46,804 results match your criteria structural characteristics

Intra- and inter-hemispheric structural connectome in agenesis of the corpus callosum.

Neuroimage Clin 2021 Jun 5;31:102709. Epub 2021 Jun 5.

Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland; Brain and Mind Research, Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Division of Development and Growth, Department of Paediatrics, Faculty of Medicine, University of Geneva, Switzerland. Electronic address:

Agenesis of the corpus callosum (AgCC) is a congenital brain malformation characterized by the complete or partial failure to develop the corpus callosum. Despite missing the largest white matter bundle connecting the left and right hemispheres of the brain, studies have shown preserved inter-hemispheric communication in individuals with AgCC. It is likely that plasticity provides mechanisms for the brain to adjust in the context of AgCC, as the malformation disrupts programmed developmental brain processes very early on. Read More

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Quantifying effects of reverse linear perspective as a visual cue on vehicle and platoon crash risk variations in car-following using path analysis.

Accid Anal Prev 2021 Jun 12;159:106215. Epub 2021 Jun 12.

School of Civil Engineering and Architecture, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address:

Road markings are prevalent in practice as perceptual countermeasures to crashes, and a great deal of them have been used for speed reduction. However, there is rare seen any equivalent measures especially for distance control. More importantly, the visual perceptual mechanism of road markings on driving behaviors and crash risk is still blur. Read More

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Stimuli-responsive surfaces for switchable wettability and adhesion.

J R Soc Interface 2021 Jun 16;18(179):20210162. Epub 2021 Jun 16.

Centre of Advanced Structural Ceramics, Department of Materials, Imperial College London, London SW7 2AZ, UK.

Diverse unique surfaces exist in nature, e.g. lotus leaf, rose petal and rice leaf. Read More

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Palatability and Physical and Chemical Defenses in Five Annelid Polychaetes from Tropical Brazilian Beaches.

Biol Bull 2021 Jun 5;240(3):157-168. Epub 2021 May 5.

AbstractAlthough researchers have examined numerous marine organisms' compensatory characteristics to minimize predation pressure, few have investigated the defensive mechanisms of polychaetes, despite their diversity. Thus, our study's aim was to evaluate the palatability and defensive strategies, both chemical and structural, in the polychaetes , , , , and sp. Another twofold aim was to determine, by comparing our results with the literature, any latitudinal difference in the defensive strategies of and to assess defensive mechanisms and palatability in relation to individuals' mobility, overtness, body regionalization, and color. Read More

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Clinical Characteristics of Patients with Adrenal Insufficiency and Fever.

J Korean Med Sci 2021 Jun 14;36(23):e152. Epub 2021 Jun 14.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: Because persistent fever often occurs in adrenal insufficiency, it might be confused with infectious diseases. This study aimed to identify clinical characteristics and risk factors of patients with adrenal insufficiency and fever.

Methods: All adult patients (n = 150) admitted to a tertiary care hospital in South Korea and diagnosed with adrenal insufficiency between 1 March 2018, and 30 June 2019, were recruited. Read More

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Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine.

Biofactors 2021 Jun 15. Epub 2021 Jun 15.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

Selenium (Se) plays a crucial role in intestinal health. However, the specific mechanism by which deficiency of Se causes intestinal damage remains unclear. This study was to explore whether Se deficiency can cause ER stress and induce apoptosis in swine small intestine. Read More

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Molecular cloning, characterization and expression analysis of three key starch synthesis-related genes from the bulb of a rare lily germplasm, var. .

J Zhejiang Univ Sci B 2021 Jun;22(6):476-491

Genomics and Genetic Engineering Laboratory of Ornamental Plants, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.

Starch is the predominant compound in bulb scales, and previous studies have shown that bulblet development is closely associated with starch enrichment. However, how starch synthesis affects bulbification at the molecular level is unclear. In this study, we demonstrate that var. Read More

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Pitt-Hopkins syndrome: phenotypic and genotypic description of four unrelated patients and structural analysis of corresponding missense mutations.

Neurogenetics 2021 Jun 14. Epub 2021 Jun 14.

Department of Rehabilitation, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Pitt-Hopkins syndrome is an underdiagnosed neurodevelopmental disorder which is characterized by specific facial features, early-onset developmental delay, and moderate to severe intellectual disability. The genetic cause, a deficiency of the TCF4 gene, has been established; however, the underlying pathological mechanisms of this disease are still unclear. Herein, we report four unrelated children with different de novo mutations (T606A, K607E, R578C, and V617I) located at highly conserved sites and with clinical phenotypes which present variable degrees of developmental delay and intellectual disability. Read More

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Formation of Al aggregates and its correlation to the coagulation effect.

Chemosphere 2021 Sep 5;278:130493. Epub 2021 Apr 5.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, No. 18, Shuangqing Road, Haidian District, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Yangtze River Delta Branch, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Yiwu, Zhejiang, 322000, China. Electronic address:

Al is the polycation with the highest degree of polymerization and surface charge in the currently known structural aluminum species. It shows excellent coagulation performance in water treatment process, and has the characteristics of wide application range of pH and dosage. pH value is one of the most important factors affecting the aggregation and coagulation process of Al, but the influence of Al aggregation reaction on its coagulation effect is still unclear. Read More

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September 2021

Regio- and diastereoselective dearomatizations of -alkyl activated azaarenes: the maximization of the reactive sites.

Chem Sci 2019 Dec 17;11(5):1418-1424. Epub 2019 Dec 17.

College of Chemistry and Chemical Engineering, Henan University Kaifeng 475004 China

An unprecedented base-promoted multi-component one-pot dearomatization of -alkyl activated azaarenes was developed, which enabled the synthesis of complex and diverse bridged cyclic polycycles with multiple stereocenters in a highly regio- and diastereoselective manner. Besides, we realized the step-controlled dearomative bi- and trifunctionalization of quinolinium salts. These transformations not only achieved the maximization of the reaction sites of pyridinium, quinolinium and isoquinolinium salts to enhance structural complexity and diversity, but also opened up a new reaction mode of these -activated azaarenes. Read More

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December 2019

Tackling the chemical diversity of microbial nonulosonic acids - a universal large-scale survey approach.

Chem Sci 2020 Feb 24;11(11):3074-3080. Epub 2020 Feb 24.

Department of Biotechnology, Delft University of Technology 2629 HZ Delft The Netherlands

Nonulosonic acids, commonly referred to as sialic acids, are a highly important group of nine-carbon sugars common to all domains of life. They all share biosynthetic and structural features, but otherwise display a remarkable chemical diversity. In humans, sialic acids cover all cells which makes them important for processes such as cellular protection, immunity and brain development. Read More

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February 2020

Characterization and biogeochemical implications of dissolved organic matter in aquatic environments.

J Environ Manage 2021 Jun 12;294:113041. Epub 2021 Jun 12.

Key Laboratory of Northwest Water Resource, Environment and Ecology, MOE, Xi'an University of Architecture and Technology, Xi'an, 710055, People's Republic of China; International Science & Technology Cooperation Center for Urban Alternative Water Resources Development, Xi'an University of Architecture and Technology, Xi'an, 710055, People's Republic of China. Electronic address:

Dissolved organic matter (DOM) is viewed as one of the most chemically active organic substances on earth. It plays vital roles in the fate, bioavailability and toxicity of aquatic exogenous chemical species (e.g. Read More

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Autograft long head biceps tendon can be used as a scaffold for biologically augmenting rotator cuff repairs.

Arthroscopy 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Orthopaedic Tissue Regeneration & Orthobiologics, Department of Bioengineering, Clemson University, Clemson, SC; Frank H. Stelling and C. Dayton Riddle Orthopaedic Education and Research Laboratory, Clemson University Biomedical Engineering Innovation Campus, Greenville, SC.

Purpose: To create a viable, mechanically expanded autograft long head biceps tendon (LHBT) scaffold for biologically augmenting the repair of torn rotator cuffs.

Methods: The proximal aspect of the tenotomized LHBTs were harvested from patients during rotator cuff repair surgery and were mechanically formed into porous scaffolds using a surgical graft expander. LHBT scaffolds were evaluated for change in area, tensile properties, and tenocyte viability before and after expansion. Read More

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Photoconductive Properties and Electronic Structure in 3,5-Disubstituted 2-(2'-Pyridyl)Pyrroles Coordinated to a Pd(II) Salicylideneiminate Synthon.

Inorg Chem 2021 Jun 14. Epub 2021 Jun 14.

MAT-INLAB (Laboratorio di Materiali Molecolari Inorganici) and LASCAMM-CR INSTM, Unità INSTM della Calabria, Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy.

The synthesis and the electrochemical, photophysical, structural, and photoconductive properties of three new heteroleptic Pd(II) complexes with various 3',5'- disubstituted-2-(2'-pyridil) pyrroles H(N^N) as coordinated ligands are reported. The coordination of the metal center was completed by a functionalized Schiff base H(O^N) used as an ancillary ligand. The [(N^N)Pd(O^N)] complexes showed highly interesting photoconductive properties which have been correlated to their electronic and molecular structures. Read More

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Tuneable Hybrid Hydrogels via Complementary Self-Assembly of a Bioactive Peptide with a Robust Polysaccharide.

ACS Biomater Sci Eng 2021 Jun 14. Epub 2021 Jun 14.

Biofab3D, Aikenhead Centre for Medical Discovery, St Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.

Synthetic materials designed for improved biomimicry of the extracellular matrix must contain fibrous, bioactive, and mechanical cues. Self-assembly of low molecular weight gelator (LMWG) peptides Fmoc-DIKVAV (Fmoc-aspartic acid-isoleucine-lysine-valine-alanine-valine) and Fmoc-FRGDF (Fmoc-phenylalanine-arginine-glycine-aspartic acid-phenylalanine) creates fibrous and bioactive hydrogels. Polysaccharides such as agarose are biocompatible, degradable, and non-toxic. Read More

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Pathways of emotional autonomy, problem-solving ability, self-efficacy, and self-management on the glycemic control of adolescents with type 1 diabetes: A prospective study.

Res Nurs Health 2021 Jun 14. Epub 2021 Jun 14.

College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan.

This prospective study tested a model to depict associations between a number of individual characteristics and 6-month glycated hemoglobin (HbA1c) levels in adolescents with type 1 diabetes (T1D). Adolescents (N = 232) aged 10-19 years with T1D were recruited from a medical center in Taiwan. Demographic characteristics, emotional autonomy, problem-solving ability, self-efficacy at baseline, and self-management information three months after baseline were collected using a self-reported questionnaire. Read More

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Structure and concept of ICU rounds: the VIS-ITS survey.

Med Klin Intensivmed Notfmed 2021 Jun 14. Epub 2021 Jun 14.

Medical ICU, Department of Medicine, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

Objective: To gather data about structural and procedural characteristics of patient rounds in the intensive care unit (ICU) setting.

Design: A structured online survey was offered to members of two German intensive care medicine societies.

Measurements And Main Results: Intensivists representing 390 German ICUs participated in this study (university hospitals 25%, tertiary hospitals 23%, secondary hospitals 36%, primary hospitals 16%). Read More

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Conformational changes in three-dimensional chromatin structure in after phytoplasma infection.

Phytopathology 2021 Jun 14. Epub 2021 Jun 14.

Beijing, China;

Higher-order chromatin structures play important roles in regulating multiple biological processes, growth and development, biotic and abiotic stress response. However, little is known about three-dimensional chromatin structures in Paulownia, or about whole-genome chromatin conformational changes that occur in response to Paulownia witches' broom (PaWB) disease. We used high-throughput chromosome conformation capture (Hi-C) to obtain genome-wide profiles of chromatin conformation in healthy and phytoplasma-infected genome. Read More

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Modelling the leadership characteristics for organizational readiness: a context of lean implementation in healthcare.

Leadersh Health Serv (Bradf Engl) 2021 Jun;ahead-of-print(ahead-of-print)

Amrita School of Business, Amrita Vishwa Vidyapeetham, Coimbatore, India.

Purpose: The purpose of this study is to identify the leadership characteristics that make a health-care organization ready for lean implementation, analyse the interdependence among them and determine the rank of each characteristic based on their influence in the overall phenomenon.

Design/methodology/approach: The leadership characteristics were identified through a review followed by an expert interview. Then, total interpretive structural modelling (TISM) was used to analyse the interdependence and determine the rank, driving power and dependence of each characteristic. Read More

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New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells.

RSC Med Chem 2021 Apr 19;12(5):767-778. Epub 2021 Apr 19.

School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo PO Box 1068 Blindern N0316 Oslo Norway

Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin () and myxin () exhibit potent and hypoxia-selective cell death on MOLM-13 human AML cells, and that the -oxide functionalities are pivotal for the cytotoxic activity. Very few structure-activity relationship studies dedicated to phenazine 5,10-dioxides exist on mammalian cell lines and the present work describes our efforts regarding lead optimizations of the natural compounds iodinin () and myxin (). Read More

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Effects of Strain and Electric Field on Molecular Doping in MoSSe.

ACS Omega 2021 Jun 25;6(22):14639-14647. Epub 2021 May 25.

College of Physics and Communication Electronics, Laboratory of Computational Material Physics, Jiangxi Normal University, Nanchang 330022, China.

Recently, synthesized Janus MoSSe monolayers have attracted tremendous attention in science and technology due to their novel properties and promising applications. In this work, we investigate their molecular adsorption-induced structural and electronic properties and tunable doping effects under biaxial strain and external electric field by first-principles calculations. We find an effective n-type or p-type doping in the MoSSe monolayer caused by noncovalent tetrathiafulvalene (TTF) or tetracyanoquinodimethane (TCNQ) molecular adsorption. Read More

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Investigation of the Mechanism of Complement System in Diabetic Nephropathy via Bioinformatics Analysis.

J Diabetes Res 2021 24;2021:5546199. Epub 2021 May 24.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072 Sichuan, China.

Objectives: Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) throughout the world, and the identification of novel biomarkers via bioinformatics analysis could provide research foundation for future experimental verification and large-group cohort in DN models and patients.

Methods: GSE30528, GSE47183, and GSE104948 were downloaded from Gene Expression Omnibus (GEO) database to find differentially expressed genes (DEGs). The difference of gene expression between normal renal tissues and DN renal tissues was firstly screened by GEO2R. Read More

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A Dual Peptide Sustained-Release System Based on Nanohydroxyapatite/Polyamide 66 Scaffold for Synergistic-Enhancing Diabetic Rats' Fracture Healing in Osteogenesis and Angiogenesis.

Front Bioeng Biotechnol 2021 26;9:657699. Epub 2021 May 26.

Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Diabetes mellitus impairs fracture healing and function of stem cells related to bone regeneration; thus, effective bone tissue engineering therapies can intervene with those dysfunctions. Nanohydroxyapatite/polyamide 66 (n-HA/PA66) scaffold has been used in fracture healing, whereas the low bioactivity limits its further application. Herein, we developed a novel bone morphogenetic protein-2- (BMP-2) and vascular endothelial growth factor- (VEGF) derived peptides-decorated n-HA/PA66 (BVHP66) scaffold for diabetic fracture. Read More

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Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images.

Biomed Opt Express 2021 May 8;12(5):2647-2660. Epub 2021 Apr 8.

Department of Electrical and Computer Engineering, New Jersey Institute of Technology, University Heights, Newark, New Jersey 07105, USA.

In this study, we performed dual-modality optical coherence tomography (OCT) characterization (volumetric OCT imaging and quantitative optical coherence elastography) on human breast tissue specimens. We trained and validated a U-Net for automatic image segmentation. Our results demonstrated that U-Net segmentation can be used to assist clinical diagnosis for breast cancer, and is a powerful enabling tool to advance our understanding of the characteristics for breast tissue. Read More

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Isolation, characterization, and genomic analysis of the novel T4-like bacteriophage ΦCJ20.

Food Sci Biotechnol 2021 May 11;30(5):735-744. Epub 2021 May 11.

Department of Biological Science and Technology, Yonsei University, 1 Yeonsedae-gil, Heungeop-myeon, Wonju-si, Gangwon-do 26493 Republic of Korea.

Pathogenic infections have been consistently reported annually. The basic characteristics and genome of the newly isolated ΦCJ20 from swine feces was analyzed. To determine basic characteristics, dotting assays and double-layer agar assays were conducted. Read More

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Simultaneous structural and elemental nano-imaging of human brain tissue.

Chem Sci 2020 Aug 10;11(33):8919-8927. Epub 2020 Aug 10.

Brain and Mind Centre and Discipline of Pharmacology, The University of Sydney Camperdown NSW 2050 Australia

Examining chemical and structural characteristics of micro-features in complex tissue matrices is essential for understanding biological systems. Advances in multimodal chemical and structural imaging using synchrotron radiation have overcome many issues in correlative imaging, enabling the characterization of distinct microfeatures at nanoscale resolution in tissues. We present a nanoscale imaging method that pairs X-ray ptychography and X-ray fluorescence microscopy (XFM) to simultaneously examine structural features and quantify elemental content of microfeatures in complex tissues. Read More

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Driving high quantum yield NIR emission through proquinoidal linkage motifs in conjugated supermolecular arrays.

Chem Sci 2020 Aug 5;11(31):8095-8104. Epub 2020 Aug 5.

Department of Chemistry, French Family Science Center, Duke University 124 Science Drive Durham North Carolina 27708-0346 USA

High quantum yield NIR fluorophores are rare. Factors that drive low emission quantum yields at long wavelength include the facts that radiative rate constants increase proportional to the cube of the emission energy, while nonradiative rate constants increase in an approximately exponentially with decreasing S-S energy gaps (in accordance with the energy gap law). This work demonstrates how the proquinoidal BTD building blocks can be utilized to minimize the extent of excited-state structural relaxation relative to the ground-state conformation in highly conjugated porphyrin oligomers, and shows that 4-ethynylbenzo[][1,2,5]thiadiazole () units that terminate -to- ethyne-bridged (porphinato)zinc () arrays, and 4,7-diethynylbenzo[][1,2,5]thiadiazole () spacers that are integrated into the backbone of these compositions, elucidate new classes of impressive NIR fluorophores. Read More

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Diversity of the Tellurite Resistance Gene Operon in .

Front Microbiol 2021 28;12:681175. Epub 2021 May 28.

Department of Environment and Resource Sciences, University of Miyazaki, Miyazaki, Japan.

Tellurite is highly toxic to most bacteria owing to its strong oxidative ability. However, some bacteria demonstrate tellurite resistance. In particular, some strains, including Shiga toxin-producing O157:H7, are known to be resistant to tellurite. Read More

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Long-Term Results of Ultrasound-Guided Radiofrequency Ablation of Benign Thyroid Nodules: State of the Art and Future Perspectives-A Systematic Review.

Front Endocrinol (Lausanne) 2021 26;12:622996. Epub 2021 May 26.

American Hospital of Paris, Thyroid Unit, Neuilly-sur-Seine, France.

Background: Nearly 20 years after the first feasibility study, minimally invasive ultrasound (US)-guided therapeutic techniques are now considered as a safe and effective alternative to surgery for symptomatic benign thyroid nodules. Radiofrequency ablation (RFA) is one of the most widely used treatment in specialized thyroid centers but, due to the relatively recent introduction into clinical practice, there are limited long-term follow-up studies. Aim of our work was to review the outcomes of RFA on solid nonfunctioning and on autonomous thyroid nodules (AFTN) on a long-time period for assessing the results in term of efficacy, complications, and costs and to compare them to the current indications of RFA. Read More

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Animal and Organoid Models of Liver Fibrosis.

Front Physiol 2021 26;12:666138. Epub 2021 May 26.

Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.

Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver. Liver fibrosis thus constitutes the pathological repair response of the liver to chronic injury. Hepatic fibrosis is a key step in the progression of chronic liver disease to cirrhosis and an important factor affecting the prognosis of chronic liver disease. Read More

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