63,014 results match your criteria structural oct

Recanalized Coronary Thrombus: Role of OCT in Identifying a Slow-Evolving and Underestimated Coronary Lesion.

JACC Case Rep 2020 Dec 16;2(15):2411-2413. Epub 2020 Dec 16.

Cardiology Department, Nîmes University Hospital, Montpellier University, ACTION Study Group, Nîmes, France.

Pathological studies have revealed spontaneous recanalized coronary thrombi as a frequent evolution of coronary occlusions; however, they are poorly recognized on coronary angiography, and the optimal therapeutic strategy for clinical evolution is unknown. We report the role of optical coherence tomography in identifying a recanalized coronary thrombus causing myocardial ischemia after 11 years of follow-up. (). Read More

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December 2020

MitraClip Implantation in a Patient With Post-Surgical Repair of Primum Atrial Septal Defect and Residual Mitral Cleft.

JACC Case Rep 2020 Oct 21;2(12):2027-2029. Epub 2020 Oct 21.

Advanced Cardiac Imaging, Robert Wood Johnson Medical School, Rutgers, New Jersey.

This paper presents the case of a 67-year-old female with primum atrial septal defect and congenital mitral cleft status-post surgical repair 40 years previously who was recently found to have severe mitral regurgitation. Percutaneous mitral valve repair was successfully performed using implantation of 2 MitraClips with mild residual mitral regurgitation. (). Read More

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October 2020

Vacuuming in Crowded Dangerous Spaces: Aspiration of Large Ascending Aortic Thrombus.

JACC Case Rep 2020 Oct 21;2(12):1979-1983. Epub 2020 Oct 21.

Division of Cardiology, Center for Structural Heart Disease, Henry Ford Health System, Detroit, Michigan.

A patient had a stroke caused by a large, pedunculated aortic ascending mass and was deemed at high risk for near-term recurrent stroke. This case illustrates percutaneous aspiration thrombectomy of ascending aortic thrombus with the AngioVac system (Angiodynamics, Latham, New York), with conscious sedation for early stroke detection and with endovascular cerebral embolic protection. (). Read More

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October 2020

Rotational Atherectomy and Mechanical Support to Treat Left Main.

JACC Case Rep 2019 Dec 18;1(5):811-814. Epub 2019 Dec 18.

Valve and Structural Heart Disease Intervention Center, Division of Cardiovascular Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

We describe a complex percutaneous coronary intervention using rotational atherectomy (Rotablator, Boston Scientific, Marlborough, Massachusetts) and mechanical circulatory support (Impella, Abiomed, Danvers, Massachusetts) in a patient with multiple comorbidities scheduled to undergo a left main coronary percutaneous coronary intervention using a 2-stent technique based on angiography. However, intracoronary optical coherence tomography changed our strategy to a successful single-stent procedure. (). Read More

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December 2019

Imaging in Structural Heart Disease: The Evolution of a New Subspecialty.

JACC Case Rep 2019 Oct 2;1(3):440-445. Epub 2019 Oct 2.

Columbia University Medical Center/NewYork-Presbyterian Hospital, New York, New York.

Structural heart disease is a new field in cardiovascular medicine, which has resulted in the creation of a new imaging subspecialty. Structural heart disease imagers have been instrumental in stimulating innovations in both the imaging and interventional spheres. Perhaps most importantly, they play a key role on the clinical heart team, interacting with team members and patients before, during, and long after a structural procedure is performed. Read More

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October 2019

Anti-HIV activity of new pyrazolobenzothiazine 5,5-dioxide-based acetohydrazides.

Med Chem Res 2015 Oct 19;24(10):3671-3680. Epub 2015 Jul 19.

Center for AIDS Research, Laboratory of Biochemical Pharmacology, Emory University School of Medicine/Veterans Affairs Medical Center, 1760 Haygood Drive, Atlanta, GA 30322, USA.

A series of fifteen new 2-[3-(3-chlorophenyl)-5,5-dioxidobenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(2H)-yl]-'-arylmethyleneacetohydrazides () were synthesized and screened for their anti-HIV-1 and cytotoxicity activity. Out of fifteen pyrazolobenzothiazine-based hydrazones, thirteen were found to be active inhibitors of HIV with EC values <20 μM. Moreover, the cytotoxicity results showed that most of the compounds were toxic to PBM, CEM and Vero cell lines. Read More

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October 2015

Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model.

Stem Cell Res Ther 2021 Jul 27;12(1):423. Epub 2021 Jul 27.

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Background: Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell replacement therapy but often lack standardized cell production and live-cell shipment logistics as well as rigorous analyses of surgical procedures for cell transplantation in the delicate macula area. We have previously established a xeno- and feeder cell-free production system for hPSC differentiated retinal pigment epithelial (RPE) cells, and herein, a novel immunosuppressed non-human primate (NHP) model with a disrupted ocular immune privilege is presented for transplanting human embryonic stem cell (hESC)-derived RPE on a scaffold, and the safety and submacular graft integration are assessed. Furthermore, the feasibility of intercontinental shipment of live hESC-RPE is examined. Read More

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Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis.

Psychopharmacology (Berl) 2021 Jul 27. Epub 2021 Jul 27.

Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Numerous studies based on voxel-based morphometry (VBM) have revealed gray matter (GM) alterations in multiple brain regions for addiction. However, findings are poorly replicated, and it remains elusive whether distinct diagnoses of addiction are underpinned by shared abnormalities. Our aim was to conduct a quantitative meta-analysis of structural neuroimaging studies investigating GM abnormalities in two main categories of addiction: substance use disorders (SUD) and behavioral addictions (BA). Read More

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Insight into levofloxacin loaded biocompatible electrospun scaffolds for their potential as conjunctival substitutes.

Carbohydr Polym 2021 Oct 17;269:118341. Epub 2021 Jun 17.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address:

The rehabilitation of visual acuity with severe conjunctival fibrosis depends on ocular reconstruction with suitable conjunctival substitutes. In this study, we have developed poly(lactic acid) (PLA) electrospun nanofibrous membranes (EFMs) surface coated by cellulose nanofibrils (CNF) and/or silk peptide (SP). The CNF coating improved the hydrophilicity and the SP coating proliferated conjunctival epithelial cells (CjECs). Read More

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October 2021

Chitosan grafted butein: A metal-free transducer for electrochemical genosensing of exosomal CD24.

Carbohydr Polym 2021 Oct 15;269:118333. Epub 2021 Jun 15.

Electrodics and Electrocatalysis Division, CSIR-Central Electrochemical Research Institute (CECRI), Karaikudi 630 003, Tamil Nadu, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201 002, India. Electronic address:

Metal-free cost-efficient biocompatible molecules are beneficial for opto-electrochemical bioassays. Herein, chitosan (CS) conjugated butein is prepared via graft polymerization. Structural integrity between radical active sites of CS and its probable conjugation routes with reactive OH group of butein during grafting were comprehensively studied using optical absorbance/emission property, NMR, FT-IR and XPS analysis. Read More

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October 2021

Structural characterization of novel arabinoxylan and galactoarabinan from citron with potential antitumor and immunostimulatory activities.

Carbohydr Polym 2021 Oct 11;269:118331. Epub 2021 Jun 11.

College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

This study aimed to extract polysaccharides from citron and analyze their structures and potential bioactivities. Two novel polysaccharides CM-1 and CM-2 were purified from citron by DEAE-Sepharose Fast Flow and Sephadex G-100 column chromatography. Monosaccharide composition, linkage and NMR data were used to infer their sugar chains composition. Read More

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October 2021

Pectin and homogalacturonan with small molecular mass modulate microbial community and generate high SCFAs via in vitro gut fermentation.

Carbohydr Polym 2021 Oct 10;269:118326. Epub 2021 Jun 10.

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Hebei Normal University of Science & Technology, Qin Huangdao 066000, Heibei, China. Electronic address:

The intestinal fermentability of pectic polysaccharides is largely determined by its molecular size. In this study, fermentation properties of enzymatic-modified apple pectin (AP) and homogalacturonans (HG) with high, medium and low molecular weight (Mw) were evaluated by in vitro fermentation model, and their structural changes were also investigated. Results showed that Mw, monosaccharide contents and molecular linearity of the AP hydrolysates were reduced after microbial degradation. Read More

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October 2021

Exploiting diol reactivity for the access to unprecedented low molecular weight curdlan sulfate polysaccharides.

Carbohydr Polym 2021 Oct 10;269:118324. Epub 2021 Jun 10.

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S.Angelo, via Cintia 4, I-80126 Napoli, Italy. Electronic address:

Curdlan is a bacterial sourced polysaccharide, consisting of a linear backbone of β-1 → 3-linked glucose (Glc) units. The high interest in pharmaceutical applications of curdlan and derivatives thereof is fueling the study of multi-step sequences for regioselective modifications of its structure. Here we have developed semi-synthetic sequences based on a regioselective protection-sulfation-deprotection approach, allowing the access to some, new, low molecular weight curdlan polysaccharide derivatives with unprecedented sulfation patterns. Read More

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October 2021

Pretreatment of pine lignocelluloses by recyclable deep eutectic solvent for elevated enzymatic saccharification and lignin nanoparticles extraction.

Carbohydr Polym 2021 Oct 10;269:118321. Epub 2021 Jun 10.

State Key Laboratory of Pulp and Paper Engineering, Plant Fiber Research Center, South China University of Technology, Guangzhou, CN 510640, China.. Electronic address:

This study investigated the process intensification strategies for the pretreatment of Radiata Pine with the green deep eutectic solvent (DES) system composed of benzyltrimethylammonium chloride/formic acid (BTMAC/FA). The results showed that DES pretreatment drastically improved the delignification and hemicelluloses-removal capacity. The conducted process acceptably remained most of the cellulose in pretreated biomass (88. Read More

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October 2021

Delineating the inherent functional descriptors and biofunctionalities of pectic polysaccharides.

Carbohydr Polym 2021 Oct 9;269:118319. Epub 2021 Jun 9.

Chembiotech Laboratories, Advanced Science and Technology Institute, Kyrewood House, Tenbury Wells, Worcs WR15 8FF, UK.

Pectin is a plant-based heteropolysaccharide macromolecule predominantly found in the cell wall of plants. Pectin is commercially extracted from apple pomace, citrus peels and sugar beet pulp and is widely used in the food industry as a stabilizer, emulsifier, encapsulant, and gelling agent. This review highlights various parameters considered important for describing the inherent properties and biofunctionalities of pectins in food systems. Read More

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October 2021

Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis.

Carbohydr Polym 2021 Oct 2;269:118290. Epub 2021 Jun 2.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, Nanning 530022, China. Electronic address:

Glycosaminoglycan HnFG was extracted from sea cucumber Holothuria nobilis. Its chemical structure was characterized by analyzing the physicochemical properties, oligosaccharides from its mild acid hydrolysates and depolymerized products. The disaccharide d-GalNAc-α1,2-l-Fuc-ol found in its mild acid hydrolysates provided a clue for the presence of a unique disaccharide-branch in HnFG. Read More

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October 2021

Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.

Carbohydr Polym 2021 Oct 2;269:118288. Epub 2021 Jun 2.

College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, Beijing 100083, China. Electronic address:

A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography. On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→. Read More

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October 2021

Structural characterization and antitumor activity of a polysaccharide from Dendrobium wardianum.

Carbohydr Polym 2021 Oct 28;269:118253. Epub 2021 May 28.

Guangdong Provincial Key Lab of Ornamental Plant Germplasm Innovation and Utilization, Environmental Horticulture Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China. Electronic address:

Through hot water extraction, protein removal and chromatographic purification, DWPP-Is was found to be the major polysaccharide present in the stem of D. wardianum. The Mn and Mw of DWPP-Is were 29. Read More

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October 2021

Molecular modification, structural characterization, and biological activity of xylans.

Carbohydr Polym 2021 Oct 26;269:118248. Epub 2021 May 26.

College of Light Industry and Food Engineering, Guangxi University, Guangxi, Nanning 530004, China; Collaborative Innovation Center for Guangxi Sugarcane Industry, Guangxi University, Nanning 530004, China. Electronic address:

The differences in the source and structure of xylans make them have various biological activities. However, due to their inherent structural limitations, the various biological activities of xylans are far lower than those of commercial drugs. Currently, several types of molecular modification methods have been developed to address these limitations, and many derivatives with specific biological activity have been obtained. Read More

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October 2021

Primary visual cortex of the brain is associated with optic nerve head changes in neuromyelitis optica spectrum disorders.

Clin Neurol Neurosurg 2021 Jul 22;208:106822. Epub 2021 Jul 22.

Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Anhui 230022, China. Electronic address:

Objective: To explore the association between the primary visual cortex in the brain and optic nerve head changes, ONH, (structural thickness and microvascular changes) in neuromyelitis optica spectrum disorder (NMOSD).

Methods: Nineteen patients who were aquaporin-4 (AQP-4) seropositive NMOSD patients and twenty-two healthy controls (HC) were enrolled for this cross-sectional study. Optical coherence tomographic angiography (OCT-A) was used to image and measure the capillaries density (RPC, radial peripapillary capillaries) and structural thickness (pRNFL, peripapillary retinal nerve fiber layer) around the optic nerve head. Read More

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Swept-Source OCT En Face Imaging of Paravascular Inner Retinal Defects.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(7):407-411. Epub 2021 Jul 1.

Widefield swept-source optical coherence tomography angiography (SS-OCTA) was performed on eyes with paravascular inner retinal defects (PIRDs) and the morphological alterations of PIRDs were described. Patients with PIRDs were imaged using 12 mm × 12 mm SS-OCTA scans. En face structural and angiographic images of the superficial retinal layers were reviewed along with retinal thickness maps. Read More

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Preliminary investigation of drug impurities associated with the anti-influenza drug Favipiravir - An insilico approach.

Comput Theor Chem 2021 Oct 17;1204:113375. Epub 2021 Jul 17.

Department of Chemistry, Amrita School of Engineering, Bengaluru Amrita Vishwa Vidyapeetham, India.

The role of repurposed or modified antiviral drugs has become more significant during the current global pandemic of SARS Covid-19. In the present study, four structurally analogous impurity molecules of antiviral drug Favipiravir are selected for preliminary computational investigation for assessing the structure-activity relationship. The optimized geometry and the electronic structures of the compounds are computed using Density Functional Theory as a precursor to evaluating their physical, chemical and spectral properties. Read More

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October 2021

Fluorophore Coupling to Internal Modes of Bragg Gratings.

J Phys Chem C Nanomater Interfaces 2020 Oct 30;124(41):22743-22752. Epub 2020 Sep 30.

Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.

Multilayer structures with two dielectrics having different optical constants and no structural features in the - plane can display photonic band gaps (PBGs) and are called one-dimensional photonic crystals (1DPCs). If the top layer thickness is carefully selected, the electromagnetic energy can be trapped at the top surface. These highly enhanced fields are called Bloch surface waves (BSWs). Read More

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October 2020

Children's Dysregulated Representations Mediate Ineffective Parenting Practices and Effortful Control in Lower Income Families.

Fam Relat 2020 Oct 29;69(4):698-713. Epub 2020 Jun 29.

University of Wisconsin-Madison.

Objective: Rooted in attachment theory, we tested the degree to which children's dysregulated representations mediate linkages between ineffective parenting and children's effortful control in a sample of lower income families.

Background: Children in lower income households are at greater risk for difficulties with effortful control. Although ineffective parenting practices may influence children's development of effortful control, there is limited knowledge related to the mechanisms underlying this association. Read More

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October 2020

A comparison of posterior segment optical coherence tomography findings in full-term and preterm children without retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2151-2156

Ophthalmology and Optometry Department - Hospital Militar Central, Bogotá, Colombia.

Purpose: Structural differences have been described in the retina of prematurely born children, including increased macular thickness caused by failed migration of the inner retina during development and retinal nerve fiber layer (RNFL) thinning related to low birth weight. The present study aimed to evaluate the differences in macular and RNFL optical coherence tomography (OCT) findings between full-term and preterm children without retinopathy of prematurity (ROP).

Methods: Thirty-four premature (study group) and 43 full-term patients (control group)-aged 3 to 8 years-were studied. Read More

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Impact of stent malapposition on intracoronary flow dynamics: An optical coherence tomography-based patient-specific study.

Med Eng Phys 2021 Aug 8;94:26-32. Epub 2021 Jun 8.

Biomechanics Laboratory, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, PR China; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane QLD 4001, Australia. Electronic address:

Percutaneous coronary intervention with stent implantation has emerged as a popular approach to treat coronary artery stenosis. Stent malapposition (SM), also referred as incomplete stent apposition, could reduce stent tissue coverage and hence increase the risk of late stent thrombosis. The objective of this study was to investigate the impact of SM on intracoronary flow dynamics by combining optical coherence tomography (OCT) image-based model reconstruction and computational analysis. Read More

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Wide-field optical coherence tomography deviation map for early glaucoma detection.

Br J Ophthalmol 2021 Jul 22. Epub 2021 Jul 22.

Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea

Background/aims: This study aimed to establish a wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans. Moreover, it also aimed to compare the diagnostic ability of this wide-field deviation map with that of the peripapillary and macular deviation maps currently being used for the detection of early glaucoma (EG).

Methods: Four hundred eyes, including 200 healthy eyes and 200 eyes with EG were enrolled in this retrospective observational study. Read More

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Multimodal imaging of Hypotrichosis with juvenile macular dystrophy: a case report.

BMC Ophthalmol 2021 Jul 23;21(1):284. Epub 2021 Jul 23.

Department of Ophthalmology, University "Magna Græcia", Viale Europa, Loc. Germaneto, Catanzaro, Italy.

Background: To report the first Italian case of hypotrichosis with juvenile macular dystrophy complicated by macular neovascularization diagnosed through multimodal imaging.

Case Presentation: An 11-year-old boy was referred to our Institution for bilateral maculopathy of unknown origin. Multimodal imaging helps the diagnosis of Juvenile Macular Dystrophy with Hypotrichosis (HJMD). Read More

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Age of Speech Onset in Autism Relates to Structural Connectivity in the Language Network.

Cereb Cortex Commun 2020 23;1(1):tgaa077. Epub 2020 Oct 23.

Département de Psychiatrie et d'addictologie, de l'Université de Montréal, Montréal, QC H3T 1J4, Canada.

Speech onset delays (SOD) and language atypicalities are central aspects of the autism spectrum (AS), despite not being included in the categorical diagnosis of AS. Previous studies separating participants according to speech onset history have shown distinct patterns of brain organization and activation in perceptual tasks. One major white matter tract, the arcuate fasciculus (AF), connects the posterior temporal and left frontal language regions. Read More

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October 2020

Intrinsic Connectivity Changes Mediate the Beneficial Effect of Cardiovascular Exercise on Sustained Visual Attention.

Cereb Cortex Commun 2020 9;1(1):tgaa075. Epub 2020 Oct 9.

Department of Sport Science, Faculty of Human Sciences, Institute III, Otto von Guericke University, Magdeburg 39104, Germany.

Cardiovascular exercise (CE) is an evidence-based healthy lifestyle strategy. Yet, little is known about its effects on brain and cognition in young adults. Furthermore, evidence supporting a causal path linking CE to human cognitive performance via neuroplasticity is currently lacking. Read More

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October 2020