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Bimanual Coordination in a Whole-Body Dynamic Balance Sport, Slacklining: A Comparison of Novice and Expert.

Motor Control 2021 May 13:1-13. Epub 2021 May 13.

Waseda University.

As previous studies have suggested that bimanual coordination is important for slacklining, the authors questioned whether this important skill plays a role in the performance of a fundamental task of slacklining. To address this question, the authors compared single-leg standing on the slackline between novices and experts in terms of bimanual coordination dynamics within a dynamical systems framework using relative phase and recurrence quantification analysis measures. Five novices and five experts participated in the experiment. Read More

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2D confinement freestanding graphene oxide composite membranes with enriched oxygen vacancies for enhanced organic contaminants removal via peroxymonosulfate activation.

J Hazard Mater 2021 May 8;417:126028. Epub 2021 May 8.

Institute of Green Chemistry and Chemical Technology, Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu Province, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Introducing membrane filtration into advanced oxidation processes to decrease energy and cost consumption has been considered as a promising direction in environmental remediation. In this work, we firstly developed a kind of novel lawn-like FeO@CoFe@nitrogen-doped reduced graphene oxide@carbon nanotube composites (FeCo@GCTs) through in-situ pyrolysis of self-assembly of Prussian blue analogues and GO, followed through a vacuum-assisted filtration strategy to fabricate 2D confinement freestanding GO composite membrane. Electrochemical analysis and H-TPR revealed the superiority of FeCo@GCTs as ideal electron acceptor, and this unique lawn-like structure concentrated active sites with a confined space and enriched oxygen vacancies that realized 98. Read More

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GO-TiC two-dimensional heterojunction nanomaterial for anticorrosion enhancement of epoxy zinc-rich coatings.

J Hazard Mater 2021 May 7;417:126048. Epub 2021 May 7.

School of Materials Science and Engineering, Yancheng Institute of Technology, Yancheng 224051, PR China.

MXenes are a unique family of two-dimensional (2D) transition metal carbides and/or nitrides, which have been proven useful for energy storage, water purification, and biomedical applications. Herein, a kind of heterojunction structure was designed by grafting highly conductive MXene (TiC) on the graphene oxide (GO) nanosheets, which was confirmed by Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectronic spectroscopy (XPS) and Raman results. Open circuit potential (OCP), electrochemical impedance spectroscopy (EIS) and salt spray measurements corroborated that inclusion of 0. Read More

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G-triplex: A new type of CRISPR-Cas12a reporter enabling highly sensitive nucleic acid detection.

Biosens Bioelectron 2021 May 9;187:113292. Epub 2021 May 9.

State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan National Laboratory for Optoelectronics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 10049, China. Electronic address:

CRISPR-Cas12a (Cpf1) trans-cleaves ssDNA and this feature has been widely harnessed for nucleic acid detection. Herein, we introduce a new type of Cas12a reporter, G-triplex (G3), and a highly sensitive biosensor termed G-CRISPR. We proved that Cas12a trans-cleaves G3 structures in about 10 min and G3 can serve as an excellent reporter based on the cleavage-induced high-order structure disruption. Read More

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Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents.

J Mol Graph Model 2021 May 5;106:107933. Epub 2021 May 5.

Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics, Sambalpur University, Jyoti Vihar, Burla, Sambalpur-768019, Odisha, India. Electronic address:

We present a new class of derivatives of noscapine, 1,3-diynyl-noscapinoids of an antitussive plant alkaloid, noscapine based on our in silico efforts that binds tubulin and displays anticancer activity against a panel of breast cancer cells. Structure-activity analyses pointed the C-9 position of the isoquinoline ring which was modified by coupling of 1,3-diynyl structural motifs to rationally design and screened a series of novel 1,3-diynyl-noscapinoids (20-22) with robust binding affinity with tubulin. The selected 1,3-diynyl-noscapinoids, 20-22 revealed improved predicted binding energy of -6. Read More

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Artificial M2 macrophages for disease-modifying osteoarthritis therapeutics.

Biomaterials 2021 May 3;274:120865. Epub 2021 May 3.

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Engineering Technology Research Center of Drug Carrier of Guangdong, Department of Biomedical Engineering Jinan University Guangzhou, 510632, China. Electronic address:

Osteoarthritis (OA) is one of the most common joint diseases worldwide and the focus is shifting to disease prevention and the pharmaceutical and surgical treatment of early OA. However, at present few have proven ability to block or delay the progression of OA. Nevertheless, M2 macrophages present an anti-inflammatory function and promote cartilage repair, thereby alleviating OA in mice. Read More

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Bacteriophage-host depth distribution patterns in soil are maintained after nutrient stimulation in vitro.

Sci Total Environ 2021 May 12;787:147589. Epub 2021 May 12.

Department of Biosystems Engineering and Soil Science, The University of Tennessee, Knoxville, TN 37996, USA. Electronic address:

Previous research has revealed the ecological importance of viruses in different ecosystems. However, bacteriophage-host distribution patterns in soil depth profiles have not been investigated. Environmental factors such as nutrient availability and physiological stress can impact the mode (either lytic or lysogenic) of viral reproduction and subsequent influence of virus infection on ecological processes. Read More

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Trophic transfer and dietary exposure risk of mercury in aquatic organisms from urbanized coastal ecosystems.

Chemosphere 2021 May 10;281:130836. Epub 2021 May 10.

State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, 100875, China; Advanced Interdisciplinary Institute of Environment and Ecology, Beijing Normal University, Zhuhai, 519087, China.

In this study, 26 surface seawater samples, 26 surface sediment samples and 114 organisms were collected to study the trophic transfer and dietary exposure risk of mercury (Hg) in organisms from the Jiaozhou Bay, which is a typical semi-enclosed urbanized bay. The total mercury (THg) and methylmercury (MeHg) concentrations did not exceed the threshold limits and performed as: fish > crustaceans > mollusks. The trophic level values (TLs) were less than 3 in all the groups, indicating simple structure of food chain. Read More

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Continuous insulation strategy of organic waste composting in cold region: Based on cold-adapted consortium.

Bioresour Technol 2021 May 7;335:125257. Epub 2021 May 7.

College of Life Science, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Compost is a self-heating process for organic waste. Microbes are the main executors in composting process. However, due to low temperature in winter and low efficiency of composting, a lot of heat is lost in composting. Read More

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Calcium modified basalt fiber bio-carrier for wastewater treatment: Investigation on bacterial community and nitrogen removal enhancement of bio-nest.

Bioresour Technol 2021 May 7;335:125259. Epub 2021 May 7.

School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Institute of Environmental Health and Ecological Security, Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:

Modified basalt fiber (MBF) is a sustainable material studied as novel wastewater treatment bio-carrier recently. This work studied the effects of calcium modification on the bacterial affinity of modified fiber (Ca-MBF), bacterial community, and nitrogen removal performance. Results showed that Ca-MBF with hydrophilic (62. Read More

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Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism.

Bioorg Chem 2021 May 5;112:104963. Epub 2021 May 5.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

Pseudolaric acid A (PAA), one of the main bioactive ingredients in traditional medicine Pseudolarix cortex, exhibits remarkable anticancer activities. Yet its mechanism of action and molecular target have not been investigated and remain unclear. In this work, mechanistic study showed that PAA induced cell cycle arrest at G2/M phase and promoted cell death through caspase-8/caspase-3 pathway, demonstrating potent antiproliferation and anticancer activities. Read More

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Three-dimensional MoS nanoflowers supported Prussian blue and Au nanoparticles: A peroxidase-mimicking catalyst for the colorimetric detection of hydrogen peroxide and glucose.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 30;259:119886. Epub 2021 Apr 30.

Life and Health Research Institute, Tianjin Key Laboratory of Organic Solar Cells and photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address:

Well-dispersed Prussian blue (PB) and Au nanoparticles (Au NPs) loaded three dimensional MoS nanoflowers (PB-Au@MoS NFs) was synthesized by a simple and economical method. The structure, morphology and composition of the hybrid were characterized by XRD, SEM and EDS. Similar to the reported literature, MoS nanoflowers showed peroxidase-like activity in catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB). Read More

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Structural dynamics and vibrational feature of N-Acetyl-d-glucosamine in aqueous solution.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 5;259:119918. Epub 2021 May 5.

College of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Normal University, Fuzhou 350007, PR China; Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, Xiamen 361005, PR China. Electronic address:

Molecular dynamics simulations and DFT calculations were performed for the demonstration of the structural dynamics and vibrational feature of N-Acetyl-d-glucosamine (NAG) in solution phase. The interactions between NAG and solvent molecules were evaluated through spatial distribution function and radial distribution function, and the preferred conformations of NAG in aqueous solution were revealed by cluster analysis. Results from normal mode analysis show that the solvent induced structural fluctuation of NAG could be reflected in the vibrational feature of specific chromophores, thus we can evaluate the molecular structure with the help of its vibrational signature based on the built correlation between molecular structure and vibrational frequencies of specific groups. Read More

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High temperature induced S vacancies in natural molybdenite for robust electrocatalytic nitrogen reduction.

J Colloid Interface Sci 2021 Mar 31;599:849-856. Epub 2021 Mar 31.

School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China; School of Materials Science and Engineering, Dongguan University of Technology, Dongguan 523808, China. Electronic address:

Defect engineering is an important strategy to regulate electronic structure of electrocatalysts for electrochemical N fixation, aiming at improving the electron state density and enhancing the adsorption and activation of inert N. In this paper, a high-temperature strategy to anneal the natural molybdenite under Ar atmosphere was developed, and the as-obtained molybdenite with S vacancies boosted a high activity for N reduction reaction. In 0. Read More

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Improvement of quality and flavor of salted egg yolks by ultrasonic assisted cooking.

Ultrason Sonochem 2021 May 6;75:105579. Epub 2021 May 6.

School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, Hubei, China; Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology/School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, Anhui, China. Electronic address:

Physicochemical, texture indexes, microstructure and volatiles were used to characterize the changes in quality, structure and flavor of cooked salted egg yolks (SEYs) with or without ultrasonic treatment. Experimental results indicated that ultrasonic significantly increased cooking (water) loss, oil exudation, lipids oxidation (TBARS), accelerated the doneness of cooked SEYs and then promoted the generation of volatiles. These results were further confirmed by the improvement of thermal stability, the changes in color, secondary structure of proteins, water distribution and mobility. Read More

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Nitrile-based peptoids as cysteine protease inhibitors.

Bioorg Med Chem 2021 May 10;41:116211. Epub 2021 May 10.

Medicinal and Biological Chemistry Group (NEQUIMED), Institute of Chemistry of São Carlos, University of São Paulo, São Carlos/SP, Brazil.

Peptidomimetics of the class of dipeptidyl nitrile analog peptoids were synthesized as inhibitors of mammalian cysteine proteases of the papain superfamily. The dipeptidyl nitrile side chains were attached to the peptide backbone's nitrogen atom, not to the α-carbons. Synthesized nitrile-based peptoid analogs that lack the hydrogen amide at P2-P3 are responsible for many of the secondary structure elements in peptides and proteins, making them resistant to proteolysis. Read More

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Preparation and evaluation of virus-like particle vaccine against H3N8 subtype equine influenza.

Microb Pathog 2021 May 12:104885. Epub 2021 May 12.

Laboratory of Infectious Diseases, College of Veterinary Medicine, Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun, 130062, China. Electronic address:

To prevent and control H3N8 subtype equine influenza, we prepared virus-like particles (VLPs) comprising the HA, NA and M1 proteins of H3N8 equine influenza virus (EIV) through the insect cell-baculovirus expression system. The results of Western blot and hemagglutination analyses demonstrated that the constructed VLPs comprising HA, NA and M1 proteins have good hemagglutination activity. Immunoelectron microscope revealed that the VLPs share similar morphology and structure with natural virus particles. Read More

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Semi-enzymatic synthesis of pseudouridine.

Bioorg Med Chem Lett 2021 May 12:128105. Epub 2021 May 12.

Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, United States. Electronic address:

Modifications of RNA molecules have a significant effect on their structure and function. One of the most common modifications is the isomerization from uridine to pseudouridine. Despite its prevalence in natural RNA sequences, organic synthesis of pseudouridine has been challenging because of the stereochemistry requirement and the sensitivity of reaction steps to moisture. Read More

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Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation.

Bioorg Med Chem Lett 2021 May 12:128106. Epub 2021 May 12.

School of Pharmaceutical Science, University of South China, Hengyang 421001, China; School of Pharmacy, Lanzhou University, Lanzhou 730000, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address:

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthesis of marine natural product Chrysamide B, it and series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure-activity relationships were conducted. Read More

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Discovery of a new class of JMJD6 inhibitors and structure-activity relationship study.

Bioorg Med Chem Lett 2021 May 12:128109. Epub 2021 May 12.

Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin 300071, PR China. Electronic address:

JmjC domain-containing protein 6 (JMJD6) has been thought as a potential target for various diseases particularly cancer. However, few selective JMJD6 inhibitors have been reported. In this investigation, molecular docking and biological activity evaluation were performed to retrieve new JMJD6 inhibitors, which led to the identification of a hit compound, J2. Read More

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Cytotoxicity, anti-tumor effects and structure-activity relationships of nickel and palladium S,C,S pincer complexes against double and triple-positive and triple-negative breast cancer (TNBC) cells.

Bioorg Med Chem Lett 2021 May 12:128107. Epub 2021 May 12.

Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Triple-Negative Breast Cancer (TNBC) is a highly aggressive form of breast cancer. The high rate of metastasis associated with TNBC is attributed to its multidrug resistance, making the treatment of this metastatic condition difficult. The development of metal-based antitumor agents was launched with the discovery of cisplatin, followed by the development of related antitumor drugs such as carboplatin and oxaliplatin. Read More

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Human cancer xenografts in immunocompromised mice provide an advanced genuine tumor model for research and drug development-A revisit of murine models for human cancers.

Quan-En Yang

Biochim Biophys Acta Gen Subj 2021 May 12:129929. Epub 2021 May 12.

Phycin, LLC., 4539 Metropolitan Court, Frederick, MD 21704, United States of America. Electronic address:

Molecular and cell biology studies have proven that human cancers are an enormously heterogenous disease, even if they originate from the same organ and tissue with identical morphological characteristics. Cancer cells in tumors from different individuals exhibit somewhat different characteristics on multiple levels, such as with respect to 1) their genetic polymorphism; 2) epigenetic mechanisms; 3) group gene activation/inactivation; 4) cell metabolism behavior; 5) aberrant incomplete terminal differentiation; 6) proliferative potential; and 7) hierarchical structure. These multiple parameters and their different combinations determine the biological characteristics of the cancer cells and their malignant/metastatic manifestations. Read More

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Variation-Set Structure: Extraction of Important Segments in Pigeon Learning.

Behav Processes 2021 May 12:104420. Epub 2021 May 12.

School of Zoology, Faculty of Life Sciences, Tel-Aviv University, Israel.

The ability to extract reliable segments from the sensory data-stream is necessary for learning and for creating a reliable representation of the environment. Here we focused on segmentation in visual learning associated with foraging. Fifty-one pigeons (Columba livia) were trained to recognize two food-predicting signals, one presented against fixed background elements and the other against varying backgrounds. Read More

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Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.

J Allergy Clin Immunol 2021 May 12. Epub 2021 May 12.

Department of Structural Biology, Stanford University School of Medicine, Stanford California 94305; Progam in Immunology, Stanford University School of Medicine, Stanford California 94305; Sean N. Parker Center for Allergy Research at Stanford University. Electronic address:

Background: Anaphylaxis represents one of the most severe and fatal forms of allergic reactions. Like most other allergies, it is caused upon activation of basophils and mast cells by allergen-mediated cross-linking of immunoglobulin E (IgE) bound to its high affinity receptor FcεRI on the cell surface. The systemic release of soluble mediators induces an inflammatory cascade rapidly causing symptoms with peak severity in minutes to hours after allergen exposure. Read More

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Curation and Expansion of Human Phenotype Ontology for Defined Groups of Inborn Errors of Immunity.

J Allergy Clin Immunol 2021 May 12. Epub 2021 May 12.

Department of immunology, Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust, London, United Kingdom.

Background: Accurate, detailed and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. However, to date the use of HPO has not yet been widely implemented in the field of inborn errors of immunity (IEIs), mainly due to a lack of comprehensive IEI-related terms. Read More

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A comparative study for phosphate adsorption on amorphous FeOOH and goethite (α-FeOOH): an investigation of relationship between the surface chemistry and structure.

Environ Res 2021 May 12:111223. Epub 2021 May 12.

Department of Civil Engineering, University of Louisiana at Lafayette, Lafayette, LA, 70504, USA. Electronic address:

Eutrophication is generally caused by excess nitrogen and phosphorus being released into surface waters by runoff. Developing adsorbents for adsorbing phosphate within soil buffer zones and/or water treatment columns may be effective methods to mitigate this problem. In this study, an amorphous FeOOH (AF) and a well-crystallized α-FeOOH (CF) was formulated to compare phosphate adsorption behavior. Read More

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In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives.

Environ Res 2021 May 12:111320. Epub 2021 May 12.

Department of Chemistry, Organic and Biomolecular Chemistry Laboratories, Yogi Vemana University, Kadapa-516005, Andhra Pradesh, India.

Cholinesterase enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) cause hydrolysis of acetylcholine (ACh), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. Therefore, inhibition of these enzymes is an effective process to curb the progressive and fatal neurological Alzheimer's disease (AD). Herein, we explored the potential inhibitory activities of various pyridine, quinoxaline, and triazine derivatives (3a-k, 6a-j and 11a-h) against AChE and BuChE enzymes by following the modified Ellman's method. Read More

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Neurophysiological tracking of speech-structure learning in typical and dyslexic readers.

Neuropsychologia 2021 May 12:107889. Epub 2021 May 12.

Maastricht Brain Imaging Center, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.

Statistical learning, or the ability to extract statistical regularities from the sensory environment, plays a critical role in language acquisition and reading development. Here we employed electroencephalography (EEG) with frequency-tagging measures to track the temporal evolution of speech-structure learning in individuals with reading difficulties due to developmental dyslexia and in typical readers. We measured EEG while participants listened to (a) a structured stream of repeated tri-syllabic pseudowords, (b) a random stream of the same isochronous syllables, and (c) a series of tri-syllabic real Dutch words. Read More

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β-Glucan: A dual regulator of apoptosis and cell proliferation.

Int J Biol Macromol 2021 May 12. Epub 2021 May 12.

Department of Biotechnology, University of Kashmir, Srinagar 190006, J&K, India. Electronic address:

β-Glucans are polysaccharides generally obtained from the cell wall of bacteria, fungi, yeasts, and aleurone layer of cereals. β-Glucans are polymers, with β-1,3 glucose as core linear structure, but they differ in their main branch length, linkages, and branching patterns, giving rise to high and low-molecular-weight β-glucans. They are well-known cell response modifiers with immune-modulating, nutraceutical, and health beneficial effects, including anticancer and pro-apoptotic properties. Read More

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Propolis loaded and genipin-crosslinked PVA/chitosan membranes; characterization properties and cytocompatibility/genotoxicity response for wound dressing applications.

Seda Ceylan

Int J Biol Macromol 2021 May 12. Epub 2021 May 12.

Bioengineering Department, Faculty of Engineering, Adana Alparslan Türkeş Science and Technology University, Adana, Turkey. Electronic address:

Loading propolis by a simple process using genipin as a crosslinking agent and fabrication of a novel PVA/Chitosan-Propolis membrane scaffolds were reported for wound dressing applications. The research is focused on the effects of propolis on characterization properties of membrane such as chemical structure, surface morphology, degradation ratio, crystallinity, hydrophilicity, water uptake capacity, water vapour transmission rate and mechanical aspect. It was noticed that water uptake capacity and hydrophilicity properties of membrane considerably affected by the propolis. Read More

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