34,689 results match your criteria strong signal

Testing general relativity with gravitational-wave catalogs: The insidious nature of waveform systematics.

iScience 2021 Jun 16;24(6):102577. Epub 2021 Jun 16.

School of Physics and Astronomy & Institute for Gravitational Wave Astronomy, University of Birmingham, Birmingham B15 2TT, UK.

Gravitational-wave observations of binary black holes allow new tests of general relativity (GR) to be performed on strong, dynamical gravitational fields. These tests require accurate waveform models of the gravitational-wave signal; otherwise waveform errors can erroneously suggest evidence for new physics. Existing waveforms are generally thought to be accurate enough for current observations, and each of the events observed to date appears to be individually consistent with GR. Read More

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Surface-Enhanced Raman Spectroscopy Characterization of Breast Cell Phenotypes: Effect of Nanoparticle Geometry.

ACS Appl Nano Mater 2019 Nov 20;2(11):6960-6970. Epub 2019 Oct 20.

Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York 11794, United States.

The use of surface-enhanced Raman spectroscopy (SERS) to delineate between the breast epithelial cell lines MCF10A, SK-BR-3, and MDA-MB-231 is explored utilizing varied morphologies of gold nanoparticles. The nanoparticles studied had spherical, star-like, and quasi-fractal (nanocaltrop) morphologies and possessed varying degrees of surface inhomogeneity and complexity. The efficacy of Raman enhancement of these nanoparticles was a function of their size, their surface morphology, and the associated density of "hot spots," as well as their cellular uptake. Read More

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November 2019

Binary Surfactant-Mediated Tunable Nanotip Growth on Gold Nanoparticles and Applications in Photothermal Catalysis.

Front Chem 2021 7;9:699548. Epub 2021 Jul 7.

School of Physics and Information Technology, Shaanxi Normal University, Xi'an, China.

Plasmonic nanostructures with sharp tips are widely used for optical signal enhancement because of their strong light-confining abilities. These structures have a wide range of potential applications, for example, in sensing, bioimaging, and surface-enhanced Raman scattering. Au nanoparticles, which are important plasmonic materials with high photothermal conversion efficiencies in the visible to near-infrared region, have contributed greatly to the development of photothermal catalysis. Read More

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Biomechanical adaptations for burrowing in the incisor enamel microstructure of Geomyidae and Heteromyidae (Rodentia: Geomyoidea).

Ecol Evol 2021 Jul 16;11(14):9447-9459. Epub 2021 Jun 16.

Department of Palaeobiology Swedish Museum of Natural History Stockholm Sweden.

The enamel microstructure of fossil and extant Geomyoidea (Geomyidae, Heteromyidae) lower incisors incorporates three- or two-layered schmelzmusters with uniserial, transverse Hunter-Schreger bands having parallel and perpendicular or exclusively perpendicular oriented interprismatic matrix. Phylogenetically, these schmelzmusters are regarded as moderately (enamel type 2) to highly derived (enamel type 3). Our analysis detected a zone of modified radial enamel close to the enamel-dentine junction. Read More

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Inhibitory Role of an TIR Domain Effector in Antibacterial Immunity by Targeting TLR Signaling Complexes in Zebrafish.

Front Microbiol 2021 8;12:694081. Epub 2021 Jul 8.

College of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, Hangzhou, China.

The Toll/interleukin-1 receptor (TIR) domain is a structural unit responsible for the assembly of signal protein complexes in Toll-like receptor (TLR) and interleukin-1 receptor signaling pathways. TIR domain homologs are found in a considerable number of bacteria and enhance bacterial infection and survival in host organisms. However, whether TIR domain homologs exist in , a ubiquitous waterborne bacterium in aquatic environments, remains poorly understood. Read More

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[The New Federal Fiscal Equalisation System 2020: First Results and Evaluation].

Wirtschaftsdienst 2021 19;101(7):544-551. Epub 2021 Jul 19.

FB Wirtschaftswissenschaft, Universität Bremen, Wilhelm-Herbst-Straße 12, 28359 Bremen, Deutschland.

The new Federal Fiscal Equalization System became effective on 1 January, 2020. While all public budgets in the federal system of Germany were faced with high decreases in revenues caused by the measures to fight the impacts of the COVID-19 pandemic in 2020, a first evaluation shows that the differences to the old system are rather marginal. The focus now lies on the vertical distribution of the value-added tax, whereas for the fiscal capacity equalisation only revenue of the Laender are used as before. Read More

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Anosmia, ageusia, and other COVID-19-like symptoms in association with a positive SARS-CoV-2 test, across six national digital surveillance platforms: an observational study.

Lancet Digit Health 2021 Jul 22. Epub 2021 Jul 22.

Computational Epidemiology Lab, Boston Children's Hospital, Boston, MA, USA; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.

Background: Multiple voluntary surveillance platforms were developed across the world in response to the COVID-19 pandemic, providing a real-time understanding of population-based COVID-19 epidemiology. During this time, testing criteria broadened and health-care policies matured. We aimed to test whether there were consistent associations of symptoms with SARS-CoV-2 test status across three surveillance platforms in three countries (two platforms per country), during periods of testing and policy changes. Read More

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Role of TRPV1 channels on glycogen synthase kinase-3β and oxidative stress in ouabain-induced bipolar disease.

J Recept Signal Transduct Res 2021 Jul 26:1-11. Epub 2021 Jul 26.

Department of Pharmacology, School of Medicine, Ondokuz Mayıs University, Samsun, Turkey.

Bipolar disorder (BD) is a multifactorial chronic and refractory disease characterized by manic, depressive, and mixed mood episodes. Although epidemiological, and pathophysiological studies demonstrated a strong correlation between bipolar disorder and oxidative stress, precise etiology is still missing. Recent studies suggested the possible role of transient receptor potential channels (TRP) in the BD but, current knowledge is limited. Read More

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Signal envelope and speech intelligibility differentially impact auditory motion perception.

Sci Rep 2021 Jul 23;11(1):15117. Epub 2021 Jul 23.

University of Wisconsin-Madison, Waisman Center, 1500 Highland Ave, Madison, WI, 53705, USA.

Our acoustic environment contains a plethora of complex sounds that are often in motion. To gauge approaching danger and communicate effectively, listeners need to localize and identify sounds, which includes determining sound motion. This study addresses which acoustic cues impact listeners' ability to determine sound motion. Read More

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M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.

Cancer Res 2021 Jul 23. Epub 2021 Jul 23.

The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital,Eastern Hepatobiliary Surgery Institute, Second Military Medical University, National center for liver cancer

N6-methyladenosine (m6A) has been reported as an important mechanism of post-transcriptional regulation. Programmed death-ligand 1 (PD-L1) is a primary immune inhibitory molecule expressed on tumor cells that promotes immune evasion. Here we report ALKBH5 as an important m6A demethylase that orchestrates PD-L1 expression in intrahepatic cholangiocarcinoma (ICC). Read More

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Mitochondrial Metal Ion Transport in Cell Metabolism and Disease.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.

Mitochondria are vital to life and provide biological energy for other organelles and cell physiological processes. On the mitochondrial double layer membrane, there are a variety of channels and transporters to transport different metal ions, such as Ca, K, Na, Mg, Zn and Fe/Fe. Emerging evidence in recent years has shown that the metal ion transport is essential for mitochondrial function and cellular metabolism, including oxidative phosphorylation (OXPHOS), ATP production, mitochondrial integrity, mitochondrial volume, enzyme activity, signal transduction, proliferation and apoptosis. Read More

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Modulation of the Earliest Component of the Human VEP by Spatial Attention: An Investigation of Task Demands.

Cereb Cortex Commun 2020 5;1(1):tgaa045. Epub 2020 Aug 5.

Cognitive Neural Systems Lab, School of Electrical and Electronic Engineering and UCD Centre for Biomedical Engineering, University College Dublin, Dublin 4, Ireland.

Spatial attention modulations of initial afferent activity in area V1, indexed by the first component "C1" of the human visual evoked potential, are rarely found. It has thus been suggested that early modulation is induced only by special task conditions, but what these conditions are remains unknown. Recent failed replications-findings of no C1 modulation using a certain task that had previously produced robust modulations-present a strong basis for examining this question. Read More

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Strong near band-edge excited second-harmonic generation from multilayer 2H Tin diselenide.

Sci Rep 2021 Jul 22;11(1):15017. Epub 2021 Jul 22.

Department of Electrical Communication Engineering, Indian Institution of Science, Bangalore, 560012, India.

We report strong second-harmonic generation (SHG) from 2H polytype of multilayer Tin diselenide (SnSe) for fundamental excitation close to the indirect band-edge in the absence of excitonic resonances. Comparison of SHG and Raman spectra from exfoliated SnSe flakes of different polytypes shows strong (negligible) SHG and Raman E mode at 109 cm (119 cm), consistent with 2H (1T) polytypes. The difference between the A-E Raman peak positions is found to exhibit significant thickness dependent for the 1T form, which is found to be absent for the 2H form. Read More

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Highly sensitive magnetic relaxation sensing method for aflatoxin B1 detection based on Au NP-assisted triple self-assembly cascade signal amplification.

Biosens Bioelectron 2021 Jul 9;192:113489. Epub 2021 Jul 9.

Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Science/Key Laboratory of Agro-Products Quality and Safety of MOA, Beijing, 100081, PR China. Electronic address:

Highly sensitive detection of aflatoxin B (AFB) is of great significance because of its high toxicity and carcinogenesis. We propose a magnetic relaxation sensing method based on gold nanoparticles (Au NPs)-assisted triple self-assembly cascade signal amplification for highly sensitive detection of AFB. Both AFB antibody and initiator DNA (iDNA) are labeled on Au NPs to form Ab-Au-iDNA probe. Read More

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Fabrication of high quality electrochemical SERS (EC-SERS) substrates using physical vapour deposition.

Phys Chem Chem Phys 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia B3H3C3, Canada.

Screen-printed electrodes (SPEs) are an efficient and inexpensive substrate for electrochemical surface-enhanced Raman spectroscopy (EC-SERS) studies. Traditionally, the working electrode of the SPE is modified with either a colloidal paste of metal nanoparticles or an electrodeposited metallic film. These methods can be time-consuming and often produce non-uniform nanostructured films. Read More

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Strong Polarized Photoluminescence CsPbBr Nanowire Composite Films for UV Spectral Conversion Polarization Photodetector Enhancement.

ACS Appl Mater Interfaces 2021 Jul 21. Epub 2021 Jul 21.

Key Laboratory of Advanced Display Materials and Devices, Ministry of Industry and Information Technology, Institute of Optoelectronics & Nanomaterials, School of Material Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

In this work, we proposed a fluorescence conversion layer with polarization characteristics to enhance UV polarization detection for the first time. To achieve this goal, the colloidal lead halide CsPbBr nanowires (NWs) with appropriate lengths were synthesized by the method of ultrasonication synthesis assisted by the addition of hydrobromic acid (HBr) ligands. By adding HBr, the properties of synthesized NWs are improved, and due to the controllable perovskite-stretched NWs, polymer composite films were fabricated, which can generate photoluminescence (PL) with strong polarization. Read More

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A Perceptual Learning Approach for Dysarthria Remediation: An Updated Review.

J Speech Lang Hear Res 2021 Jul 21:1-14. Epub 2021 Jul 21.

Department of Communication Science and Disorders, Florida State University, Tallahassee.

Purpose Early studies of perceptual learning of dysarthric speech, those summarized in Borrie, McAuliffe, and Liss (2012), yielded preliminary evidence that listeners could to better understand the speech of a person with dysarthria, revealing a potentially promising avenue for future intelligibility interventions. Since then, a programmatic body of research grounded in models of perceptual processing has unfolded. The current review provides an updated account of the state of the evidence in this area and offers direction for moving this work toward clinical implementation. Read More

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Adjuvants: friends in vaccine formulations against infectious diseases.

Hum Vaccin Immunother 2021 Jul 21:1-12. Epub 2021 Jul 21.

Faculty of Science and Phylosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.

Infectious diseases represent a major cause of deaths worldwide. No vaccine or effective treatment exists nowadays, especially against intracellular pathogens. The increase in multiple drug and superbug antibiotic resistance strains, excessive medication, or misuse of drugs has prompted the search for other safe and effective alternatives. Read More

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A low-noise photonic heterodyne synthesizer and its application to millimeter-wave radar.

Nat Commun 2021 Jul 20;12(1):4397. Epub 2021 Jul 20.

Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA.

Microwave photonics offers transformative capabilities for ultra-wideband electronic signal processing and frequency synthesis with record-low phase noise levels. Despite the intrinsic bandwidth of optical systems operating at ~200 THz carrier frequencies, many schemes for high-performance photonics-based microwave generation lack broadband tunability, and experience tradeoffs between noise level, complexity, and frequency. An alternative approach uses direct frequency down-mixing of two tunable semiconductor lasers on a fast photodiode. Read More

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Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A-secreting γδ T cells.

Sci Signal 2021 Jul 20;14(692). Epub 2021 Jul 20.

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.

Murine γδ cells, which are T cells that bear the γδ T cell receptor (TCRγδ) and secrete interleukin-17A (IL-17A), are generated in the thymus and are critical for various immune responses. Although strong TCRγδ signals are required for the development of interferon-γ (IFN-γ)-secreting γδ cells (γδ cells), the generation of γδ cells requires weaker TCRγδ signaling. Here, we demonstrated that constrained activation of the kinase Syk downstream of TCRγδ was required for the thymic development of γδ cells. Read More

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JUNB suppresses distant metastasis by influencing the initial metastatic stage.

Clin Exp Metastasis 2021 Jul 19. Epub 2021 Jul 19.

Division of Signal Transduction and Growth Control, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

The complex interactions between cells of the tumor microenvironment and cancer cells are considered a major determinant of cancer progression and metastasis. Yet, our understanding of the mechanisms of metastatic disease is not sufficient to successfully treat patients with advanced-stage cancer. JUNB is a member of the AP-1 transcription factor family shown to be frequently deregulated in human cancer and associated with invasion and metastasis. Read More

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Elimination of noise in optically rephased photon echoes.

Nat Commun 2021 Jul 19;12(1):4378. Epub 2021 Jul 19.

CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei, China.

Photon echo is a fundamental tool for the manipulation of electromagnetic fields. Unavoidable spontaneous emission noise is generated in this process due to the strong rephasing pulse, which limits the achievable signal-to-noise ratio and represents a fundamental obstacle towards their applications in the quantum regime. Here we propose a noiseless photon-echo protocol based on a four-level atomic system. Read More

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Comparison of SARS-CoV-2 Detection by Rapid Antigen and by Three Commercial RT-qPCR Tests: A Study from Martin University Hospital in Slovakia.

Int J Environ Res Public Health 2021 07 1;18(13). Epub 2021 Jul 1.

Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.

The global pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is having a tremendous impact on the global economy, health care systems and the lives of almost all people in the world. The Central European country of Slovakia reached one of the highest daily mortality rates per 100,000 inhabitants in the first 3 months of 2021, despite implementing strong prophylactic measures, lockdowns and repeated nationwide antigen testing. The present study reports a comparison of the performance of the Standard Q COVID-19 antigen test (SD Biosensor) with three commercial RT-qPCR kits (vDetect COVID-19-MultiplexDX, gb SARS-CoV-2 Multiplex-GENERI BIOTECH Ltd. Read More

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Amino group-driven distinguishing homocysteine from cysteine and glutathione in photoluminesecent signal of the iridium(III) complexes.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 10;263:120167. Epub 2021 Jul 10.

Key Laboratory of Analytical Science for Food Safety and Biology (Ministry of Education and Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 350116, PR China. Electronic address:

In this work, six iridium(III) complexes have been designed, synthesized and characterized. The molecular structures of complex 1 ([(pba)Ir(bpy-2N(CH))]PF), 2 ([(pba)Ir(bpy-2NH)]PF) and 3 ([(pba)Ir(bpy-2CH)]PF) were determined by single crystal X-ray diffraction. Upon addition of Hcy (homocysteine) to the solution of complex 1, a luminescent variation from orange red to green was observed by the naked eye, corresponding to a large blue shift from 604 nm to 498 nm (~106 nm). Read More

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Application of multi-layer denoising based on ensemble empirical mode decomposition in extraction of fault feature of rotating machinery.

PLoS One 2021 19;16(7):e0254747. Epub 2021 Jul 19.

National Engineering Laboratory for Highway Maintenance Equipment, Chang'an University, Xi'an, China.

Aiming at the problem that the weak features of non-stationary vibration signals are difficult to extract under strong background noise, a multi-layer noise reduction method based on ensemble empirical mode decomposition (EEMD) is proposed. First, the original vibration signal is decomposed by EEMD, and the main intrinsic modal components (IMF) are selected using comprehensive evaluation indicators; the second layer of filtering uses wavelet threshold denoising (WTD) to process the main IMF components. Finally, the virtual noise channel is introduced, and FastICA is used to de-noise and unmix the IMF components processed by the WTD. Read More

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Monolayer and Bilayer Graphene on Ru(0001): Layer-Specific and Moiré-Site-Dependent Phonon Excitations.

J Phys Chem Lett 2021 Jul 19:6889-6894. Epub 2021 Jul 19.

Institut für Physik, Technische Universität Ilmenau, D-98693 Ilmenau, Germany.

Graphene phonons are excited by the local injection of electrons and holes from the tip of a scanning tunneling microscope. Despite the strong graphene-Ru(0001) hybridization, monolayer graphene unexpectedly exhibits pronounced phonon signatures in inelastic electron tunneling spectroscopy. Spatially resolved spectroscopy reveals that the strength of the phonon signal depends on the site of the moiré lattice with a substantial red-shift of phonon energies compared to those of free graphene. Read More

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Transparent, Flexible Plasmonic Ag NP/PMMA Substrates Using Chemically Patterned Ferroelectric Crystals for Detecting Pesticides on Curved Surfaces.

ACS Appl Mater Interfaces 2021 Jul 18. Epub 2021 Jul 18.

CL Technology Co., Ltd., New Taipei 24158, Taiwan.

Transparent and flexible surface-enhanced Raman scattering (SERS) substrates have attracted much interest for the detection of probe molecules on the curved surfaces of real samples, but a facile route to fabricate such substrates is still lacking. Herein, we present a rationally designed, high-performance flexible SERS substrate fabricated using a simple drop and peel-off technique for the ultrasensitive detection of pesticides. The proposed SERS substrate consists of a polymethyl methacrylate (PMMA) film anchored with plasmonic silver nanoparticles (Ag NPs), which are photoreduced using chemically patterned ferroelectric templates. Read More

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Identification of a Putative β-Arrestin Superagonist of the Growth Hormone Secretagogue Receptor (GHSR).

ChemMedChem 2021 Jul 18. Epub 2021 Jul 18.

Kitasato University: Kitasato Daigaku, School of Pharmacy, JAPAN.

Ghrelin is a pleiotropic feeding hormone which also has a pivotal role in the central nervous system. Upon the activation of its receptor, growth hormone secretagogue receptor (GHSR), the Gα q/11 -mediated and the β-arrestin-mediated signaling pathways are activated. As the β-arrestin pathway is a potential drug target, there is a strong need for β-arrestin-biased GHSR modulators. Read More

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Chemistry platform for the ultrafast continuous synthesis of high quality III-V quantum dots.

Chemistry 2021 Jul 18. Epub 2021 Jul 18.

Institut de Chimie de la Matière Condensée de Bordeaux, Supercritical Fluids, 87 Avenue du Dr Albert Schweitzer, 33608, Pessac Cedex, FRANCE.

A chemistry platform for the fast continuous synthesis of III-V quantum dots is demonstrated. III-nitride QDs are prepared using short residence times (less than 30 s) in a one-step continuous process with supercritical solvents. GaN QDs prepared via this route exhibit strong UV photoluminescence with a structuring of the emission signal at low temperature (5K), confirming their high quality. Read More

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