685,062 results match your criteria structure formation

Insights into the vertical distribution of the microbiota in steel plant soils with potentially toxic elements and PAHs contamination after 60 years operation: Abundance, structure, co-occurrence network and functionality.

Sci Total Environ 2021 Apr 26;786:147338. Epub 2021 Apr 26.

Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Qingdao, Shandong 266237, China; Suzhou Research Institute, Shandong University, Suzhou, Jiangsu 215123, China. Electronic address:

Both potentially toxic elements (PTEs) and polycyclic aromatic hydrocarbons (PAHs) are widely present in soil contaminated by steel industries. This study assessed the vertical variation (at 20 cm, 40 cm, 60 cm, 80 cm, 120 cm, and 150 cm depth) of bacterial abundance, community structure, functional genes related to PAHs degradation, and community co-occurrence patterns in an old steel plant soils which contaminated by PTEs and PAHs for 60 years. The excessive PAHs and PTEs in steel plant soils were benzo (a) pyrene, benzo (b) fluoranthene, dibenzo (a, h) anthracene, indeno (1,2,3-c, d) pyrene, and lead (Pb). Read More

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The transcriptomic profile of endometrial receptivity in recurrent miscarriage.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 30;261:211-216. Epub 2021 Apr 30.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Objective: To characterise the endometrial transcriptomic profiles of women who suffered recurrent miscarriage and to set the foundation for the development of an endometrial receptivity test that could predict the fate of subsequent pregnancies.

Study Design: This was a prospective multicentre cohort study performed at the Tommy's National Centre for Miscarriage Research in Birmingham, Saint Mary's Hospital in Manchester and Royal Devon & Exeter Hospital, United Kingdom. The study was conducted between December 2017 and December 2019. Read More

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Structure and properties of in situ reactive blend of polylactide and thermoplastic starch.

Int J Biol Macromol 2021 May 7. Epub 2021 May 7.

The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

In this study, in situ reactive extrusion of polylactide and thermoplastic starch modified with chloropropyl trimethoxysilane coupling agent (PLA/mTPS) is proposed. The success of covalent bond formation between PLA matrix and mTPS phase is clarified by two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy with HH TOCSY mode. This chemically bound PLA with starch gives the remarkable compatibility in the PLA/mTPS film, with not only a decreased glass transition temperature (47 °C) but also an increased crystallinity of PLA (Χ of 50%). Read More

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Structural characterisation of the Chaetomium thermophilum Chl1 helicase.

PLoS One 2021 10;16(5):e0251261. Epub 2021 May 10.

Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute, London, United Kingdom.

Chl1 is a member of the XPD family of 5'-3' DNA helicases, which perform a variety of roles in genome maintenance and transmission. They possess a variety of unique structural features, including the presence of a highly variable, partially-ordered insertion in the helicase domain 1. Chl1 has been shown to be required for chromosome segregation in yeast due to its role in the formation of persistent chromosome cohesion during S-phase. Read More

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Local Polarization Reversal by Ion Beam Irradiation in SBN Single Crystals Covered by Dielectric Layer.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 10;PP. Epub 2021 May 10.

Formation of the domain structure by ion beam irradiation was studied in thermally depolarized Ce-doped strontium barium niobate single crystals covered by a dielectric layer. Three types of irradiation regimes were used: dot exposure, stripe exposure, and line exposure. The dependences of the domain size and depth on the irradiated dose were measured. Read More

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Effect of local anesthetic drug procaine hydrochloride on the conformational stability of bovine hemoglobin: Multi-spectroscopic and computational approaches.

J Biomol Struct Dyn 2021 May 10:1-11. Epub 2021 May 10.

Department of Chemistry, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

The interaction between bovine hemoglobin (BHb) and local anesthetic drug procaine hydrochloride (PCH) was examined by spectroscopic and computational studies. Intrinsic fluorescence analysis explored the ground-state complex formation in the binding of PCH with BHb through static quenching mechanism. The binding constants () are 29. Read More

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Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations.

J Biomol Struct Dyn 2021 May 10:1-12. Epub 2021 May 10.

Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey.

Phenylketonuria is an autosomal recessive disorder caused by mutations in the phenylalanine hydroxylase gene. In phenylketonuria causes various symptoms including severe mental retardation. PAH gene of a classical Phenylketonuria patient was sequenced, and two novel heterozygous mutations, p. Read More

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Selective Preparation of MoN and MoN with High Surface Area for Flexible SERS Sensing.

Nano Lett 2021 May 10. Epub 2021 May 10.

Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, P. R. China.

γ-MoN and δ-MoN are the two most important molybdenum nitrides, but controllable preparation of them with high surface area has not been achieved. Herein, we achieved selective preparation of γ-MoN and δ-MoN. The key factor for the selective preparation of γ-MoN and δ-MoN is to control the crystal phase of the precursor MoO. Read More

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Surface Selenylation Engineering for Construction of a Hierarchical NiSe/Carbon Nanorod: A High-Performance Nonenzymatic Glucose Sensor.

ACS Appl Mater Interfaces 2021 May 10. Epub 2021 May 10.

College of Food Science and Engineering, Northwest A&F University, Yangling, 712100 Xianyang, Shaanxi, China.

As glucose (Glu) is an essential substance for metabolism as well as a symbol to diagnose diabetes, the demand of Glu sensors has increased significantly in recent decades. In this work, a hierarchical Ni-based electrochemical enzyme-free Glu sensor, namely, NiSe/CNR (carbon nanorod), was engineered through a facile thermal treatment using dimethylglyoxime dinickel salt with selenium (Se) powder. The prepared NiSe/CNR not only subtly introduces a hierarchical structure with rod-like carbon nanorods and rock-like NiSe nanoparticles, which are extremely helpful in offering a greater catalytic activity area and more catalytic active sites, but also incorporates the Se element to increase the inherent activity. Read More

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The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge.

Endokrynol Pol 2021 ;72(2):153-162

Department of Endocrinology, Metabolism, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Selenium (Se) supplements are commonly prescribed to autoimmune thyroiditis (AIT) patients by European endocrinologists, despite the lack of official guidelines. The majority of Europe is depleted of natural Se sources, and the daily population intake does not comply with recommended values. Optimal individual plasma Se concentration is reached when the selenoproteins (selenoprotein P, glutathione peroxidase) are fully saturated. Read More

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January 2021

Synthesis and characterization of promising insensitive energetic salts based on 3-amino-5-hydrazinopyrazole.

Dalton Trans 2021 May 10. Epub 2021 May 10.

State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081, P. R. China.

The development of green energetic materials is based on environmental friendliness, safety and performance improvement. It is of great significance to design and synthesize new nitrogen rich salts for a new generation of green energetic materials. In the present work, a series of 3-amino-5-hydrazinopyrazole energetic salts comprising energetic anions were synthesized and were characterized using elemental analysis, IR spectroscopy and differential scanning calorimetry (DSC). Read More

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Response of a Zn(II)-based metal-organic coordination polymer towards trivalent metal ions (Al, Fe and Cr) probed by spectroscopic methods.

Dalton Trans 2021 May 10. Epub 2021 May 10.

Department of Chemistry, Siksha-Bhavana, Visva-Bharati University, Santiniketan-731235, West Bengal, India.

A new zinc-based two-dimensional coordination polymer, [Zn(5-AIP)(Ald-4)]·H2O (5-AIP = 5-amino isophthalate, Ald-4 = aldrithiol-4), 1, has been synthesized at room temperature by the layer diffusion technique. Single-crystal X-ray diffraction analysis of 1 showed a two-dimensional bilayer structure. An aqueous suspension of 1 upon excitation at 300 nm displayed an intense blue emission at 403 nm. Read More

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Computational Structure Prediction Provides a Plausible Mechanism for Electron Transfer by the Outer Membrane Protein Cyc2 from Acidithiobacillus ferrooxidans.

Protein Sci 2021 May 9. Epub 2021 May 9.

Department of Chemical Engineering, Columbia University in the City of New York, New York, New York, USA.

Cyc2 is the key protein in the outer membrane of Acidithiobacillus ferrooxidans that mediates electron transfer between extracellular inorganic iron and the intracellular central metabolism. This cytochrome c is specific for iron and interacts with periplasmic proteins to complete a reversible electron transport chain. A structure of Cyc2 has not yet been characterized experimentally. Read More

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Reflection on modern methods: understanding bias and data analytical strategies through DAG-based data simulations.

Int J Epidemiol 2021 May 10. Epub 2021 May 10.

Department of Gastroenterology, Endocrinology, Metabolism, and Infectiology, Philipps University of Marburg, Marburg, Germany.

Directed acyclic graphs (DAGs) are increasingly used in epidemiology to identify and address different types of bias. The present work aims to demonstrate how DAG-based data simulation can be used to understand bias and compare data analytical strategies in an educational context. Examples based on classical confounding situations and an M-DAG are examined and used to introduce basic concepts and demonstrate some important features of regression analysis, as well as the harmful effect of adjusting for a collider variable. Read More

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The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide.

Front Mol Biosci 2021 22;8:657946. Epub 2021 Apr 22.

Department of Chemistry, Aarhus University, Aarhus, Denmark.

Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation. Cholesterol is present at high concentrations in the pancreatic beta-cells, and in-vitro experiments have indicated that it affects the amyloid formation of IAPP either by direct interactions or by changing the properties of the membrane. Read More

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Seeded Growth of Au@CuO Core-Shell Mesoporous Nanospheres and Their Photocatalytic Properties.

Front Chem 2021 23;9:671220. Epub 2021 Apr 23.

Department of Chemistry and Chemical Engineering, Jining University, Qufu, China.

We report a facile synthesis of Au@CuO core-shell mesoporous nanospheres with tunable size in the aqueous phase seeded growth. The success of the current work relies on the use of a halide-free copper (Cu) precursor and n-oleyl-1,3-propanediamine as a capping agent to facilitate the formation of a copperish oxide shell with a mesoporous structure and the presence of mixed oxidation states of Cu. By varying the amount of spherical Au seeds while keeping other parameters unchanged, their diameters could be readily tuned without noticeable change in morphology. Read More

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Investigation of Triple Symmetric Non-halogen Benzene Derivative Solvent for Spray-Coated Polymer Solar Cells.

Front Chem 2021 23;9:651281. Epub 2021 Apr 23.

Research Institute for New Materials and Technology, Chongqing University of Arts and Sciences, Chongqing, China.

The performance of spray-coated polymer solar cells could be largely improved via morphologies and phase optimization by solvent engineering. However, there is still a lack of fundamental knowledge and know-how in controlling blend morphology by using various solvents. Here, the effect of adding low polar benzene and non-halogen benzene derivatives with triple symmetric molecular has been systematically investigated and discussed. Read More

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Microbial composition and dynamic succession during the Daqu production process of Northern Jiang-flavored liquor in China.

3 Biotech 2021 May 18;11(5):224. Epub 2021 Apr 18.

School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083 China.

The microbial community structure and succession regularity of six key periods during high-temperature Daqu production were revealed using high-throughput sequencing to explore the factors affecting the flavor formation of Northern Jiang-flavored Baijiu technology. The results showed that among the six Daqu samples, the bacteria mainly included Firmicutes, Actinobacteriota, and Proteobacteria, of which Proteobacteria was the most dominant. The primary fungus was Ascomycota. Read More

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Gestational and Breastfeeding Low-Protein Intake on Blood Pressure, Kidney Structure, and Renal Function in Male Rat Offspring in Adulthood.

Front Physiol 2021 22;12:658431. Epub 2021 Apr 22.

Fetal Programming and Hydroelectrolyte Metabolism Laboratory, Nucleus of Medicine and Experimental Surgery, Department of Internal Medicine, Faculty of Medical Sciences at State University of Campinas, Campinas, Brazil.

: Our previous studies demonstrated that maternal protein-restricted (low-protein, LP) 16-week-old offspring had pronounced nephron number reduction and arterial hypertension associated with an unchanged glomerular filtration rate (GFR). An enhanced gomerular area may be related to increased glomerular filtration and overflow, which accounts for glomerular filtration barrier breakdown and early glomerulosclerosis. The effect of protein restriction during gestational and breastfeeding periods is unknown. Read More

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A Biomimetic System for Studying Salicylate Dioxygenase.

ACS Symp Ser Am Chem Soc 2019 Jan 12;1317(4):71-83. Epub 2019 Jul 12.

Department of Chemistry, University of Rochester, Rochester, NY 14627-0216, United States.

We report the characterization of [Fe(T1Et4iPrIP)(sal)] () (T1Et4iPrIP = tris(1-ethyl-4-isopropyl-imidazolyl)phosphine; sal = salicylate dianion), which serves as a model for substrate-bound salicylate dioxygenase (SDO). Complex crystallizes in the monoclinic space group 2/n with = 10.7853(12) Å, = 16. Read More

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January 2019

Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice.

Endocr J 2021 May 7. Epub 2021 May 7.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Nonalcoholic fatty liver disease (NAFLD) is a clinical spectrum that encompasses simple steatosis to nonalcoholic steatohepatitis (NASH), the latter of which is characterized by chronic inflammation and fibrosis. NASH is now becoming the leading cause of cirrhosis and hepatocellular carcinoma worldwide. The pathophysiology of NASH is multifactorial and, therefore, not yet completely understood, although it is pointed out that hepatocyte death and subsequent inflammation play a central roles in disease pathogenesis. Read More

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Entorhinal Perfusion Predicts Future Memory Decline, Neurodegeneration, and White Matter Hyperintensity Progression in Older Adults.

J Alzheimers Dis 2021 May 3. Epub 2021 May 3.

Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.

Background: Altered cerebral blood flow (CBF) has been linked to increased risk for Alzheimer's disease (AD). However, whether altered CBF contributes to AD risk by accelerating cognitive decline remains unclear. It also remains unclear whether reductions in CBF accelerate neurodegeneration and development of small vessel cerebrovascular disease. Read More

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Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells.

Bioorg Med Chem 2021 Apr 30;40:116187. Epub 2021 Apr 30.

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Carboxylesterase 2 (CES2) is one of the most important Phase I drug metabolizing enzymes in the carboxylesterase family. It plays crucial roles in the bioavailability of oral ester prodrugs and the therapeutic effect of some anticancer drugs such as irinotecan (CPT11) and capecitabine. In addition to the well-known roles of CES2 in xenobiotic metabolism, the enzyme also participates in endogenous metabolism and the production of lipids. Read More

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N-methyladenosine modification underlies messenger RNA metabolism and plant development.

Curr Opin Plant Biol 2021 May 6;63:102047. Epub 2021 May 6.

Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, 117604, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543, Singapore. Electronic address:

RNA modifications constitute an essential layer of gene regulation in living organisms. As the most prevalent internal modification on eukaryotic mRNAs, N-methyladenosine (mA) exists in many plant species and requires the evolutionarily conserved methyltransferases, demethylases, and mA binding proteins for writing, erasing, and reading mA, respectively. In plants, mA affects many aspects of mRNA metabolism, including alternative polyadenylation, secondary structure, translation, and decay, which underlies various plant developmental processes and stress responses. Read More

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Procyanidine resists the fibril formation of human islet amyloid polypeptide.

Int J Biol Macromol 2021 May 6. Epub 2021 May 6.

Department of Chemistry, Renmin University of China, Beijing 100872, China. Electronic address:

Human islet amyloid polypeptide (hIAPP) is widely studied due to its close correlation with the pathogenic mechanism of type II diabetes mellitus (T2DM). Bioflavonoids have been used in the neurodegeneration and diabetes studies. However, the structure-activity relationship remains unclear in many of these compounds. Read More

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Non-enzymatic Covalent Modifications as a New Chapter in the Histone Code.

Trends Biochem Sci 2021 May 5. Epub 2021 May 5.

Tri-Institutional PhD Program in Chemical Biology, New York, NY, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA. Electronic address:

The interior of the cell abounds with reactive species that can accumulate as non-enzymatic covalent modifications (NECMs) on biological macromolecules. These adducts interfere with many cellular processes, for example, by altering proteins' surface topology, enzymatic activity, or interactomes. Here, we discuss dynamic NECMs on chromatin, which serves as the cellular blueprint. Read More

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Characterization of magnesium doped sol-gel biomaterial for bone tissue regeneration: The effect of Mg ion in protein adsorption.

Mater Sci Eng C Mater Biol Appl 2021 Jun 17;125:112114. Epub 2021 Apr 17.

Departament of Science and Technology of Polymers, Universidad del País Vasco, P. M. de Lardizábal, 3, 20018 San Sebastián, Spain.

Magnesium is the fourth most abundant element in the human body with a wide battery of functions in the maintenance of normal cell homeostasis. In the bone, this element incorporates in the hydroxyapatite structure and it takes part in mineral metabolism and regulates osteoclast functions. In this study, sol-gel materials with increasing concentrations of MgCl (0. Read More

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Patients- and tissue-specific bio-inks with photoactivated PRP and methacrylated gelatin for the fabrication of osteochondral constructs.

Mater Sci Eng C Mater Biol Appl 2021 Jun 1;125:112092. Epub 2021 Apr 1.

Hacettepe University, Bioengineering Department, 06800 Beytepe, Ankara, Turkey; Hacettepe University, Chemical Engineering Department, 06800 Beytepe, Ankara, Turkey. Electronic address:

In osteochondral tissue engineering, while the biochemical and mechanical properties of hydrogels guide stem cell proliferation and differentiation, physical and chemical stimulators also affect the differentiation of stem cells. Herein, we presented a patient and tissue-specific strategy for the development of biomimetic osteochondral constructs with gradient compositions. Osteochondral constructs were fabricated by gradually printing of bio-inks consisting of therapeutic platelet-rich plasma (PRP), adipose tissue-derived mesenchymal stem cells (AdMSCs), and extracellular matrix (ECM) mimetic hydrogel, microwave-assisted methacrylated gelatin (Gel-MA). Read More

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Polybutylene-adipate-terephthalate and niobium-containing bioactive glasses composites: Development of barrier membranes with adjusted properties for guided bone regeneration.

Mater Sci Eng C Mater Biol Appl 2021 Jun 19;125:112115. Epub 2021 Apr 19.

Dental Materials Laboratory, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

This study aimed to develop bioactive guided bone regeneration (GBR) membranes by manufacturing PBAT/BAGNb composites as casting films. Composites were produced by melt-extrusion, and BAGNb was added at 10 wt%, 20 wt%, and 30 wt% concentration. Pure PBAT membranes were used as a control (0wt%BAGNb). Read More

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Surfactant protein D and bronchopulmonary dysplasia: a new way to approach an old problem.

Respir Res 2021 May 8;22(1):141. Epub 2021 May 8.

Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. ML7029, Cincinnati, OH, 45229-3039, USA.

Surfactant protein D (SP-D) is a collectin protein synthesized by alveolar type II cells in the lungs. SP-D participates in the innate immune defense of the lungs by helping to clear infectious pathogens and modulating the immune response. SP-D has shown an anti-inflammatory role by down-regulating the release of pro-inflammatory mediators in different signaling pathways such as the TLR4, decreasing the recruitment of inflammatory cells to the lung, and modulating the oxidative metabolism in the lungs. Read More

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