishable disorders, but are considered to lack a genetic basis. Read More

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